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GPR182 G protein-coupled receptor 182 [ Homo sapiens (human) ]

Gene ID: 11318, updated on 3-Apr-2024

Summary

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Official Symbol
GPR182provided by HGNC
Official Full Name
G protein-coupled receptor 182provided by HGNC
Primary source
HGNC:HGNC:13708
See related
Ensembl:ENSG00000166856 MIM:605307; AllianceGenome:HGNC:13708
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AMR; 7TMR; ADMR; AM-R; G10D; L1-R; gamrh; hrhAMR
Summary
Adrenomedullin is a potent vasodilator peptide that exerts major effects on cardiovascular function. This gene encodes a seven-transmembrane protein that belongs to the family 1 of G-protein coupled receptors. Studies of the rat counterpart suggest that the encoded protein may function as a receptor for adrenomedullin. [provided by RefSeq, Jul 2008]
Expression
Biased expression in spleen (RPKM 5.1), testis (RPKM 0.9) and 4 other tissues See more
Orthologs
mouse all
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Genomic context

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See GPR182 in Genome Data Viewer
Location:
12q13.3
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (56994492..56998877)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (56962361..56966316)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (57388276..57392231)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene retinol dehydrogenase 16 Neighboring gene origin of replication ori6 Neighboring gene uncharacterized LOC124902945 Neighboring gene retinol dehydrogenase 16 (all-trans) pseudogene Neighboring gene CRISPRi-validated cis-regulatory element chr12.2240 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4567 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4568 Neighboring gene zinc finger and BTB domain containing 39 Neighboring gene tachykinin precursor 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:57423222-57424059 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6520 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6521 Neighboring gene myosin IA Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr12:57440635-57441834

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Localization and distribution of adrenomedullin receptor in the human placenta: changes with gestational age. Marinoni E, et al. J Reprod Med, 2007 Sep. PMID 17939601
  2. Genomic organization and regulation of a human 7-helix transmembrane receptor which is expressed in pulmonary epithelial cells and induced in hypoxia. Hänze J, et al. Biochem Biophys Res Commun, 2002 Mar 15. PMID 11883938
  3. Role of adrenomedullin and its receptor system in renal pathophysiology. Mukoyama M, et al. Peptides, 2001 Nov. PMID 11754983
  4. Adrenomedullin: a vasoactive and natriuretic peptide with therapeutic potential. Lah JJ, et al. Heart Dis, 2000 May-Jun. PMID 11728267
  5. Expression of adrenomedullin and proadrenomedullin N-terminal 20 peptide in human and rat prostate. Jiménez N, et al. J Histochem Cytochem, 1999 Sep. PMID 10449538

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GPR182 limits antitumor immunity via chemokine scavenging in mouse melanoma models.
    Title: GPR182 limits antitumor immunity via chemokine scavenging in mouse melanoma models.
  2. GPR182 is an endothelium-specific atypical chemokine receptor that maintains hematopoietic stem cell homeostasis.
    Title: GPR182 is an endothelium-specific atypical chemokine receptor that maintains hematopoietic stem cell homeostasis.
  3. Our data demonstrate that GPR182 is an endothelial subtype-specific marker for human sinusoidal EC of the liver, spleen, lymph node and bone marrow. In addition, we provide evidence for GPR182-dependent downstream signaling via ERK and SRF pathways that may be involved in regulating endothelial subtype-specific sinusoidal differentiation and sinusoidal functions such as permeability.
    Title: GPR182 is a novel marker for sinusoidal endothelial differentiation with distinct GPCR signaling activity in vitro.
  4. Gene expression of adrenomedullin receptor components are differentially regulated in the uterus during the estrous cycle.
    Title: Intermedin in rat uterus: changes in gene expression and peptide levels across the estrous cycle and its effects on uterine contraction.
  5. ADMR mediates the stimulatory effects of adrenomedullin on cancer cells and on endothelial and stellate cells within the tumor microenvironment
    Title: The ADMR receptor mediates the effects of adrenomedullin on pancreatic cancer cells and on cells of the tumor microenvironment.
  6. distribution of adrenomedullin receptor (AM-R )in the villous and extravillous trophoblast cells of the placenta and in chorion and decidua cells of the fetal membranes changed with gestational age but not with labor
    Title: Localization and distribution of adrenomedullin receptor in the human placenta: changes with gestational age.
  7. Hybridization in situ showed that ADMR mRNA expression was significantly higher in pulmonary artery walls in patients with chronic obstructive pulmonary disease.
    Title: [Study of the expression and role of adrenomedullin and adrenomedullin receptor in patients with chronic obstructive pulmonary disease].
  8. The cardiovascular response in sepsis: proposed mechanisms of the beneficial effect of adrenomedullin and its binding protein (review).
    Title: The cardiovascular response in sepsis: proposed mechanisms of the beneficial effect of adrenomedullin and its binding protein (review).
  9. Endogenous ADM system plays a potentially important role in the paracrine or autocrine functional control of Conn's adenomas.
    Title: Expression and function of adrenomedullin and its receptors in Conn's adenoma cells.
  10. The co-expression of Adm and its receptor in perineural fibroblasts and the expression of an Adm receptor in Schwann cells suggest autocrine and/or paracrine modes of action of Adm in peripheral nerves.
    Title: Paracrine/autocrine function of adrenomedullin in peripheral nerves of rats.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of G protein-coupled receptor 182 (GPR182) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC34399

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane signaling receptor activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in cell surface receptor signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane TAS
Traceable Author Statement
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
G-protein coupled receptor 182
Names
adrenomedullin receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007264.4 → NP_009195.1  G-protein coupled receptor 182

    See identical proteins and their annotated locations for NP_009195.1

    Status: REVIEWED

    Source sequence(s)
    AC026120, BC034761
    Consensus CDS
    CCDS8927.1
    UniProtKB/Swiss-Prot
    O15218
    UniProtKB/TrEMBL
    Q6LAJ3
    Related
    ENSP00000300098.1, ENST00000300098.3
    Conserved Domains (1) summary
    cd14988
    Location:54 → 331
    7tmA_GPR182; G protein-coupled receptor 182, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    56994492..56998877
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047428198.1 → XP_047284154.1  G-protein coupled receptor 182 isoform X1

    UniProtKB/Swiss-Prot
    O15218

  2. XM_011537827.4 → XP_011536129.1  G-protein coupled receptor 182 isoform X1

    See identical proteins and their annotated locations for XP_011536129.1

    UniProtKB/Swiss-Prot
    O15218
    UniProtKB/TrEMBL
    Q6LAJ3
    Conserved Domains (1) summary
    cd14988
    Location:54 → 331
    7tmA_GPR182; G protein-coupled receptor 182, member of the class A family of seven-transmembrane G protein-coupled receptors

  3. XM_011537824.4 → XP_011536126.1  G-protein coupled receptor 182 isoform X1

    See identical proteins and their annotated locations for XP_011536126.1

    UniProtKB/Swiss-Prot
    O15218
    UniProtKB/TrEMBL
    Q6LAJ3
    Conserved Domains (1) summary
    cd14988
    Location:54 → 331
    7tmA_GPR182; G protein-coupled receptor 182, member of the class A family of seven-transmembrane G protein-coupled receptors

  4. XM_011537825.4 → XP_011536127.1  G-protein coupled receptor 182 isoform X1

    See identical proteins and their annotated locations for XP_011536127.1

    UniProtKB/Swiss-Prot
    O15218
    UniProtKB/TrEMBL
    Q6LAJ3
    Conserved Domains (1) summary
    cd14988
    Location:54 → 331
    7tmA_GPR182; G protein-coupled receptor 182, member of the class A family of seven-transmembrane G protein-coupled receptors

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    56962361..56966316
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054370942.1 → XP_054226917.1  G-protein coupled receptor 182 isoform X1

    UniProtKB/Swiss-Prot
    O15218

  2. XM_054370943.1 → XP_054226918.1  G-protein coupled receptor 182 isoform X1

    UniProtKB/Swiss-Prot
    O15218

  3. XM_054370944.1 → XP_054226919.1  G-protein coupled receptor 182 isoform X1

    UniProtKB/Swiss-Prot
    O15218
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O15218.1 GenPept UniProtKB/Swiss-Prot:O15218

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