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SLC34A2 solute carrier family 34 member 2 [ Homo sapiens (human) ]

Gene ID: 10568, updated on 5-Mar-2024

Summary

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Official Symbol
SLC34A2provided by HGNC
Official Full Name
solute carrier family 34 member 2provided by HGNC
Primary source
HGNC:HGNC:11020
See related
Ensembl:ENSG00000157765 MIM:604217; AllianceGenome:HGNC:11020
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PULAM; NPTIIb; NaPi2b; NAPI-3B; NAPI-IIb
Summary
The protein encoded by this gene is a pH-sensitive sodium-dependent phosphate transporter. Phosphate uptake is increased at lower pH. Defects in this gene are a cause of pulmonary alveolar microlithiasis. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, May 2010]
Expression
Restricted expression toward lung (RPKM 380.9) See more
Orthologs
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Genomic context

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See SLC34A2 in Genome Data Viewer
Location:
4p15.2
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (25655851..25678748)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (25637821..25660720)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (25657473..25680370)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124900687 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:25621229-25621730 Neighboring gene S-phase kinase associated protein 1 pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr4:25647409-25647582 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:25656923-25657836 Neighboring gene ribosomal protein S29 pseudogene 11 Neighboring gene SLIRP. pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. New insights in the genetic variant spectrum of SLC34A2 in pulmonary alveolar microlithiasis; a systematic review. Jönsson ÅLM, et al. Orphanet J Rare Dis, 2023 May 31. PMID 37259144, Free PMC Article
  2. Impaired phosphate transport in SLC34A2 variants in patients with pulmonary alveolar microlithiasis. Jönsson ÅLM, et al. Hum Genomics, 2022 Apr 20. PMID 35443721, Free PMC Article
  3. Characterization of SLC34A2 as a Potential Prognostic Marker of Oncological Diseases. Vlasenkova R, et al. Biomolecules, 2021 Dec 14. PMID 34944522, Free PMC Article
  4. SLC34A2 simultaneously promotes papillary thyroid carcinoma growth and invasion through distinct mechanisms. He J, et al. Oncogene, 2020 Mar. PMID 32005974
  5. Eight novel variants in the SLC34A2 gene in pulmonary alveolar microlithiasis. Jönsson ÅLM, et al. Eur Respir J, 2020 Feb. PMID 31831582

See all (60) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. New insights in the genetic variant spectrum of SLC34A2 in pulmonary alveolar microlithiasis; a systematic review.
    Title: New insights in the genetic variant spectrum of SLC34A2 in pulmonary alveolar microlithiasis; a systematic review.
  2. Impaired phosphate transport in SLC34A2 variants in patients with pulmonary alveolar microlithiasis.
    Title: Impaired phosphate transport in SLC34A2 variants in patients with pulmonary alveolar microlithiasis.
  3. Characterization of SLC34A2 as a Potential Prognostic Marker of Oncological Diseases.
    Title: Characterization of SLC34A2 as a Potential Prognostic Marker of Oncological Diseases.
  4. Eight novel variants in the SLC34A2 gene in pulmonary alveolar microlithiasis.
    Title: Eight novel variants in the SLC34A2 gene in pulmonary alveolar microlithiasis.
  5. SLC34A2 simultaneously promotes papillary thyroid carcinoma growth and invasion through distinct mechanisms.
    Title: SLC34A2 simultaneously promotes papillary thyroid carcinoma growth and invasion through distinct mechanisms.
  6. Phase Ia Study of Anti-NaPi2b Antibody-Drug Conjugate Lifastuzumab Vedotin DNIB0600A in Patients with Non-Small Cell Lung Cancer and Platinum-Resistant Ovarian Cancer.
    Title: Phase Ia Study of Anti-NaPi2b Antibody-Drug Conjugate Lifastuzumab Vedotin DNIB0600A in Patients with Non-Small Cell Lung Cancer and Platinum-Resistant Ovarian Cancer.
  7. Findings suggest that solute carrier 34 A2 (SLC34A2) might be a potential therapeutic target for the therapy of glioma patients.
    Title: Knockdown of SLC34A2 inhibits cell proliferation, metastasis, and elevates chemosensitivity in glioma.
  8. he SLC34A2-ROS-HIF-1-induced overexpression of EZH2 promotes colorectal cancer (CRC) cells proliferation and chemo-resistance to apoptosis. SLC34A2-ROS-HIF-1-EZH2 signaling pathway might serve as a novel therapeutic target against CRC.
    Title: The SLC34A2-ROS-HIF-1-induced up-regulation of EZH2 expression promotes proliferation and chemo-resistance to apoptosis in colorectal cancer.
  9. The results demonstrate that miR-25/Gsk3beta-mediated activation of Wnt signaling is responsible for SLC34A2-induced enhancement of neuroblastoma cell stemness.
    Title: SLC34A2 promotes neuroblastoma cell stemness via enhancement of miR-25/Gsk3β-mediated activation of Wnt/β-catenin signaling.
  10. SLC34A2 regulated sphere formation and self-renewal properties of CD44(+) gastric cancer stem cell-like cells (GCSCs), in vitro and in vivo. Mechanistic investigations revealed that Gsk3beta was the most strikingly up-regulated gene in response to SLC34A2 knockdown in GCSCs and Wnt/beta-cantenin signaling was required for SLC34A2-mediated sphere formation.
    Title: SLC34A2 regulates miR-25-Gsk3β signaling pathway to affect tumor progression in gastric cancer stem cell-like cells.
Submit: New GeneRIF Correction See all GeneRIFs (42)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
PULMONARY ALVEOLAR MICROLITHIASIS
MedGen: C0155912 OMIM: 265100 GeneReviews: Not available
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Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ90534

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables phosphate ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables sodium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables sodium:phosphate symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sodium:phosphate symporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables sodium:phosphate symporter activity TAS
Traceable Author Statement
more info
  
Process Evidence Code Pubs
involved_in in utero embryonic development IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular phosphate ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular phosphate ion homeostasis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phosphate ion transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein metabolic process TAS
Traceable Author Statement
more info
  
involved_in response to estrogen IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in sodium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in sodium-dependent phosphate transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in apical plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in apical plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in brush border IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in brush border membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 
located_in plasma membrane NAS
Non-traceable Author Statement
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in vesicle HDA PubMed 
is_active_in vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
sodium-dependent phosphate transport protein 2B
Names
sodium/phosphate cotransporter 2B
solute carrier family 34 (sodium phosphate), member 2
solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
type II sodium-dependent phosphate transporter 3b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021185.2 RefSeqGene

    Range
    5002..27899
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001177998.2 → NP_001171469.2  sodium-dependent phosphate transport protein 2B isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is 1 aa shorter compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
    Source sequence(s)
    AC092436
    Consensus CDS
    CCDS54750.1
    UniProtKB/TrEMBL
    A8K9G0
    Related
    ENSP00000425501.1, ENST00000504570.5
    Conserved Domains (1) summary
    TIGR01013
    Location:104 → 603
    2a58; Phosphate:Na+ Symporter (PNaS) Family

  2. NM_001177999.2 → NP_001171470.2  sodium-dependent phosphate transport protein 2B isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is 1 aa shorter compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
    Source sequence(s)
    AC092436
    Consensus CDS
    CCDS54750.1
    UniProtKB/TrEMBL
    A8K9G0
    Related
    ENSP00000423021.1, ENST00000503434.5
    Conserved Domains (1) summary
    TIGR01013
    Location:104 → 603
    2a58; Phosphate:Na+ Symporter (PNaS) Family

  3. NM_006424.3 → NP_006415.3  sodium-dependent phosphate transport protein 2B isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AC092436
    Consensus CDS
    CCDS3435.1
    UniProtKB/Swiss-Prot
    A5PL17, O95436, Q8N2K2, Q8WYA9, Q9P0V7
    UniProtKB/TrEMBL
    A0A0B5E3E9
    Related
    ENSP00000371483.3, ENST00000382051.8
    Conserved Domains (1) summary
    TIGR01013
    Location:105 → 604
    2a58; Phosphate:Na+ Symporter (PNaS) Family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    25655851..25678748
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    25637821..25660720
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O95436.3 GenPept UniProtKB/Swiss-Prot:O95436

Gene LinkOut

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