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TUBGCP3 tubulin gamma complex component 3 [ Homo sapiens (human) ]

Gene ID: 10426, updated on 3-Apr-2024

Summary

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Official Symbol
TUBGCP3provided by HGNC
Official Full Name
tubulin gamma complex component 3provided by HGNC
Primary source
HGNC:HGNC:18598
See related
Ensembl:ENSG00000126216 MIM:617818; AllianceGenome:HGNC:18598
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
104p; ALP6; GCP3; Spc98; SPBC98; Spc98p; Grip104
Summary
Enables gamma-tubulin binding activity. Predicted to be involved in meiotic cell cycle; microtubule cytoskeleton organization; and mitotic cell cycle. Located in cytoplasm and microtubule cytoskeleton. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 8.5), ovary (RPKM 6.0) and 25 other tissues See more
Orthologs
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Genomic context

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See TUBGCP3 in Genome Data Viewer
Location:
13q34
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (112485011..112605630, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (111732118..111854172, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (113139325..113242467, complement)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370373 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr13:113032121-113033320 Neighboring gene uncharacterized LOC105370372 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr13:113046012-113046542 Neighboring gene sperm acrosome associated 7 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:113161934-113162852 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:113233725-113234278 Neighboring gene uncharacterized LOC124903251 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:113242463-113243282 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5531 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5530 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5529 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5532 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5533 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:113271950-113272450 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:113279517-113280017 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:113291197-113291866 Neighboring gene ReSE screen-validated silencer GRCh37_chr13:113296973-113297156 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:113302064-113302958 Neighboring gene ATP11A upstream neighbor lncRNA Neighboring gene Sharpr-MPRA regulatory region 9322 Neighboring gene uncharacterized LOC102725228 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:113343189-113343706 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5534

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. CircTUBGCP3 Contributes to the Malignant Progression of Rectal Cancer. Wang Y, et al. Dig Dis Sci, 2022 Jul. PMID 34515875
  2. The implications of a paternally derived centrosome during human fertilization: consequences for reproduction and the treatment of male factor infertility. Navara CS, et al. Am J Reprod Immunol, 1997 Jan. PMID 9138452
  3. NMR secondary structure and interactions of recombinant human MOZART1 protein, a component of the gamma-tubulin complex. Cukier CD, et al. Protein Sci, 2017 Nov. PMID 28851027, Free PMC Article
  4. Overexpression and Nucleolar Localization of γ-Tubulin Small Complex Proteins GCP2 and GCP3 in Glioblastoma. Dráberová E, et al. J Neuropathol Exp Neurol, 2015 Jul. PMID 26079448
  5. The mammalian gamma-tubulin complex contains homologues of the yeast spindle pole body components spc97p and spc98p. Murphy SM, et al. J Cell Biol, 1998 May 4. PMID 9566967, Free PMC Article

See all (81) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CircTUBGCP3 Contributes to the Malignant Progression of Rectal Cancer.
    Title: CircTUBGCP3 Contributes to the Malignant Progression of Rectal Cancer.
  2. NMR secondary structure and interactions of recombinant human MOZART1 protein with its binding partner, GCP3, has been presented.
    Title: NMR secondary structure and interactions of recombinant human MOZART1 protein, a component of the gamma-tubulin complex.
  3. This study demonstrated that Overexpression and Nucleolar Localization gcp3 in glioblastoma.
    Title: Overexpression and Nucleolar Localization of γ-Tubulin Small Complex Proteins GCP2 and GCP3 in Glioblastoma.
  4. Authors show genetically that GCP3/Spc98 function is fully conserved with Alp6 across species but that functional differences exist between GCP2/Spc97 and Alp4.
    Title: Functional replacement of fission yeast γ-tubulin small complex proteins Alp4 and Alp6 by human GCP2 and GCP3.
  5. Observational study, meta-analysis, and genome-wide association study of gene-disease association. (HuGE Navigator)
    Title: Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways.
  6. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  7. Stability of the small gamma-tubulin complex (gamma tubulin/GCP2/GCP3) requires HCA66, a protein of the centrosome and the nucleolus.
    Title: Stability of the small gamma-tubulin complex requires HCA66, a protein of the centrosome and the nucleolus.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables gamma-tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables gamma-tubulin binding IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to microtubule minus-end binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables structural constituent of cytoskeleton NAS
Non-traceable Author Statement
more info
 PubMed 
enables structural molecule activity NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in cytoplasmic microtubule organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in meiotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule nucleation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule nucleation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in single fertilization NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in centriole IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in centrosome NAS
Non-traceable Author Statement
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
is_active_in equatorial microtubule organizing center IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of gamma-tubulin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane HDA PubMed 
located_in polar microtubule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in spindle NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
gamma-tubulin complex component 3
Names
gamma-ring complex protein 104 kDa
spindle pole body protein Spc98 homolog
tubulin gamma complex associated protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286277.2 → NP_001273206.1  gamma-tubulin complex component 3 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AA720688, AF042378, AK302537, AK314785, AL139384, BC046634
    UniProtKB/TrEMBL
    B4DYP7
    Conserved Domains (1) summary
    pfam04130
    Location:243 → 753
    Spc97_Spc98; Spc97 / Spc98 family

  2. NM_001286278.2 → NP_001273207.1  gamma-tubulin complex component 3 isoform 3

    See identical proteins and their annotated locations for NP_001273207.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks multiple 3' exons and contains an alternate 3' terminal exon, resulting in a distinct 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (3) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AK314785, BC013781
    Consensus CDS
    CCDS66584.1
    UniProtKB/TrEMBL
    B4DYP7
    Related
    ENSP00000364821.3, ENST00000375669.7
    Conserved Domains (1) summary
    pfam04130
    Location:253 → 763
    Spc97_Spc98; Spc97 / Spc98 family

  3. NM_001286279.2 → NP_001273208.1  gamma-tubulin complex component 3 isoform 4

    See identical proteins and their annotated locations for NP_001273208.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks multiple 3' exons and its 3' terminal exon extends past a splice site that is used in variant 1, resulting in a distinct 3' coding region and 3' UTR. The encoded isoform (4) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AK314785, BC007763, BP381545
    Consensus CDS
    CCDS73599.1
    UniProtKB/TrEMBL
    A0A087WU06
    Related
    ENSP00000478276.1, ENST00000464139.5
    Conserved Domains (1) summary
    pfam04130
    Location:253 → 389
    Spc97_Spc98; Spc97 / Spc98 family

  4. NM_006322.6 → NP_006313.1  gamma-tubulin complex component 3 isoform 1

    See identical proteins and their annotated locations for NP_006313.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AA720688, AF042378, BC046634
    Consensus CDS
    CCDS9525.1
    UniProtKB/Swiss-Prot
    O43631, O60852, O60853, Q5T8L2, Q7Z4K1, Q96CW5, Q96I79
    UniProtKB/TrEMBL
    B4DYP7
    Related
    ENSP00000261965.3, ENST00000261965.8
    Conserved Domains (2) summary
    pfam04130
    Location:555 → 886
    Spc97_Spc98; Spc97 / Spc98 family
    pfam17681
    Location:251 → 552
    GCP_N_terminal; Gamma tubulin complex component N-terminal

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

    Range
    112485011..112605630 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017020323.3 → XP_016875812.1  gamma-tubulin complex component 3 isoform X5

    Conserved Domains (1) summary
    pfam04130
    Location:24 → 534
    Spc97_Spc98; Spc97 / Spc98 family

  2. XM_011537462.3 → XP_011535764.1  gamma-tubulin complex component 3 isoform X2

    UniProtKB/TrEMBL
    B4DYP7
    Conserved Domains (1) summary
    pfam04130
    Location:253 → 663
    Spc97_Spc98; Spc97 / Spc98 family

  3. XM_047430039.1 → XP_047285995.1  gamma-tubulin complex component 3 isoform X5

  4. XM_047430038.1 → XP_047285994.1  gamma-tubulin complex component 3 isoform X5

  5. XM_047430036.1 → XP_047285992.1  gamma-tubulin complex component 3 isoform X3

  6. XM_047430037.1 → XP_047285993.1  gamma-tubulin complex component 3 isoform X4

  7. XM_005268293.3 → XP_005268350.1  gamma-tubulin complex component 3 isoform X1

    UniProtKB/TrEMBL
    B4DYP7
    Conserved Domains (1) summary
    pfam04130
    Location:253 → 763
    Spc97_Spc98; Spc97 / Spc98 family

RNA

  1. XR_007063655.1 RNA Sequence

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187592.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    285981..305687 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060937.1 Alternate T2T-CHM13v2.0

    Range
    111732118..111854172 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054374010.1 → XP_054229985.1  gamma-tubulin complex component 3 isoform X5

  2. XM_054374009.1 → XP_054229984.1  gamma-tubulin complex component 3 isoform X5

  3. XM_054374006.1 → XP_054229981.1  gamma-tubulin complex component 3 isoform X2

  4. XM_054374004.1 → XP_054229979.1  gamma-tubulin complex component 3 isoform X6

  5. XM_054374003.1 → XP_054229978.1  gamma-tubulin complex component 3 isoform X6

  6. XM_054374007.1 → XP_054229982.1  gamma-tubulin complex component 3 isoform X3

  7. XM_054374008.1 → XP_054229983.1  gamma-tubulin complex component 3 isoform X4

  8. XM_054374005.1 → XP_054229980.1  gamma-tubulin complex component 3 isoform X1

RNA

  1. XR_008488725.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96CW5.2 GenPept UniProtKB/Swiss-Prot:Q96CW5

Gene LinkOut

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