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TSPAN5 tetraspanin 5 [ Homo sapiens (human) ]

Gene ID: 10098, updated on 11-Apr-2024

Summary

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Official Symbol
TSPAN5provided by HGNC
Official Full Name
tetraspanin 5provided by HGNC
Primary source
HGNC:HGNC:17753
See related
Ensembl:ENSG00000168785 MIM:613136; AllianceGenome:HGNC:17753
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NET4; NET-4; TM4SF9; TSPAN-5
Summary
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. [provided by RefSeq, Jul 2008]
Expression
Broad expression in brain (RPKM 32.0), ovary (RPKM 24.8) and 18 other tissues See more
Orthologs
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Genomic context

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See TSPAN5 in Genome Data Viewer
Location:
4q23
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (98470367..98658611, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (101785330..101973565, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (99391518..99579762, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene Rap1 GTPase-GDP dissociation stimulator 1 Neighboring gene uncharacterized LOC124900919 Neighboring gene ribosomal protein L21 pseudogene 48 Neighboring gene Sharpr-MPRA regulatory region 12770 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21734 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:99457519-99458032 Neighboring gene Sharpr-MPRA regulatory region 11258 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:99518736-99519334 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21735 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr4:99574420-99575619 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:99579327-99579486 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15578 Neighboring gene uncharacterized LOC112267901 Neighboring gene TSPAN5 divergent transcript Neighboring gene CRISPRi-validated cis-regulatory element chr4.2289 Neighboring gene CRISPRi-validated cis-regulatory element chr4.2290 Neighboring gene mitochondrial import receptor subunit TOM7 homolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Tspan5 promotes epithelial-mesenchymal transition and tumour metastasis of hepatocellular carcinoma by activating Notch signalling. Xie Q, et al. Mol Oncol, 2021 Nov. PMID 33955149, Free PMC Article
  2. TSPAN5 influences serotonin and kynurenine: pharmacogenomic mechanisms related to alcohol use disorder and acamprosate treatment response. Ho MF, et al. Mol Psychiatry, 2021 Jul. PMID 32753686, Free PMC Article
  3. The increased level of Tspan5 in villi suggests more proliferation and invasiveness of trophoblasts in tubal pregnancy. Gao T, et al. Eur J Obstet Gynecol Reprod Biol, 2018 Sep. PMID 29908376
  4. Tspan5 is an independent favourable prognostic factor and suppresses tumour growth in gastric cancer. He P, et al. Oncotarget, 2016 Jun 28. PMID 27223087, Free PMC Article
  5. miR-155 increases stemness and decitabine resistance in triple-negative breast cancer cells by inhibiting TSPAN5. Yang LW, et al. Mol Carcinog, 2020 Apr. PMID 32096299

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Tspan5 promotes epithelial-mesenchymal transition and tumour metastasis of hepatocellular carcinoma by activating Notch signalling.
    Title: Tspan5 promotes epithelial-mesenchymal transition and tumour metastasis of hepatocellular carcinoma by activating Notch signalling.
  2. TSPAN5 influences serotonin and kynurenine: pharmacogenomic mechanisms related to alcohol use disorder and acamprosate treatment response.
    Title: TSPAN5 influences serotonin and kynurenine: pharmacogenomic mechanisms related to alcohol use disorder and acamprosate treatment response.
  3. TSPAN5 Enriched Microdomains Provide a Platform for Dendritic Spine Maturation through Neuroligin-1 Clustering.
    Title: TSPAN5 Enriched Microdomains Provide a Platform for Dendritic Spine Maturation through Neuroligin-1 Clustering.
  4. Data show that gene tetraspanin-5 (TSPAN5) is the target of miR-155 in breast cancer (BC).
    Title: miR-155 increases stemness and decitabine resistance in triple-negative breast cancer cells by inhibiting TSPAN5.
  5. intensity in villi in tubal pregnancy was significantly higher than that in normal intrauterine pregnancy
    Title: The increased level of Tspan5 in villi suggests more proliferation and invasiveness of trophoblasts in tubal pregnancy.
  6. Tspan5 may serve as a prognostic biomarker for predicting outcome of gastric cancer patients. Tspan5 functions as a tumour suppressor in stomach to control the tumour growth.
    Title: Tspan5 is an independent favourable prognostic factor and suppresses tumour growth in gastric cancer.
  7. Endothelial Tspan5- and Tspan17-ADAM10 complexes may regulate inflammation by maintaining normal VE-cadherin expression and promoting T lymphocyte transmigration.
    Title: ADAM10-Interacting Tetraspanins Tspan5 and Tspan17 Regulate VE-Cadherin Expression and Promote T Lymphocyte Transmigration.
  8. two TspanC8-specific motifs in the large extracellular domain of Tspan5 that are important for ADAM10 interaction and exit from the endoplasmic reticulum. One of the anti-Tspan5 mAbs does not recognize Tspan5 associated with ADAM10, providing a convenient way to measure the fraction of Tspan5 not associated with ADAM10.
    Title: New insights into the tetraspanin Tspan5 using novel monoclonal antibodies.
  9. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of tetraspanin 5 (TSPAN5) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables enzyme binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of Notch signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein maturation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of membrane protein ectodomain proteolysis IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in actin cytoskeleton IDA
Inferred from Direct Assay
more info
  
located_in endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
tetraspanin-5
Names
tetraspan NET-4
tetraspan TM4SF
transmembrane 4 superfamily member 9
transmembrane 4 superfamily, member 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046902.1 RefSeqGene

    Range
    5051..193295
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_005723.4 → NP_005714.2  tetraspanin-5

    See identical proteins and their annotated locations for NP_005714.2

    Status: REVIEWED

    Source sequence(s)
    AC058823, AC114811, AI089708, BC009704
    Consensus CDS
    CCDS3646.1
    UniProtKB/Swiss-Prot
    B2RDY2, O60628, O60746, P62079, Q6FHE5, Q9JLY1
    UniProtKB/TrEMBL
    Q6FHC5
    Related
    ENSP00000307701.3, ENST00000305798.8
    Conserved Domains (2) summary
    cd03159
    Location:113 → 233
    TM4SF9_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:15 → 257
    Tetraspannin; Tetraspanin family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    98470367..98658611 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005262680.2 → XP_005262737.1  tetraspanin-5 isoform X1

    See identical proteins and their annotated locations for XP_005262737.1

    UniProtKB/TrEMBL
    Q6FHC5
    Conserved Domains (1) summary
    cd03159
    Location:64 → 184
    TM4SF9_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...

  2. XM_047449475.1 → XP_047305431.1  tetraspanin-5 isoform X2

    UniProtKB/TrEMBL
    B7Z317
    Related
    ENSP00000423916.1, ENST00000505184.5

  3. XM_047449473.1 → XP_047305429.1  tetraspanin-5 isoform X2

    UniProtKB/TrEMBL
    B7Z317

  4. XM_047449472.1 → XP_047305428.1  tetraspanin-5 isoform X2

    UniProtKB/TrEMBL
    B7Z317

  5. XM_047449477.1 → XP_047305433.1  tetraspanin-5 isoform X4

  6. XM_047449476.1 → XP_047305432.1  tetraspanin-5 isoform X3

    UniProtKB/TrEMBL
    D6RAR1
    Related
    ENSP00000421808.1, ENST00000508798.5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    101785330..101973565 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054348694.1 → XP_054204669.1  tetraspanin-5 isoform X1

  2. XM_054348695.1 → XP_054204670.1  tetraspanin-5 isoform X2

    UniProtKB/TrEMBL
    B7Z317

  3. XM_054348697.1 → XP_054204672.1  tetraspanin-5 isoform X4

  4. XM_054348696.1 → XP_054204671.1  tetraspanin-5 isoform X3

    UniProtKB/TrEMBL
    D6RAR1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P62079.1 GenPept UniProtKB/Swiss-Prot:P62079

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