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FCGR1CP Fc gamma receptor Ic, pseudogene [ Homo sapiens (human) ]

Gene ID: 100132417, updated on 10-Oct-2023

Summary

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Official Symbol
FCGR1CPprovided by HGNC
Official Full Name
Fc gamma receptor Ic, pseudogeneprovided by HGNC
Primary source
HGNC:HGNC:3615
See related
Ensembl:ENSG00000265531 MIM:601503; AllianceGenome:HGNC:3615
Gene type
pseudo
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD64c; FCRIC; IGFR1; IGFRC; FCGR1C
Summary
The gene represents one of three related immunoglobulin gamma Fc receptor genes located on chromosome 1. This family member lacks the transmembrane and coiled-coiled domains found in other family members and is thought to be a pseudogene of Fc-gamma-receptor 1A. [provided by RefSeq, Apr 2009]
Expression
Biased expression in appendix (RPKM 19.1), placenta (RPKM 14.5) and 11 other tissues See more
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Genomic context

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See FCGR1CP in Genome Data Viewer
Location:
1q21.1
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (143874743..143883733)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (142946774..142955758)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (149369294..149378303)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ubiquitin conjugating enzyme E2 D4 (putative) pseudogene Neighboring gene tRNA-Arg (anticodon CCT) 7-1 Neighboring gene H2B histone pseudogene 2 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:149362195-149362753 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1255 Neighboring gene NANOG hESC enhancer GRCh37_chr1:149396107-149396742 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:149398885-149399385 Neighboring gene uncharacterized LOC105371209 Neighboring gene H3.7 histone (putative) Neighboring gene ribosomal protein L22 pseudogene 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Two cis-DNA elements involved in myeloid-cell-specific expression and gamma interferon (IFN-gamma) activation of the human high-affinity Fc gamma receptor gene: a novel IFN regulatory mechanism. Perez C, et al. Mol Cell Biol, 1993 Apr. PMID 8455606, Free PMC Article
  2. Phagocytic signaling strategies: Fc(gamma)receptor-mediated phagocytosis as a model system. Cox D, et al. Semin Immunol, 2001 Dec. PMID 11708889
  3. Molecular characterization of six variant Fcgamma receptor class I (CD64) transcripts. Ernst LK, et al. Mol Immunol, 1998 Oct. PMID 9881690
  4. The three genes of the human FCGR1 gene family encoding Fc gamma RI flank the centromere of chromosome 1 at 1p12 and 1q21. Maresco DL, et al. Cytogenet Cell Genet, 1996. PMID 8697799
  5. Localization of FCGR1 encoding Fcgamma receptor class I in primates: molecular evidence for two pericentric inversions during the evolution of human chromosome 1. Maresco DL, et al. Cytogenet Cell Genet, 1998. PMID 9763663

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Other Names

  • Fc fragment of IgG receptor Ic, pseudogene
  • Fc fragment of IgG, high affinity Ic, receptor (CD64), pseudogene
  • Fc fragment of IgG, high affinity Ic, receptor for (CD64)
  • immunoglobulin gamma Fc receptor 1C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_027484.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC239798, BF061349, CA309927, DA463656, EB386870, T29148
    Related
    ENST00000579737.3

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    143874743..143883733
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    142946774..142955758
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001128589.1: Suppressed sequence

    Description
    NM_001128589.1: This RefSeq was permanently suppressed because it is now thought that this gene is a pseudogene.
Nucleotide Protein
Heading Accession and Version

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