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ZNF660-ZNF197 ZNF660-ZNF197 readthrough [ Homo sapiens (human) ]

Gene ID: 110354863, updated on 15-Mar-2024

Summary

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Gene symbol
ZNF660-ZNF197
Gene description
ZNF660-ZNF197 readthrough
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene represents naturally-occurring readthrough transcription between the adjacent zinc finger protein 660 (ZNF660) and zinc finger protein 197 (ZNF197) genes. Readthrough transcripts may encode proteins similar to the proteins encoded by ZNF197. [provided by RefSeq, May 2017]
Orthologs
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Genomic context

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Location:
3p21.31
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (44584964..44648471)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (44600686..44664179)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (44626456..44689963)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene zinc finger protein 852 pseudogene Neighboring gene Sharpr-MPRA regulatory region 15293 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14268 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14269 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:44598251-44598752 Neighboring gene ZKSCAN7 ZNF cluster antisense RNA 1 Neighboring gene zinc finger with KRAB and SCAN domains 7 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:44622134-44622634 Neighboring gene myosin phosphatase Rho interacting protein pseudogene 1 Neighboring gene zinc finger protein 660 Neighboring gene ZNF197 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14270 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:44666861-44667363 Neighboring gene zinc finger protein 197 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:44689909-44690468 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19768 Neighboring gene zinc finger protein 35 Neighboring gene zinc finger protein 251 pseudogene Neighboring gene zinc finger protein OZF-like Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14271 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14272 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19769

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. YAC-assisted cloning of transcribed sequences from the human chromosome 3p21 region. Pengue G, et al. Hum Mol Genet, 1993 Jun. PMID 8353497
  2. Identification of rapid turnover transcripts overexpressed in thyroid tumors and thyroid cancer cell lines: use of a targeted differential RNA display method to select for mRNA subsets. Gonsky R, et al. Nucleic Acids Res, 1997 Oct 1. PMID 9380504, Free PMC Article
  3. The VHL protein recruits a novel KRAB-A domain protein to repress HIF-1alpha transcriptional activity. Li Z, et al. EMBO J, 2003 Apr 15. PMID 12682018, Free PMC Article
  4. The DNA sequence, annotation and analysis of human chromosome 3. Muzny DM, et al. Nature, 2006 Apr 27. PMID 16641997
  5. A census of human transcription factors: function, expression and evolution. Vaquerizas JM, et al. Nat Rev Genet, 2009 Apr. PMID 19274049

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

Genotypes

General gene information

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Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 197
Names
pVHL-associated KRAB domain-containing protein
zinc finger protein with KRAB and SCAN domains 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001351732.2 → NP_001338661.1  zinc finger protein 197 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC099669
    UniProtKB/Swiss-Prot
    B2RAH8, O14709, Q86VG0
    Conserved Domains (5) summary
    smart00431
    Location:38 → 150
    SCAN; leucine rich region
    COG5048
    Location:424 → 853
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:400 → 420
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:216 → 256
    KRAB; KRAB box
    pfam13465
    Location:384 → 409
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001351733.2 → NP_001338662.1  zinc finger protein 197 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC099669
    UniProtKB/Swiss-Prot
    B2RAH8, O14709, Q86VG0
    Conserved Domains (5) summary
    smart00431
    Location:38 → 150
    SCAN; leucine rich region
    COG5048
    Location:424 → 853
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:400 → 420
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:216 → 256
    KRAB; KRAB box
    pfam13465
    Location:384 → 409
    zf-H2C2_2; Zinc-finger double domain

  3. NM_001351734.2 → NP_001338663.1  zinc finger protein 197 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC099669
    Conserved Domains (2) summary
    smart00431
    Location:38 → 150
    SCAN; leucine rich region
    pfam01352
    Location:216 → 257
    KRAB; KRAB box

  4. NM_001351735.2 → NP_001338664.1  zinc finger protein 197 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC099669
    Conserved Domains (2) summary
    smart00431
    Location:38 → 150
    SCAN; leucine rich region
    pfam01352
    Location:216 → 257
    KRAB; KRAB box

RNA

  1. NR_147691.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC099669

  2. NR_147692.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC099669

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    44584964..44648471
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_009646197.1 Reference GRCh38.p14 PATCHES

    Range
    110318..173825
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    44600686..44664179
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O14709.1 GenPept UniProtKB/Swiss-Prot:O14709

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Molecular Biology Databases