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SRRM1 serine and arginine repetitive matrix 1 [ Homo sapiens (human) ]

Gene ID: 10250, updated on 7-Apr-2024

Summary

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Official Symbol
SRRM1provided by HGNC
Official Full Name
serine and arginine repetitive matrix 1provided by HGNC
Primary source
HGNC:HGNC:16638
See related
Ensembl:ENSG00000133226 MIM:605975; AllianceGenome:HGNC:16638
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
160-KD; POP101; SRM160
Summary
Enables RNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Located in nuclear speck. Part of catalytic step 2 spliceosome. Biomarker of gestational diabetes. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary (RPKM 22.6), prostate (RPKM 22.3) and 25 other tissues See more
Orthologs
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Genomic context

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See SRRM1 in Genome Data Viewer
Location:
1p36.11
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (24643302..24673281)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (24481714..24511711)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (24969793..24999772)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene RCAN family member 3 Neighboring gene Sharpr-MPRA regulatory region 2491 Neighboring gene NCMAP divergent transcript Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:24894097-24894598 Neighboring gene NANOG hESC enhancer GRCh37_chr1:24895749-24896251 Neighboring gene ribosomal protein L26 pseudogene 8 Neighboring gene non-compact myelin associated protein Neighboring gene ATAC-STARR-seq lymphoblastoid active region 405 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 434 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 435 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:24981406-24981591 Neighboring gene small nucleolar RNA U13 Neighboring gene Sharpr-MPRA regulatory region 11281 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 436 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:25041190-25042389 Neighboring gene Sharpr-MPRA regulatory region 6401 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:25050611-25051418 Neighboring gene Sharpr-MPRA regulatory region 445 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:25056667-25057257 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:25069429-25070034 Neighboring gene hESC enhancers GRCh37_chr1:25071247-25071852 and GRCh37_chr1:25071853-25072458 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 439 Neighboring gene chloride intracellular channel 4 Neighboring gene RNA, U6 small nuclear 1208, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:25173940-25174664 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 440 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 441 Neighboring gene uncharacterized LOC105376876

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. In vitro FRAP reveals the ATP-dependent nuclear mobilization of the exon junction complex protein SRm160. Wagner S, et al. J Cell Biol, 2004 Mar 15. PMID 15024032, Free PMC Article
  2. The spatial targeting and nuclear matrix binding domains of SRm160. Wagner S, et al. Proc Natl Acad Sci U S A, 2003 Mar 18. PMID 12624182, Free PMC Article
  3. Structure and function of the PWI motif: a novel nucleic acid-binding domain that facilitates pre-mRNA processing. Szymczyna BR, et al. Genes Dev, 2003 Feb 15. PMID 12600940, Free PMC Article
  4. 1H, 13C, and 15N resonance assignments and secondary structure of the PWI domain from SRm160 using reduced dimensionality NMR. Szymczyna BR, et al. J Biomol NMR, 2002 Mar. PMID 11991360
  5. A cell-based splicing reporter system to identify regulators of cis-splicing between adjacent genes. Chwalenia K, et al. Nucleic Acids Res, 2019 Feb 28. PMID 30590765, Free PMC Article

See all (156) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. We discovered that two factors, SRRM1 and SF3B1, affect not only cis-SAGe chimeras, but also other types of chimeric RNAs in a genome-wide fashion.
    Title: A cell-based splicing reporter system to identify regulators of cis-splicing between adjacent genes.
  2. two contiguous sequences that independently target SRm160 to nuclear matrix sites at splicing speckled domains: amino acids 300-350 and 351-688
    Title: The spatial targeting and nuclear matrix binding domains of SRm160.
  3. Proto-oncoprotein TLS/FUS is associated to the nuclear matrix and complexed with splicing factors PTB, SRm160, and SR proteins and plays a role in spliceosome assembly
    Title: Proto-oncoprotein TLS/FUS is associated to the nuclear matrix and complexed with splicing factors PTB, SRm160, and SR proteins.
  4. SRm160, a splicing coactivator, regulates CD44 alternative splicing in a Ras-dependent manner.
    Title: Regulation of CD44 alternative splicing by SRm160 and its potential role in tumor cell invasion.
  5. found that the majority of proteins identified in SRm160-containing complexes are associated with pre-mRNA processing. Interestingly, SRm160 is also associated with factors involved in chromatin regulation and sister chromatid cohesion
    Title: Proteomic analysis of SRm160-containing complexes reveals a conserved association with cohesin.
  6. Data show that SRm160, a splicing coactivator and component of the exon junction complex (EJC) involved in RNA export, has an adenosine triphosphate (ATP)-dependent mobility.
    Title: In vitro FRAP reveals the ATP-dependent nuclear mobilization of the exon junction complex protein SRm160.
  7. 1H, 13C, and 15N resonance assignments and secondary structure of the PWI domain from SRm160 was determined using reduced dimensionality NMR.
    Title: 1H, 13C, and 15N resonance assignments and secondary structure of the PWI domain from SRm160 using reduced dimensionality NMR.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human serine/arginine repetitive matrix 1 (SRRM1) at amino acid residues 123-124 by the HIV-1 protease PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC39488

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding HDA PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in RNA splicing TAS
Traceable Author Statement
more info
 PubMed 
involved_in RNA splicing, via transesterification reactions TAS
Traceable Author Statement
more info
 PubMed 
involved_in localization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mRNA splicing, via spliceosome IC
Inferred by Curator
more info
 PubMed 
involved_in regulation of mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of catalytic step 2 spliceosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in nuclear matrix IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus TAS
Traceable Author Statement
more info
 PubMed 
part_of spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
serine/arginine repetitive matrix protein 1
Names
SR-related nuclear matrix protein of 160 kDa
Ser/Arg-related nuclear matrix protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001303448.2 → NP_001290377.1  serine/arginine repetitive matrix protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001290377.1

    Status: VALIDATED

    Source sequence(s)
    AA744578, AF419855, AK302498, AW958761, BG178896, CX782666
    UniProtKB/TrEMBL
    B7Z7U0
    Conserved Domains (2) summary
    PHA03307
    Location:618 → 752
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam01480
    Location:46 → 115
    PWI; PWI domain

  2. NM_001303449.1 → NP_001290378.1  serine/arginine repetitive matrix protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001290378.1

    Status: VALIDATED

    Source sequence(s)
    AA744578, AF419855, AK302498, AK307419, AW958761, BG178896, CX782666, DC353932
    UniProtKB/TrEMBL
    B7Z7U0
    Conserved Domains (2) summary
    pfam01480
    Location:7 → 76
    PWI; PWI domain
    pfam15087
    Location:573 → 702
    DUF4551; Protein of unknown function (DUF4551)

  3. NM_001366565.1 → NP_001353494.1  serine/arginine repetitive matrix protein 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL445648, AL445686
    UniProtKB/TrEMBL
    B7Z7U0
    Conserved Domains (2) summary
    PHA03307
    Location:523 → 657
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam01480
    Location:1 → 32
    PWI; PWI domain

  4. NM_001366566.1 → NP_001353495.1  serine/arginine repetitive matrix protein 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL445648, AL445686
    UniProtKB/TrEMBL
    B7Z7U0
    Conserved Domains (2) summary
    PHA03307
    Location:523 → 657
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam01480
    Location:1 → 32
    PWI; PWI domain

  5. NM_001366567.1 → NP_001353496.1  serine/arginine repetitive matrix protein 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL445648, AL445686
    UniProtKB/TrEMBL
    B7Z7U0
    Conserved Domains (2) summary
    PHA03307
    Location:521 → 655
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam01480
    Location:1 → 32
    PWI; PWI domain

  6. NM_001366568.1 → NP_001353497.1  serine/arginine repetitive matrix protein 1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL445648, AL445686
    UniProtKB/TrEMBL
    B7Z7U0
    Conserved Domains (2) summary
    PHA03307
    Location:537 → 671
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam01480
    Location:1 → 32
    PWI; PWI domain

  7. NM_001366569.1 → NP_001353498.1  serine/arginine repetitive matrix protein 1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL445648, AL445686
    Consensus CDS
    CCDS90885.1
    UniProtKB/TrEMBL
    A0A994J7V4, B7Z7U0
    Related
    ENSP00000516158.1, ENST00000705663.1
    Conserved Domains (3) summary
    PHA03247
    Location:414 → 743
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:619 → 753
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam01480
    Location:46 → 115
    PWI; PWI domain

  8. NM_001366570.1 → NP_001353499.1  serine/arginine repetitive matrix protein 1 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AL445648, AL445686
    UniProtKB/TrEMBL
    B7Z7U0
    Conserved Domains (2) summary
    PHA03247
    Location:298 → 658
    PHA03247; large tegument protein UL36; Provisional
    pfam01480
    Location:1 → 32
    PWI; PWI domain

  9. NM_001366571.1 → NP_001353500.1  serine/arginine repetitive matrix protein 1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL445648, AL445686
    UniProtKB/TrEMBL
    B7Z7U0
    Conserved Domains (2) summary
    PHA03307
    Location:537 → 671
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam01480
    Location:1 → 32
    PWI; PWI domain

  10. NM_001366572.1 → NP_001353501.1  serine/arginine repetitive matrix protein 1 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AL445648, AL445686
    UniProtKB/TrEMBL
    B7Z7U0
    Conserved Domains (2) summary
    PHA03307
    Location:522 → 656
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam01480
    Location:1 → 32
    PWI; PWI domain

  11. NM_001366573.1 → NP_001353502.1  serine/arginine repetitive matrix protein 1 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AL445648, AL445686
    UniProtKB/TrEMBL
    B7Z7U0
    Conserved Domains (2) summary
    PHA03307
    Location:535 → 669
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam01480
    Location:1 → 32
    PWI; PWI domain

  12. NM_001366575.1 → NP_001353504.1  serine/arginine repetitive matrix protein 1 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AL445648, AL445686
    Consensus CDS
    CCDS90883.1
    UniProtKB/TrEMBL
    A0A994J7H1, B7Z7U0
    Related
    ENSP00000516160.1, ENST00000705682.1
    Conserved Domains (3) summary
    PHA03247
    Location:381 → 741
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:617 → 751
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam01480
    Location:46 → 115
    PWI; PWI domain

  13. NM_001366576.1 → NP_001353505.1  serine/arginine repetitive matrix protein 1 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AL445648, AL445686
    UniProtKB/TrEMBL
    B7Z7U0
    Conserved Domains (4) summary
    PHA03247
    Location:384 → 713
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:589 → 723
    PHA03307; transcriptional regulator ICP4; Provisional
    PRK04195
    Location:121 → 209
    PRK04195; replication factor C large subunit; Provisional
    pfam01480
    Location:46 → 115
    PWI; PWI domain

  14. NM_001366577.1 → NP_001353506.1  serine/arginine repetitive matrix protein 1 isoform 13

    Status: VALIDATED

    Source sequence(s)
    AL445648, AL445686
    UniProtKB/TrEMBL
    B7Z7U0
    Conserved Domains (3) summary
    PHA03307
    Location:590 → 724
    PHA03307; transcriptional regulator ICP4; Provisional
    PRK04195
    Location:121 → 209
    PRK04195; replication factor C large subunit; Provisional
    pfam01480
    Location:46 → 115
    PWI; PWI domain

  15. NM_001366578.1 → NP_001353507.1  serine/arginine repetitive matrix protein 1 isoform 14

    Status: VALIDATED

    Source sequence(s)
    AL445648, AL445686
    UniProtKB/TrEMBL
    B7Z7U0
    Conserved Domains (3) summary
    PHA03247
    Location:301 → 630
    PHA03247; large tegument protein UL36; Provisional
    PRK04195
    Location:38 → 126
    PRK04195; replication factor C large subunit; Provisional
    pfam01480
    Location:1 → 32
    PWI; PWI domain

  16. NM_001366581.1 → NP_001353510.1  serine/arginine repetitive matrix protein 1 isoform 15

    Status: VALIDATED

    Source sequence(s)
    AL445648, AL445686
    UniProtKB/TrEMBL
    B7Z7U0
    Conserved Domains (3) summary
    PHA03307
    Location:588 → 722
    PHA03307; transcriptional regulator ICP4; Provisional
    PRK04195
    Location:121 → 209
    PRK04195; replication factor C large subunit; Provisional
    pfam01480
    Location:46 → 115
    PWI; PWI domain

  17. NM_001366582.1 → NP_001353511.1  serine/arginine repetitive matrix protein 1 isoform 16

    Status: VALIDATED

    Source sequence(s)
    AL445648, AL445686
    Consensus CDS
    CCDS90886.1
    UniProtKB/TrEMBL
    A0A994J4Y3, B7Z7U0
    Related
    ENSP00000516159.1, ENST00000705681.1
    Conserved Domains (2) summary
    PHA03307
    Location:605 → 739
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam01480
    Location:46 → 115
    PWI; PWI domain

  18. NM_001366584.1 → NP_001353513.1  serine/arginine repetitive matrix protein 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL445648, AL445686
    UniProtKB/TrEMBL
    B7Z7U0
    Conserved Domains (2) summary
    PHA03307
    Location:521 → 655
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam01480
    Location:1 → 32
    PWI; PWI domain

  19. NM_001366585.1 → NP_001353514.1  serine/arginine repetitive matrix protein 1 isoform 18

    Status: VALIDATED

    Source sequence(s)
    AL445648, AL445686
    UniProtKB/TrEMBL
    B7Z7U0
    Conserved Domains (2) summary
    PHA03247
    Location:331 → 660
    PHA03247; large tegument protein UL36; Provisional
    pfam01480
    Location:1 → 32
    PWI; PWI domain

  20. NM_001366586.1 → NP_001353515.1  serine/arginine repetitive matrix protein 1 isoform 19

    Status: VALIDATED

    Source sequence(s)
    AL445648, AL445686
    UniProtKB/TrEMBL
    B7Z7U0
    Conserved Domains (3) summary
    PHA03307
    Location:493 → 627
    PHA03307; transcriptional regulator ICP4; Provisional
    PRK04195
    Location:38 → 126
    PRK04195; replication factor C large subunit; Provisional
    pfam01480
    Location:1 → 32
    PWI; PWI domain

  21. NM_001366587.1 → NP_001353516.1  serine/arginine repetitive matrix protein 1 isoform 20

    Status: VALIDATED

    Source sequence(s)
    AL445648, AL445686
    UniProtKB/TrEMBL
    B7Z7U0
    Conserved Domains (3) summary
    PHA03307
    Location:507 → 641
    PHA03307; transcriptional regulator ICP4; Provisional
    PRK04195
    Location:38 → 126
    PRK04195; replication factor C large subunit; Provisional
    pfam01480
    Location:1 → 32
    PWI; PWI domain

  22. NM_001366588.1 → NP_001353517.1  serine/arginine repetitive matrix protein 1 isoform 21

    Status: VALIDATED

    Source sequence(s)
    AL445648, AL445686
    UniProtKB/TrEMBL
    B7Z7U0
    Conserved Domains (2) summary
    PHA03307
    Location:604 → 738
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam01480
    Location:46 → 115
    PWI; PWI domain

  23. NM_001366589.1 → NP_001353518.1  serine/arginine repetitive matrix protein 1 isoform 22

    Status: VALIDATED

    Source sequence(s)
    AL445648, AL445686
    UniProtKB/TrEMBL
    B7Z7U0
    Conserved Domains (2) summary
    PHA03307
    Location:603 → 737
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam01480
    Location:46 → 115
    PWI; PWI domain

  24. NM_001366590.1 → NP_001353519.1  serine/arginine repetitive matrix protein 1 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AL445648, AL445686
    UniProtKB/TrEMBL
    B7Z7U0
    Conserved Domains (2) summary
    PHA03307
    Location:535 → 669
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam01480
    Location:1 → 32
    PWI; PWI domain

  25. NM_001366591.1 → NP_001353520.1  serine/arginine repetitive matrix protein 1 isoform 20

    Status: VALIDATED

    Source sequence(s)
    AL445648, AL445686
    UniProtKB/TrEMBL
    B7Z7U0
    Conserved Domains (3) summary
    PHA03307
    Location:507 → 641
    PHA03307; transcriptional regulator ICP4; Provisional
    PRK04195
    Location:38 → 126
    PRK04195; replication factor C large subunit; Provisional
    pfam01480
    Location:1 → 32
    PWI; PWI domain

  26. NM_001366592.1 → NP_001353521.1  serine/arginine repetitive matrix protein 1 isoform 23

    Status: VALIDATED

    Source sequence(s)
    AL445648, AL445686
    UniProtKB/TrEMBL
    B7Z7U0
    Conserved Domains (4) summary
    PHA03247
    Location:350 → 709
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:574 → 708
    PHA03307; transcriptional regulator ICP4; Provisional
    PRK04195
    Location:121 → 209
    PRK04195; replication factor C large subunit; Provisional
    pfam01480
    Location:46 → 115
    PWI; PWI domain

  27. NM_001366593.1 → NP_001353522.1  serine/arginine repetitive matrix protein 1 isoform 18

    Status: VALIDATED

    Source sequence(s)
    AL445648, AL445686
    UniProtKB/TrEMBL
    B7Z7U0
    Conserved Domains (2) summary
    PHA03247
    Location:331 → 660
    PHA03247; large tegument protein UL36; Provisional
    pfam01480
    Location:1 → 32
    PWI; PWI domain

  28. NM_001366594.1 → NP_001353523.1  serine/arginine repetitive matrix protein 1 isoform 14

    Status: VALIDATED

    Source sequence(s)
    AL445648, AL445686
    UniProtKB/TrEMBL
    B7Z7U0
    Conserved Domains (3) summary
    PHA03247
    Location:301 → 630
    PHA03247; large tegument protein UL36; Provisional
    PRK04195
    Location:38 → 126
    PRK04195; replication factor C large subunit; Provisional
    pfam01480
    Location:1 → 32
    PWI; PWI domain

  29. NM_001366595.1 → NP_001353524.1  serine/arginine repetitive matrix protein 1 isoform 24

    Status: VALIDATED

    Source sequence(s)
    AL445648, AL445686, KU178513
    Consensus CDS
    CCDS90884.1
    UniProtKB/TrEMBL
    A0A0S2Z4Z6, B7Z7U0
    Related
    ENSP00000516157.1, ENST00000705662.1
    Conserved Domains (2) summary
    PHA03307
    Location:620 → 754
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam01480
    Location:46 → 115
    PWI; PWI domain

  30. NM_001366596.1 → NP_001353525.1  serine/arginine repetitive matrix protein 1 isoform 25

    Status: VALIDATED

    Source sequence(s)
    AL445648, AL445686
    UniProtKB/TrEMBL
    B7Z7U0
    Conserved Domains (2) summary
    pfam01480
    Location:7 → 76
    PWI; PWI domain
    cl28033
    Location:551 → 685
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

  31. NM_001366597.1 → NP_001353526.1  serine/arginine repetitive matrix protein 1 isoform 26

    Status: VALIDATED

    Source sequence(s)
    AL445648, AL445686
    UniProtKB/TrEMBL
    B7Z7U0
    Conserved Domains (2) summary
    pfam01480
    Location:7 → 76
    PWI; PWI domain
    cl28033
    Location:581 → 715
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

  32. NM_001366598.1 → NP_001353527.1  serine/arginine repetitive matrix protein 1 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AL445648, AL445686
    UniProtKB/TrEMBL
    B7Z7U0
    Conserved Domains (2) summary
    PHA03307
    Location:522 → 656
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam01480
    Location:1 → 32
    PWI; PWI domain

  33. NM_001366599.1 → NP_001353528.1  serine/arginine repetitive matrix protein 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL445648, AL445686
    UniProtKB/TrEMBL
    B7Z7U0
    Conserved Domains (2) summary
    PHA03307
    Location:521 → 655
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam01480
    Location:1 → 32
    PWI; PWI domain

  34. NM_001366600.1 → NP_001353529.1  serine/arginine repetitive matrix protein 1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL445648, AL445686
    UniProtKB/TrEMBL
    B7Z7U0
    Conserved Domains (2) summary
    PHA03307
    Location:537 → 671
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam01480
    Location:1 → 32
    PWI; PWI domain

  35. NM_005839.4 → NP_005830.2  serine/arginine repetitive matrix protein 1 isoform 2

    See identical proteins and their annotated locations for NP_005830.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AF048977, BC017315, BC036187, CX782666
    Consensus CDS
    CCDS255.1
    UniProtKB/Swiss-Prot
    O60585, Q5VVN4, Q8IYB3
    UniProtKB/TrEMBL
    A0A0S2Z4W1, B7Z7U0
    Related
    ENSP00000326261.8, ENST00000323848.14
    Conserved Domains (2) summary
    PHA03307
    Location:606 → 740
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam01480
    Location:46 → 115
    PWI; PWI domain

RNA

  1. NR_159378.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL445648, AL445686

  2. NR_159379.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL445648, AL445686

  3. NR_159380.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL445648, AL445686

  4. NR_159382.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL445648, AL445686

  5. NR_159383.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL445648, AL445686

  6. NR_159384.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL445648, AL445686

  7. NR_159385.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL445648, AL445686

  8. NR_159386.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL445648, AL445686

  9. NR_159387.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL445648, AL445686

  10. NR_159388.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL445648, AL445686

  11. NR_159389.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL445648, AL445686

  12. NR_159390.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL445648, AL445686

  13. NR_159391.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL445648, AL445686

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    24643302..24673281
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047427188.1 → XP_047283144.1  serine/arginine repetitive matrix protein 1 isoform X14

  2. XM_047427220.1 → XP_047283176.1  serine/arginine repetitive matrix protein 1 isoform X15

  3. XM_047427154.1 → XP_047283110.1  serine/arginine repetitive matrix protein 1 isoform X13

  4. XM_047427247.1 → XP_047283203.1  serine/arginine repetitive matrix protein 1 isoform X16

  5. XM_047427394.1 → XP_047283350.1  serine/arginine repetitive matrix protein 1 isoform X22

  6. XM_047427397.1 → XP_047283353.1  serine/arginine repetitive matrix protein 1 isoform X23

  7. XM_017000013.2 → XP_016855502.1  serine/arginine repetitive matrix protein 1 isoform X3

    UniProtKB/TrEMBL
    B7Z7U0

  8. XM_017000011.2 → XP_016855500.1  serine/arginine repetitive matrix protein 1 isoform X1

    UniProtKB/TrEMBL
    B7Z7U0

  9. XM_017000014.2 → XP_016855503.1  serine/arginine repetitive matrix protein 1 isoform X4

    UniProtKB/TrEMBL
    B7Z7U0

  10. XM_017000015.2 → XP_016855504.1  serine/arginine repetitive matrix protein 1 isoform X5

    UniProtKB/TrEMBL
    B7Z7U0

  11. XM_017000012.2 → XP_016855501.1  serine/arginine repetitive matrix protein 1 isoform X2

    UniProtKB/TrEMBL
    B7Z7U0

  12. XM_047427027.1 → XP_047282983.1  serine/arginine repetitive matrix protein 1 isoform X6

  13. XM_047427068.1 → XP_047283024.1  serine/arginine repetitive matrix protein 1 isoform X9

  14. XM_017000017.2 → XP_016855506.1  serine/arginine repetitive matrix protein 1 isoform X7

    UniProtKB/TrEMBL
    B7Z7U0

  15. XM_047427112.1 → XP_047283068.1  serine/arginine repetitive matrix protein 1 isoform X10

  16. XM_047427056.1 → XP_047283012.1  serine/arginine repetitive matrix protein 1 isoform X8

  17. XM_047427126.1 → XP_047283082.1  serine/arginine repetitive matrix protein 1 isoform X11

  18. XM_047427145.1 → XP_047283101.1  serine/arginine repetitive matrix protein 1 isoform X12

  19. XM_017000034.2 → XP_016855523.1  serine/arginine repetitive matrix protein 1 isoform X21

    UniProtKB/TrEMBL
    B4DED5

  20. XM_047427315.1 → XP_047283271.1  serine/arginine repetitive matrix protein 1 isoform X18

  21. XM_047427340.1 → XP_047283296.1  serine/arginine repetitive matrix protein 1 isoform X19

  22. XM_047427357.1 → XP_047283313.1  serine/arginine repetitive matrix protein 1 isoform X20

  23. XM_047427270.1 → XP_047283226.1  serine/arginine repetitive matrix protein 1 isoform X17

  24. XM_047427257.1 → XP_047283213.1  serine/arginine repetitive matrix protein 1 isoform X17

RNA

  1. XR_007062492.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    24481714..24511711
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054333782.1 → XP_054189757.1  serine/arginine repetitive matrix protein 1 isoform X14

  2. XM_054333783.1 → XP_054189758.1  serine/arginine repetitive matrix protein 1 isoform X15

  3. XM_054333781.1 → XP_054189756.1  serine/arginine repetitive matrix protein 1 isoform X13

  4. XM_054333784.1 → XP_054189759.1  serine/arginine repetitive matrix protein 1 isoform X16

  5. XM_054333791.1 → XP_054189766.1  serine/arginine repetitive matrix protein 1 isoform X22

  6. XM_054333792.1 → XP_054189767.1  serine/arginine repetitive matrix protein 1 isoform X23

  7. XM_054333771.1 → XP_054189746.1  serine/arginine repetitive matrix protein 1 isoform X3

  8. XM_054333769.1 → XP_054189744.1  serine/arginine repetitive matrix protein 1 isoform X1

  9. XM_054333772.1 → XP_054189747.1  serine/arginine repetitive matrix protein 1 isoform X4

  10. XM_054333773.1 → XP_054189748.1  serine/arginine repetitive matrix protein 1 isoform X5

  11. XM_054333770.1 → XP_054189745.1  serine/arginine repetitive matrix protein 1 isoform X2

  12. XM_054333774.1 → XP_054189749.1  serine/arginine repetitive matrix protein 1 isoform X6

  13. XM_054333777.1 → XP_054189752.1  serine/arginine repetitive matrix protein 1 isoform X9

  14. XM_054333775.1 → XP_054189750.1  serine/arginine repetitive matrix protein 1 isoform X7

  15. XM_054333778.1 → XP_054189753.1  serine/arginine repetitive matrix protein 1 isoform X10

  16. XM_054333776.1 → XP_054189751.1  serine/arginine repetitive matrix protein 1 isoform X8

  17. XM_054333779.1 → XP_054189754.1  serine/arginine repetitive matrix protein 1 isoform X11

  18. XM_054333780.1 → XP_054189755.1  serine/arginine repetitive matrix protein 1 isoform X12

  19. XM_054333790.1 → XP_054189765.1  serine/arginine repetitive matrix protein 1 isoform X21

  20. XM_054333787.1 → XP_054189762.1  serine/arginine repetitive matrix protein 1 isoform X18

  21. XM_054333788.1 → XP_054189763.1  serine/arginine repetitive matrix protein 1 isoform X19

  22. XM_054333789.1 → XP_054189764.1  serine/arginine repetitive matrix protein 1 isoform X20

  23. XM_054333786.1 → XP_054189761.1  serine/arginine repetitive matrix protein 1 isoform X17

  24. XM_054333785.1 → XP_054189760.1  serine/arginine repetitive matrix protein 1 isoform X17

RNA

  1. XR_008485863.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IYB3.2 GenPept UniProtKB/Swiss-Prot:Q8IYB3

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