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SUB1 SUB1 regulator of transcription [ Homo sapiens (human) ]

Gene ID: 10923, updated on 7-Apr-2024

Summary

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Official Symbol
SUB1provided by HGNC
Official Full Name
SUB1 regulator of transcriptionprovided by HGNC
Primary source
HGNC:HGNC:19985
See related
Ensembl:ENSG00000113387 MIM:600503; AllianceGenome:HGNC:19985
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P15; PC4; p14
Summary
Enables identical protein binding activity; single-stranded DNA binding activity; and transcription coactivator activity. Involved in negative regulation of DNA metabolic process and regulation of transcription by RNA polymerase II. Located in nucleolus and nucleoplasm. Part of transcription regulator complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in brain (RPKM 41.5), fat (RPKM 34.4) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
5p13.3
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (32585557..32604079)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (32699227..32717759)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (32585663..32604185)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene zinc finger RNA binding protein Neighboring gene microRNA 579 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:32443940-32444497 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15958 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr5:32501369-32502015 Neighboring gene uncharacterized LOC124900954 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:32511632-32512132 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22445 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22446 Neighboring gene TMEM183A pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22447 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22448 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22449 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22450 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22451 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:32576632-32576802 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22452 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15959 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15960 Neighboring gene long intergenic non-protein coding RNA 2061 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:32653566-32654765 Neighboring gene Sharpr-MPRA regulatory region 158 Neighboring gene natriuretic peptide receptor 3 Neighboring gene NPR3 intron CAGE-defined low expression enhancer Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr5:32767828-32769027

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Phosphorylation-dependent association of human chromatin protein PC4 to linker histone H1 regulates genome organization and transcription. Mustafi P, et al. Nucleic Acids Res, 2022 Jun 24. PMID 35670677, Free PMC Article
  2. Knockdown of PC4 increases chemosensitivity of Oxaliplatin in triple negative breast cancer by suppressing mTOR pathway. Wang Q, et al. Biochem Biophys Res Commun, 2021 Mar 12. PMID 33524870
  3. Nonhistone human chromatin protein PC4 is critical for genomic integrity and negatively regulates autophagy. Sikder S, et al. FEBS J, 2019 Nov. PMID 31169983
  4. Transcriptional positive cofactor 4 promotes breast cancer proliferation and metastasis through c-Myc mediated Warburg effect. Luo P, et al. Cell Commun Signal, 2019 Apr 16. PMID 30992017, Free PMC Article
  5. Positive cofactor 4 (PC4) contributes to the regulation of replication-dependent canonical histone gene expression. Brzek A, et al. BMC Mol Biol, 2018 Jul 27. PMID 30053800, Free PMC Article

See all (159) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Periodic changes of cyclin D1 mRNA stability are regulated by PC4 modifications in the cell cycle.
    Title: Periodic changes of cyclin D1 mRNA stability are regulated by PC4 modifications in the cell cycle.
  2. Phosphorylation-dependent association of human chromatin protein PC4 to linker histone H1 regulates genome organization and transcription.
    Title: Phosphorylation-dependent association of human chromatin protein PC4 to linker histone H1 regulates genome organization and transcription.
  3. CircVCAN/SUB1 up-regulates MYC/HSP90beta to enhance the proliferation and migration of glioma cells.
    Title: CircVCAN/SUB1 up-regulates MYC/HSP90β to enhance the proliferation and migration of glioma cells.
  4. The Transcription Factor SUB1 Is a Master Regulator of the Macrophage TLR Response in Atherosclerosis.
    Title: The Transcription Factor SUB1 Is a Master Regulator of the Macrophage TLR Response in Atherosclerosis.
  5. Chromatin Protein PC4 Orchestrates B Cell Differentiation by Collaborating with IKAROS and IRF4.
    Title: Chromatin Protein PC4 Orchestrates B Cell Differentiation by Collaborating with IKAROS and IRF4.
  6. Knockdown of PC4 increases chemosensitivity of Oxaliplatin in triple negative breast cancer by suppressing mTOR pathway.
    Title: Knockdown of PC4 increases chemosensitivity of Oxaliplatin in triple negative breast cancer by suppressing mTOR pathway.
  7. PC4 is essential for genomic integrity and autophagy regulation.
    Title: Nonhistone human chromatin protein PC4 is critical for genomic integrity and negatively regulates autophagy.
  8. PC4 emerges as a global co-regulator of p53 and a therapeutic target against pathogeneses where the p53-dependent cell death process plays a crucial role.
    Title: Multifunctional transcriptional coactivator PC4 is a global co-regulator of p53-dependent stress response and gene regulation.
  9. this study reveals for the first time that PC4 promotes breast cancer progression by directly regulating c-Myc transcription to promote Warburg effect, implying a novel therapeutic target for breast cancer.
    Title: Transcriptional positive cofactor 4 promotes breast cancer proliferation and metastasis through c-Myc mediated Warburg effect.
  10. PC4 expression correlated with radiosensitivity and was an independent prognostic factor of progression-free survival (PFS) in patients with NSCLC.
    Title: Inhibition of PC4 radiosensitizes non-small cell lung cancer by transcriptionally suppressing XLF.
Submit: New GeneRIF Correction See all GeneRIFs (35)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of SUB1 PubMed
Knockdown of SUB1 homolog by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Protein interactions

Protein Gene Interaction Pubs
Rev rev HIV-1 Rev interacting protein, SUB1 homolog (positive cofactor 4), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells PubMed
Tat tat Through amino acids 22-91, PC4 binds to the basic TAR binding domain of HIV-1 Tat (amino acids 49-57) and enhances activation of the HIV-1 LTR promoter in a Tat dependent manner PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC102747

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables single-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in RNA polymerase II promoter clearance IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of DNA duplex unwinding IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of DNA metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription initiation by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular exosome HDA PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription regulator complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
activated RNA polymerase II transcriptional coactivator p15
Names
SUB1 homolog, transcriptional regulator
activated RNA polymerase II transcription cofactor 4
positive cofactor 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006713.4 → NP_006704.3  activated RNA polymerase II transcriptional coactivator p15

    See identical proteins and their annotated locations for NP_006704.3

    Status: VALIDATED

    Source sequence(s)
    AC074134, BC010537, BC071655, BX472106
    Consensus CDS
    CCDS3897.1
    UniProtKB/Swiss-Prot
    P53999, Q96L29
    UniProtKB/TrEMBL
    Q59G24, Q6IBA2
    Related
    ENSP00000265073.4, ENST00000265073.9
    Conserved Domains (1) summary
    pfam02229
    Location:68 → 115
    PC4; Transcriptional Coactivator p15 (PC4)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    32585557..32604079
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047416661.1 → XP_047272617.1  activated RNA polymerase II transcriptional coactivator p15 isoform X1

    UniProtKB/Swiss-Prot
    P53999, Q96L29
    UniProtKB/TrEMBL
    Q6IBA2
    Related
    ENSP00000426850.1, ENST00000515355.5

  2. XM_011513944.4 → XP_011512246.1  activated RNA polymerase II transcriptional coactivator p15 isoform X1

    See identical proteins and their annotated locations for XP_011512246.1

    UniProtKB/Swiss-Prot
    P53999, Q96L29
    UniProtKB/TrEMBL
    Q59G24, Q6IBA2
    Conserved Domains (1) summary
    pfam02229
    Location:68 → 115
    PC4; Transcriptional Coactivator p15 (PC4)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    32699227..32717759
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53999.3 GenPept UniProtKB/Swiss-Prot:P53999

Gene LinkOut

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