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PRSS23 serine protease 23 [ Homo sapiens (human) ]

Gene ID: 11098, updated on 30-Mar-2024

Summary

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Official Symbol
PRSS23provided by HGNC
Official Full Name
serine protease 23provided by HGNC
Primary source
HGNC:HGNC:14370
See related
Ensembl:ENSG00000150687 MIM:618376; AllianceGenome:HGNC:14370
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SIG13; SPUVE; ZSIG13
Summary
This gene encodes a conserved member of the trypsin family of serine proteases. Mouse studies found a decrease of mRNA levels of this gene after ovulation was induced. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
Expression
Ubiquitous expression in gall bladder (RPKM 19.0), urinary bladder (RPKM 17.9) and 24 other tissues See more
Orthologs
mouse all
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Genomic context

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See PRSS23 in Genome Data Viewer
Location:
11q14.2
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (86791071..86952910)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (86731821..86893752)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (86502113..86663952)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr11:86153050-86154249 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:86158730-86158943 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:86171015-86171543 Neighboring gene Sharpr-MPRA regulatory region 11231 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:86208417-86209018 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:86209019-86209620 Neighboring gene MPRA-validated peak1375 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3827 Neighboring gene malic enzyme 3 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:86234525-86235724 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:86270243-86270744 Neighboring gene MPRA-validated peak1376 silencer Neighboring gene Sharpr-MPRA regulatory region 6909 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_21738 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr11:86451485-86452099 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:86452100-86452713 Neighboring gene uncharacterized LOC102724775 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_21766 Neighboring gene NANOG hESC enhancer GRCh37_chr11:86522581-86523167 Neighboring gene Sharpr-MPRA regulatory region 1521 Neighboring gene MPRA-validated peak1379 silencer Neighboring gene MOB4 pseudogene 2 Neighboring gene olfactory receptor family 7 subfamily E member 13 pseudogene Neighboring gene MPRA-validated peak1380 silencer Neighboring gene PRSS23 antisense RNA 1 Neighboring gene olfactory receptor family 7 subfamily E member 2 pseudogene Neighboring gene Sharpr-MPRA regulatory region 12486 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:86651451-86651950 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3828 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3829 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3830 Neighboring gene FZD4 divergent transcript Neighboring gene frizzled class receptor 4 Neighboring gene uncharacterized LOC105369422 Neighboring gene heterogeneous nuclear ribonucleoprotein C pseudogene 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. PRSS23 knockdown inhibits gastric tumorigenesis through EIF2 signaling. Han B, et al. Pharmacol Res, 2019 Apr. PMID 30769097
  2. Serine protease PRSS23 drives gastric cancer by enhancing tumor associated macrophage infiltration via FGF2. Qin S, et al. Front Immunol, 2022. PMID 36189305, Free PMC Article
  3. Exosomal microRNA-1246 from human umbilical cord mesenchymal stem cells potentiates myocardial angiogenesis in chronic heart failure. Wang Z, et al. Cell Biol Int, 2021 Nov. PMID 34270841
  4. Identification of human epididymis protein-4 as a fibroblast-derived mediator of fibrosis. LeBleu VS, et al. Nat Med, 2013 Feb. PMID 23353556, Free PMC Article
  5. Serine protease PRSS23 is upregulated by estrogen receptor α and associated with proliferation of breast cancer cells. Chan HS, et al. PLoS One, 2012. PMID 22291950, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Serine protease PRSS23 drives gastric cancer by enhancing tumor associated macrophage infiltration via FGF2.
    Title: Serine protease PRSS23 drives gastric cancer by enhancing tumor associated macrophage infiltration via FGF2.
  2. Exosomal microRNA-1246 from human umbilical cord mesenchymal stem cells potentiates myocardial angiogenesis in chronic heart failure.
    Title: Exosomal microRNA-1246 from human umbilical cord mesenchymal stem cells potentiates myocardial angiogenesis in chronic heart failure.
  3. PRSS23 knockdown could suppress tumor growth of gastric cancer in vitro and in vivo through inhibiting EIF2 signaling, and EIF4E maybe a potential target of PRSS23. PRSS23 could serve as a potential target for gastric cancer therapy, and also a biomarker for the prediction of prognosis of gastric cancer.
    Title: PRSS23 knockdown inhibits gastric tumorigenesis through EIF2 signaling.
  4. PRSS23 might be a critical component of estrogen-mediated cell proliferation of ERalpha-positive breast cancer cells.
    Title: Serine protease PRSS23 is upregulated by estrogen receptor α and associated with proliferation of breast cancer cells.
  5. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
    Title: Use of genome-wide expression data to mine the "Gray Zone" of GWA studies leads to novel candidate obesity genes.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC5107, DKFZp451O043

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
  
located_in extracellular exosome HDA PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
serine protease 23
Names
protease, serine 23
putative secreted protein Zsig13
serine protease, umbilical endothelium
NP_001280108.1
NP_001280109.1
NP_009104.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001293179.2 → NP_001280108.1  serine protease 23 precursor

    See identical proteins and their annotated locations for NP_001280108.1

    Status: REVIEWED

    Source sequence(s)
    AP000654, BP206707
    Consensus CDS
    CCDS8278.1
    UniProtKB/Swiss-Prot
    B2RDJ1, B4E2J3, O95084, Q6IBI0
    UniProtKB/TrEMBL
    B3KQQ9
    Conserved Domains (1) summary
    cl21584
    Location:147 → 255
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  2. NM_001293180.2 → NP_001280109.1  serine protease 23 precursor

    See identical proteins and their annotated locations for NP_001280109.1

    Status: REVIEWED

    Source sequence(s)
    AP000654, DA895063
    Consensus CDS
    CCDS8278.1
    UniProtKB/Swiss-Prot
    B2RDJ1, B4E2J3, O95084, Q6IBI0
    UniProtKB/TrEMBL
    B3KQQ9
    Conserved Domains (1) summary
    cl21584
    Location:147 → 255
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  3. NM_007173.6 → NP_009104.3  serine protease 23 precursor

    Status: REVIEWED

    Source sequence(s)
    AP000654, DA910788
    UniProtKB/Swiss-Prot
    B2RDJ1, B4E2J3, O95084, Q6IBI0
    UniProtKB/TrEMBL
    B3KQQ9
    Related
    ENSP00000280258.4, ENST00000280258.6
    Conserved Domains (1) summary
    cl21584
    Location:147 → 255
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RNA

  1. NR_120591.3 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an exon and contains four alternate 3' exons, compared to variant 1. This variant is represented as non-coding because its lacks the ORF found in variant 1.
    Source sequence(s)
    BC063022, BU634437, CX871294
    Related
    ENST00000532234.5

  2. NR_120592.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks an exon and contains two alternate 3' exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AP000654, AP001528
    Related
    ENST00000533902.2

  3. NR_120593.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) lacks an exon and contains two alternate 3' exons, compared to variant 1. This variant is represented as non-coding because it lacks the ORF found in variant 1.
    Source sequence(s)
    AP001528, CX871294, DA600625

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    86791071..86952910
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    86731821..86893752
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001293178.1: Suppressed sequence

    Description
    NM_001293178.1: This RefSeq was removed because currently there is insufficient support for the transcript and protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O95084.1 GenPept UniProtKB/Swiss-Prot:O95084

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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