ADRM1 ADRM1 26S proteasome ubiquitin receptor [Homo sapiens (human)] - Gene

Summary

Official Symbol: ADRM1provided by HGNC
Official Full Name: ADRM1 26S proteasome ubiquitin receptorprovided by HGNC
Primary source: HGNC:HGNC:15759
See related: Ensembl:ENSG00000130706 MIM:610650; AllianceGenome:HGNC:15759
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ARM1; ARM-1; GP110; PSMD16
Summary: This gene encodes a member of the adhesion regulating molecule 1 protein family. The encoded protein is a component of the proteasome where it acts as a ubiquitin receptor and recruits the deubiquitinating enzyme, ubiquitin carboxyl-terminal hydrolase L5. Increased levels of the encoded protein are associated with increased cell adhesion, which is likely an indirect effect of this intracellular protein. Dysregulation of this gene has been implicated in carcinogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Expression: Ubiquitous expression in testis (RPKM 31.4), fat (RPKM 17.5) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 20q13.33

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	20	NC_000020.11 (62302896..62308862)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	20	NC_060944.1 (64093845..64099811)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	20	NC_000020.10 (60877952..60883918)

Chromosome 20 - NC_000020.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

hRpn13 shapes the proteome and transcriptome through epigenetic factors HDAC8, PADI4, and transcription factor NF-kappaB p50.
Title: hRpn13 shapes the proteome and transcriptome through epigenetic factors HDAC8, PADI4, and transcription factor NF-κB p50.
Potential of adhesion-regulating molecule 1 (ADRM1) as a biomarker for patients with renal clear-cell carcinoma or papillary-cell carcinoma.
Title: Potential of adhesion-regulating molecule 1 (ADRM1) as a biomarker for patients with renal clear-cell carcinoma or papillary-cell carcinoma.
LIM Homeobox 2 Increases Adhesion-Regulating Molecule 1 Transcription to Facilitate the Pathological Progression of Oxidized Low-Density Lipoprotein-Stimulated Atherosclerotic Cell Models.
Title: LIM Homeobox 2 Increases Adhesion-Regulating Molecule 1 Transcription to Facilitate the Pathological Progression of Oxidized Low-Density Lipoprotein-Stimulated Atherosclerotic Cell Models.
Structure-guided bifunctional molecules hit a DEUBAD-lacking hRpn13 species upregulated in multiple myeloma.
Title: Structure-guided bifunctional molecules hit a DEUBAD-lacking hRpn13 species upregulated in multiple myeloma.
ADRM1 as a therapeutic target in hepatocellular carcinoma.
Title: ADRM1 as a therapeutic target in hepatocellular carcinoma.
Identification of novel anti-tumor therapeutic target via proteomic characterization of ubiquitin receptor ADRM1/Rpn13.
Title: Identification of novel anti-tumor therapeutic target via proteomic characterization of ubiquitin receptor ADRM1/Rpn13.
An Extended Conformation for K48 Ubiquitin Chains Revealed by the hRpn2:Rpn13:K48-Diubiquitin Structure.
Title: An Extended Conformation for K48 Ubiquitin Chains Revealed by the hRpn2:Rpn13:K48-Diubiquitin Structure.
Prognostic and Therapeutic Significance of Adhesion-regulating Molecule 1 in Estrogen Receptor-positive Breast Cancer.
Title: Prognostic and Therapeutic Significance of Adhesion-regulating Molecule 1 in Estrogen Receptor-positive Breast Cancer.
Proteomic analysis identifies mechanism(s) of overcoming bortezomib resistance via targeting ubiquitin receptor Rpn13.
Title: Proteomic analysis identifies mechanism(s) of overcoming bortezomib resistance via targeting ubiquitin receptor Rpn13.
The CCDC43-ADRM1 axis regulated by YY1, promotes proliferation and metastasis of gastric cancer.
Title: The CCDC43-ADRM1 axis regulated by YY1, promotes proliferation and metastasis of gastric cancer.

Submit: New GeneRIF Correction See all GeneRIFs (44)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH91973 (e-PCR)
- UniSTS:92800

RH79208 (e-PCR)
- UniSTS:88253

RH17482 (e-PCR)
- UniSTS:37365

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables endopeptidase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables endopeptidase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables molecular function inhibitor activity	EXP Inferred from Experiment more info	PubMed
enables protease binding	IPI Inferred from Physical Interaction more info	PubMed
enables proteasome binding	IBA Inferred from Biological aspect of Ancestor more info
enables proteasome binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in proteasome assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	NAS Non-traceable Author Statement more info	PubMed
involved_in transcription elongation by RNA polymerase II	IMP Inferred from Mutant Phenotype more info

Component	Evidence Code	Pubs
located_in cytosol	IDA Inferred from Direct Assay more info
located_in cytosol	TAS Traceable Author Statement more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in plasma membrane	IDA Inferred from Direct Assay more info
part_of proteasome complex	IDA Inferred from Direct Assay more info	PubMed
part_of proteasome complex	NAS Non-traceable Author Statement more info	PubMed
part_of proteasome regulatory particle, lid subcomplex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: proteasomal ubiquitin receptor ADRM1

Names: 110 kDa cell membrane glycoprotein; M(r) 110,000 surface antigen; adhesion regulating molecule 1; proteasome regulatory particle non-ATPase 13; proteasome ubiquitin receptor; rpn13 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_050661.2 RefSeqGene

Range

5103..10968

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001281437.1 → NP_001268366.1 proteasomal ubiquitin receptor ADRM1 isoform 2

See identical proteins and their annotated locations for NP_001268366.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and lacks an in-frame exon in the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1. Variants 3 and 4 encode the same isoform.

Source sequence(s)

BC017245, BR000321, HY029018, HY178253

Consensus CDS

CCDS74747.1

UniProtKB/TrEMBL

A0A087WX59

Conserved Domains (2) summary

pfam16550
Location:235 → 342

RPN13_C; UCH-binding domain

cl17171
Location:24 → 89

PH-like; Pleckstrin homology-like domain
NM_001281438.1 → NP_001268367.1 proteasomal ubiquitin receptor ADRM1 isoform 2

See identical proteins and their annotated locations for NP_001268367.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) lacks an in-frame exon in the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1. Variants 3 and 4 encode the same isoform.

Source sequence(s)

BC017245, BG337785, BR000321, HY029018

Consensus CDS

CCDS74747.1

UniProtKB/TrEMBL

A0A087WX59

Related

ENSP00000480756.1, ENST00000620230.4

Conserved Domains (2) summary

pfam16550
Location:235 → 342

RPN13_C; UCH-binding domain

cl17171
Location:24 → 89

PH-like; Pleckstrin homology-like domain
NM_007002.4 → NP_008933.2 proteasomal ubiquitin receptor ADRM1 isoform 1

See identical proteins and their annotated locations for NP_008933.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Variants 1 and 2 encode the same isoform.

Source sequence(s)

AL354836

Consensus CDS

CCDS13496.1

UniProtKB/Swiss-Prot

A0PKB1, Q16186, Q96FJ7, Q9H1P2

Related

ENSP00000253003.2, ENST00000253003.7

Conserved Domains (2) summary

cd13314
Location:24 → 128

PH_Rpn13; Pleckstrin homology-like domain of Regulatory Particle Non-ATPase 13

pfam16550
Location:274 → 381

RPN13_C; UCH-binding domain
NM_175573.2 → NP_783163.1 proteasomal ubiquitin receptor ADRM1 isoform 1

See identical proteins and their annotated locations for NP_783163.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform (1).

Source sequence(s)

BC017245, BR000321, HY029018

Consensus CDS

CCDS13496.1

UniProtKB/Swiss-Prot

A0PKB1, Q16186, Q96FJ7, Q9H1P2

Related

ENSP00000478877.1, ENST00000491935.5

Conserved Domains (2) summary

cd13314
Location:24 → 128

PH_Rpn13; Pleckstrin homology-like domain of Regulatory Particle Non-ATPase 13

pfam16550
Location:274 → 381

RPN13_C; UCH-binding domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000020.11 Reference GRCh38.p14 Primary Assembly

Range

62302896..62308862

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011528503.2 → XP_011526805.1 proteasomal ubiquitin receptor ADRM1 isoform X1

UniProtKB/TrEMBL

Q68E00

Conserved Domains (2) summary

cd13314
Location:24 → 128

PH_Rpn13; Pleckstrin homology-like domain of Regulatory Particle Non-ATPase 13

pfam16550
Location:274 → 338

RPN13_C; UCH-binding domain
XM_047439841.1 → XP_047295797.1 proteasomal ubiquitin receptor ADRM1 isoform X2