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GPR45 G protein-coupled receptor 45 [ Homo sapiens (human) ]

Gene ID: 11250, updated on 5-Mar-2024

Summary

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Official Symbol
GPR45provided by HGNC
Official Full Name
G protein-coupled receptor 45provided by HGNC
Primary source
HGNC:HGNC:4503
See related
Ensembl:ENSG00000135973 MIM:604838; AllianceGenome:HGNC:4503
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PSP24; PSP24A; PSP24(ALPHA)
Summary
This intronless gene encodes a member of the G protein-coupled receptor (GPCR) family. Members of this protein family contain seven putative transmembrane domains and may mediate signaling processes to the interior of the cell via activation of heterotrimeric G proteins. This protein may function in the central nervous system. [provided by RefSeq, Jul 2008]
Orthologs
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Genomic context

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See GPR45 in Genome Data Viewer
Location:
2q12.1
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (105241743..105243467)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (105702860..105704584)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (105858200..105859924)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1918 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr2:105794407-105794906 Neighboring gene uncharacterized LOC105373528 Neighboring gene NANOG hESC enhancer GRCh37_chr2:105813700-105814274 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:105866724-105867602 Neighboring gene transforming growth factor beta receptor associated protein 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16313 Neighboring gene Sharpr-MPRA regulatory region 6730 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11837 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16314 Neighboring gene C2orf49 divergent transcript

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mammalian PSP24s (alpha and beta isoforms) are not responsive to lysophosphatidic acid in mammalian expression systems. Kawasawa Y, et al. Biochem Biophys Res Commun, 2000 Oct 5. PMID 11027575
  2. Brain-specific expression of novel G-protein-coupled receptors, with homologies to Xenopus PSP24 and human GPR45. Kawasawa Y, et al. Biochem Biophys Res Commun, 2000 Oct 5. PMID 11027574
  3. Discovery of three novel orphan G-protein-coupled receptors. Marchese A, et al. Genomics, 1999 Feb 15. PMID 10036181
  4. Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. Perry JR, et al. Nature, 2014 Oct 2. PMID 25231870, Free PMC Article
  5. Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening. Wu C, et al. Proteomics, 2007 Jun. PMID 17474147

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
probable G-protein coupled receptor 45
Names
PSP24-1
PSP24-alpha
high-affinity lysophosphatidic acid receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007227.3 → NP_009158.3  probable G-protein coupled receptor 45

    See identical proteins and their annotated locations for NP_009158.3

    Status: REVIEWED

    Source sequence(s)
    AC012360, BC066880
    Consensus CDS
    CCDS2066.1
    UniProtKB/Swiss-Prot
    Q6NWS4, Q6NXU6, Q9Y5Y3
    UniProtKB/TrEMBL
    B5B0C1, O43898
    Related
    ENSP00000258456.1, ENST00000258456.3
    Conserved Domains (1) summary
    cd15403
    Location:35 → 335
    7tmA_GPR45; G protein-coupled receptor 45, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    105241743..105243467
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    105702860..105704584
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y5Y3.2 GenPept UniProtKB/Swiss-Prot:Q9Y5Y3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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