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PARP3 poly(ADP-ribose) polymerase family member 3 [ Homo sapiens (human) ]

Gene ID: 10039, updated on 3-Apr-2024

Summary

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Official Symbol
PARP3provided by HGNC
Official Full Name
poly(ADP-ribose) polymerase family member 3provided by HGNC
Primary source
HGNC:HGNC:273
See related
Ensembl:ENSG00000041880 MIM:607726; AllianceGenome:HGNC:273
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IRT1; ARTD3; ADPRT3; ADPRTL2; ADPRTL3; PADPRT-3
Summary
The protein encoded by this gene belongs to the PARP family. These enzymes modify nuclear proteins by poly-ADP-ribosylation, which is required for DNA repair, regulation of apoptosis, and maintenance of genomic stability. This gene encodes the poly(ADP-ribosyl)transferase 3, which is preferentially localized to the daughter centriole throughout the cell cycle. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in duodenum (RPKM 12.4), small intestine (RPKM 11.6) and 24 other tissues See more
Orthologs
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Genomic context

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Location:
3p21.2
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (51942363..51948867)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (51975282..51981786)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (51976379..51982883)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr3:51935927-51937126 Neighboring gene IQ motif containing F1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:51975282-51975930 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19921 Neighboring gene ribosomal RNA processing 9, U3 small nucleolar RNA binding protein Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:51990057-51990645 Neighboring gene G protein-coupled receptor 62 Neighboring gene poly(rC) binding protein 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:51999749-52000312 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:52000313-52000874 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14418 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14419 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14420 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:52002001-52002564 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:52002565-52003126 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:52007254-52008190 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19922 Neighboring gene abhydrolase domain containing 14B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. PARP3 inhibitors ME0328 and olaparib potentiate vinorelbine sensitization in breast cancer cell lines. Sharif-Askari B, et al. Breast Cancer Res Treat, 2018 Nov. PMID 30039287
  2. The Development of a Biotinylated NAD(+)-Applied Human Poly(ADP-Ribose) Polymerase 3 (PARP3) Enzymatic Assay. Ji M, et al. SLAS Discov, 2018 Jul. PMID 29676938
  3. Dna is a New Target of Parp3. Belousova EA, et al. Sci Rep, 2018 Mar 8. PMID 29520010, Free PMC Article
  4. Reversible mono-ADP-ribosylation of DNA breaks. Munnur D, et al. FEBS J, 2017 Dec. PMID 29054115, Free PMC Article
  5. PARP-3 associates with polycomb group bodies and with components of the DNA damage repair machinery. Rouleau M, et al. J Cell Biochem, 2007 Feb 1. PMID 16924674

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Progress and outlook in studying the substrate specificities of PARPs and related enzymes.
    Title: Progress and outlook in studying the substrate specificities of PARPs and related enzymes.
  2. PARP Power: A Structural Perspective on PARP1, PARP2, and PARP3 in DNA Damage Repair and Nucleosome Remodelling.
    Title: PARP Power: A Structural Perspective on PARP1, PARP2, and PARP3 in DNA Damage Repair and Nucleosome Remodelling.
  3. gapped DNA that was ADP-ribosylated by PARP3 could be ligated to double-stranded DNA by DNA ligases. Moreover, this ADP-ribosylated DNA could serve as a primed DNA substrate for PAR chain elongation by the purified proteins PARP1 and PARP2 as well as by cell-free extracts.
    Title: Dna is a New Target of Parp3.
  4. The integral roles of PARP3 in DNA damage repair.
    Title: The Development of a Biotinylated NAD(+)-Applied Human Poly(ADP-Ribose) Polymerase 3 (PARP3) Enzymatic Assay.
  5. PARP3 can PARylate and mono(ADP-ribosyl)ate (MARylate), respectively, 5'- and 3'-terminal phosphate residues at double- and single-strand break termini of a DNA molecule containing multiple strand breaks.
    Title: Characterization of DNA ADP-ribosyltransferase activities of PARP2 and PARP3: new insights into DNA ADP-ribosylation.
  6. Our results indicated this approach with PARP3 inhibitors and vinorelbine is unique and promising for breast cancer patients with metastases. This combination could significantly increase the survival of breast cancer patients with metastases
    Title: PARP3 inhibitors ME0328 and olaparib potentiate vinorelbine sensitization in breast cancer cell lines.
  7. These data identify PARP3 as a molecular sensor of nicked nucleosomes.
    Title: PARP3 is a sensor of nicked nucleosomes and monoribosylates histone H2B(Glu2).
  8. PARP3 controls of TGFbeta-induced epithelial mesenchymal transformation and acquisition of stem-like cell features by stimulation transglutaminase 2/SNAI1 signaling.
    Title: PARP3 controls TGFβ and ROS driven epithelial-to-mesenchymal transition and stemness by stimulating a TG2-Snail-E-cadherin axis.
  9. Data indicate that PARP3, a DNA damage-activated ADP-ribosyltransferase, can mono-ADP-ribosylate double-stranded DNA ends.
    Title: Reversible mono-ADP-ribosylation of DNA breaks.
  10. In a process of single-strand DNA repair, PARP3 mono-ADP-ribosylates nucleosomal histone H2B.
    Title: Nick Your DNA, Mark Your Chromatin.
Submit: New GeneRIF Correction See all GeneRIFs (22)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables NAD DNA ADP-ribosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables NAD+ ADP-ribosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables NAD+ ADP-ribosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables NAD+- protein-aspartate ADP-ribosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables NAD+- protein-lysine ADP-ribosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables NAD+-protein ADP-ribosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables NAD+-protein ADP-ribosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables NAD+-protein-glutamate ADP-ribosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables catalytic activity TAS
Traceable Author Statement
more info
  
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA ADP-ribosylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in double-strand break repair IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within double-strand break repair IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within double-strand break repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of isotype switching ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of telomerase RNA reverse transcriptase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of DNA ligation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of double-strand break repair via nonhomologous end joining IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein auto-ADP-ribosylation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within protein localization to site of double-strand break IMP
Inferred from Mutant Phenotype
more info
 PubMed 
NOT involved_in protein poly-ADP-ribosylation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of mitotic spindle organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within telomere maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in centriole IEA
Inferred from Electronic Annotation
more info
  
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in intercellular bridge IDA
Inferred from Direct Assay
more info
  
located_in nuclear body IDA
Inferred from Direct Assay
more info
  
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
is_active_in site of double-strand break IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in site of double-strand break IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
protein mono-ADP-ribosyltransferase PARP3
Names
ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)-like 2
ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)-like 3
ADP-ribosyltransferase diphtheria toxin-like 3
ADPRT-3
DNA ADP-ribosyltransferase PARP3
NAD(+) ADP-ribosyltransferase 3
NAD+ ADP-ribosyltransferase 3
poly [ADP-ribose] polymerase 3
poly(ADP-ribose) synthetase-3
poly[ADP-ribose] synthase 3
poly[ADP-ribose] synthetase 3
NP_001003931.4
NP_001357168.1
NP_001357169.1
NP_005476.4
XP_047303043.1
XP_054200797.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003931.4 → NP_001003931.4  protein mono-ADP-ribosyltransferase PARP3 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform b.
    Source sequence(s)
    CA309713, CA394313, Y16836
    Consensus CDS
    CCDS43097.1
    UniProtKB/Swiss-Prot
    Q8NER9, Q96CG2, Q9UG81, Q9Y6F1
    UniProtKB/TrEMBL
    Q59HF6
    Related
    ENSP00000381740.4, ENST00000398755.8
    Conserved Domains (2) summary
    cd08002
    Location:58 → 157
    WGR_PARP3_like; WGR domain of poly(ADP-ribose) polymerase 3 and similar proteins
    cd01437
    Location:182 → 532
    parp_like; Poly(ADP-ribose) polymerase (parp) catalytic domain catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a ...

  2. NM_001370239.1 → NP_001357168.1  protein mono-ADP-ribosyltransferase PARP3 isoform a

    Status: REVIEWED

    Source sequence(s)
    AC115284, KF459622
    Consensus CDS
    CCDS43097.1
    UniProtKB/Swiss-Prot
    Q8NER9, Q96CG2, Q9UG81, Q9Y6F1
    UniProtKB/TrEMBL
    Q59HF6
    Related
    ENSP00000395951.2, ENST00000417220.6
    Conserved Domains (2) summary
    cd08002
    Location:58 → 157
    WGR_PARP3_like; WGR domain of poly(ADP-ribose) polymerase 3 and similar proteins
    cd01437
    Location:182 → 532
    parp_like; Poly(ADP-ribose) polymerase (parp) catalytic domain catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a ...

  3. NM_001370240.1 → NP_001357169.1  protein mono-ADP-ribosyltransferase PARP3 isoform a

    Status: REVIEWED

    Source sequence(s)
    AC115284, KF459622
    Consensus CDS
    CCDS43097.1
    UniProtKB/Swiss-Prot
    Q8NER9, Q96CG2, Q9UG81, Q9Y6F1
    UniProtKB/TrEMBL
    Q59HF6
    Related
    ENSP00000417396.2, ENST00000471971.6
    Conserved Domains (2) summary
    cd08002
    Location:58 → 157
    WGR_PARP3_like; WGR domain of poly(ADP-ribose) polymerase 3 and similar proteins
    cd01437
    Location:182 → 532
    parp_like; Poly(ADP-ribose) polymerase (parp) catalytic domain catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a ...

  4. NM_005485.6 → NP_005476.4  protein mono-ADP-ribosyltransferase PARP3 isoform a

    See identical proteins and their annotated locations for NP_005476.4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses a downstream translational start codon, compared to variant 1. The resulting isoform (b) is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    BI554046, CA309713, CA394313, Y16836
    Consensus CDS
    CCDS43097.1
    UniProtKB/Swiss-Prot
    Q8NER9, Q96CG2, Q9UG81, Q9Y6F1
    UniProtKB/TrEMBL
    Q59HF6
    Related
    ENSP00000401511.1, ENST00000431474.6
    Conserved Domains (2) summary
    cd08002
    Location:58 → 157
    WGR_PARP3_like; WGR domain of poly(ADP-ribose) polymerase 3 and similar proteins
    cd01437
    Location:182 → 532
    parp_like; Poly(ADP-ribose) polymerase (parp) catalytic domain catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    51942363..51948867
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047447087.1 → XP_047303043.1  protein mono-ADP-ribosyltransferase PARP3 isoform X1

    UniProtKB/Swiss-Prot
    Q8NER9, Q96CG2, Q9UG81, Q9Y6F1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    51975282..51981786
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054344822.1 → XP_054200797.1  protein mono-ADP-ribosyltransferase PARP3 isoform X1

    UniProtKB/Swiss-Prot
    Q8NER9, Q96CG2, Q9UG81, Q9Y6F1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001003935.2: Suppressed sequence

    Description
    NM_001003935.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y6F1.4 GenPept UniProtKB/Swiss-Prot:Q9Y6F1

Gene LinkOut

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