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POSTN periostin [ Homo sapiens (human) ]

Gene ID: 10631, updated on 7-Apr-2024

Summary

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Official Symbol
POSTNprovided by HGNC
Official Full Name
periostinprovided by HGNC
Primary source
HGNC:HGNC:16953
See related
Ensembl:ENSG00000133110 MIM:608777; AllianceGenome:HGNC:16953
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PN; OSF2; OSF-2; PDLPOSTN
Summary
This gene encodes a secreted extracellular matrix protein that functions in tissue development and regeneration, including wound healing, and ventricular remodeling following myocardial infarction. The encoded protein binds to integrins to support adhesion and migration of epithelial cells. This protein plays a role in cancer stem cell maintenance and metastasis. Mice lacking this gene exhibit cardiac valve disease, and skeletal and dental defects. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]
Expression
Broad expression in skin (RPKM 83.7), urinary bladder (RPKM 52.8) and 14 other tissues See more
Orthologs
mouse all
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Genomic context

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See POSTN in Genome Data Viewer
Location:
13q13.3
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (37562585..37598768, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (36781967..36818162, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (38136722..38172905, complement)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903159 Neighboring gene long intergenic non-protein coding RNA 1048 Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:38120407-38120907 Neighboring gene long intergenic non-protein coding RNA 547 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr13:38169125-38169774 Neighboring gene transient receptor potential cation channel subfamily C member 4 Neighboring gene Sharpr-MPRA regulatory region 14178 Neighboring gene Sharpr-MPRA regulatory region 929 Neighboring gene uncharacterized LOC124903160 Neighboring gene RNA, 5S ribosomal pseudogene 26

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Cancer cell-derived novel periostin isoform promotes invasion in head and neck squamous cell carcinoma. Wenhua S, et al. Cancer Med, 2023 Apr. PMID 36691359, Free PMC Article
  2. Periostin regulation and cartilage degradation early after anterior cruciate ligament reconstruction. Jacobs CA, et al. Inflamm Res, 2023 Mar. PMID 36562795
  3. Bioinformatics analysis and identification of dysregulated POSTN in the pathogenesis of keloid. Xu H, et al. Int Wound J, 2023 May. PMID 36517972, Free PMC Article
  4. Periostin Plasma Levels and Changes on Physical and Cognitive Capacities in Community-Dwelling Older Adults. Sánchez-Sánchez JL, et al. J Gerontol A Biol Sci Med Sci, 2023 Mar 1. PMID 36373873, Free PMC Article
  5. Stable and exacerbation period serum cytokine and periostin levels of the five distinct phenotypes of severe asthma. Türk M, et al. Turk J Med Sci, 2022 Aug. PMID 36326393, Free PMC Article

See all (387) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ALK upregulates POSTN and WNT signaling to drive neuroblastoma.
    Title: ALK upregulates POSTN and WNT signaling to drive neuroblastoma.
  2. The gene expression of CALD1, CDH2, and POSTN in fibroblast are related to idiopathic pulmonary fibrosis.
    Title: The gene expression of CALD1, CDH2, and POSTN in fibroblast are related to idiopathic pulmonary fibrosis.
  3. Research progress of periostin and osteoporosis.
    Title: Research progress of periostin and osteoporosis.
  4. Periostin regulates integrin expression in gingival epithelial cells.
    Title: Periostin regulates integrin expression in gingival epithelial cells.
  5. The role of periostin in cardiac fibrosis.
    Title: The role of periostin in cardiac fibrosis.
  6. Expression of Periostin in Benign Salivary Gland Tumors.
    Title: Expression of Periostin in Benign Salivary Gland Tumors.
  7. Periostin is associated with prognosis and immune cell infiltration in pancreatic adenocarcinoma based on integrated bioinformatics analysis.
    Title: Periostin is associated with prognosis and immune cell infiltration in pancreatic adenocarcinoma based on integrated bioinformatics analysis.
  8. Biases related to periostin levels in chronic rhinosinusitis with nasal polyposis: a systematic review.
    Title: Biases related to periostin levels in chronic rhinosinusitis with nasal polyposis: a systematic review.
  9. The effect of light compressive and tensile mechanical forces on SOST and POSTN expressions in human periodontal ligament cells: an in vitro study.
    Title: The effect of light compressive and tensile mechanical forces on SOST and POSTN expressions in human periodontal ligament cells: an in vitro study.
  10. Single-cell Transcriptomic Analysis Reveals an Immunosuppressive Network Between POSTN CAFs and ACKR1 ECs in TKI-resistant Lung Cancer.
    Title: Single-cell Transcriptomic Analysis Reveals an Immunosuppressive Network Between POSTN CAFs and ACKR1 ECs in TKI-resistant Lung Cancer.
Submit: New GeneRIF Correction See all GeneRIFs (378)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Cross-Disorder Genome-Wide Analyses Suggest a Complex Genetic Relationship Between Tourette's Syndrome and OCD.
EBI GWAS Catalog
Insights into the genetic architecture of early stage age-related macular degeneration: a genome-wide association study meta-analysis.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Tat tat Microarray analysis indicates HIV-1 Tat-induced downregulation of periostin, osteoblast specific factor (POSTN) in primary human brain microvascular endothelial cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC119510, MGC119511

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cell adhesion molecule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables extracellular matrix structural constituent RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
enables heparin binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables metal ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in bone regeneration IEA
Inferred from Electronic Annotation
more info
  
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell adhesion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to fibroblast growth factor stimulus IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to transforming growth factor beta stimulus IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to tumor necrosis factor IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to vitamin K IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in extracellular matrix organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of cell-matrix adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of substrate adhesion-dependent cell spreading IEA
Inferred from Electronic Annotation
more info
  
involved_in neuron projection extension IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of chemokine (C-X-C motif) ligand 2 production IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of smooth muscle cell migration IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of systemic arterial blood pressure IEA
Inferred from Electronic Annotation
more info
  
involved_in response to estradiol IEA
Inferred from Electronic Annotation
more info
  
involved_in response to hypoxia IEA
Inferred from Electronic Annotation
more info
  
involved_in response to mechanical stimulus IEA
Inferred from Electronic Annotation
more info
  
involved_in response to muscle activity IEA
Inferred from Electronic Annotation
more info
  
involved_in tissue development IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
colocalizes_with collagen-containing extracellular matrix HDA PubMed 
located_in collagen-containing extracellular matrix HDA PubMed 
located_in collagen-containing extracellular matrix IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular matrix ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in neuromuscular junction IEA
Inferred from Electronic Annotation
more info
  
located_in trans-Golgi network IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
periostin
Names
osteoblast specific factor 2 (fasciclin I-like)
periodontal ligament-specific periostin
periostin, osteoblast specific factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135934.2 → NP_001129406.1  periostin isoform 2 precursor

    See identical proteins and their annotated locations for NP_001129406.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks two alternate in-frame exons, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AI580215, BC106710, BG938993, DC403736
    Consensus CDS
    CCDS45034.1
    UniProtKB/TrEMBL
    C0IMJ3
    Related
    ENSP00000369066.4, ENST00000379742.4
    Conserved Domains (1) summary
    pfam02469
    Location:245 → 367
    Fasciclin; Fasciclin domain

  2. NM_001135935.2 → NP_001129407.1  periostin isoform 3 precursor

    See identical proteins and their annotated locations for NP_001129407.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two alternate in-frame exons, compared to variant 1. The encoded isoform (3, also known as thy6) is shorter than isoform 1.
    Source sequence(s)
    AI580215, AY140646, BQ575951, DC403736
    Consensus CDS
    CCDS53864.1
    UniProtKB/TrEMBL
    C0IMJ3
    Related
    ENSP00000437959.1, ENST00000541179.5
    Conserved Domains (1) summary
    pfam02469
    Location:245 → 367
    Fasciclin; Fasciclin domain

  3. NM_001135936.2 → NP_001129408.1  periostin isoform 4 precursor

    See identical proteins and their annotated locations for NP_001129408.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks three alternate in-frame exons, compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
    Source sequence(s)
    AI580215, AY918092, BP335818, BQ575951, BY795054, DC403736
    UniProtKB/TrEMBL
    C0IMJ3
    Conserved Domains (1) summary
    pfam02469
    Location:245 → 367
    Fasciclin; Fasciclin domain

  4. NM_001286665.2 → NP_001273594.1  periostin isoform 5 precursor

    See identical proteins and their annotated locations for NP_001273594.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (5, also known as thy2) is shorter than isoform 1.
    Source sequence(s)
    AI580215, AY140646, BQ575951, DC403736, EU262883
    Consensus CDS
    CCDS66531.1
    UniProtKB/TrEMBL
    C0IMJ3
    Related
    ENSP00000369067.4, ENST00000379743.8
    Conserved Domains (1) summary
    pfam02469
    Location:245 → 367
    Fasciclin; Fasciclin domain

  5. NM_001286666.2 → NP_001273595.1  periostin isoform 6 precursor

    See identical proteins and their annotated locations for NP_001273595.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks three alternate in-frame exons, compared to variant 1. The encoded isoform (6, also known as thy4) is shorter than isoform 1.
    Source sequence(s)
    AI580215, AY140646, BQ575951, DC403736, EU262884
    Consensus CDS
    CCDS66530.1
    UniProtKB/TrEMBL
    C0IMJ3
    Related
    ENSP00000437953.1, ENST00000541481.5
    Conserved Domains (1) summary
    pfam02469
    Location:245 → 367
    Fasciclin; Fasciclin domain

  6. NM_001286667.2 → NP_001273596.1  periostin isoform 7 precursor

    See identical proteins and their annotated locations for NP_001273596.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) lacks four alternate in-frame exons, compared to variant 1. The encoded isoform (7, also known as thy8) is shorter than isoform 1.
    Source sequence(s)
    AI580215, AY140646, BQ575951, DC403736, EU262886
    UniProtKB/TrEMBL
    C0IMJ3
    Conserved Domains (1) summary
    pfam02469
    Location:245 → 367
    Fasciclin; Fasciclin domain

  7. NM_001330517.2 → NP_001317446.1  periostin isoform 8 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (8) is shorter than isoform 1.
    Source sequence(s)
    AI580215, BC106709, BQ575951, DC403736, JG969042
    Consensus CDS
    CCDS81764.1
    UniProtKB/TrEMBL
    C0IMJ3
    Related
    ENSP00000369073.4, ENST00000379749.8

  8. NM_001424172.1 → NP_001411101.1  periostin isoform 9 precursor

    Status: REVIEWED

    Source sequence(s)
    AL138679, AL646087

  9. NM_001424173.1 → NP_001411102.1  periostin isoform 10 precursor

    Status: REVIEWED

    Source sequence(s)
    AL138679, AL646087

  10. NM_001424174.1 → NP_001411103.1  periostin isoform 11 precursor

    Status: REVIEWED

    Source sequence(s)
    AL138679, AL646087

  11. NM_006475.3 → NP_006466.2  periostin isoform 1 precursor

    See identical proteins and their annotated locations for NP_006466.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AI580215, BC106709, BQ575951, D13666, DC403736
    Consensus CDS
    CCDS9364.1
    UniProtKB/Swiss-Prot
    B1ALD8, B1ALD9, C0IMJ1, C0IMJ2, C0IMJ4, D2KRH7, F5H628, Q15063, Q15064, Q29XZ0, Q3KPJ5, Q5VSY5, Q8IZF9
    UniProtKB/TrEMBL
    C0IMJ3
    Related
    ENSP00000369071.4, ENST00000379747.9
    Conserved Domains (1) summary
    pfam02469
    Location:245 → 367
    Fasciclin; Fasciclin domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

    Range
    37562585..37598768 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047430052.1 → XP_047286008.1  periostin isoform X4

  2. XM_017020355.2 → XP_016875844.1  periostin isoform X1

    UniProtKB/TrEMBL
    C0IMJ3

  3. XM_017020356.2 → XP_016875845.1  periostin isoform X2

    UniProtKB/TrEMBL
    C0IMJ3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060937.1 Alternate T2T-CHM13v2.0

    Range
    36781967..36818162 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054374032.1 → XP_054230007.1  periostin isoform X4

  2. XM_054374029.1 → XP_054230004.1  periostin isoform X1

  3. XM_054374030.1 → XP_054230005.1  periostin isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q15063.2 GenPept UniProtKB/Swiss-Prot:Q15063

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous