NOD1 nucleotide binding oligomerization domain containing 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: NOD1provided by HGNC
Official Full Name: nucleotide binding oligomerization domain containing 1provided by HGNC
Primary source: HGNC:HGNC:16390
See related: Ensembl:ENSG00000106100 MIM:605980; AllianceGenome:HGNC:16390
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CARD4; NLRC1; hNod1; CLR7.1
Summary: This gene encodes a member of the nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family of proteins. The encoded protein plays a role in innate immunity by acting as a pattern-recognition receptor (PRR) that binds bacterial peptidoglycans and initiates inflammation. This protein has also been implicated in the immune response to viral and parasitic infection. Major structural features of this protein include an N-terminal caspase recruitment domain (CARD), a centrally located nucleotide-binding domain (NBD), and 10 tandem leucine-rich repeats (LRRs) in its C terminus. The CARD is involved in apoptotic signaling, LRRs participate in protein-protein interactions, and mutations in the NBD may affect the process of oligomerization and subsequent function of the LRR domain. Mutations in this gene are associated with asthma, inflammatory bowel disease, Behcet disease and sarcoidosis in human patients. [provided by RefSeq, Aug 2017]
Expression: Ubiquitous expression in lung (RPKM 5.7), spleen (RPKM 4.5) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 7p14.3

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	7	NC_000007.14 (30424527..30478784, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	7	NC_060931.1 (30562221..30616484, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	7	NC_000007.13 (30464143..30518400, complement)

Chromosome 7 - NC_000007.14 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Nod1-dependent NF-kB activation initiates hematopoietic stem cell specification in response to small Rho GTPases.
Title: Nod1-dependent NF-kB activation initiates hematopoietic stem cell specification in response to small Rho GTPases.
NOD1 cooperates with HAX-1 to promote cell migration in a RIPK2- and NF-kB-independent manner.
Title: NOD1 cooperates with HAX-1 to promote cell migration in a RIPK2- and NF-ĸB-independent manner.
Association between genetic polymorphisms of NOD1, Interleukin-1B, and cagA strain with low-grade duodenal eosinophilia in Helicobacter pylori-related dyspepsia.
Title: Association between genetic polymorphisms of NOD1, Interleukin-1B, and cagA strain with low-grade duodenal eosinophilia in Helicobacter pylori-related dyspepsia.
NOD1 mediated D. pteronyssinus-induced allergic airway inflammation through RIP2/NF-kappaB.
Title: NOD1 mediated D. pteronyssinus-induced allergic airway inflammation through RIP2/NF-κB.
Association of NOD1 and NOD2 Polymorphisms With Susceptibility to Subacute Sclerosing Panencephalitis.
Title: Association of NOD1 and NOD2 Polymorphisms With Susceptibility to Subacute Sclerosing Panencephalitis.
NOD1 activation in 3T3-L1 adipocytes confers lipid accumulation in HepG2 cells.
Title: NOD1 activation in 3T3-L1 adipocytes confers lipid accumulation in HepG2 cells.
Activation of the pattern recognition receptor NOD1 in periodontitis impairs the osteogenic capacity of human periodontal ligament stem cells via p38/MAPK signalling.
Title: Activation of the pattern recognition receptor NOD1 in periodontitis impairs the osteogenic capacity of human periodontal ligament stem cells via p38/MAPK signalling.
Activation of NOD1 and NOD2 in the development of liver injury and cancer.
Title: Activation of NOD1 and NOD2 in the development of liver injury and cancer.
Nucleotide-Binding Oligomerization Domain-Containing Protein 1 Regulates Inflammatory Response in Endometriosis.
Title: Nucleotide-Binding Oligomerization Domain-Containing Protein 1 Regulates Inflammatory Response in Endometriosis.
The AmiC/NlpD Pathway Dominates Peptidoglycan Breakdown in Neisseria meningitidis and Affects Cell Separation, NOD1 Agonist Production, and Infection.
Title: The AmiC/NlpD Pathway Dominates Peptidoglycan Breakdown in Neisseria meningitidis and Affects Cell Separation, NOD1 Agonist Production, and Infection.

Submit: New GeneRIF Correction See all GeneRIFs (197)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

CARD4_3524 (e-PCR)
- UniSTS:462080

GDB:4585724 (e-PCR)
- UniSTS:10045

NOD1 (e-PCR)
- UniSTS:503630

GDB:4585415 (e-PCR)
- UniSTS:76633

STS-R02588 (e-PCR)
- UniSTS:7022

GDB:1317654 (e-PCR)
- UniSTS:3764

SHGC-56016 (e-PCR)
- UniSTS:5352

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables CARD domain binding	IDA Inferred from Direct Assay more info	PubMed
enables cysteine-type endopeptidase activator activity involved in apoptotic process	TAS Traceable Author Statement more info	PubMed
enables identical protein binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables pattern recognition receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables peptidoglycan binding	IDA Inferred from Direct Assay more info	PubMed
enables peptidoglycan binding	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info
involved_in JNK cascade	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within activation of cysteine-type endopeptidase activity involved in apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in cellular response to muramyl dipeptide	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response	TAS Traceable Author Statement more info	PubMed
involved_in defense response to Gram-negative bacterium	IDA Inferred from Direct Assay more info	PubMed
involved_in defense response to Gram-positive bacterium	IEA Inferred from Electronic Annotation more info
involved_in defense response to bacterium	IDA Inferred from Direct Assay more info	PubMed
involved_in detection of bacterium	IDA Inferred from Direct Assay more info	PubMed
involved_in detection of biotic stimulus	TAS Traceable Author Statement more info	PubMed
involved_in inflammatory response	TAS Traceable Author Statement more info	PubMed
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in nucleotide-binding oligomerization domain containing 1 signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in pattern recognition receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of JNK cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of NF-kappaB transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of canonical NF-kappaB signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of canonical NF-kappaB signal transduction	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of dendritic cell antigen processing and presentation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of interleukin-1 beta production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-6 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-8 production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of macrophage cytokine production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of non-canonical NF-kappaB signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of stress-activated MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of tumor necrosis factor production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of xenophagy	IEA Inferred from Electronic Annotation more info
involved_in response to endoplasmic reticulum stress	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	TAS Traceable Author Statement more info	PubMed
involved_in stress-activated MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in xenophagy	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	TAS Traceable Author Statement more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in phagocytic vesicle	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: nucleotide-binding oligomerization domain-containing protein 1

Names: NLR family, CARD domain containing 1; caspase recruitment domain family, member 4; caspase recruitment domain-containing protein 4; nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_013025.1 RefSeqGene

Range

4994..59251

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001354849.2 → NP_001341778.1 nucleotide-binding oligomerization domain-containing protein 1 isoform 2

Status: REVIEWED

Source sequence(s)

AA845215, AC005154, AC006027

UniProtKB/TrEMBL

B3KN80

Conserved Domains (5) summary

COG5635
Location:170 → 542

COG5635; Predicted NTPase, NACHT family domain [Signal transduction mechanisms]

cd08324
Location:21 → 105

CARD_NOD1_CARD4; Caspase activation and recruitment domain similar to that found in NOD1

sd00033
Location:730 → 757

LRR_RI; leucine-rich repeat [structural motif]

pfam05729
Location:197 → 367

NACHT; NACHT domain

cl26161
Location:676 → 914

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
NM_006092.4 → NP_006083.1 nucleotide-binding oligomerization domain-containing protein 1 isoform 1

See identical proteins and their annotated locations for NP_006083.1

Status: REVIEWED

Source sequence(s)

AA845215, AC005154, AF113925, BC040339, CV569884

Consensus CDS

CCDS5427.1

UniProtKB/Swiss-Prot

B4DTU3, Q549U4, Q8IWF5, Q9Y239

UniProtKB/TrEMBL

A0A024RA73

Related

ENSP00000222823.4, ENST00000222823.9

Conserved Domains (5) summary

smart00382
Location:194 → 291

AAA; ATPases associated with a variety of cellular activities

cd00116
Location:676 → 941

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

cd08324
Location:21 → 105

CARD_NOD1_CARD4; Caspase activation and recruitment domain similar to that found in NOD1

sd00033
Location:730 → 757

LRR_RI; leucine-rich repeat [structural motif]

pfam05729
Location:197 → 367

NACHT; NACHT domain

RNA

NR_149002.2 RNA Sequence

Status: REVIEWED

Source sequence(s)

AA845215, AC005154, AF113925, AK023969

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000007.14 Reference GRCh38.p14 Primary Assembly

Range

30424527..30478784 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047419760.1 → XP_047275716.1 nucleotide-binding oligomerization domain-containing protein 1 isoform X3
XM_005249572.1 → XP_005249629.1 nucleotide-binding oligomerization domain-containing protein 1 isoform X1

See identical proteins and their annotated locations for XP_005249629.1

UniProtKB/Swiss-Prot

B4DTU3, Q549U4, Q8IWF5, Q9Y239

UniProtKB/TrEMBL

A0A024RA73

Conserved Domains (5) summary

smart00382
Location:194 → 291

AAA; ATPases associated with a variety of cellular activities

cd00116
Location:676 → 941

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

cd08324
Location:21 → 105

CARD_NOD1_CARD4; Caspase activation and recruitment domain similar to that found in NOD1

sd00033
Location:730 → 757

LRR_RI; leucine-rich repeat [structural motif]

pfam05729
Location:197 → 367

NACHT; NACHT domain
XM_047419763.1 → XP_047275719.1 nucleotide-binding oligomerization domain-containing protein 1 isoform X4
XM_047419753.1 → XP_047275709.1 nucleotide-binding oligomerization domain-containing protein 1 isoform X2
XM_047419765.1 → XP_047275721.1 nucleotide-binding oligomerization domain-containing protein 1 isoform X6
XM_047419759.1 → XP_047275715.1 nucleotide-binding oligomerization domain-containing protein 1 isoform X3
XM_047419768.1 → XP_047275724.1 nucleotide-binding oligomerization domain-containing protein 1 isoform X7
XM_047419762.1 → XP_047275718.1 nucleotide-binding oligomerization domain-containing protein 1 isoform X4
XM_011515083.2 → XP_011513385.1 nucleotide-binding oligomerization domain-containing protein 1 isoform X2

UniProtKB/TrEMBL

B3KN80

Conserved Domains (5) summary

smart00382
Location:194 → 291

AAA; ATPases associated with a variety of cellular activities

cd00116
Location:676 → 925

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

cd08324
Location:21 → 105

CARD_NOD1_CARD4; Caspase activation and recruitment domain similar to that found in NOD1

sd00033
Location:730 → 757

LRR_RI; leucine-rich repeat [structural motif]

pfam05729
Location:197 → 367

NACHT; NACHT domain
XM_011515085.2 → XP_011513387.1 nucleotide-binding oligomerization domain-containing protein 1 isoform X6

UniProtKB/TrEMBL

B3KN80

Conserved Domains (4) summary

cd00116
Location:723 → 858

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

cd08324
Location:21 → 105

CARD_NOD1_CARD4; Caspase activation and recruitment domain similar to that found in NOD1

sd00033
Location:730 → 754

LRR_RI; leucine-rich repeat [structural motif]

pfam05729
Location:197 → 367

NACHT; NACHT domain
XM_011515084.2 → XP_011513386.1 nucleotide-binding oligomerization domain-containing protein 1 isoform X3

UniProtKB/TrEMBL

B3KN80

Conserved Domains (5) summary

COG5635
Location:170 → 542

COG5635; Predicted NTPase, NACHT family domain [Signal transduction mechanisms]

cd08324
Location:21 → 105

CARD_NOD1_CARD4; Caspase activation and recruitment domain similar to that found in NOD1

sd00033
Location:730 → 757

LRR_RI; leucine-rich repeat [structural motif]

pfam05729
Location:197 → 367

NACHT; NACHT domain

cl26161
Location:676 → 914

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
XM_005249568.2 → XP_005249625.1 nucleotide-binding oligomerization domain-containing protein 1 isoform X1

See identical proteins and their annotated locations for XP_005249625.1

UniProtKB/Swiss-Prot

B4DTU3, Q549U4, Q8IWF5, Q9Y239

UniProtKB/TrEMBL

A0A024RA73

Conserved Domains (5) summary

smart00382
Location:194 → 291

AAA; ATPases associated with a variety of cellular activities

cd00116
Location:676 → 941

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

cd08324
Location:21 → 105

CARD_NOD1_CARD4; Caspase activation and recruitment domain similar to that found in NOD1

sd00033
Location:730 → 757

LRR_RI; leucine-rich repeat [structural motif]

pfam05729
Location:197 → 367

NACHT; NACHT domain
XM_047419761.1 → XP_047275717.1 nucleotide-binding oligomerization domain-containing protein 1 isoform X3
XM_047419766.1 → XP_047275722.1 nucleotide-binding oligomerization domain-containing protein 1 isoform X6
XM_047419755.1 → XP_047275711.1 nucleotide-binding oligomerization domain-containing protein 1 isoform X3
XM_047419752.1 → XP_047275708.1 nucleotide-binding oligomerization domain-containing protein 1 isoform X1

UniProtKB/Swiss-Prot

B4DTU3, Q549U4, Q8IWF5, Q9Y239

UniProtKB/TrEMBL

A0A024RA73
XM_047419758.1 → XP_047275714.1 nucleotide-binding oligomerization domain-containing protein 1 isoform X3
XM_006715633.3 → XP_006715696.1 nucleotide-binding oligomerization domain-containing protein 1 isoform X1

See identical proteins and their annotated locations for XP_006715696.1

UniProtKB/Swiss-Prot

B4DTU3, Q549U4, Q8IWF5, Q9Y239

UniProtKB/TrEMBL

A0A024RA73

Conserved Domains (5) summary

smart00382
Location:194 → 291

AAA; ATPases associated with a variety of cellular activities

cd00116
Location:676 → 941

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

cd08324
Location:21 → 105

CARD_NOD1_CARD4; Caspase activation and recruitment domain similar to that found in NOD1

sd00033
Location:730 → 757

LRR_RI; leucine-rich repeat [structural motif]

pfam05729
Location:197 → 367

NACHT; NACHT domain
XM_047419767.1 → XP_047275723.1 nucleotide-binding oligomerization domain-containing protein 1 isoform X6
XM_047419756.1 → XP_047275712.1 nucleotide-binding oligomerization domain-containing protein 1 isoform X3
XM_011515079.1 → XP_011513381.1 nucleotide-binding oligomerization domain-containing protein 1 isoform X1

See identical proteins and their annotated locations for XP_011513381.1

UniProtKB/Swiss-Prot

B4DTU3, Q549U4, Q8IWF5, Q9Y239

UniProtKB/TrEMBL

A0A024RA73

Conserved Domains (5) summary

smart00382
Location:194 → 291

AAA; ATPases associated with a variety of cellular activities

cd00116
Location:676 → 941

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

cd08324
Location:21 → 105

CARD_NOD1_CARD4; Caspase activation and recruitment domain similar to that found in NOD1

sd00033
Location:730 → 757

LRR_RI; leucine-rich repeat [structural motif]

pfam05729
Location:197 → 367

NACHT; NACHT domain
XM_047419754.1 → XP_047275710.1 nucleotide-binding oligomerization domain-containing protein 1 isoform X2
XM_047419757.1 → XP_047275713.1 nucleotide-binding oligomerization domain-containing protein 1 isoform X3
XM_047419764.1 → XP_047275720.1 nucleotide-binding oligomerization domain-containing protein 1 isoform X5
XM_047419770.1 → XP_047275726.1 nucleotide-binding oligomerization domain-containing protein 1 isoform X12
XM_005249576.1 → XP_005249633.1 nucleotide-binding oligomerization domain-containing protein 1 isoform X11

Conserved Domains (3) summary

cd00116
Location:428 → 693

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:482 → 509

LRR_RI; leucine-rich repeat [structural motif]

cl21455
Location:3 → 119

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
XM_011515087.2 → XP_011513389.1 nucleotide-binding oligomerization domain-containing protein 1 isoform X8

UniProtKB/TrEMBL

B3KN80

Conserved Domains (5) summary

COG5635
Location:89 → 542

COG5635; Predicted NTPase, NACHT family domain [Signal transduction mechanisms]

cd00116
Location:723 → 821

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

cd08324
Location:21 → 105

CARD_NOD1_CARD4; Caspase activation and recruitment domain similar to that found in NOD1

sd00033
Location:730 → 757

LRR_RI; leucine-rich repeat [structural motif]

pfam05729
Location:197 → 367

NACHT; NACHT domain
XM_011515088.3 → XP_011513390.1 nucleotide-binding oligomerization domain-containing protein 1 isoform X9

See identical proteins and their annotated locations for XP_011513390.1

UniProtKB/TrEMBL

B3KN80, G3XAL1

Related

ENSP00000416946.1, ENST00000434755.5

Conserved Domains (3) summary

smart00382
Location:194 → 291

AAA; ATPases associated with a variety of cellular activities

cd08324
Location:21 → 105

CARD_NOD1_CARD4; Caspase activation and recruitment domain similar to that found in NOD1

pfam05729
Location:197 → 367

NACHT; NACHT domain
XM_047419769.1 → XP_047275725.1 nucleotide-binding oligomerization domain-containing protein 1 isoform X10

RNA

XR_007059981.1 RNA Sequence
XR_926910.2 RNA Sequence
XR_001744530.2 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

NC_060931.1 Alternate T2T-CHM13v2.0

Range

30562221..30616484 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054357066.1 → XP_054213041.1 nucleotide-binding oligomerization domain-containing protein 1 isoform X3
XM_054357056.1 → XP_054213031.1 nucleotide-binding oligomerization domain-containing protein 1 isoform X1

UniProtKB/Swiss-Prot

B4DTU3, Q549U4, Q8IWF5, Q9Y239

UniProtKB/TrEMBL

A0A024RA73
XM_054357069.1 → XP_054213044.1 nucleotide-binding oligomerization domain-containing protein 1 isoform X4
XM_054357058.1 → XP_054213033.1 nucleotide-binding oligomerization domain-containing protein 1 isoform X2
XM_054357072.1 → XP_054213047.1 nucleotide-binding oligomerization domain-containing protein 1 isoform X6
XM_054357065.1 → XP_054213040.1 nucleotide-binding oligomerization domain-containing protein 1 isoform X3
XM_054357075.1 → XP_054213050.1 nucleotide-binding oligomerization domain-containing protein 1 isoform X7
XM_054357068.1 → XP_054213043.1 nucleotide-binding oligomerization domain-containing protein 1 isoform X4
XM_054357057.1 → XP_054213032.1 nucleotide-binding oligomerization domain-containing protein 1 isoform X2
XM_054357071.1 → XP_054213046.1 nucleotide-binding oligomerization domain-containing protein 1 isoform X6
XM_054357060.1 → XP_054213035.1 nucleotide-binding oligomerization domain-containing protein 1 isoform X3
XM_054357052.1 → XP_054213027.1 nucleotide-binding oligomerization domain-containing protein 1 isoform X1

UniProtKB/Swiss-Prot

B4DTU3, Q549U4, Q8IWF5, Q9Y239

UniProtKB/TrEMBL

A0A024RA73
XM_054357067.1 → XP_054213042.1 nucleotide-binding oligomerization domain-containing protein 1 isoform X3
XM_054357073.1 → XP_054213048.1 nucleotide-binding oligomerization domain-containing protein 1 isoform X6
XM_054357061.1 → XP_054213036.1 nucleotide-binding oligomerization domain-containing protein 1 isoform X3
XM_054357053.1 → XP_054213028.1 nucleotide-binding oligomerization domain-containing protein 1 isoform X1

UniProtKB/Swiss-Prot

B4DTU3, Q549U4, Q8IWF5, Q9Y239

UniProtKB/TrEMBL

A0A024RA73
XM_054357064.1 → XP_054213039.1 nucleotide-binding oligomerization domain-containing protein 1 isoform X3
XM_054357055.1 → XP_054213030.1 nucleotide-binding oligomerization domain-containing protein 1 isoform X1

UniProtKB/Swiss-Prot

B4DTU3, Q549U4, Q8IWF5, Q9Y239

UniProtKB/TrEMBL

A0A024RA73
XM_054357074.1 → XP_054213049.1 nucleotide-binding oligomerization domain-containing protein 1 isoform X6
XM_054357062.1 → XP_054213037.1 nucleotide-binding oligomerization domain-containing protein 1 isoform X3
XM_054357054.1 → XP_054213029.1 nucleotide-binding oligomerization domain-containing protein 1 isoform X1

UniProtKB/Swiss-Prot

B4DTU3, Q549U4, Q8IWF5, Q9Y239

UniProtKB/TrEMBL

A0A024RA73
XM_054357059.1 → XP_054213034.1 nucleotide-binding oligomerization domain-containing protein 1 isoform X2
XM_054357063.1 → XP_054213038.1 nucleotide-binding oligomerization domain-containing protein 1 isoform X3
XM_054357070.1 → XP_054213045.1 nucleotide-binding oligomerization domain-containing protein 1 isoform X5
XM_054357080.1 → XP_054213055.1 nucleotide-binding oligomerization domain-containing protein 1 isoform X12
XM_054357079.1 → XP_054213054.1 nucleotide-binding oligomerization domain-containing protein 1 isoform X11
XM_054357076.1 → XP_054213051.1 nucleotide-binding oligomerization domain-containing protein 1 isoform X8
XM_054357077.1 → XP_054213052.1 nucleotide-binding oligomerization domain-containing protein 1 isoform X9

UniProtKB/TrEMBL

G3XAL1
XM_054357078.1 → XP_054213053.1 nucleotide-binding oligomerization domain-containing protein 1 isoform X10