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TACC3 transforming acidic coiled-coil containing protein 3 [ Homo sapiens (human) ]

Gene ID: 10460, updated on 3-Apr-2024

Summary

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Official Symbol
TACC3provided by HGNC
Official Full Name
transforming acidic coiled-coil containing protein 3provided by HGNC
Primary source
HGNC:HGNC:11524
See related
Ensembl:ENSG00000013810 MIM:605303; AllianceGenome:HGNC:11524
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ERIC1; Tacc4; ERIC-1; maskin
Summary
This gene encodes a member of the transforming acidic colied-coil protein family. The encoded protein is a motor spindle protein that may play a role in stabilization of the mitotic spindle. This protein may also play a role in growth a differentiation of certain cancer cells. [provided by RefSeq, Nov 2011]
Expression
Broad expression in testis (RPKM 25.6), bone marrow (RPKM 24.9) and 16 other tissues See more
Orthologs
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Genomic context

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See TACC3 in Genome Data Viewer
Location:
4p16.3
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (1721521..1745171)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (1719323..1742998)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (1723248..1746898)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene stem-loop histone mRNA binding protein Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:1707982-1708482 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15138 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15139 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21155 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21156 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21157 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21158 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21159 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21160 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15140 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:1723083-1724078 Neighboring gene transmembrane protein 129, E3 ubiquitin ligase Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:1732480-1732980 Neighboring gene uncharacterized LOC112268460 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15142 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:1755043-1755650 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:1767895-1768754 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:1769833-1770398 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:1770399-1770964 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15143 Neighboring gene uncharacterized LOC124900648 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:1779273-1780036 Neighboring gene CRISPRi-validated cis-regulatory element chr4.260 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15144 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15145 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:1796986-1797514 Neighboring gene fibroblast growth factor receptor 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Targeting TACC3 represents a novel vulnerability in highly aggressive breast cancers with centrosome amplification. Saatci O, et al. Cell Death Differ, 2023 May. PMID 36864125, Free PMC Article
  2. Elevated expression of transforming acidic coiled-coil-containing protein 3 (TACC3) reflects aggressiveness of primary central nervous system lymphomas. Matsuda K, et al. Pathol Int, 2022 Sep. PMID 35959857
  3. High Expression of TACC3 Is Associated with the Poor Prognosis and Immune Infiltration in Lung Adenocarcinoma Patients. Chen Y, et al. Dis Markers, 2022. PMID 35855850, Free PMC Article
  4. Transforming acidic coiled-coil protein-3: a novel marker for differential diagnosis and prognosis prediction in endocervical adenocarcinoma. Wen YL, et al. Mol Med, 2021 Jun 10. PMID 34134633, Free PMC Article
  5. TACC3 is a prognostic biomarker for kidney renal clear cell carcinoma and correlates with immune cell infiltration and T cell exhaustion. Fan X, et al. Aging (Albany NY), 2021 Mar 10. PMID 33714201, Free PMC Article

See all (134) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cellular senescence gene TACC3 associated with colorectal cancer risk via genetic and DNA methylated alteration.
    Title: Cellular senescence gene TACC3 associated with colorectal cancer risk via genetic and DNA methylated alteration.
  2. Non-Small Cell Lung Carcinoma With Clear Cell Features and FGFR3::TACC3 Gene Rearrangement : Clinicopathologic and Next Generation Sequencing Study of 7 Cases.
    Title: Non-Small Cell Lung Carcinoma With Clear Cell Features and FGFR3::TACC3 Gene Rearrangement : Clinicopathologic and Next Generation Sequencing Study of 7 Cases.
  3. TACC3 is an independent prognostic marker, and knockdown of TACC3 enhances the efficacy of CDK1 inhibitor RO3306 in liver cancer cells.
    Title: TACC3 is an independent prognostic marker, and knockdown of TACC3 enhances the efficacy of CDK1 inhibitor RO3306 in liver cancer cells.
  4. Targeting TACC3 represents a novel vulnerability in highly aggressive breast cancers with centrosome amplification.
    Title: Targeting TACC3 represents a novel vulnerability in highly aggressive breast cancers with centrosome amplification.
  5. TACC3-ch-TOG interaction regulates spindle microtubule assembly by controlling centrosomal recruitment of gamma-TuRC.
    Title: TACC3-ch-TOG interaction regulates spindle microtubule assembly by controlling centrosomal recruitment of γ-TuRC.
  6. Oncogenic driver FGFR3-TACC3 requires five coiled-coil heptads for activation and disulfide bond formation for stability.
    Title: Oncogenic driver FGFR3-TACC3 requires five coiled-coil heptads for activation and disulfide bond formation for stability.
  7. Elevated expression of transforming acidic coiled-coil-containing protein 3 (TACC3) reflects aggressiveness of primary central nervous system lymphomas.
    Title: Elevated expression of transforming acidic coiled-coil-containing protein 3 (TACC3) reflects aggressiveness of primary central nervous system lymphomas.
  8. High Expression of TACC3 Is Associated with the Poor Prognosis and Immune Infiltration in Lung Adenocarcinoma Patients.
    Title: High Expression of TACC3 Is Associated with the Poor Prognosis and Immune Infiltration in Lung Adenocarcinoma Patients.
  9. Transforming acidic coiled-coil protein-3: a novel marker for differential diagnosis and prognosis prediction in endocervical adenocarcinoma.
    Title: Transforming acidic coiled-coil protein-3: a novel marker for differential diagnosis and prognosis prediction in endocervical adenocarcinoma.
  10. TACC3 is a prognostic biomarker for kidney renal clear cell carcinoma and correlates with immune cell infiltration and T cell exhaustion.
    Title: TACC3 is a prognostic biomarker for kidney renal clear cell carcinoma and correlates with immune cell infiltration and T cell exhaustion.
Submit: New GeneRIF Correction See all GeneRIFs (76)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci.
EBI GWAS Catalog
A sequence variant at 4p16.3 confers susceptibility to urinary bladder cancer.
EBI GWAS Catalog
Genome-wide association study identifies multiple loci associated with bladder cancer risk.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC117382, MGC133242

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cerebral cortex development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in metaphase/anaphase transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule cytoskeleton organization involved in mitosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic spindle organization IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of mitotic spindle organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in centriolar satellite IDA
Inferred from Direct Assay
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
  
located_in mitotic spindle IDA
Inferred from Direct Assay
more info
  
located_in spindle pole IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transforming acidic coiled-coil-containing protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_064424.1 RefSeqGene

    Range
    5032..28682
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1367

mRNA and Protein(s)

  1. NM_001410699.1 → NP_001397628.1  transforming acidic coiled-coil-containing protein 3 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC016773
    Consensus CDS
    CCDS93465.1
    UniProtKB/TrEMBL
    A0A087WUE2
    Related
    ENSP00000478580.2, ENST00000612220.5

  2. NM_006342.3 → NP_006333.1  transforming acidic coiled-coil-containing protein 3 isoform 1

    See identical proteins and their annotated locations for NP_006333.1

    Status: REVIEWED

    Source sequence(s)
    AF093543, AI684124, DB098941
    Consensus CDS
    CCDS3352.1
    UniProtKB/Swiss-Prot
    Q2NKK4, Q3KQS5, Q9UMQ1, Q9Y6A5
    UniProtKB/TrEMBL
    A0A494BZT8
    Related
    ENSP00000326550.4, ENST00000313288.9
    Conserved Domains (2) summary
    pfam05010
    Location:639 → 832
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    cl23765
    Location:652 → 753
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    1721521..1745171
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017007653.2 → XP_016863142.1  transforming acidic coiled-coil-containing protein 3 isoform X2

    UniProtKB/Swiss-Prot
    Q2NKK4, Q3KQS5, Q9UMQ1, Q9Y6A5
    UniProtKB/TrEMBL
    A0A494BZT8
    Conserved Domains (2) summary
    pfam05010
    Location:639 → 832
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    cl23765
    Location:652 → 753
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

  2. XM_005247929.4 → XP_005247986.1  transforming acidic coiled-coil-containing protein 3 isoform X1

    UniProtKB/TrEMBL
    A0A494BZT8
    Conserved Domains (2) summary
    pfam05010
    Location:639 → 836
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    cl23765
    Location:656 → 757
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

  3. XM_005247930.4 → XP_005247987.1  transforming acidic coiled-coil-containing protein 3 isoform X5

    Conserved Domains (1) summary
    pfam05010
    Location:279 → 476
    TACC; Transforming acidic coiled-coil-containing protein (TACC)

  4. XM_011513386.4 → XP_011511688.1  transforming acidic coiled-coil-containing protein 3 isoform X3

    UniProtKB/TrEMBL
    B4DYJ1
    Conserved Domains (2) summary
    PRK12323
    Location:239 → 482
    PRK12323; DNA polymerase III subunits gamma and tau; Provisional
    pfam05010
    Location:639 → 691
    TACC; Transforming acidic coiled-coil-containing protein (TACC)

  5. XM_047449523.1 → XP_047305479.1  transforming acidic coiled-coil-containing protein 3 isoform X4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    1719323..1742998
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054348765.1 → XP_054204740.1  transforming acidic coiled-coil-containing protein 3 isoform X2

    UniProtKB/Swiss-Prot
    Q2NKK4, Q3KQS5, Q9UMQ1, Q9Y6A5

  2. XM_054348763.1 → XP_054204738.1  transforming acidic coiled-coil-containing protein 3 isoform X1

  3. XM_054348770.1 → XP_054204745.1  transforming acidic coiled-coil-containing protein 3 isoform X5

  4. XM_054348768.1 → XP_054204743.1  transforming acidic coiled-coil-containing protein 3 isoform X3

  5. XM_054348769.1 → XP_054204744.1  transforming acidic coiled-coil-containing protein 3 isoform X4

  6. XM_054348766.1 → XP_054204741.1  transforming acidic coiled-coil-containing protein 3 isoform X2

    UniProtKB/Swiss-Prot
    Q2NKK4, Q3KQS5, Q9UMQ1, Q9Y6A5

  7. XM_054348767.1 → XP_054204742.1  transforming acidic coiled-coil-containing protein 3 isoform X2

    UniProtKB/Swiss-Prot
    Q2NKK4, Q3KQS5, Q9UMQ1, Q9Y6A5

  8. XM_054348764.1 → XP_054204739.1  transforming acidic coiled-coil-containing protein 3 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y6A5.1 GenPept UniProtKB/Swiss-Prot:Q9Y6A5

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