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CCNI cyclin I [ Homo sapiens (human) ]

Gene ID: 10983, updated on 5-Mar-2024

Summary

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Official Symbol
CCNIprovided by HGNC
Official Full Name
cyclin Iprovided by HGNC
Primary source
HGNC:HGNC:1595
See related
Ensembl:ENSG00000118816 MIM:618783; AllianceGenome:HGNC:1595
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CYI; CYC1; CCNI1
Summary
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin shows the highest similarity with cyclin G. The transcript of this gene was found to be expressed constantly during cell cycle progression. [provided by RefSeq, Jan 2017]
Expression
Ubiquitous expression in thyroid (RPKM 185.4), ovary (RPKM 178.6) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
4q21.1
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (77047155..77075989, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (80387967..80416780, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (77968308..77997142, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene septin 11 Neighboring gene thioredoxin pseudogene 6 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21633 Neighboring gene uncharacterized LOC105377291 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:77936428-77936960 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr4:77944028-77944647 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21634 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21635 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15499 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15500 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:77997338-77998308 Neighboring gene ribosomal protein L7 pseudogene 17 Neighboring gene ubiquitin family domain containing 1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Cyclin I is involved in the regulation of cell cycle progression. Nagano T, et al. Cell Cycle, 2013 Aug 15. PMID 23907122, Free PMC Article
  2. Expression of a novel isoform of cyclin I in human testis. Zhu X, et al. Biochem Biophys Res Commun, 1998 Aug 10. PMID 9705831
  3. Cyclin I: a new cyclin encoded by a gene isolated from human brain. Nakamura T, et al. Exp Cell Res, 1995 Dec. PMID 7493655
  4. CDK6 is activated by the atypical cyclin I to promote E2F-mediated gene expression and cancer cell proliferation. Quandt E, et al. Mol Oncol, 2023 Jul. PMID 37081792, Free PMC Article
  5. Cyclin I promotes cisplatin resistance via Cdk5 activation in cervical cancer. Li R, et al. Eur Rev Med Pharmacol Sci, 2015 Dec. PMID 26698249

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CDK6 is activated by the atypical cyclin I to promote E2F-mediated gene expression and cancer cell proliferation.
    Title: CDK6 is activated by the atypical cyclin I to promote E2F-mediated gene expression and cancer cell proliferation.
  2. A cyclin I-Cdk5 complex forms a critical antiapoptotic factor in the process of generating cisplatin resistance in cervical cancer.
    Title: Cyclin I promotes cisplatin resistance via Cdk5 activation in cervical cancer.
  3. Knockdown of Cyclin I induced cell cycle arrest at S/G2/M phases.
    Title: Cyclin I is involved in the regulation of cell cycle progression.
  4. The increased levels of cyclin I and GDI2 found to be associated with pancreatic carcinoma were further confirmed by Western blot analyses in an independent series of serum samples and/or pancreatic juice samples
    Title: Serum proteomic-based analysis of pancreatic carcinoma for the identification of potential cancer biomarkers.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in mitotic cell cycle phase transition IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cyclin-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spermatogenesis NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of cyclin-dependent protein kinase holoenzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cyclin-I
Names
cyclin ITI

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001348132.2 → NP_001335061.1  cyclin-I isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2), as well as variants 1 and 3, encodes isoform a.
    Source sequence(s)
    AC104771, AC111196
    Consensus CDS
    CCDS3580.1
    UniProtKB/Swiss-Prot
    B2R6M0, B7Z6X4, Q14094
    UniProtKB/TrEMBL
    Q6FHH0
    Conserved Domains (1) summary
    pfam00134
    Location:34 → 142
    Cyclin_N; Cyclin, N-terminal domain

  2. NM_001348133.2 → NP_001335062.1  cyclin-I isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), as well as variants 1 and 2, encodes isoform a.
    Source sequence(s)
    AC104771, AC111196
    Consensus CDS
    CCDS3580.1
    UniProtKB/Swiss-Prot
    B2R6M0, B7Z6X4, Q14094
    UniProtKB/TrEMBL
    Q6FHH0
    Conserved Domains (1) summary
    pfam00134
    Location:34 → 142
    Cyclin_N; Cyclin, N-terminal domain

  3. NM_001348134.2 → NP_001335063.1  cyclin-I isoform b

    Status: REVIEWED

    Source sequence(s)
    AC104771, AC111196
    UniProtKB/TrEMBL
    Q53GK0
    Conserved Domains (1) summary
    cd20526
    Location:30 → 128
    CYCLIN_CCNI-like; cyclin box found in cyclin-I (CCNI) and similar proteins

  4. NM_001348135.2 → NP_001335064.1  cyclin-I isoform c

    Status: REVIEWED

    Source sequence(s)
    AC104771, AC111196
    UniProtKB/TrEMBL
    Q6FHH0
    Conserved Domains (1) summary
    pfam00134
    Location:28 → 112
    Cyclin_N; Cyclin, N-terminal domain

  5. NM_001348136.2 → NP_001335065.1  cyclin-I isoform d

    Status: REVIEWED

    Source sequence(s)
    AC104771, AC111196
    UniProtKB/TrEMBL
    Q6FHH0
    Conserved Domains (2) summary
    cl00050
    Location:47 → 99
    CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
    cl25647
    Location:29 → 171
    Cyclin_N2; N-terminal region of cyclin_N

  6. NM_001348137.2 → NP_001335066.1  cyclin-I isoform e

    Status: REVIEWED

    Source sequence(s)
    AC104771, AC111196
    UniProtKB/TrEMBL
    Q6FHH0
    Conserved Domains (1) summary
    cl00050
    Location:28 → 88
    CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...

  7. NM_001348138.2 → NP_001335067.1  cyclin-I isoform f

    Status: REVIEWED

    Source sequence(s)
    AC104771, AC111196
    Conserved Domains (1) summary
    cl00050
    Location:1 → 37
    CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...

  8. NM_001348139.2 → NP_001335068.1  cyclin-I isoform g

    Status: REVIEWED

    Source sequence(s)
    AC104771, AC111196

  9. NM_001348140.2 → NP_001335069.1  cyclin-I isoform h

    Status: REVIEWED

    Source sequence(s)
    AC104771, AC111196
    Conserved Domains (1) summary
    pfam00134
    Location:28 → 142
    Cyclin_N; Cyclin, N-terminal domain

  10. NM_006835.3 → NP_006826.1  cyclin-I isoform a

    See identical proteins and their annotated locations for NP_006826.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Variants 1, 2, and 3 all encode the same isoform (a).
    Source sequence(s)
    AC104771, AC111196
    Consensus CDS
    CCDS3580.1
    UniProtKB/Swiss-Prot
    B2R6M0, B7Z6X4, Q14094
    UniProtKB/TrEMBL
    Q6FHH0
    Related
    ENSP00000237654.4, ENST00000237654.9
    Conserved Domains (1) summary
    pfam00134
    Location:34 → 142
    Cyclin_N; Cyclin, N-terminal domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    77047155..77075989 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    80387967..80416780 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q14094.1 GenPept UniProtKB/Swiss-Prot:Q14094

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