U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

CDCA5 cell division cycle associated 5 [ Homo sapiens (human) ]

Gene ID: 113130, updated on 8-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
CDCA5provided by HGNC
Official Full Name
cell division cycle associated 5provided by HGNC
Primary source
HGNC:HGNC:14626
See related
Ensembl:ENSG00000146670 MIM:609374; AllianceGenome:HGNC:14626
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SORORIN
Summary
Predicted to enable chromatin binding activity. Involved in double-strand break repair; mitotic sister chromatid segregation; and regulation of cell cycle process. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in bone marrow (RPKM 12.1), testis (RPKM 11.0) and 13 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
11q13.1
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (65061093..65084040, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (65054375..65077318, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (64844925..64851512, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ARL2-SNX15 readthrough (NMD candidate) Neighboring gene Sharpr-MPRA regulatory region 4003 Neighboring gene sorting nexin 15 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4937 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4938 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3506 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3507 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:64811302-64811848 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:64814570-64815448 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:64815449-64816327 Neighboring gene SAC3 domain containing 1 Neighboring gene N-acetylated alpha-linked acidic dipeptidase like 1 Neighboring gene Sharpr-MPRA regulatory region 288 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:64846103-64846604 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4939 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4940 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:64852413-64852997 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:64857368-64857540 Neighboring gene zinc finger protein like 1 Neighboring gene transmembrane protein 262 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:64863491-64864285 Neighboring gene Sharpr-MPRA regulatory region 6888 Neighboring gene VPS51 subunit of GARP complex Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:64877599-64878526 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:64878527-64879452

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. CDCA5 promotes the progression of breast cancer and serves as a potential prognostic biomarker. Hu H, et al. Oncol Rep, 2022 Oct. PMID 36004470, Free PMC Article
  2. Loss of cell division cycle‑associated 5 promotes cell apoptosis by activating DNA damage response in clear cell renal cell carcinoma. Huang X, et al. Int J Oncol, 2022 Jul. PMID 35642672, Free PMC Article
  3. Silencing oncogene cell division cycle associated 5 induces apoptosis and G1 phase arrest of non-small cell lung cancer cells via p53-p21 signaling pathway. Shen W, et al. J Clin Lab Anal, 2022 May. PMID 35373420, Free PMC Article
  4. CDCA5 promotes the progression of prostate cancer by affecting the ERK signalling pathway. Ji J, et al. Oncol Rep, 2021 Mar. PMID 33650660, Free PMC Article
  5. Downregulation of CDCA5 Can Inhibit Cell Proliferation, Migration, and Invasion, and Induce Apoptosis of Prostate Cancer Cells. Chong Y, et al. Crit Rev Eukaryot Gene Expr, 2021. PMID 33639053

See all (73) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CDCA5 promoted cell invasion and migration by activating TGF-beta1 pathway in human ovarian cancer cells.
    Title: CDCA5 promoted cell invasion and migration by activating TGF-β1 pathway in human ovarian cancer cells.
  2. KLF5-mediated CDCA5 expression promotes tumor development and progression of epithelial ovarian carcinoma.
    Title: KLF5-mediated CDCA5 expression promotes tumor development and progression of epithelial ovarian carcinoma.
  3. CDCA5 promotes the progression of breast cancer and serves as a potential prognostic biomarker.
    Title: CDCA5 promotes the progression of breast cancer and serves as a potential prognostic biomarker.
  4. Loss of cell division cycleassociated 5 promotes cell apoptosis by activating DNA damage response in clear cell renal cell carcinoma.
    Title: Loss of cell division cycle‑associated 5 promotes cell apoptosis by activating DNA damage response in clear cell renal cell carcinoma.
  5. Knockdown of CDCA5 suppresses malignant progression of breast cancer cells by regulating PDS5A.
    Title: Knockdown of CDCA5 suppresses malignant progression of breast cancer cells by regulating PDS5A.
  6. Silencing oncogene cell division cycle associated 5 induces apoptosis and G1 phase arrest of non-small cell lung cancer cells via p53-p21 signaling pathway.
    Title: Silencing oncogene cell division cycle associated 5 induces apoptosis and G1 phase arrest of non-small cell lung cancer cells via p53-p21 signaling pathway.
  7. TPI1 activates the PI3K/AKT/mTOR signaling pathway to induce breast cancer progression by stabilizing CDCA5.
    Title: TPI1 activates the PI3K/AKT/mTOR signaling pathway to induce breast cancer progression by stabilizing CDCA5.
  8. CDCA5 is negatively regulated by miR-326 and boosts ovarian cancer progression.
    Title: CDCA5 is negatively regulated by miR-326 and boosts ovarian cancer progression.
  9. LINC01515 promotes nasopharyngeal carcinoma progression by serving as a sponge for miR-325 to up-regulate CDCA5.
    Title: LINC01515 promotes nasopharyngeal carcinoma progression by serving as a sponge for miR-325 to up-regulate CDCA5.
  10. Downregulation of CDCA5 Can Inhibit Cell Proliferation, Migration, and Invasion, and Induce Apoptosis of Prostate Cancer Cells.
    Title: Downregulation of CDCA5 Can Inhibit Cell Proliferation, Migration, and Invasion, and Induce Apoptosis of Prostate Cancer Cells.
Submit: New GeneRIF Correction See all GeneRIFs (35)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC16386

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables chromatin binding TAS
Traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in double-strand break repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in double-strand break repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic cell cycle IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mitotic chromosome condensation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic metaphase chromosome alignment IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic metaphase chromosome alignment IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic sister chromatid cohesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic sister chromatid cohesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic sister chromatid cohesion IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in positive regulation of exit from mitosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of exit from mitosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of chromatin ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in chromosome TAS
Traceable Author Statement
more info
  
located_in chromosome, centromeric region TAS
Traceable Author Statement
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

Go to the top of the page Help
Preferred Names
sororin
Names
cell division cycle-associated protein 5
p35

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_080668.4 → NP_542399.1  sororin

    See identical proteins and their annotated locations for NP_542399.1

    Status: VALIDATED

    Source sequence(s)
    AP003068, BC011000
    Consensus CDS
    CCDS8091.1
    UniProtKB/Swiss-Prot
    A8K625, Q96FF9
    UniProtKB/TrEMBL
    B5MBX0
    Related
    ENSP00000275517.3, ENST00000275517.8
    Conserved Domains (1) summary
    pfam09666
    Location:89 → 209
    Sororin; Sororin protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    65061093..65084040 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011544743.4 → XP_011543045.1  sororin isoform X3

    Conserved Domains (1) summary
    pfam09666
    Location:89 → 209
    Sororin; Sororin protein

  2. XM_017017158.3 → XP_016872647.1  sororin isoform X4

  3. XM_011544747.4 → XP_011543049.1  sororin isoform X5

  4. XM_005273734.5 → XP_005273791.1  sororin isoform X2

    Conserved Domains (1) summary
    pfam09666
    Location:89 → 209
    Sororin; Sororin protein

  5. XM_005273733.5 → XP_005273790.1  sororin isoform X1

    Conserved Domains (1) summary
    pfam09666
    Location:89 → 209
    Sororin; Sororin protein

  6. XM_011544749.4 → XP_011543051.1  sororin isoform X7

    Conserved Domains (1) summary
    pfam09666
    Location:89 → 209
    Sororin; Sororin protein

  7. XM_011544748.4 → XP_011543050.1  sororin isoform X6

    Conserved Domains (1) summary
    pfam09666
    Location:89 → 209
    Sororin; Sororin protein

RNA

  1. XR_001747758.3 RNA Sequence

  2. XR_001747757.3 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    65054375..65077318 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054367586.1 → XP_054223561.1  sororin isoform X3

  2. XM_054367587.1 → XP_054223562.1  sororin isoform X4

  3. XM_054367588.1 → XP_054223563.1  sororin isoform X5

  4. XM_054367584.1 → XP_054223559.1  sororin isoform X1

  5. XM_054367585.1 → XP_054223560.1  sororin isoform X2

  6. XM_054367590.1 → XP_054223565.1  sororin isoform X7

  7. XM_054367589.1 → XP_054223564.1  sororin isoform X6

RNA

  1. XR_008488337.1 RNA Sequence

  2. XR_008488336.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96FF9.1 GenPept UniProtKB/Swiss-Prot:Q96FF9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous