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LILRB1 leukocyte immunoglobulin like receptor B1 [ Homo sapiens (human) ]

Gene ID: 10859, updated on 11-Apr-2024

Summary

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Official Symbol
LILRB1provided by HGNC
Official Full Name
leukocyte immunoglobulin like receptor B1provided by HGNC
Primary source
HGNC:HGNC:6605
See related
Ensembl:ENSG00000104972 MIM:604811; AllianceGenome:HGNC:6605
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ILT2; LIR1; MIR7; PIRB; CD85J; ILT-2; LIR-1; MIR-7; PIR-B
Summary
This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Biased expression in appendix (RPKM 25.9), spleen (RPKM 20.5) and 10 other tissues See more
Orthologs
all
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Genomic context

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Location:
19q13.42
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (54616322..54638022)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (57709827..57731530)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (55127776..55149473)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene leukocyte immunoglobulin like receptor A2 Neighboring gene leukocyte immunoglobulin like receptor A1 Neighboring gene microRNA 8061 Neighboring gene vomeronasal 1 receptor 105 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Elevated LILRB1 expression predicts poor prognosis and is associated with tumor immune infiltration in patients with glioma. Zou R, et al. BMC Cancer, 2023 May 4. PMID 37142967, Free PMC Article
  2. Increased ILT2 expression contributes to dysfunction of CD56(dim)CD16(+)NK cells in chronic hepatitis B virus infection. Zhang Y, et al. Antiviral Res, 2022 Sep. PMID 35917968
  3. HLA-G-ILT2 interaction contributes to suppression of bone marrow B cell proliferation in acquired aplastic anemia. Sun YX, et al. Ann Hematol, 2022 Apr. PMID 35041051
  4. B Cells Control Mucosal-Associated Invariant T Cell Responses to Salmonella enterica Serovar Typhi Infection Through the CD85j HLA-G Receptor. Salerno-Gonçalves R, et al. Front Immunol, 2021. PMID 34659215, Free PMC Article
  5. Tumor infiltrating and peripheral CD4(+)ILT2(+) T cells are a cytotoxic subset selectively inhibited by HLA-G in clear cell renal cell carcinoma patients. Jacquier A, et al. Cancer Lett, 2021 Oct 28. PMID 34186161

See all (164) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. HLA-F and LILRB1 Genetic Polymorphisms Associated with Alloimmunisation in Sickle Cell Disease.
    Title: HLA-F and LILRB1 Genetic Polymorphisms Associated with Alloimmunisation in Sickle Cell Disease.
  2. Peripheral HLA-G/ILT-2 immune checkpoint axis in acute and convalescent COVID-19 patients.
    Title: Peripheral HLA-G/ILT-2 immune checkpoint axis in acute and convalescent COVID-19 patients.
  3. EIF4A3-induced circular RNA SCAP facilitates tumorigenesis and progression of non-small-cell lung cancer via miR-7/SMAD2 signaling.
    Title: EIF4A3-induced circular RNA SCAP facilitates tumorigenesis and progression of non-small-cell lung cancer via miR-7/SMAD2 signaling.
  4. Elevated LILRB1 expression predicts poor prognosis and is associated with tumor immune infiltration in patients with glioma.
    Title: Elevated LILRB1 expression predicts poor prognosis and is associated with tumor immune infiltration in patients with glioma.
  5. TET2 and LILRB1 mutations are frequent in Epstein-Barr virus-positive diffuse large B-cell lymphoma especially in elderly patients.
    Title: TET2 and LILRB1 mutations are frequent in Epstein-Barr virus-positive diffuse large B-cell lymphoma especially in elderly patients.
  6. Evidence for Epistatic Interaction between HLA-G and LILRB1 in the Pathogenesis of Nonsegmental Vitiligo.
    Title: Evidence for Epistatic Interaction between HLA-G and LILRB1 in the Pathogenesis of Nonsegmental Vitiligo.
  7. Uterine NK cells underexpress KIR2DL1/S1 and LILRB1 in reproductive failure.
    Title: Uterine NK cells underexpress KIR2DL1/S1 and LILRB1 in reproductive failure.
  8. Dual checkpoint blockade of CD47 and LILRB1 enhances CD20 antibody-dependent phagocytosis of lymphoma cells by macrophages.
    Title: Dual checkpoint blockade of CD47 and LILRB1 enhances CD20 antibody-dependent phagocytosis of lymphoma cells by macrophages.
  9. Natural killer cell profiles in recurrent pregnancy loss: Increased expression and positive associations with TACTILE and LILRB1.
    Title: Natural killer cell profiles in recurrent pregnancy loss: Increased expression and positive associations with TACTILE and LILRB1.
  10. A LILRB1 variant with a decreased ability to phosphorylate SHP-1 leads to autoimmune diseases.
    Title: A LILRB1 variant with a decreased ability to phosphorylate SHP-1 leads to autoimmune diseases.
Submit: New GeneRIF Correction See all GeneRIFs (116)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 downregulates the expression of leukocyte immunoglobulin-like receptor, subfamily B, member 1 (LILRB1) in human B cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ37515

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables HLA-A specific inhibitory MHC class I receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables HLA-B specific inhibitory MHC class I receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables MHC class I protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables MHC class I protein binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables MHC class I protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables MHC class I receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables MHC class Ib protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables MHC class Ib protein complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables MHC class Ib receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables SH2 domain binding IDA
Inferred from Direct Assay
more info
 PubMed 
NOT enables amyloid-beta binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables inhibitory MHC class I receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein phosphatase 1 binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Fc receptor mediated inhibitory signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in T cell proliferation involved in immune response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in adaptive immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in defense response to virus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in dendritic cell differentiation IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in immune response-inhibiting cell surface receptor signaling pathway NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in immune response-regulating signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in interleukin-10-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of CD8-positive, alpha-beta T cell activation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of T cell mediated cytotoxicity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of T cell proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of alpha-beta T cell activation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of calcium ion transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of cell cycle IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of cytokine production involved in immune response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of dendritic cell apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of dendritic cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of endocytosis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of interferon-beta production IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of interleukin-10 production IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of interleukin-12 production IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of mononuclear cell proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of natural killer cell mediated cytotoxicity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of osteoclast development IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of serotonin secretion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of transforming growth factor beta production IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of tumor necrosis factor production IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of type II interferon production IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of defense response to virus by host IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of gamma-delta T cell activation involved in immune response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of gene expression IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of macrophage cytokine production IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of type II interferon production IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in receptor internalization TAS
Traceable Author Statement
more info
 PubMed 
involved_in response to virus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
leukocyte immunoglobulin-like receptor subfamily B member 1
Names
CD85 antigen-like family member J
Ig-like transcript 2
immunoglobulin heavy chain variable region
leucocyte Ig-like receptor B1
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
monocyte/macrophage immunoglobulin-like receptor 7
myeloid inhibitory receptor 7

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081637.3 → NP_001075106.2  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has a shorter 5' UTR and uses two alternate in-frame splice sites in the coding region, compared to variant 1. The resulting protein (isoform 2) is longer, compared to isoform 1.
    Source sequence(s)
    AC245036
    Consensus CDS
    CCDS42614.1
    UniProtKB/TrEMBL
    A0A087WSV6, A0A0G2JNQ6
    Related
    ENSP00000315997.7, ENST00000324602.12
    Conserved Domains (3) summary
    cd00096
    Location:125 → 129
    Ig; Ig strand A [structural motif]
    cd05751
    Location:28 → 118
    IgC2_D1_LILR_KIR_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILRs), Natural killer inhibitory receptors (KIRs) and similar domains; member of Immunoglobulin Constant-2 set of IgSF domains
    cl11960
    Location:124 → 219
    Ig; Immunoglobulin domain

  2. NM_001081638.4 → NP_001075107.2  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform 3 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the central coding region and differs in the 5' UTR, compared to variant 1. The resulting protein (isoform 3) is longer, compared to isoform 1.
    Source sequence(s)
    AF283984, AK223310, BC015731, DQ655953, EU915608
    Consensus CDS
    CCDS42615.1
    UniProtKB/TrEMBL
    A0A087WSX8, A0A0G2JQ44
    Related
    ENSP00000379618.3, ENST00000396327.7
    Conserved Domains (3) summary
    cd00096
    Location:125 → 129
    Ig; Ig strand A [structural motif]
    cd05751
    Location:28 → 118
    IgC2_D1_LILR_KIR_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILRs), Natural killer inhibitory receptors (KIRs) and similar domains; member of Immunoglobulin Constant-2 set of IgSF domains
    cl11960
    Location:124 → 219
    Ig; Immunoglobulin domain

  3. NM_001081639.4 → NP_001075108.2  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform 4 precursor

    See identical proteins and their annotated locations for NP_001075108.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice site in the 3' coding region and differs in the 5' UTR, compared to variant 1. The resulting protein (isoform 4) is longer, compared to isoform 1.
    Source sequence(s)
    AF004230, AF283984, AK223310, BC015731, DQ655953, EU915608
    Consensus CDS
    CCDS42616.1
    UniProtKB/TrEMBL
    D9IDM5, D9IDM8
    Related
    ENSP00000379623.4, ENST00000396332.8
    Conserved Domains (3) summary
    cd00096
    Location:125 → 129
    Ig; Ig strand A [structural motif]
    cd05751
    Location:28 → 118
    IgC2_D1_LILR_KIR_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILRs), Natural killer inhibitory receptors (KIRs) and similar domains; member of Immunoglobulin Constant-2 set of IgSF domains
    cl11960
    Location:124 → 219
    Ig; Immunoglobulin domain

  4. NM_001278398.2 → NP_001265327.2  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform 5 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) has a shorter 5' UTR, lacks an internal in-frame exon, and uses an alternate splice site in the central coding region, compared to variant 1. The resulting protein (isoform 5) is shorter, compared to isoform 1.
    Source sequence(s)
    AF009006, AF283984, BC015731, EU915608
    Consensus CDS
    CCDS62803.1
    UniProtKB/TrEMBL
    A0A0G2JQ46, A8MVE2
    Related
    ENSP00000379610.1, ENST00000396317.5
    Conserved Domains (3) summary
    cd05751
    Location:27 → 119
    Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins
    smart00410
    Location:335 → 397
    IG_like; Immunoglobulin like
    cl11960
    Location:124 → 219
    Ig; Immunoglobulin domain

  5. NM_001278399.2 → NP_001265328.2  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform 6 precursor

    See identical proteins and their annotated locations for NP_001265328.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) has a shorter 5' UTR, lacks several exons, and its 3'-terminal exon extends past a splice site that is used in variant 1. The resulting protein (isoform 6) has a shorter and distinct C-terminus, compared to isoform 1. Isoform 6 lacks the transmembrane domain found in isoform 1 and is suspected to be soluble (PMID: 19658091).
    Source sequence(s)
    AK223310, DA991480, EU915608
    UniProtKB/TrEMBL
    F6RVM3
    Conserved Domains (3) summary
    cd05751
    Location:27 → 119
    Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins
    smart00410
    Location:335 → 397
    IG_like; Immunoglobulin like
    cl11960
    Location:124 → 219
    Ig; Immunoglobulin domain

  6. NM_001388355.1 → NP_001375284.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform 3 precursor

    Status: REVIEWED

    Source sequence(s)
    AC245036
    Consensus CDS
    CCDS42615.1
    UniProtKB/TrEMBL
    A0A087WSX8, A0A0G2JQ44
    Conserved Domains (3) summary
    cd00096
    Location:125 → 129
    Ig; Ig strand A [structural motif]
    cd05751
    Location:28 → 118
    IgC2_D1_LILR_KIR_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILRs), Natural killer inhibitory receptors (KIRs) and similar domains; member of Immunoglobulin Constant-2 set of IgSF domains
    cl11960
    Location:124 → 219
    Ig; Immunoglobulin domain

  7. NM_001388356.1 → NP_001375285.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform 4 precursor

    Status: REVIEWED

    Source sequence(s)
    AC245036
    Consensus CDS
    CCDS42616.1
    UniProtKB/TrEMBL
    D9IDM5, D9IDM8
    Conserved Domains (3) summary
    cd00096
    Location:125 → 129
    Ig; Ig strand A [structural motif]
    cd05751
    Location:28 → 118
    IgC2_D1_LILR_KIR_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILRs), Natural killer inhibitory receptors (KIRs) and similar domains; member of Immunoglobulin Constant-2 set of IgSF domains
    cl11960
    Location:124 → 219
    Ig; Immunoglobulin domain

  8. NM_001388357.1 → NP_001375286.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform 3 precursor

    Status: REVIEWED

    Source sequence(s)
    AC245036
    Consensus CDS
    CCDS42615.1
    UniProtKB/TrEMBL
    A0A087WSX8, A0A0G2JQ44
    Conserved Domains (3) summary
    cd00096
    Location:125 → 129
    Ig; Ig strand A [structural motif]
    cd05751
    Location:28 → 118
    IgC2_D1_LILR_KIR_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILRs), Natural killer inhibitory receptors (KIRs) and similar domains; member of Immunoglobulin Constant-2 set of IgSF domains
    cl11960
    Location:124 → 219
    Ig; Immunoglobulin domain

  9. NM_001388358.1 → NP_001375287.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform 2 precursor

    Status: REVIEWED

    Source sequence(s)
    AC245036
    Consensus CDS
    CCDS42614.1
    UniProtKB/TrEMBL
    A0A087WSV6, A0A0G2JNQ6
    Conserved Domains (3) summary
    cd00096
    Location:125 → 129
    Ig; Ig strand A [structural motif]
    cd05751
    Location:28 → 118
    IgC2_D1_LILR_KIR_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILRs), Natural killer inhibitory receptors (KIRs) and similar domains; member of Immunoglobulin Constant-2 set of IgSF domains
    cl11960
    Location:124 → 219
    Ig; Immunoglobulin domain

  10. NM_006669.7 → NP_006660.4  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_006660.4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
    Source sequence(s)
    AF283984, AK223310, AK292156, BC015731
    Consensus CDS
    CCDS42617.1
    UniProtKB/Swiss-Prot
    A2IXV4, A8MXT0, O75024, O75025, Q8NHJ9, Q8NHK0, Q8NHL6
    UniProtKB/TrEMBL
    A0A0B4J1W1
    Related
    ENSP00000379622.1, ENST00000396331.5
    Conserved Domains (3) summary
    cd05751
    Location:27 → 119
    Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins
    smart00410
    Location:335 → 397
    IG_like; Immunoglobulin like
    cl11960
    Location:124 → 219
    Ig; Immunoglobulin domain

RNA

  1. NR_103518.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) has a shorter 5' UTR and lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AF283984, AK223310, BC015731

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    54616322..54638022
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047438080.1 → XP_047294036.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X1

  2. XM_047438081.1 → XP_047294037.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X2

  3. XM_047438082.1 → XP_047294038.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X3

  4. XM_047438083.1 → XP_047294039.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X4

  5. XM_047438084.1 → XP_047294040.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X5

  6. XM_047438085.1 → XP_047294041.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X6

  7. XM_047438086.1 → XP_047294042.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X7

  8. XM_047438087.1 → XP_047294043.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X8

  9. XM_017026192.2 → XP_016881681.2  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X9

  10. XM_047438088.1 → XP_047294044.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X10

    Related
    ENSP00000410165.1, ENST00000421584.5

  11. XM_047438089.1 → XP_047294045.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X11

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NW_003571054.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    522708..544408
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054329622.1 → XP_054185597.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X1

  2. XM_054329623.1 → XP_054185598.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X2

  3. XM_054329624.1 → XP_054185599.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X3

  4. XM_054329625.1 → XP_054185600.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X4

  5. XM_054329626.1 → XP_054185601.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X5

  6. XM_054329627.1 → XP_054185602.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X6

  7. XM_054329628.1 → XP_054185603.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X7

  8. XM_054329629.1 → XP_054185604.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X8

  9. XM_054329630.1 → XP_054185605.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X9

  10. XM_054329631.1 → XP_054185606.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X10

  11. XM_054329632.1 → XP_054185607.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X11

Reference GRCh38.p14 ALT_REF_LOCI_7

Genomic

  1. NW_003571060.1 Reference GRCh38.p14 ALT_REF_LOCI_7

    Range
    521195..542900
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054331448.1 → XP_054187423.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X1

  2. XM_054331449.1 → XP_054187424.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X2

  3. XM_054331450.1 → XP_054187425.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X3

  4. XM_054331451.1 → XP_054187426.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X4

  5. XM_054331452.1 → XP_054187427.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X12

  6. XM_054331453.1 → XP_054187428.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X13

  7. XM_054331454.1 → XP_054187429.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X14

  8. XM_054331455.1 → XP_054187430.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X5

  9. XM_054331457.1 → XP_054187432.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X6

    UniProtKB/TrEMBL
    A0A0G2JQ15

  10. XM_054331458.1 → XP_054187433.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X7

    UniProtKB/TrEMBL
    A0A0G2JP64

  11. XM_054331459.1 → XP_054187434.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X8

    UniProtKB/TrEMBL
    A0A0G2JNM2

  12. XM_054331456.1 → XP_054187431.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X5

  13. XM_054331460.1 → XP_054187435.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X9

  14. XM_054331461.1 → XP_054187436.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X10

  15. XM_054331462.1 → XP_054187437.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X11

Reference GRCh38.p14 ALT_REF_LOCI_9

Genomic

  1. NT_187693.1 Reference GRCh38.p14 ALT_REF_LOCI_9

    Range
    598890..620587
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054333582.1 → XP_054189557.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X1

  2. XM_054333583.1 → XP_054189558.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X2

  3. XM_054333584.1 → XP_054189559.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X3

  4. XM_054333585.1 → XP_054189560.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X4

  5. XM_054333586.1 → XP_054189561.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X5

  6. XM_054333588.1 → XP_054189563.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X6

    UniProtKB/TrEMBL
    A0A0G2JQ15

  7. XM_054333589.1 → XP_054189564.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X7

    UniProtKB/TrEMBL
    A0A0G2JP64

  8. XM_054333591.1 → XP_054189566.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X8

    UniProtKB/TrEMBL
    A0A0G2JNM2

  9. XM_054333587.1 → XP_054189562.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X1

  10. XM_054333590.1 → XP_054189565.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X7

    UniProtKB/TrEMBL
    A0A0G2JP64

  11. XM_054333592.1 → XP_054189567.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X9

  12. XM_054333593.1 → XP_054189568.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X10

  13. XM_054333594.1 → XP_054189569.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X11

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    57709827..57731530
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054319577.1 → XP_054175552.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X1

  2. XM_054319578.1 → XP_054175553.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X2

  3. XM_054319579.1 → XP_054175554.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X3

  4. XM_054319580.1 → XP_054175555.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X4

  5. XM_054319581.1 → XP_054175556.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X15

  6. XM_054319582.1 → XP_054175557.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X16

  7. XM_054319583.1 → XP_054175558.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X17

  8. XM_054319584.1 → XP_054175559.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X5

  9. XM_054319587.1 → XP_054175562.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X6

  10. XM_054319588.1 → XP_054175563.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X7

  11. XM_054319590.1 → XP_054175565.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X8

  12. XM_054319586.1 → XP_054175561.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X1

  13. XM_054319585.1 → XP_054175560.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X5

  14. XM_054319589.1 → XP_054175564.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X7

  15. XM_054319591.1 → XP_054175566.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X9

  16. XM_054319592.1 → XP_054175567.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X10

  17. XM_054319593.1 → XP_054175568.1  leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X11

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8NHL6.1 GenPept UniProtKB/Swiss-Prot:Q8NHL6

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