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ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 [ Homo sapiens (human) ]

Gene ID: 10402, updated on 5-Mar-2024

Summary

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Official Symbol
ST3GAL6provided by HGNC
Official Full Name
ST3 beta-galactoside alpha-2,3-sialyltransferase 6provided by HGNC
Primary source
HGNC:HGNC:18080
See related
Ensembl:ENSG00000064225 MIM:607156; AllianceGenome:HGNC:18080
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SIAT10; ST3GALVI
Summary
The protein encoded by this gene is a member of the sialyltransferase family. Members of this family are enzymes that transfer sialic acid from the activated cytidine 5'-monophospho-N-acetylneuraminic acid to terminal positions on sialylated glycolipids (gangliosides) or to the N- or O-linked sugar chains of glycoproteins. This protein has high specificity for neolactotetraosylceramide and neolactohexaosylceramide as glycolipid substrates and may contribute to the formation of selectin ligands and sialyl Lewis X, a carbohydrate important for cell-to-cell recognition and a blood group antigen. [provided by RefSeq, Apr 2016]
Expression
Broad expression in heart (RPKM 8.2), liver (RPKM 7.6) and 24 other tissues See more
Orthologs
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Genomic context

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Location:
3q12.1
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (98732262..98795852)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (101440560..101504133)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (98451106..98514696)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ribosomal protein L19 pseudogene 7 Neighboring gene Sharpr-MPRA regulatory region 220 Neighboring gene WW domain containing E3 ubiquitin protein ligase 1 pseudogene 1 Neighboring gene ST3GAL6 antisense RNA 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:98450961-98451709 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:98451710-98452457 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14561 Neighboring gene PDZ and LIM domain 1 pseudogene 4 Neighboring gene discoidin, CUB and LCCL domain containing 2 Neighboring gene RNA, U6 small nuclear 26, pseudogene Neighboring gene uncharacterized LOC124906384

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The sialyltransferase ST3GAL6 influences homing and survival in multiple myeloma. Glavey SV, et al. Blood, 2014 Sep 11. PMID 25061176, Free PMC Article
  2. A fine-mapping study of 7 top scoring genes from a GWAS for major depressive disorder. Verbeek EC, et al. PLoS One, 2012. PMID 22649524, Free PMC Article
  3. A functional analysis of N-glycosylation-related genes on sialylation of recombinant erythropoietin in six commonly used mammalian cell lines. Zhang P, et al. Metab Eng, 2010 Nov. PMID 20826224
  4. N-glycan structures and associated gene expression reflect the characteristic N-glycosylation pattern of human hematopoietic stem and progenitor cells. Hemmoranta H, et al. Exp Hematol, 2007 Aug. PMID 17662891
  5. Gene structure and transcriptional regulation of human Gal beta1,4(3) GlcNAc alpha2,3-sialyltransferase VI (hST3Gal VI) gene in prostate cancer cell line. Taniguchi A, et al. Biochem Biophys Res Commun, 2001 Oct 12. PMID 11587543

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. lncRNA ST3GAL6AS1 promotes invasion by inhibiting hnRNPA2B1mediated ST3GAL6 expression in multiple myeloma.
    Title: lncRNA ST3GAL6‑AS1 promotes invasion by inhibiting hnRNPA2B1‑mediated ST3GAL6 expression in multiple myeloma.
  2. a cross-restoration of each of the three genes in ST3GAL6 KO cells showed that overexpression of ST3GAL6 sufficiently rescued the total alpha2,3-sialylation levels, cell morphology, and alpha2,3-sialylation of EGFR, whereas the alpha2,3-sialylation levels of beta1 were greatly enhanced by an overexpression of ST3GAL4
    Title: ST3GAL3, ST3GAL4, and ST3GAL6 differ in their regulation of biological functions via the specificities for the α2,3-sialylation of target proteins.
  3. The sialyltransferase ST3GAL6 influences homing and survival in multiple myeloma.
    Title: The sialyltransferase ST3GAL6 influences homing and survival in multiple myeloma.
  4. the occurrence of CD75s- and iso-CD75s-gangliosides in tumor tissues is largely independent of the transcriptional expression of ST6GAL1 and ST3GAL6
    Title: Differences in CD75s- and iso-CD75s-ganglioside content and altered mRNA expression of sialyltransferases ST6GAL1 and ST3GAL6 in human hepatocellular carcinomas and nontumoral liver tissues.
  5. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
    Title: Use of genome-wide expression data to mine the "Gray Zone" of GWA studies leads to novel candidate obesity genes.
  6. Expression of ST3Gal IV in several gastrointestinal cell lines is correlated with the expression of sialyl Lewis x at the cell surface.
    Title: Differential expression of alpha-2,3-sialyltransferases and alpha-1,3/4-fucosyltransferases regulates the levels of sialyl Lewis a and sialyl Lewis x in gastrointestinal carcinoma cells.
  7. Epigenetic changes in a group of glycosyltransferases including B4GALNT2 and ST3GAL6 represent a malignant phenotype of gastric cancer caused by silencing of the activity of these enzymes
    Title: DNA hypermethylation contributes to incomplete synthesis of carbohydrate determinants in gastrointestinal cancer.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity TAS
Traceable Author Statement
more info
  
enables sialyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cellular response to interleukin-6 IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in glycolipid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in keratan sulfate biosynthetic process TAS
Traceable Author Statement
more info
  
involved_in oligosaccharide biosynthetic process TAS
Traceable Author Statement
more info
  
involved_in protein glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein glycosylation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi membrane TAS
Traceable Author Statement
more info
  
located_in extracellular exosome HDA PubMed 
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
type 2 lactosamine alpha-2,3-sialyltransferase
Names
CMP-NeuAc:beta-galactoside alpha-2,3-sialyltransferase VI
alpha2,3-sialyltransferase ST3Gal VI
sialyltransferase 10 (alpha-2,3-sialyltransferase VI)
NP_001258071.1
NP_001258074.1
NP_001258075.1
NP_001258076.1
NP_001258077.1
NP_001310281.1
NP_001310282.1
NP_001310287.1
NP_001310288.1
NP_001310289.1
NP_001310291.1
NP_001310292.1
NP_001310293.1
NP_001310294.1
NP_001310295.1
NP_001310296.2
NP_001310297.1
NP_006091.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271142.2 → NP_001258071.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform 2

    See identical proteins and their annotated locations for NP_001258071.1

    Status: REVIEWED

    Description
    Transcript Variant: Variants 2, 10 and 11 encode the same isoform (2).
    Source sequence(s)
    AC106728, BC001266, DB036799
    Conserved Domains (1) summary
    pfam00777
    Location:23 → 238
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  2. NM_001271145.2 → NP_001258074.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform 3

    See identical proteins and their annotated locations for NP_001258074.1

    Status: REVIEWED

    Source sequence(s)
    AC106728, AF119391, CB960395
    UniProtKB/TrEMBL
    A0A087WXB8
    Conserved Domains (1) summary
    pfam00777
    Location:161 → 383
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  3. NM_001271146.2 → NP_001258075.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform 1

    See identical proteins and their annotated locations for NP_001258075.1

    Status: REVIEWED

    Description
    Transcript Variant: Variants 1, 4, 7, 8 and 9 encode the same isoform (1).
    Source sequence(s)
    AB022918, AC106728, DB036799
    Consensus CDS
    CCDS2933.1
    UniProtKB/Swiss-Prot
    B2RCH2, B3KMI1, D3DN39, F8W6U0, Q9Y274
    Related
    ENSP00000265261.7, ENST00000265261.11
    Conserved Domains (1) summary
    pfam00777
    Location:85 → 329
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  4. NM_001271147.2 → NP_001258076.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform 4

    See identical proteins and their annotated locations for NP_001258076.1

    Status: REVIEWED

    Source sequence(s)
    AC106728, AK001922, BC001266, HY123342
    UniProtKB/Swiss-Prot
    Q9Y274
    Conserved Domains (1) summary
    pfam00777
    Location:22 → 211
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  5. NM_001271148.2 → NP_001258077.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform 5

    See identical proteins and their annotated locations for NP_001258077.1

    Status: REVIEWED

    Description
    Transcript Variant: Variants 6, 12, 13, 14 and 15 encode the same isoform (5).
    Source sequence(s)
    AC106728, AL539506, BC001266, HY123342
    Conserved Domains (1) summary
    pfam00777
    Location:1 → 185
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  6. NM_001323352.2 → NP_001310281.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: Variants 1, 4, 7, 8 and 9 encode the same isoform (1).
    Source sequence(s)
    AC106728
    Consensus CDS
    CCDS2933.1
    UniProtKB/Swiss-Prot
    B2RCH2, B3KMI1, D3DN39, F8W6U0, Q9Y274
    Conserved Domains (1) summary
    pfam00777
    Location:85 → 329
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  7. NM_001323353.2 → NP_001310282.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: Variants 6, 12, 13, 14 and 15 encode the same isoform (5).
    Source sequence(s)
    AC106728
    Conserved Domains (1) summary
    pfam00777
    Location:1 → 185
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  8. NM_001323358.2 → NP_001310287.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform 7

    Status: REVIEWED

    Description
    Transcript Variant: Variants 17 and 18 encode the same isoform (7).
    Source sequence(s)
    AC106728

  9. NM_001323359.2 → NP_001310288.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform 7

    Status: REVIEWED

    Description
    Transcript Variant: Variants 17 and 18 encode the same isoform (7).
    Source sequence(s)
    AC106728

  10. NM_001323360.2 → NP_001310289.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: Variants 2, 10 and 11 encode the same isoform (2).
    Source sequence(s)
    AC106728
    Conserved Domains (1) summary
    pfam00777
    Location:23 → 238
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  11. NM_001323362.2 → NP_001310291.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: Variants 6, 12, 13, 14 and 15 encode the same isoform (5).
    Source sequence(s)
    AC106728
    Conserved Domains (1) summary
    pfam00777
    Location:1 → 185
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  12. NM_001323363.2 → NP_001310292.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: Variants 6, 12, 13, 14 and 15 encode the same isoform (5).
    Source sequence(s)
    AC106728
    Conserved Domains (1) summary
    pfam00777
    Location:1 → 185
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  13. NM_001323364.2 → NP_001310293.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: Variants 6, 12, 13, 14 and 15 encode the same isoform (5).
    Source sequence(s)
    AC106728
    Conserved Domains (1) summary
    pfam00777
    Location:1 → 185
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  14. NM_001323365.2 → NP_001310294.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: Variants 1, 4, 7, 8 and 9 encode the same isoform (1).
    Source sequence(s)
    AC106728
    Consensus CDS
    CCDS2933.1
    UniProtKB/Swiss-Prot
    B2RCH2, B3KMI1, D3DN39, F8W6U0, Q9Y274
    Conserved Domains (1) summary
    pfam00777
    Location:85 → 329
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  15. NM_001323366.2 → NP_001310295.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: Variants 2, 10 and 11 encode the same isoform (2).
    Source sequence(s)
    AC106728
    Conserved Domains (1) summary
    pfam00777
    Location:23 → 238
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  16. NM_001323367.4 → NP_001310296.2  type 2 lactosamine alpha-2,3-sialyltransferase isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC106728
    Consensus CDS
    CCDS2933.1
    UniProtKB/Swiss-Prot
    B2RCH2, B3KMI1, D3DN39, F8W6U0, Q9Y274
    Conserved Domains (1) summary
    pfam00777
    Location:85 → 329
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  17. NM_001323368.2 → NP_001310297.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: Variants 1, 4, 7, 8 and 9 encode the same isoform (1).
    Source sequence(s)
    AC106728
    Consensus CDS
    CCDS2933.1
    UniProtKB/Swiss-Prot
    B2RCH2, B3KMI1, D3DN39, F8W6U0, Q9Y274
    Related
    ENSP00000417376.1, ENST00000483910.6
    Conserved Domains (1) summary
    pfam00777
    Location:85 → 329
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  18. NM_006100.4 → NP_006091.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform 1

    See identical proteins and their annotated locations for NP_006091.1

    Status: REVIEWED

    Description
    Transcript Variant: Variants 1, 4, 7, 8 and 9 encode the same isoform (1).
    Source sequence(s)
    AC106728, AK315111, BC023312, CB960395
    Consensus CDS
    CCDS2933.1
    UniProtKB/Swiss-Prot
    B2RCH2, B3KMI1, D3DN39, F8W6U0, Q9Y274
    Related
    ENSP00000377717.1, ENST00000394162.5
    Conserved Domains (1) summary
    pfam00777
    Location:85 → 329
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    98732262..98795852
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    101440560..101504133
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y274.1 GenPept UniProtKB/Swiss-Prot:Q9Y274

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