PCAT6 prostate cancer associated transcript 6 [Homo sapiens (human)] - Gene

Summary

Official Symbol: PCAT6provided by HGNC
Official Full Name: prostate cancer associated transcript 6provided by HGNC
Primary source: HGNC:HGNC:43714
See related: Ensembl:ENSG00000228288 AllianceGenome:HGNC:43714
Gene type: ncRNA
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PCAN-R1; KDM5BAS1; ncRNA-a2; KDM5B-AS1; onco-lncRNA-96
Expression: Biased expression in testis (RPKM 17.7), skin (RPKM 2.8) and 6 other tissues See more
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Genomic context

Location:: 1q32.1

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (202810946..202811913)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (202073605..202074572)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (202780074..202781041)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pan-cancer analysis of PCAT6 and its effect on oesophageal squamous cell carcinoma cell proliferation and migration.
Title: Pan-cancer analysis of PCAT6 and its effect on oesophageal squamous cell carcinoma cell proliferation and migration.
LncRNA PCAT6 promotes proliferation, migration, invasion, and epithelial-mesenchymal transition of lung adenocarcinoma cell by targeting miR-545-3p.
Title: LncRNA PCAT6 promotes proliferation, migration, invasion, and epithelial-mesenchymal transition of lung adenocarcinoma cell by targeting miR-545-3p.
Knockdown of lncRNA PCAT6 suppresses the growth of non-small cell lung cancer cells by inhibiting macrophages M2 polarization via miR-326/KLF1 axis.
Title: Knockdown of lncRNA PCAT6 suppresses the growth of non-small cell lung cancer cells by inhibiting macrophages M2 polarization via miR-326/KLF1 axis.
Long non-coding RNA prostate cancer-associated transcript 6 inhibited gefitinib sensitivity of non-small cell lung cancer by serving as a competing endogenous RNA of miR-326 to up-regulate interferon-alpha receptor 2.
Title: Long non-coding RNA prostate cancer-associated transcript 6 inhibited gefitinib sensitivity of non-small cell lung cancer by serving as a competing endogenous RNA of miR-326 to up-regulate interferon-alpha receptor 2.
m(6) A modification of lncRNA PCAT6 promotes bone metastasis in prostate cancer through IGF2BP2-mediated IGF1R mRNA stabilization.
Title: m(6) A modification of lncRNA PCAT6 promotes bone metastasis in prostate cancer through IGF2BP2-mediated IGF1R mRNA stabilization.
LncRNA PCAT6: A potential biomarker for diagnosis and prognosis of bladder cancer.
Title: LncRNA PCAT6: A potential biomarker for diagnosis and prognosis of bladder cancer.
Long noncoding RNA PCAT6 promotes the development of osteosarcoma by increasing MDM2 expression.
Title: Long non‑coding RNA PCAT6 promotes the development of osteosarcoma by increasing MDM2 expression.
Promising role of long non-coding RNA PCAT6 in malignancies.
Title: Promising role of long non-coding RNA PCAT6 in malignancies.
LncRNA PCAT6 Regulated by YY1 Accelerates the Progression of Glioblastoma via miR-513/IGF2BP1.
Title: LncRNA PCAT6 Regulated by YY1 Accelerates the Progression of Glioblastoma via miR-513/IGF2BP1.
LncRNA PCAT6 aggravates the progression of bladder cancer cells by targeting miR-513a-5p.
Title: LncRNA PCAT6 aggravates the progression of bladder cancer cells by targeting miR-513a-5p.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Other Names

KDM5B antisense RNA 1 (head to head)
KDM5B antisense RNA 1 (non-protein coding)
noncoding RNA-activating 2
prostate cancer associated transcript 6 (non-protein coding)
prostate cancer-associated noncoding RNA 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

NR_046325.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript.

Source sequence(s)

AC098934

Related

ENST00000417262.5
NR_046326.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate splice site resulting in a shorter transcript, compared to variant 1.

Source sequence(s)

AC098934

Related

ENST00000425295.3