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KATNA1 katanin catalytic subunit A1 [ Homo sapiens (human) ]

Gene ID: 11104, updated on 11-Apr-2024

Summary

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Official Symbol
KATNA1provided by HGNC
Official Full Name
katanin catalytic subunit A1provided by HGNC
Primary source
HGNC:HGNC:6216
See related
Ensembl:ENSG00000186625 MIM:606696; AllianceGenome:HGNC:6216
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. This gene encodes the p80 subunit. This protein is a member of the AAA family of ATPases. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Feb 2011]
Expression
Broad expression in testis (RPKM 18.8), ovary (RPKM 7.2) and 24 other tissues See more
Orthologs
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Genomic context

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Location:
6q25.1
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (149594873..149648990, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (150794606..150848774, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (149916009..149969850, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA2/SNORA34 family Neighboring gene ribosomal protein S18 pseudogene 9 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25266 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17664 Neighboring gene large tumor suppressor kinase 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:150022675-150023256 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17665 Neighboring gene uncharacterized LOC645967 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:150045663-150045865 Neighboring gene nucleoporin 43 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25267 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:150069877-150070842

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. SUMOylation of microtubule-cleaving enzyme KATNA1 promotes microtubule severing and neurite outgrowth. Li S, et al. J Biol Chem, 2022 Sep. PMID 35868557, Free PMC Article
  2. Katanin P60: a potential biomarker for lymph node metastasis and prognosis for non-small cell lung cancer. Wang L, et al. World J Surg Oncol, 2020 Jul 6. PMID 32631334, Free PMC Article
  3. Structural and Molecular Basis for Katanin-Mediated Severing of Glutamylated Microtubules. Shin SC, et al. Cell Rep, 2019 Jan 29. PMID 30699360
  4. Katanin Severing and Binding Microtubules Are Inhibited by Tubulin Carboxy Tails. Bailey ME, et al. Biophys J, 2015 Dec 15. PMID 26682813, Free PMC Article
  5. Aberrant expression of katanin p60 in prostate cancer bone metastasis. Ye X, et al. Prostate, 2012 Feb. PMID 21681775, Free PMC Article

See all (58) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SUMOylation of microtubule-cleaving enzyme KATNA1 promotes microtubule severing and neurite outgrowth.
    Title: SUMOylation of microtubule-cleaving enzyme KATNA1 promotes microtubule severing and neurite outgrowth.
  2. Katanin P60 and P80 in papillary thyroid carcinoma patients: Indicators for exacerbated tumor features and worse disease-free survival.
    Title: Katanin P60 and P80 in papillary thyroid carcinoma patients: Indicators for exacerbated tumor features and worse disease-free survival.
  3. Katanin P60: a potential biomarker for lymph node metastasis and prognosis for non-small cell lung cancer.
    Title: Katanin P60: a potential biomarker for lymph node metastasis and prognosis for non-small cell lung cancer.
  4. A chemical genetics approach to examine the functions of AAA proteins.
    Title: A chemical genetics approach to examine the functions of AAA proteins.
  5. structures of the apo and ATPgammaS-bound states of the catalytic AAA domain of human katanin p60 at 3.0 and 2.9 A resolution, respectively, are reported.
    Title: Structural and Molecular Basis for Katanin-Mediated Severing of Glutamylated Microtubules.
  6. In this study, we identified the main regulatory region of KATNA1 gene encoding katanin-p60 as 5' UTR, which has a key role for its expression, and showed Elk1 binding to KATNA1. Furthermore, we identified that Elk1 decreased katanin-p60 and spastin protein expressions, while mRNA levels were increased upon Elk1 overexpression.
    Title: Elk1 affects katanin and spastin proteins via differential transcriptional and post-transcriptional regulations.
  7. targeting an active version of katanin p60 to the kinetochore can reduce the fidelity of achieving full chromosome alignment in metaphase and could serve as a microtubule disruption tool for the future.
    Title: Creation and testing of a new, local microtubule-disruption tool based on the microtubule-severing enzyme, katanin p60.
  8. CAMSAP3 precisely coordinates with dynein and katanin to regulate the microtubule detachment process.
    Title: CAMSAP3 accumulates in the pericentrosomal area and accompanies microtubule release from the centrosome via katanin.
  9. ASPM-katanin complex controls microtubule disassembly at spindle poles and that misregulation of this process can lead to microcephaly.
    Title: Microtubule minus-end regulation at spindle poles by an ASPM-katanin complex.
  10. Katanin Severing and Binding Microtubules Are Inhibited by Tubulin Carboxy Tails
    Title: Katanin Severing and Binding Microtubules Are Inhibited by Tubulin Carboxy Tails.
Submit: New GeneRIF Correction See all GeneRIFs (16)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables microtubule binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables microtubule severing ATPase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in cytoplasmic microtubule organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cytoplasmic microtubule organization NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in microtubule severing IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
part_of katanin complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
is_active_in microtubule cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule cytoskeleton NAS
Non-traceable Author Statement
more info
 PubMed 
located_in midbody IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitotic spindle pole IDA
Inferred from Direct Assay
more info
 PubMed 
located_in spindle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in spindle pole IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
katanin p60 ATPase-containing subunit A1
Names
katanin p60 (ATPase containing) subunit A 1
katanin p60 subunit A1
p60 katanin
NP_001191005.1
NP_008975.1
XP_005266861.1
XP_016865696.1
XP_016865699.1
XP_047274067.1
XP_054210071.1
XP_054210072.1
XP_054210073.1
XP_054210074.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001204076.2 → NP_001191005.1  katanin p60 ATPase-containing subunit A1 isoform 2

    See identical proteins and their annotated locations for NP_001191005.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks two alternate in-frame exons in the central coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    BC050428, DB031858
    Consensus CDS
    CCDS56456.1
    UniProtKB/Swiss-Prot
    O75449
    Related
    ENSP00000335180.8, ENST00000335643.12
    Conserved Domains (1) summary
    pfam00004
    Location:169 → 305
    AAA; ATPase family associated with various cellular activities (AAA)

  2. NM_007044.4 → NP_008975.1  katanin p60 ATPase-containing subunit A1 isoform 1

    See identical proteins and their annotated locations for NP_008975.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK292090, BC050428, CA426364
    Consensus CDS
    CCDS5217.1
    UniProtKB/Swiss-Prot
    E1P5A3, O75449, Q5TFA8, Q5TFA9, Q86VN2, Q9NU52
    UniProtKB/TrEMBL
    A8K7S5
    Related
    ENSP00000356381.2, ENST00000367411.7
    Conserved Domains (3) summary
    smart00382
    Location:241 → 382
    AAA; ATPases associated with a variety of cellular activities
    pfam00004
    Location:245 → 381
    AAA; ATPase family associated with various cellular activities (AAA)
    pfam09336
    Location:456 → 489
    Vps4_C; Vps4 C terminal oligomerization domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    149594873..149648990 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047418111.1 → XP_047274067.1  katanin p60 ATPase-containing subunit A1 isoform X2

  2. XM_005266804.3 → XP_005266861.1  katanin p60 ATPase-containing subunit A1 isoform X1

    See identical proteins and their annotated locations for XP_005266861.1

    UniProtKB/Swiss-Prot
    E1P5A3, O75449, Q5TFA8, Q5TFA9, Q86VN2, Q9NU52
    UniProtKB/TrEMBL
    A8K7S5
    Related
    ENSP00000335106.5, ENST00000335647.9
    Conserved Domains (3) summary
    smart00382
    Location:241 → 382
    AAA; ATPases associated with a variety of cellular activities
    pfam00004
    Location:245 → 381
    AAA; ATPase family associated with various cellular activities (AAA)
    pfam09336
    Location:456 → 489
    Vps4_C; Vps4 C terminal oligomerization domain

  3. XM_017010207.3 → XP_016865696.1  katanin p60 ATPase-containing subunit A1 isoform X1

    UniProtKB/Swiss-Prot
    E1P5A3, O75449, Q5TFA8, Q5TFA9, Q86VN2, Q9NU52
    UniProtKB/TrEMBL
    A8K7S5
    Conserved Domains (3) summary
    smart00382
    Location:241 → 382
    AAA; ATPases associated with a variety of cellular activities
    pfam00004
    Location:245 → 381
    AAA; ATPase family associated with various cellular activities (AAA)
    pfam09336
    Location:456 → 489
    Vps4_C; Vps4 C terminal oligomerization domain

  4. XM_017010210.3 → XP_016865699.1  katanin p60 ATPase-containing subunit A1 isoform X1

    UniProtKB/Swiss-Prot
    E1P5A3, O75449, Q5TFA8, Q5TFA9, Q86VN2, Q9NU52
    UniProtKB/TrEMBL
    A8K7S5
    Conserved Domains (3) summary
    smart00382
    Location:241 → 382
    AAA; ATPases associated with a variety of cellular activities
    pfam00004
    Location:245 → 381
    AAA; ATPase family associated with various cellular activities (AAA)
    pfam09336
    Location:456 → 489
    Vps4_C; Vps4 C terminal oligomerization domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    150794606..150848774 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054354098.1 → XP_054210073.1  katanin p60 ATPase-containing subunit A1 isoform X2

  2. XM_054354096.1 → XP_054210071.1  katanin p60 ATPase-containing subunit A1 isoform X1

    UniProtKB/Swiss-Prot
    E1P5A3, O75449, Q5TFA8, Q5TFA9, Q86VN2, Q9NU52

  3. XM_054354097.1 → XP_054210072.1  katanin p60 ATPase-containing subunit A1 isoform X1

    UniProtKB/Swiss-Prot
    E1P5A3, O75449, Q5TFA8, Q5TFA9, Q86VN2, Q9NU52

  4. XM_054354099.1 → XP_054210074.1  katanin p60 ATPase-containing subunit A1 isoform X1

    UniProtKB/Swiss-Prot
    E1P5A3, O75449, Q5TFA8, Q5TFA9, Q86VN2, Q9NU52
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O75449.1 GenPept UniProtKB/Swiss-Prot:O75449

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