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KAT7 lysine acetyltransferase 7 [ Homo sapiens (human) ]

Gene ID: 11143, updated on 11-Apr-2024

Summary

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Official Symbol
KAT7provided by HGNC
Official Full Name
lysine acetyltransferase 7provided by HGNC
Primary source
HGNC:HGNC:17016
See related
Ensembl:ENSG00000136504 MIM:609880; AllianceGenome:HGNC:17016
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HBO1; HBOA; MYST2; ZC2HC7
Summary
The protein encoded by this gene is part of the multimeric HBO1 complex, which possesses histone H4-specific acetyltransferase activity. This activity is required for functional replication origins and is involved in transcriptional activation of some genes. In both cases, the acetylation of histone H4 helps unfold chromatin so that the DNA can be accessed and replicated or transcribed. [provided by RefSeq, Oct 2016]
Expression
Broad expression in testis (RPKM 37.1), bone marrow (RPKM 22.8) and 24 other tissues See more
Orthologs
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Genomic context

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Location:
17q21.33
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (49788681..49835026)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (50651771..50698127)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (47866043..47912388)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984999 Neighboring gene NANOG hESC enhancer GRCh37_chr17:47695165-47695679 Neighboring gene speckle type BTB/POZ protein Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12366 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12367 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12368 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:47784629-47785262 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:47785263-47785896 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:47796530-47797090 Neighboring gene solute carrier family 35 member B1 Neighboring gene family with sequence similarity 117 member A Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12370 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8674 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8675 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:47865191-47865964 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12372 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:47879701-47880202 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:47880203-47880702 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr17:47893039-47894031 Neighboring gene SRP14 pseudogene 3 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:47911219-47911431 Neighboring gene CRISPRi-validated cis-regulatory element chr17.3537 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:47938611-47939558 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:47941593-47942092 Neighboring gene uncharacterized LOC729220 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:47942923-47943617 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:47948287-47949230 Neighboring gene tachykinin precursor 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12373 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:47967128-47967965 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:47967966-47968802 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:47976271-47977012 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:47980751-47981252 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:47986569-47987069 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:47990385-47990940 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr17:47991434-47992633 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:47993407-47993919 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:48001781-48002290 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:48005674-48006873 Neighboring gene MPRA-validated peak2887 silencer Neighboring gene MRT4 homolog, ribosome maturation factor pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. KAT7 promotes radioresistance through upregulating PI3K/AKT signaling in breast cancer. Ma Y, et al. J Radiat Res, 2023 Mar 23. PMID 36724120, Free PMC Article
  2. HBO1 induces histone acetylation and is important for non-small cell lung cancer cell growth. Chen TF, et al. Int J Biol Sci, 2022. PMID 35637972, Free PMC Article
  3. The histone acetyltransferase HBO1 functions as a novel oncogenic gene in osteosarcoma. Gao YY, et al. Theranostics, 2021. PMID 33754016, Free PMC Article
  4. CircMRPS35 suppresses gastric cancer progression via recruiting KAT7 to govern histone modification. Jie M, et al. Mol Cancer, 2020 Mar 12. PMID 32164722, Free PMC Article
  5. HBO1 (KAT7) Does Not Have an Essential Role in Cell Proliferation, DNA Replication, or Histone 4 Acetylation in Human Cells. Kueh AJ, et al. Mol Cell Biol, 2020 Jan 30. PMID 31767635, Free PMC Article

See all (131) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Histone acetylation by HBO1 (KAT7) activates Wnt/beta-catenin signaling to promote leukemogenesis in B-cell acute lymphoblastic leukemia.
    Title: Histone acetylation by HBO1 (KAT7) activates Wnt/β-catenin signaling to promote leukemogenesis in B-cell acute lymphoblastic leukemia.
  2. The lncRNA ADAMTS9-AS1/miR-185-5p/KAT7 ceRNA network inhibits cardiomyocyte hypertrophy in hypertrophic obstructive cardiomyopathy.
    Title: The lncRNA ADAMTS9-AS1/miR-185-5p/KAT7 ceRNA network inhibits cardiomyocyte hypertrophy in hypertrophic obstructive cardiomyopathy.
  3. KAT7 promotes radioresistance through upregulating PI3K/AKT signaling in breast cancer.
    Title: KAT7 promotes radioresistance through upregulating PI3K/AKT signaling in breast cancer.
  4. KAT7-mediated CANX (calnexin) crotonylation regulates leucine-stimulated MTORC1 activity.
    Title: KAT7-mediated CANX (calnexin) crotonylation regulates leucine-stimulated MTORC1 activity.
  5. KAT7 promoted gastric cancer progression through promoting YAP1 activation.
    Title: KAT7 promoted gastric cancer progression through promoting YAP1 activation.
  6. HBO1 induces histone acetylation and is important for non-small cell lung cancer cell growth.
    Title: HBO1 induces histone acetylation and is important for non-small cell lung cancer cell growth.
  7. F. nucleatum targets lncRNA ENO1-IT1 to promote glycolysis and oncogenesis in colorectal cancer.
    Title: F. nucleatum targets lncRNA ENO1-IT1 to promote glycolysis and oncogenesis in colorectal cancer.
  8. LncRNA-KAT7 Negatively Regulates miR-10a Through an Epigenetic Pathway to Participate in Nonsmall Cell Lung Cancer.
    Title: LncRNA-KAT7 Negatively Regulates miR-10a Through an Epigenetic Pathway to Participate in Nonsmall Cell Lung Cancer.
  9. HBO1-MLL interaction promotes AF4/ENL/P-TEFb-mediated leukemogenesis.
    Title: HBO1-MLL interaction promotes AF4/ENL/P-TEFb-mediated leukemogenesis.
  10. HBO1 is a versatile histone acyltransferase critical for promoter histone acylations.
    Title: HBO1 is a versatile histone acyltransferase critical for promoter histone acylations.
Submit: New GeneRIF Correction See all GeneRIFs (59)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
integrase gag-pol Cellular acetyltransferase binds HIV-1 integrase both in vitro and in cells and acetylates three specific lysine's (K264, K266, K273) in the carboxy-terminus of integrase PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA replication origin binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone H3 acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone H3K14 acetyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone H3K23 acetyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone H3K4 acetyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables histone H4 acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone H4 acetyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone H4K12 acetyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
NOT enables histone H4K16 acetyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone H4K5 acetyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone H4K8 acetyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone acetyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication-dependent chromatin disassembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in internal peptidyl-lysine acetylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in natural killer cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of DNA replication IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription, elongation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of hematopoietic stem cell proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of protein localization to nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA replication IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated DNA replication initiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of cell cycle IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of cell growth IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of cell growth ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of nucleotide-excision repair IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to actinomycin D IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to anisomycin IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to dithiothreitol IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to hydroxyurea IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to sorbitol IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in stress-activated protein kinase signaling cascade IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transcription initiation-coupled chromatin remodeling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in chromosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
part_of histone H3-K14 acetyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of histone H3-K14 acetyltransferase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of histone acetyltransferase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of histone acetyltransferase complex IPI
Inferred from Physical Interaction
more info
 PubMed 
NOT located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in site of DNA damage IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
histone acetyltransferase KAT7
Names
K(lysine) acetyltransferase 7
MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2
MYST histone acetyltransferase 2
histone acetyltransferase MYST2
histone acetyltransferase binding to ORC1
NP_001186084.1
NP_001186085.1
NP_001186086.1
NP_001186087.1
NP_001333635.1
NP_008998.1

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051976.2 RefSeqGene

    Range
    5002..51347
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001199155.2 → NP_001186084.1  histone acetyltransferase KAT7 isoform 2

    See identical proteins and their annotated locations for NP_001186084.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC015795, AC027801
    Consensus CDS
    CCDS56035.1
    UniProtKB/TrEMBL
    A0A9L9PXJ9
    Related
    ENSP00000516419.1, ENST00000706506.1
    Conserved Domains (3) summary
    PLN00104
    Location:294 → 579
    PLN00104; MYST -like histone acetyltransferase; Provisional
    cd16378
    Location:209 → 262
    CcmH_N; N-terminal domain of cytochrome c-type biogenesis protein CcmH and related proteins
    pfam01530
    Location:184 → 212
    zf-C2HC; Zinc finger, C2HC type

  2. NM_001199156.2 → NP_001186085.1  histone acetyltransferase KAT7 isoform 3

    See identical proteins and their annotated locations for NP_001186085.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC015795, AC027801
    Consensus CDS
    CCDS56037.1
    UniProtKB/TrEMBL
    B3KVJ2
    Related
    ENSP00000413415.2, ENST00000454930.6
    Conserved Domains (2) summary
    PLN00104
    Location:185 → 470
    PLN00104; MYST -like histone acetyltransferase; Provisional
    pfam01530
    Location:53 → 73
    zf-C2HC; Zinc finger, C2HC type

  3. NM_001199157.2 → NP_001186086.1  histone acetyltransferase KAT7 isoform 4

    See identical proteins and their annotated locations for NP_001186086.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC015795, AC027801
    Consensus CDS
    CCDS56036.1
    UniProtKB/TrEMBL
    A0A9L9PX81
    Related
    ENSP00000424577.1, ENST00000509773.5
    Conserved Domains (3) summary
    PLN00104
    Location:214 → 499
    PLN00104; MYST -like histone acetyltransferase; Provisional
    cd16378
    Location:129 → 182
    CcmH_N; N-terminal domain of cytochrome c-type biogenesis protein CcmH and related proteins
    pfam01530
    Location:113 → 132
    zf-C2HC; Zinc finger, C2HC type

  4. NM_001199158.2 → NP_001186087.1  histone acetyltransferase KAT7 isoform 5

    See identical proteins and their annotated locations for NP_001186087.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks three alternate in-frame exons compared to variant 1. The resulting isoform (5) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC015795, AC027801
    Consensus CDS
    CCDS56038.1
    UniProtKB/TrEMBL
    A0A9L9PX81
    Related
    ENSP00000423385.1, ENST00000510819.5
    Conserved Domains (3) summary
    PLN00104
    Location:155 → 440
    PLN00104; MYST -like histone acetyltransferase; Provisional
    cd16378
    Location:70 → 123
    CcmH_N; N-terminal domain of cytochrome c-type biogenesis protein CcmH and related proteins
    pfam01530
    Location:53 → 73
    zf-C2HC; Zinc finger, C2HC type

  5. NM_001346706.2 → NP_001333635.1  histone acetyltransferase KAT7 isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (6) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC015795, AC027801
    UniProtKB/TrEMBL
    A0A9L9PX81, A0A9L9PXR9
    Related
    ENSP00000516479.1, ENST00000706640.1
    Conserved Domains (2) summary
    PLN00104
    Location:244 → 529
    PLN00104; MYST -like histone acetyltransferase; Provisional
    pfam01530
    Location:113 → 132
    zf-C2HC; Zinc finger, C2HC type

  6. NM_007067.5 → NP_008998.1  histone acetyltransferase KAT7 isoform 1

    See identical proteins and their annotated locations for NP_008998.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC015795, AC027801
    Consensus CDS
    CCDS11554.1
    UniProtKB/Swiss-Prot
    B3KN74, B4DF85, B4DFB4, B4DFE0, B4DGY4, E7ER15, G5E9K7, O95251
    UniProtKB/TrEMBL
    A0AA34QVH8
    Related
    ENSP00000259021.4, ENST00000259021.9
    Conserved Domains (2) summary
    PLN00104
    Location:324 → 609
    PLN00104; MYST -like histone acetyltransferase; Provisional
    pfam01530
    Location:184 → 212
    zf-C2HC; Zinc finger, C2HC type

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    49788681..49835026
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    50651771..50698127
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O95251.1 GenPept UniProtKB/Swiss-Prot:O95251

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