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KDM4F lysine demethylase 4F [ Homo sapiens (human) ]

Gene ID: 100129053, updated on 8-Mar-2024

Summary

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Official Symbol
KDM4Fprovided by HGNC
Official Full Name
lysine demethylase 4Fprovided by HGNC
Primary source
HGNC:HGNC:52413
See related
Ensembl:ENSG00000255855 AllianceGenome:HGNC:52413
Gene type
protein coding
RefSeq status
INFERRED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
JMJD2F
Summary
Predicted to enable histone H3-methyl-lysine-9 demethylase activity. Predicted to be involved in chromatin remodeling. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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Location:
11q21
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (95049422..95051338)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (95056459..95058375)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (94782244..94784621)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984375 Neighboring gene serine and arginine rich splicing factor 8B, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr11:94783874-94784038 Neighboring gene lysine demethylase 4D pseudogene Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:94799907-94800664 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5409 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5410 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5411 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3845 Neighboring gene serine and arginine rich splicing factor 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification and characterization of JMJD2 family genes in silico. Katoh M, et al. Int J Oncol, 2004 Jun. PMID 15138608
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

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Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables histone H3K9 demethylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
probable lysine-specific demethylase 4F
Names
lysine demethylase 4E pseudogene
NP_001400684.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001413755.1 → NP_001400684.1  probable lysine-specific demethylase 4F

    Status: INFERRED

    Source sequence(s)
    AP001264
    UniProtKB/Swiss-Prot
    A0A1W2PPD8
    Related
    ENSP00000518692.1, ENST00000711328.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    95049422..95051338
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    95056459..95058375
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A1W2PPD8.1 GenPept UniProtKB/Swiss-Prot:A0A1W2PPD8

Gene LinkOut

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Molecular Biology Databases