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FASTK Fas activated serine/threonine kinase [ Homo sapiens (human) ]

Gene ID: 10922, updated on 7-Apr-2024

Summary

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Official Symbol
FASTKprovided by HGNC
Official Full Name
Fas activated serine/threonine kinaseprovided by HGNC
Primary source
HGNC:HGNC:24676
See related
Ensembl:ENSG00000164896 MIM:606965; AllianceGenome:HGNC:24676
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FAST
Summary
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase was shown to be activated rapidly during Fas-mediated apoptosis in Jurkat cells. In response to Fas receptor ligation, it phosphorylates TIA1, an apoptosis-promoting nuclear RNA-binding protein. The encoded protein is a strong inducer of lymphocyte apoptosis. Two transcript variants encoding different isoforms have been found for this gene. Other variants exist, but their full-length natures have not yet been determined. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in duodenum (RPKM 16.4), prostate (RPKM 16.0) and 25 other tissues See more
Orthologs
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Genomic context

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See FASTK in Genome Data Viewer
Location:
7q36.1
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (151076624..151080809, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (152249742..152253931, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (150773711..150777896, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:150750636-150751136 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:150754255-150754788 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26847 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26848 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26849 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26850 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18792 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18793 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:150757470-150758377 Neighboring gene uncharacterized LOC128092247 Neighboring gene cyclin dependent kinase 5 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:150762350-150763332 Neighboring gene solute carrier family 4 member 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:150766873-150767373 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:150772333-150773310 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:150773311-150774286 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:150774287-150775262 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:150776239-150777215 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:150777216-150778191 Neighboring gene Sharpr-MPRA regulatory region 12172 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18796 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18797 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18798 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18799 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18800 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26851 Neighboring gene uncharacterized LOC124901778 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:150786615-150787125 Neighboring gene transmembrane and ubiquitin like domain containing 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:150787126-150787635 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:150787761-150788266 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:150788267-150788772 Neighboring gene ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:150800613-150801520

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Systematic Analysis of FASTK Gene Family Alterations in Cancer. Magraner-Pardo L, et al. Int J Mol Sci, 2021 Oct 20. PMID 34768773, Free PMC Article
  2. FAST is a survival protein that senses mitochondrial stress and modulates TIA-1-regulated changes in protein expression. Li W, et al. Mol Cell Biol, 2004 Dec. PMID 15572676, Free PMC Article
  3. A mitochondria-specific isoform of FASTK is present in mitochondrial RNA granules and regulates gene expression and function. Jourdain AA, et al. Cell Rep, 2015 Feb 24. PMID 25704814
  4. miR-106a-5p inhibits the proliferation and migration of astrocytoma cells and promotes apoptosis by targeting FASTK. Zhi F, et al. PLoS One, 2013. PMID 24013584, Free PMC Article
  5. Fas-activated serine/threonine phosphoprotein promotes immune-mediated pulmonary inflammation. Simarro M, et al. J Immunol, 2010 May 1. PMID 20363972, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Accuracy of FAST in detecting intraabdominal bleeding in major trauma with pelvic and/or acetabular fractures: a retrospective cohort study.
    Title: Accuracy of FAST in detecting intraabdominal bleeding in major trauma with pelvic and/or acetabular fractures: a retrospective cohort study.
  2. Systematic Analysis of FASTK Gene Family Alterations in Cancer.
    Title: Systematic Analysis of FASTK Gene Family Alterations in Cancer.
  3. FASTK binds at multiple sites along the ND6 mRNA and its precursors and cooperates with the mitochondrial degradosome to ensure regulated ND6 mRNA biogenesis.
    Title: A mitochondria-specific isoform of FASTK is present in mitochondrial RNA granules and regulates gene expression and function.
  4. MIR-106a-5p functions as a tumor suppressor during the development of astrocytomas by targeting FASTK.
    Title: miR-106a-5p inhibits the proliferation and migration of astrocytoma cells and promotes apoptosis by targeting FASTK.
  5. FAST expression on lung cells of hematopoietic origin is crucial in mediating lipopolysaccharide-induced neutrophil migration to the lung in transgenic FAST-deficient mice compared with wild type controls.
    Title: Fas-activated serine/threonine phosphoprotein promotes immune-mediated pulmonary inflammation.
  6. Observational study of gene-disease association. (HuGE Navigator)
    Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
  7. Nuclear FAST can regulate the splicing of FGFR2 transcripts.
    Title: Fas-activated serine/threonine phosphoprotein (FAST) is a regulator of alternative splicing.
  8. FAST K synergizes with TIA-1/TIAR proteins to regulate Fas alternative splicing
    Title: Fas-activated serine/threonine kinase (FAST K) synergizes with TIA-1/TIAR proteins to regulate Fas alternative splicing.
  9. FAST is a survival protein that senses mitochondrial stress and modulates TIA-1 regulated changes in protein expression.
    Title: FAST is a survival protein that senses mitochondrial stress and modulates TIA-1-regulated changes in protein expression.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables Fas-activated serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in apoptotic signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in mitochondrial RNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of RNA splicing IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of RNA splicing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of mitochondrial mRNA stability IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial matrix TAS
Traceable Author Statement
more info
  
is_active_in ribonucleoprotein granule IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
fas-activated serine/threonine kinase
Names
FAST kinase
NP_001245390.1
NP_006703.1
NP_148936.2
XP_005249989.1
XP_011514063.1
XP_011514064.1
XP_011514065.1
XP_016867194.1
XP_047275784.1
XP_047275786.1
XP_047275787.1
XP_054213124.1
XP_054213125.1
XP_054213126.1
XP_054213127.1
XP_054213128.1
XP_054213129.1
XP_054213130.1
XP_054213131.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001258461.2 → NP_001245390.1  fas-activated serine/threonine kinase isoform 5

    See identical proteins and their annotated locations for NP_001245390.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The resulting protein (isoform 5) is shorter compared to isoform 1.
    Source sequence(s)
    AB209783, AC010973, DA253544
    Consensus CDS
    CCDS59088.1
    UniProtKB/TrEMBL
    Q53FZ9
    Related
    ENSP00000418516.1, ENST00000482571.2
    Conserved Domains (3) summary
    smart00952
    Location:457 → 509
    RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
    pfam06743
    Location:250 → 316
    FAST_1; FAST kinase-like protein, subdomain 1
    pfam08368
    Location:328 → 417
    FAST_2; FAST kinase-like protein, subdomain 2

  2. NM_006712.5 → NP_006703.1  fas-activated serine/threonine kinase isoform 1

    See identical proteins and their annotated locations for NP_006703.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    BC011770, BU682096, DA253544
    Consensus CDS
    CCDS5918.1
    UniProtKB/Swiss-Prot
    A8K867, F8VTW9, Q14296, Q59EM8, Q8IVA0
    UniProtKB/TrEMBL
    A0A090N8Z7, Q53FZ9
    Related
    ENSP00000297532.6, ENST00000297532.11
    Conserved Domains (3) summary
    smart00952
    Location:484 → 536
    RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
    pfam06743
    Location:278 → 343
    FAST_1; FAST kinase-like protein, subdomain 1
    pfam08368
    Location:358 → 443
    FAST_2; FAST kinase-like protein, subdomain 2

  3. NM_033015.4 → NP_148936.2  fas-activated serine/threonine kinase isoform 4

    See identical proteins and their annotated locations for NP_148936.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC010973, BC039026
    Consensus CDS
    CCDS5919.1
    UniProtKB/TrEMBL
    A0A090N8I0
    Related
    ENSP00000324817.6, ENST00000353841.6
    Conserved Domains (3) summary
    smart00952
    Location:343 → 395
    RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
    pfam06743
    Location:137 → 202
    FAST_1; FAST kinase-like protein, subdomain 1
    pfam08368
    Location:217 → 302
    FAST_2; FAST kinase-like protein, subdomain 2

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    151076624..151080809 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011515763.2 → XP_011514065.1  fas-activated serine/threonine kinase isoform X6

    See identical proteins and their annotated locations for XP_011514065.1

    Conserved Domains (3) summary
    smart00952
    Location:316 → 368
    RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
    pfam06743
    Location:110 → 175
    FAST_1; FAST kinase-like protein, subdomain 1
    pfam08368
    Location:190 → 275
    FAST_2; FAST kinase-like protein, subdomain 2

  2. XM_047419831.1 → XP_047275787.1  fas-activated serine/threonine kinase isoform X8

  3. XM_017011705.3 → XP_016867194.1  fas-activated serine/threonine kinase isoform X7

  4. XM_047419828.1 → XP_047275784.1  fas-activated serine/threonine kinase isoform X3

  5. XM_011515762.4 → XP_011514064.1  fas-activated serine/threonine kinase isoform X4

    UniProtKB/TrEMBL
    Q9BWD7
    Conserved Domains (2) summary
    pfam06743
    Location:278 → 343
    FAST_1; FAST kinase-like protein, subdomain 1
    pfam08368
    Location:358 → 428
    FAST_2; FAST kinase-like protein, subdomain 2

  6. XM_011515761.4 → XP_011514063.1  fas-activated serine/threonine kinase isoform X2

    See identical proteins and their annotated locations for XP_011514063.1

    UniProtKB/TrEMBL
    Q9BWD7
    Conserved Domains (2) summary
    pfam06743
    Location:278 → 343
    FAST_1; FAST kinase-like protein, subdomain 1
    pfam08368
    Location:358 → 443
    FAST_2; FAST kinase-like protein, subdomain 2

  7. XM_047419830.1 → XP_047275786.1  fas-activated serine/threonine kinase isoform X5

  8. XM_005249932.2 → XP_005249989.1  fas-activated serine/threonine kinase isoform X1

    See identical proteins and their annotated locations for XP_005249989.1

    UniProtKB/TrEMBL
    Q53FZ9
    Conserved Domains (3) summary
    smart00952
    Location:450 → 502
    RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
    pfam06743
    Location:244 → 309
    FAST_1; FAST kinase-like protein, subdomain 1
    pfam08368
    Location:324 → 409
    FAST_2; FAST kinase-like protein, subdomain 2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    152249742..152253931 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054357153.1 → XP_054213128.1  fas-activated serine/threonine kinase isoform X5

  2. XM_054357154.1 → XP_054213129.1  fas-activated serine/threonine kinase isoform X6

  3. XM_054357156.1 → XP_054213131.1  fas-activated serine/threonine kinase isoform X8

  4. XM_054357155.1 → XP_054213130.1  fas-activated serine/threonine kinase isoform X7

  5. XM_054357151.1 → XP_054213126.1  fas-activated serine/threonine kinase isoform X3

  6. XM_054357152.1 → XP_054213127.1  fas-activated serine/threonine kinase isoform X4

  7. XM_054357150.1 → XP_054213125.1  fas-activated serine/threonine kinase isoform X2

  8. XM_054357149.1 → XP_054213124.1  fas-activated serine/threonine kinase isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q14296.1 GenPept UniProtKB/Swiss-Prot:Q14296

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