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MPHOSPH6 M-phase phosphoprotein 6 [ Homo sapiens (human) ]

Gene ID: 10200, updated on 3-Apr-2024

Summary

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Official Symbol
MPHOSPH6provided by HGNC
Official Full Name
M-phase phosphoprotein 6provided by HGNC
Primary source
HGNC:HGNC:7214
See related
Ensembl:ENSG00000135698 MIM:605500; AllianceGenome:HGNC:7214
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MPP; MPP6; MPP-6
Summary
Predicted to enable RNA binding activity. Involved in maturation of 5.8S rRNA. Located in cytosol; nucleolus; and nucleoplasm. Colocalizes with nuclear exosome (RNase complex). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in appendix (RPKM 8.9), urinary bladder (RPKM 8.6) and 24 other tissues See more
Orthologs
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Genomic context

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See MPHOSPH6 in Genome Data Viewer
Location:
16q23.3
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (82148162..82170224, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (88211967..88234029, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (82181767..82203829, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 16:82156398 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 16:82167193 Neighboring gene MT-CYB pseudogene 28 Neighboring gene MT-ND6 pseudogene 28 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:82173035-82173622 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 16:82185320 Neighboring gene Sharpr-MPRA regulatory region 8727 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 16:82194405 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 16:82196808 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 16:82199461 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 16:82199598 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 16:82203758 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7765 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 16:82215972 Neighboring gene RN7SK pseudogene 190 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:82293705-82294204 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:82335587-82336088 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:82336089-82336588 Neighboring gene ribosomal protein L21 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. MPP6 is an exosome-associated RNA-binding protein involved in 5.8S rRNA maturation. Schilders G, et al. Nucleic Acids Res, 2005. PMID 16396833, Free PMC Article
  2. NVL2, a nucleolar AAA-ATPase, is associated with the nuclear exosome and is involved in pre-rRNA processing. Yoshikatsu Y, et al. Biochem Biophys Res Commun, 2015 Aug 28. PMID 26166824
  3. C1D and hMtr4p associate with the human exosome subunit PM/Scl-100 and are involved in pre-rRNA processing. Schilders G, et al. Nucleic Acids Res, 2007. PMID 17412707, Free PMC Article
  4. Identification of novel M phase phosphoproteins by expression cloning. Matsumoto-Taniura N, et al. Mol Biol Cell, 1996 Sep. PMID 8885239, Free PMC Article
  5. Mpp6 Incorporation in the Nuclear Exosome Contributes to RNA Channeling through the Mtr4 Helicase. Falk S, et al. Cell Rep, 2017 Sep 5. PMID 28877463, Free PMC Article

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  2. MPP6 is a nucleolus-specific exosome co-factor required for its role in the maturation of 5.8S rRNA.
    Title: MPP6 is an exosome-associated RNA-binding protein involved in 5.8S rRNA maturation.
  3. MPP6 was found to be associated with the exosome, a multiprotein complex involved in RNA degradation.
    Title: AU binding proteins recruit the exosome to degrade ARE-containing mRNAs.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of M-phase phosphoprotein 6 (MPHOSPH6) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in maturation of 5.8S rRNA IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in maturation of 5.8S rRNA IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
  
part_of exosome (RNase complex) IDA
Inferred from Direct Assay
more info
 PubMed 
part_of nuclear exosome (RNase complex) IDA
Inferred from Direct Assay
more info
 PubMed 
part_of nuclear exosome (RNase complex) TAS
Traceable Author Statement
more info
 PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
M-phase phosphoprotein 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005792.2 → NP_005783.2  M-phase phosphoprotein 6

    See identical proteins and their annotated locations for NP_005783.2

    Status: VALIDATED

    Source sequence(s)
    AI831131, AW175781, BU595100, BU622913
    Consensus CDS
    CCDS10937.1
    UniProtKB/Swiss-Prot
    B2RAF0, Q99547
    UniProtKB/TrEMBL
    Q53HB4
    Related
    ENSP00000258169.4, ENST00000258169.9
    Conserved Domains (1) summary
    pfam10175
    Location:8 → 135
    MPP6; M-phase phosphoprotein 6

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    82148162..82170224 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011522808.4 → XP_011521110.1  M-phase phosphoprotein 6 isoform X1

    UniProtKB/TrEMBL
    H3BNT4, Q53HB4
    Related
    ENSP00000454996.1, ENST00000563100.5
    Conserved Domains (1) summary
    pfam10175
    Location:1 → 117
    MPP6; M-phase phosphoprotein 6

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    88211967..88234029 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054379376.1 → XP_054235351.1  M-phase phosphoprotein 6 isoform X1

    UniProtKB/TrEMBL
    H3BNT4
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99547.2 GenPept UniProtKB/Swiss-Prot:Q99547

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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