GEO DataSets

Analysis of 6 mm punch biopsies of lesional and non-lesional (uninvolved) skin from four chronic plaque psoriasis patients. Chronic plaque psoriasis is an inflammatory skin disease. Results provide insight into molecular mechanisms underlying this inflammatory skin disorder.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 4 individual, 2 tissue sets

Platform:

GPL570

Series:

GSE50790

8 Samples

Download data: CEL

(Submitter supplied) Psoriasis is a chronic inflammatory skin disease characterized by marked proliferation of keratinocytes leading to pronounced epidermal hyperplasia, elongation of rete ridges and hyperkeratosis. The most common form of psoriasis, chronic plaque psoriasis (Psoriasis vulgaris), involves relatively stable occurrence and progression of sharply demarcated lesions, usually on the trunk and extremities, which share a combination of trademark histological features, including tortuous and dilated dermal capillaries, loss of the epidermal granular layer, and accumulation of neutrophils beneath parakeratotic scale. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS5392

Platform:

GPL570

8 Samples

Download data: CEL

(Submitter supplied) The clinical features of psoriasis, characterized by sharply demarcated scaly erythematous plaques, are typically so distinctive that a diagnosis can easily be made on these grounds alone. However, there is great variability in treatment response between individual patients, and this may reflect heterogeneity of inflammatory networks driving the disease. In this study, whole-genome transcriptional profiling was used to characterize inflammatory and cytokine networks in 62 lesional skin samples obtained from patients with stable chronic plaque psoriasis. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS4601

Platform:

GPL570

24 Samples

Download data: CEL

Analysis of cultured keratinocytes treated with various cytokines: interleukin-4, -13, -17A, interferon-α, -γ, or TNF. Marked proliferation of keratinocytes characterizes the chronic inflammatory skin disease psoriasis. Results provide insight into cytokine activity signatures in keratinocytes.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 7 agent, 4 individual sets

Platform:

GPL570

Series:

GSE36287

24 Samples

Download data: CEL

(Submitter supplied) Background: In present study we performed whole transcriptome analysis in plaque psoriasis patients and compared lesional skin with non-lesional skin and with the skin from healthy controls. We sequenced total RNA from 12 lesional (LP), 12 non-lesional (NLP) and from 12 normal (C) skin biopsies. Results: Compared with previous gene expression profiling studies we had three groups under analysis - LP, NLP and C. more...

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL16288

36 Samples

Download data: TXT

(Submitter supplied) The interleukin (IL)-23/T-helper type 17 cell axis is a target for psoriasis. The tyrosine kinase 2 (TYK2)/Janus kinase 1 (JAK1) inhibitor, PF 06700841, will directly suppress TYK2-dependent IL-12 and IL-23 signaling and JAK1-dependent signaling in cells expressing these signaling molecules, including T cells and keratinocytes. This clinical study sought to define the inflammatory gene and cellular pathways through which PF 06700841 improves the clinical manifestations of psoriasis. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

105 Samples

Download data: CEL

(Submitter supplied) Development of a suitable mouse model would facilitate the investigation of pathomechanisms underlying human psoriasis and would also assist in development of therapeutic treatments. However, while many psoriasis mouse models have been proposed, no single model recapitulates all features of the human disease, and standardized validation criteria for psoriasis mouse models have not been widely applied. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS3907

Platform:

GPL1261

34 Samples

Download data: CEL

(Submitter supplied) Gene expression has been proposed as an intermediate phenotype that can increase power in complex trait gene-mapping studies. Psoriasis, an immune-mediated, inflammatory and hyperproliferative disease of the skin and joints, provides an ideal model system to evaluate this paradigm, as conclusive evidence demonstrates that psoriasis has a genetic basis and the disease tissue is readily accessible. To better understand the complex nature of processes in psoriasis, we characterize gene expression profiles in uninvolved and involved skin from affected individuals as well as normal skin from control individuals. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS4602

Platform:

GPL570

180 Samples

Download data: CEL

Analysis of skin punch biopsies from lesional skin (involved sample) and non-lesional skin (uninvolved sample) from each psoriatic patient. Psoriasis is an immune-mediated, inflammatory and hyperproliferative disease of skin and joints. Results provide insight into the molecular basis of psoriasis.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 disease state, 3 specimen sets

Platform:

GPL570

Series:

GSE13355

180 Samples

Download data: CEL

Analysis of psoriatic skin from back, ear from five psoriasis models (K5-Tie2, imiquimod, K14-AREG, K5-Stat3C and K5-TGFbeta1). Psoriasis is a chronic autoimmune disease characterized by patches of red, often scaly skin. Results provide insight into molecular mechanisms underlying psoriasis.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 disease state, 10 genotype/variation, 5 strain, 3 tissue sets

Platform:

GPL1261

Series:

GSE27628

34 Samples

Download data: CEL

(Submitter supplied) A gene expression profiling study was conducted in which skin biopsy samples were collected for RNA extraction and hybridization to microarrays from patients with moderate-to-severe psoriasis who participated in the phase 1, guselkumab first-in-human randomized, double-blind, placebo-controlled trial. At week 12, significant reductions in psoriasis gene expression were observed in guselkumab-treated patients.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL13158

59 Samples

Download data: CEL

(Submitter supplied) Generalized pustular psoriasis (GPP) is a rare, debilitating, and often life-threatening inflammatory disease characterized by episodic infiltration of neutrophils into the skin, pustule development, and systemic inflammation, which can manifest in the presence or absence of chronic plaque psoriasis (PV). Current treatments are unsatisfactory thus a better understanding the pathogenesis of GPP is warranted. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL19983

64 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

157 Samples

Download data: CEL

(Submitter supplied) cDNA and cRNA hybridization technologies have different, probe-specific sensitivities. We used samples from an etanercept trial (GSE11903) to explore in a real-life setting the uniqueness of each platform.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

81 Samples

Download data: CEL

(Submitter supplied) To explore the psoriasis phenotype and pathways involved in psoriasis, we characterized gene expression in lesional and non-lesional skin from psoriasis patients.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

48 Samples

Download data: CEL

(Submitter supplied) To explore the psoriasis phenotype, we characterize gene expression in lesional and non-lesional skin from psoriasis patients.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

28 Samples

Download data: CEL

(Submitter supplied) Scalp psoriasis shows a variable clinical spectrum and in many cases poses a great therapeutic challenge. However, it remains unknown whether the immune response of scalp psoriasis differs from understood pathomechanisms of psoriasis on other skin areas. We sought to determine the cellular and mollecular phenotype of scalp psoriasis by performing a comparative analysis of scalp vs skin using lesional and nonlesional samples from 20 Caucasian subjects with untreated moderate to severe psoriasis and significant scalp involvement, and 10 control subjects without psoriasis. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL571

45 Samples

Download data: CEL

(Submitter supplied) Tofacitinib is an oral Janus kinase inhibitor being investigated for psoriasis. We sought to elucidate the molecular mechanisms underlying the clinical efficacy of tofacitinib in patients with psoriasis. Twelve patients with plaque psoriasis were randomized (3:1) to receive 10 mg of tofacitinib or placebo twice daily for 12 weeks. Biopsy specimens were taken from nonlesional (baseline) and lesional (baseline, days 1 and 3, and weeks 1, 2, 4, and 12) skin. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

95 Samples

Download data: CEL

(Submitter supplied) We have worked on skin explants and activated T cells locally with a CD3 antibody, whole biopsies were activated, then epidermal and dermal RNA was sequenced. Sequencing was performed by BGI (Hong Kong) as well as the group analysis.

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL11154

36 Samples

Download data: TXT

(Submitter supplied) Skin tissues from newborn C57BL/6 mice were obtained for primary keratinocyte culture. Cells were then stimulated with or without IL-25 (Biolegend) for 8hrs. Total RNAs were isolated with RNAprep pure Tissue Kit (DP431) and the RNA-seq library was prepared by the Beijing Genomics Institute. Sequence reads were obtained using BGIseq500 (Illumina) and successfully mapped to mouse genome. Reads counts were normalized based on RPKM, fold changes were calculated for all possible comparisons.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL23479

4 Samples

Download data: TXT