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EIF3M eukaryotic translation initiation factor 3 subunit M [ Homo sapiens (human) ]

Gene ID: 10480, updated on 7-Apr-2024

Summary

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Official Symbol
EIF3Mprovided by HGNC
Official Full Name
eukaryotic translation initiation factor 3 subunit Mprovided by HGNC
Primary source
HGNC:HGNC:24460
See related
Ensembl:ENSG00000149100 MIM:609641; AllianceGenome:HGNC:24460
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
B5; GA17; PCID1; TANGO7; hfl-B5
Summary
This gene encodes a protein that is part of the eurkaryotic translation initiation factor 3 complete (eIF-3) required for protein synthesis. Elevated levels of the encoded protein are present in cancer cell lines. Inactivation of the encoded protein has been shown to interfere with translation of herpes virus mRNAs by preventing the association of mRNAs with the ribosomes. A pseudogene of this gene is located on the X chromosome. [provided by RefSeq, Dec 2011]
Expression
Ubiquitous expression in ovary (RPKM 68.3), thyroid (RPKM 54.3) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
11p13
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (32583831..32606264)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (32719345..32741774)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (32605377..32627810)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene thioesterase superfamily member 7, pseudogene Neighboring gene small nucleolar RNA, H/ACA box 88 Neighboring gene HCNE2 enhancer upstream of PAX6 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:32380174-32380395 Neighboring gene WT1 3' enhancer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3221 Neighboring gene WT1 intron 3 regulatory region Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:32449464-32450078 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:32450079-32450691 Neighboring gene WT1/WT1-AS bi-directional promoter region Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:32459559-32460416 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:32460417-32461272 Neighboring gene Sharpr-MPRA regulatory region 1868 Neighboring gene WT1 transcription factor Neighboring gene MPRA-validated peak1243 silencer Neighboring gene WT1 antisense RNA Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4564 Neighboring gene MPRA-validated peak1244 silencer Neighboring gene MPRA-validated peak1246 silencer Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:32605088-32605740 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3223 Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene 9 Neighboring gene coiled-coil domain containing 73 Neighboring gene 60S ribosomal protein L34-like Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3224 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3225 Neighboring gene ribosomal protein L34 pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3226 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4566 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4567 Neighboring gene proline rich and Gla domain 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. eIF3m expression influences the regulation of tumorigenesis-related genes in human colon cancer. Goh SH, et al. Oncogene, 2011 Jan 27. PMID 20838379
  2. HSV usurps eukaryotic initiation factor 3 subunit M for viral protein translation: novel prevention target. Cheshenko N, et al. PLoS One, 2010 Jul 27. PMID 20676407, Free PMC Article
  3. The C terminus of the B5 receptor for herpes simplex virus contains a functional region important for infection. Perez-Romero P, et al. J Virol, 2005 Jun. PMID 15919899, Free PMC Article
  4. A new class of receptor for herpes simplex virus has heptad repeat motifs that are common to membrane fusion proteins. Perez A, et al. J Virol, 2005 Jun. PMID 15919898, Free PMC Article
  5. A minor isoform of the human RNA polymerase II subunit hRPB11 (POLR2J) interacts with several components of the translation initiation factor eIF3. Proshkin SA, et al. Biochemistry (Mosc), 2011 Aug. PMID 22022972

See all (124) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. POLR2J interacts with three different subunits of eIF3, eIF3a, eIF3i, and eIF3m.
    Title: A minor isoform of the human RNA polymerase II subunit hRPB11 (POLR2J) interacts with several components of the translation initiation factor eIF3.
  2. eIF3m mediates regulation of tumorigenesis-related genes in human colon cancer
    Title: eIF3m expression influences the regulation of tumorigenesis-related genes in human colon cancer.
  3. Results demonstrate that B5 plays a major role in the initiation of HSV protein translation and could provide a novel target for strategies to prevent primary and recurrent herpetic disease.
    Title: HSV usurps eukaryotic initiation factor 3 subunit M for viral protein translation: novel prevention target.
  4. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  5. the human Tango7 counterpart, PCID1 (also known as EIF3M), impinged on caspase 9, revealing a new regulatory axis affecting the apoptosome
    Title: Genome-wide silencing in Drosophila captures conserved apoptotic effectors.
  6. Concluded that the C terminus of B5 contains a functional region that is important for the B5 receptor to mediate events in HSV entry.
    Title: The C terminus of the B5 receptor for herpes simplex virus contains a functional region important for infection.
  7. Cloned a previously uncharacterized human gene, designated hfl-B5, and showed that it encodes a type II cell surface membrane protein that can serve as a receptor for entry of HSV.
    Title: A new class of receptor for herpes simplex virus has heptad repeat motifs that are common to membrane fusion proteins.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Rev rev HIV-1 Rev interacting protein, eukaryotic translation initiation factor 3, subunit M (EIF3M), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa. The interaction of Rev with EIF3M is decreased by RRE PubMed
retropepsin gag-pol HIV-1 PR is identified to have a physical interaction with eukaryotic translation initiation factor 3, subunit M (EIF3M) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ29030

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
contributes_to translation initiation factor activity IC
Inferred by Curator
more info
 PubMed 
contributes_to translation initiation factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables translation initiation factor binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cytoplasmic translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in formation of cytoplasmic translation initiation complex NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in translational initiation IC
Inferred by Curator
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
  
part_of eukaryotic 43S preinitiation complex IEA
Inferred from Electronic Annotation
more info
  
part_of eukaryotic 48S preinitiation complex IEA
Inferred from Electronic Annotation
more info
  
part_of eukaryotic translation initiation factor 3 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of eukaryotic translation initiation factor 3 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of eukaryotic translation initiation factor 3 complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of eukaryotic translation initiation factor 3 complex, eIF3m IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
eukaryotic translation initiation factor 3 subunit M
Names
B5 receptor
PCI domain containing 1 (herpesvirus entry mediator)
PCI domain-containing protein 1
dendritic cell protein
fetal lung protein B5
transport and golgi organization 7 homolog
NP_001294858.1
NP_006351.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001307929.2 → NP_001294858.1  eukaryotic translation initiation factor 3 subunit M isoform 2

    See identical proteins and their annotated locations for NP_001294858.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks in-frame exons in the 5' coding region compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AK292139, AK304378, AL078477, AV713889, BE935691, CK002866, DB479224
    Consensus CDS
    CCDS76392.1
    UniProtKB/TrEMBL
    H0YCQ8
    Related
    ENSP00000436787.1, ENST00000524896.5
    Conserved Domains (1) summary
    smart00088
    Location:137 → 225
    PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15

  2. NM_006360.6 → NP_006351.2  eukaryotic translation initiation factor 3 subunit M isoform 1

    See identical proteins and their annotated locations for NP_006351.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK304378, AL078477, BC019103, BE935691, CK002866, DB479224
    Consensus CDS
    CCDS7880.1
    UniProtKB/Swiss-Prot
    A8K7X4, B4E2Q4, O60735, Q2F836, Q53HL6, Q7L2H7, Q9BXW1
    Related
    ENSP00000436049.1, ENST00000531120.6
    Conserved Domains (1) summary
    smart00088
    Location:269 → 357
    PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    32583831..32606264
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    32719345..32741774
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7L2H7.1 GenPept UniProtKB/Swiss-Prot:Q7L2H7

Gene LinkOut

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