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ZGLP1 zinc finger GATA like protein 1 [ Homo sapiens (human) ]

Gene ID: 100125288, updated on 8-Mar-2024

Summary

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Official Symbol
ZGLP1provided by HGNC
Official Full Name
zinc finger GATA like protein 1provided by HGNC
Primary source
HGNC:HGNC:37245
See related
Ensembl:ENSG00000220201 MIM:611639; AllianceGenome:HGNC:37245
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GLP1; GLP-1; GATAD3
Summary
ZGLP1 encodes an evolutionary conserved transcriptional regulator with GATA-like zinc fingers. In females, it is expressed in embryonic germ cells and is essential for oogenic fate determination. It acts downstream of bone morphogenetic protein (BMP) and is involved in the regulation of genes involved in RNA processing, transcription and chromatin modification, retrotransposon regulation, meiotic cell cycle, and oocyte development. In males it is not required for the germ cell sex determination but is required by the spermatogonia for efficiently completing the meiotic prophase. [provided by RefSeq, Jul 2022]
Annotation information
Note: This gene has been reviewed for its involvement in coronavirus biology, and is locus in the vicinity of disease-associated variant(s).
Expression
Ubiquitous expression in testis (RPKM 1.4), spleen (RPKM 0.9) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
19p13.2
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (10304803..10309815, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (10430915..10435928, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (10415479..10420233, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10397303-10398272 Neighboring gene ICAM4 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10061 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10062 Neighboring gene intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10402483-10403475 Neighboring gene intercellular adhesion molecule 5 Neighboring gene CRISPRi-validated cis-regulatory element chr19.1775 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr19:10415538-10416737 Neighboring gene FDX2-ZGLP1 readthrough Neighboring gene ferredoxin 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10064 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:10427579-10427770 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:10430834-10431047 Neighboring gene ribonucleoprotein, PTB binding 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10442682-10443598 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10443599-10444515

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Minor Contribution of Endogenous GLP-1 and GLP-2 to Postprandial Lipemia in Obese Men. Matikainen N, et al. PLoS One, 2016. PMID 26752550, Free PMC Article
  2. GLP-1: a novel zinc finger protein required in somatic cells of the gonad for germ cell development. Li S, et al. Dev Biol, 2007 Jan 1. PMID 16982049, Free PMC Article
  3. ZGLP1 is a determinant for the oogenic fate in mice. Nagaoka SI, et al. Science, 2020 Mar 6. PMID 32054698
  4. Whole-genome sequencing reveals host factors underlying critical COVID-19. Kousathanas A, et al. Nature, 2022 Jul. PMID 35255492, Free PMC Article
  5. The DNA sequence and biology of human chromosome 19. Grimwood J, et al. Nature, 2004 Apr 1. PMID 15057824

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. There is minor contribution of endogenous GLP-1 and GLP-2 to postprandial lipemia in obese men.
    Title: Minor Contribution of Endogenous GLP-1 and GLP-2 to Postprandial Lipemia in Obese Men.
  2. Characterization and functional analysis of the mouse GLP-1 ortholog, and comparison to the human protein.
    Title: GLP-1: a novel zinc finger protein required in somatic cells of the gonad for germ cell development.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Markers

Readthrough FDX2-ZGLP1

Readthrough gene: FDX2-ZGLP1, Included gene: FDX2

Homology

Clone Names

  • FLJ39511, FLJ39703

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISS
Inferred from Sequence or Structural Similarity
more info
  
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in oocyte development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in oocyte development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spermatogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spermatogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
GATA-type zinc finger protein 1
Names
GATA zinc finger domain containing 3
GATA-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001103167.1 → NP_001096637.1  GATA-type zinc finger protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001096637.1

    Status: VALIDATED

    Source sequence(s)
    BC029904, CK826281
    Consensus CDS
    CCDS45959.1
    UniProtKB/Swiss-Prot
    P0C6A0
    Conserved Domains (2) summary
    smart00401
    Location:202 → 240
    ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    pfam00320
    Location:206 → 240
    GATA; GATA zinc finger

  2. NM_001409033.1 → NP_001395962.1  GATA-type zinc finger protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC011511
    UniProtKB/TrEMBL
    A0A9L9PXT6
    Related
    ENSP00000516709.1, ENST00000707000.1

RNA

  1. NR_176053.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC011511
    Related
    ENST00000480726.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    10304803..10309815 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    10430915..10435928 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0C6A0.1 GenPept UniProtKB/Swiss-Prot:P0C6A0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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