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CD300A CD300a molecule [ Homo sapiens (human) ]

Gene ID: 11314, updated on 5-Mar-2024

Summary

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Official Symbol
CD300Aprovided by HGNC
Official Full Name
CD300a moleculeprovided by HGNC
Primary source
HGNC:HGNC:19319
See related
Ensembl:ENSG00000167851 MIM:606790; AllianceGenome:HGNC:19319
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IRC1; IRC2; CLM-8; IRp60; IGSF12; CMRF35H; CMRF-35H; CMRF35-H; CMRF35H9; CMRF35-H9; IRC1/IRC2; CMRF-35-H9
Summary
This gene encodes a member of the CD300 glycoprotein family of cell surface proteins found on leukocytes involved in immune response signaling pathways. This gene is located on chromosome 17 in a cluster with all but one of the other family members. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
Expression
Broad expression in spleen (RPKM 24.5), appendix (RPKM 12.1) and 14 other tissues See more
Orthologs
mouse all
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Genomic context

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See CD300A in Genome Data Viewer
Location:
17q25.1
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (74466373..74484798)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (75356904..75375324)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (72462512..72480937)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene RNA, 5S ribosomal pseudogene 448 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72420638-72421138 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72422872-72423636 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8932 Neighboring gene G protein-coupled receptor class C group 5 member C Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12705 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72440360-72440904 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72440905-72441448 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72448210-72449201 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72449202-72450192 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:72450947-72451617 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12706 Neighboring gene uncharacterized LOC124904056 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8934 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8935 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12707 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12708 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12709 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12710 Neighboring gene uncharacterized LOC107985074 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12711 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12712 Neighboring gene CD300 molecule like family member b Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72535116-72535616 Neighboring gene CD300c molecule

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The Phosphatidylserine and Phosphatidylethanolamine Receptor CD300a Binds Dengue Virus and Enhances Infection. Carnec X, et al. J Virol, 2016 Jan 1. PMID 26468529, Free PMC Article
  2. Suppression of CD300A inhibits the growth of diffuse large B-cell lymphoma. Jiang L, et al. Oncotarget, 2015 Oct 13. PMID 26435477, Free PMC Article
  3. Mechanism of phosphatidylserine inhibition of IgE/FcεRI-dependent anaphylactic human basophil degranulation via CD300a. Sabato V, et al. J Allergy Clin Immunol, 2014 Sep. PMID 24815424
  4. Identification of CD300a as a new hypoxia-inducible gene and a regulator of CCL20 and VEGF production by human monocytes and macrophages. Raggi F, et al. Innate Immun, 2014 Oct. PMID 24131792
  5. Transcriptional profiling of human monocytes identifies the inhibitory receptor CD300a as regulator of transendothelial migration. Ghavampour S, et al. PLoS One, 2013. PMID 24058511, Free PMC Article

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CD300a and CD300f molecules regulate the function of leukocytes.
    Title: CD300a and CD300f molecules regulate the function of leukocytes.
  2. CD300 molecules participate in the mechanisms that viruses employ to develop immune evasion strategies and to infect host cells [Review].
    Title: CD300 receptor family in viral infections.
  3. Results provide an insight into the novel set of paired receptors CD300a and CD300c that are distinctively expressed on CD56(bright) natural killers (NK) cells with varied effector functions and show there differential binding to their ligands phosphatidylethanolamine and phosphatidylserine (PS) resulting in their differential ability to affect CD56(bright) NK cell functions.
    Title: CD300c is uniquely expressed on CD56 bright Natural Killer Cells and differs from CD300a upon ligand recognition.
  4. High CD300A expression is associated with diffuse large B-cell lymphoma.
    Title: Suppression of CD300A inhibits the growth of diffuse large B-cell lymphoma.
  5. US3 protein kinase of pseudorabies virus triggers the binding of the inhibitory natural killer cell receptor CD300a to the surface of the infected cell, and protects of virus infected cells against natural killer cell-mediated lysis.
    Title: Pseudorabies Virus US3 Protein Kinase Protects Infected Cells from NK Cell-Mediated Lysis via Increased Binding of the Inhibitory NK Cell Receptor CD300a.
  6. Overall, these data indicate that CD300a is a novel Dengue virus binding receptor that recognizes phosphatidylethanolamine and phosphatidylserine present on virions and enhance infection.
    Title: The Phosphatidylserine and Phosphatidylethanolamine Receptor CD300a Binds Dengue Virus and Enhances Infection.
  7. Data show that peroxisome proliferator activator receptor delta (PPARdelta/beta) directly regulates CD300a protein in macrophages.
    Title: PPARβ/δ activation of CD300a controls intestinal immunity.
  8. CD300a induction by the hypoxic environment represents a mechanism of regulation of monocyte/macrophage pro-inflammatory responses at pathologic sites
    Title: Identification of CD300a as a new hypoxia-inducible gene and a regulator of CCL20 and VEGF production by human monocytes and macrophages.
  9. interaction with phosphatidylserines inhibits IgE/FcepsilonRI-dependent anaphylactic basophil degranulation
    Title: Mechanism of phosphatidylserine inhibition of IgE/FcεRI-dependent anaphylactic human basophil degranulation via CD300a.
  10. The inhibitory receptor CD300a is regulator of monocytes transendothelial migration.
    Title: Transcriptional profiling of human monocytes identifies the inhibitory receptor CD300a as regulator of transendothelial migration.
Submit: New GeneRIF Correction See all GeneRIFs (25)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif downregulates the expression of CD300a molecule (CD300A) in Vif-expression T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables phosphatidylethanolamine binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylserine binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in immune system process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of B cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of B cell receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of MAP kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of MyD88-dependent toll-like receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of NK T cell activation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of activation of Janus kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of eosinophil activation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of eosinophil migration IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of fibroblast proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of mast cell activation involved in immune response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of mast cell degranulation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of neutrophil activation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of phagocytosis, engulfment IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of phosphoprotein phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of T cell receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular exosome HDA PubMed 
located_in ficolin-1-rich granule membrane TAS
Traceable Author Statement
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in tertiary granule membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
CMRF35-like molecule 8
Names
CD300 antigen-like family member A
CD300a antigen
CMRF35H leukocyte immunoglobulin-like receptor
NK inhibitory receptor
immunoglobulin superfamily member 12
inhibitory receptor protein 60
leukocyte membrane antigen

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256841.2 → NP_001243770.1  CMRF35-like molecule 8 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001243770.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 5' coding region compared to variant 1. The resulting protein (isoform 2), also referred to as IRC1c, is shorter compared to isoform 1.
    Source sequence(s)
    AC079325, AJ010102, BF059016
    Consensus CDS
    CCDS58590.1
    UniProtKB/Swiss-Prot
    Q9UGN4
    Related
    ENSP00000308188.5, ENST00000310828.9
    Conserved Domains (1) summary
    pfam15330
    Location:86 → 160
    SIT; SHP2-interacting transmembrane adaptor protein, SIT

  2. NM_001330456.1 → NP_001317385.1  CMRF35-like molecule 8 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC079325
    Consensus CDS
    CCDS82197.1
    UniProtKB/TrEMBL
    J3QKQ4
    Related
    ENSP00000497133.1, ENST00000648095.1

  3. NM_001330457.2 → NP_001317386.1  CMRF35-like molecule 8 isoform 4 precursor

    Status: VALIDATED

    Source sequence(s)
    AC079325
    Consensus CDS
    CCDS82196.1
    UniProtKB/Swiss-Prot
    Q9UGN4
    Related
    ENSP00000376401.3, ENST00000392625.7

  4. NM_007261.4 → NP_009192.2  CMRF35-like molecule 8 isoform 1 precursor

    See identical proteins and their annotated locations for NP_009192.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1), also referred to as IRC1a.
    Source sequence(s)
    BC032352
    Consensus CDS
    CCDS32720.1
    UniProtKB/Swiss-Prot
    A8MW96, O95100, Q9HD97, Q9P0F3, Q9UBK4, Q9UGN4, Q9UMS9, Q9UMT0
    Related
    ENSP00000353259.3, ENST00000360141.8
    Conserved Domains (3) summary
    cd05716
    Location:23 → 117
    Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
    smart00410
    Location:22 → 105
    IG_like; Immunoglobulin like
    pfam15330
    Location:199 → 273
    SIT; SHP2-interacting transmembrane adaptor protein, SIT

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    74466373..74484798
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005256990.4 → XP_005257047.1  CMRF35-like molecule 8 isoform X1

    Conserved Domains (2) summary
    cd05716
    Location:23 → 117
    Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
    smart00410
    Location:22 → 105
    IG_like; Immunoglobulin like

  2. XM_005256991.6 → XP_005257048.1  CMRF35-like molecule 8 isoform X2

    Conserved Domains (2) summary
    cd05716
    Location:23 → 117
    Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
    smart00410
    Location:22 → 105
    IG_like; Immunoglobulin like

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_025791806.1 Reference GRCh38.p14 PATCHES

    Range
    42821..61246
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054333228.1 → XP_054189203.1  CMRF35-like molecule 8 isoform X1

  2. XM_054333229.1 → XP_054189204.1  CMRF35-like molecule 8 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    75356904..75375324
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054314909.1 → XP_054170884.1  CMRF35-like molecule 8 isoform X1

  2. XM_054314910.1 → XP_054170885.1  CMRF35-like molecule 8 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UGN4.2 GenPept UniProtKB/Swiss-Prot:Q9UGN4

Gene LinkOut

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