MIR103B1 microRNA 103b-1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: MIR103B1provided by HGNC
Official Full Name: microRNA 103b-1provided by HGNC
Primary source: HGNC:HGNC:35384
See related: Ensembl:ENSG00000283612 miRBase:MI0007261; AllianceGenome:HGNC:35384
Gene type: ncRNA
RefSeq status: PROVISIONAL
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MIR103-1AS; MIRN103-1AS; hsa-mir-103-1-as
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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Genomic context

Location:: 5q34

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	5	NC_000005.10 (168560904..168560965)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	5	NC_060929.1 (169095686..169095747)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	5	NC_000005.9 (167987909..167987970)

Chromosome 5 - NC_000005.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

miR-103a and miR-103b had high complementarity and conservation, modulated reporter gene expression through seed sequences in the 3'UTRs of CAV-1 and SFRP4 mRNA, and negatively regulated their mRNA and protein levels
Title: Circulating miR-103 family as potential biomarkers for type 2 diabetes through targeting CAV-1 and SFRP4.
Study results demonstrated that serum miR-103 was overexpressed in colorectal cancer (CRC) subjects, could differentiate CRC cases from controls with relatively high accuracy, and significantly correlated with worse clinical factors, as well as poorer recurrence-free survival or overall survival. Taken together, serum miR-103 might be a promising biomarker for diagnosis and prognosis of CRC.
Title: Upregulation of serum miR-103 predicts unfavorable prognosis in patients with colorectal cancer.
Clinical data indicates that a high expression of miR103 is associated with the progression of hepatocellular carcinoma (HCC). Further results suggest that miR103 promotes HCC metastasis and EMT by directly inhibiting LATS2.
Title: miR-103 promotes the metastasis and EMT of hepatocellular carcinoma by directly inhibiting LATS2.
miR-103 is involved in insulin resistance and NAFLD, and may be a molecular link between insulin resistance and NAFLD
Title: miRNA-103: molecular link between insulin resistance and nonalcoholic fatty liver disease.
MiR-103 significantly promotes cancer cell proliferation, invasion and metastasis, and, thus, could be an important mediator in the pathogenesis of colorectal cancer Through regulation of colorectal cancer cell DICER and PTEN expression.
Title: MicroRNA-103 promotes colorectal cancer by targeting tumor suppressor DICER and PTEN.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables mRNA base-pairing translational repressor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in miRNA-mediated gene silencing by mRNA destabilization	IDA Inferred from Direct Assay more info	PubMed
involved_in miRNA-mediated post-transcriptional gene silencing	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of RISC complex	IEA Inferred from Electronic Annotation more info

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.