GEO DataSets

Analysis of aneurysmal domes from ruptured intracranial aneurysms (RIAs). RIA causes subarachnoid hemorrhage associated with high morbidity and mortality. Results provides insight into molecular mechanisms that predispose to the rupture of IAs.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 3 tissue sets

Platform:

GPL4133

Series:

GSE54083

23 Samples

Download data: TXT

(Submitter supplied) The rupture of intracranial aneurysm (IA) causes subarachnoid hemorrhage associated with high morbidity and mortality. We compared gene expression profiles in aneurysmal domes between unruptured IAs (UIAs) and ruptured IAs (RIAs) to elucidate biological mechanisms predisposing to the rupture of IA. We determined gene expression levels of eight RIAs, five UIAs, and 10 superficial temporal arteries (STAs) with the Agilent microarrays. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS5186

Platform:

GPL4133

23 Samples

Download data: TXT

(Submitter supplied) Background and Purpose Aneurysmal subarachnoid hemorrhage, almost always from saccular intracranial aneurysm (sIA), is a devastating form of stroke that affects working age population. Cellular and molecular mechanisms predisposing to the rupture of the sIA wall are largely unknown. Such knowledge would facilitate the design of novel diagnostic tools and therapies for the sIA disease. Methods We compared the whole genome expression profile of eleven ruptured sIA wall samples, resected at a median of 15 hours after rupture, to that of eight unruptured ones. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

19 Samples

Download data: CEL

(Submitter supplied) The primary aim of the present study was to identify differences on the transcription level between ruptured and unruptured intracranial aneurysms as well as normal intracranial arteries in human. Keywords: Expression profiling by array

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6244

19 Samples

Download data: CEL

(Submitter supplied) The diagnosis of cerebral vasospasm after Subarachnoid-Hemorrhage is currently very difficult, additional tools such as blood biomarkers are necessary. We tested the ability of gene expression profiles of blood cells to predict vasospasm.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL13218

128 Samples

Download data: GPR

(Submitter supplied) Background and Purpose—Analyzing genes involved in development and rupture of intracranial aneurysms can enhance knowledge about the pathogenesis of aneurysms, and identify new treatment strategies. We compared gene expression between ruptured and unruptured aneurysms and control intracranial arteries. Methods—We determined expression levels with RNA sequencing. Applying a multivariate negative binomial model, we identified genes that were differentially expressed between 44 aneurysms and 16 control arteries, and between 22 ruptured and 21 unruptured aneurysms. more...

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL16791

60 Samples

Download data: TXT

(Submitter supplied) In this study, we explored transcriptional differences in human neutrophils from patients with intracranial aneurysms and a demographic and comorbidity paired population of controls

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL16791

32 Samples

Download data: TXT

(Submitter supplied) Circulating whole blood transcriptomes can detect the presence of unruptured cerebral aneurysms. Pending additional testing in larger cohorts, this could serve as a foundation to develop a simple blood-based test to facilitate screening and early detection of cerebral aneurysms.

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL16791

47 Samples

Download data: TXT

(Submitter supplied) The biological mechanisms by which cerebral aneurysms emerge, enlarge and rupture are not totally understood. In the present study, we analyzed the genome-wide gene expression profile in human intracranial aneurysms using cDNA microarrays.

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3903

Platform:

GPL570

6 Samples

Download data: CEL

Analysis of unruptured intracranial arterial aneurysm (IAA). IAA is a cerebrovascular disorder in which weakness in a cerebral artery wall causes localized dilation and possible rupture. Results provide insight into the molecular mechanisms underlying cerebral aneurysms.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 disease state sets

Platform:

GPL570

Series:

GSE26969

6 Samples

Download data: CEL

(Submitter supplied) We carried out a case control study in an attempt to identify changes in circulating microRNAs in patients with intracranial aneurysms (IAs). We selected 40 cases (20 ruptured and 20 unruptured) and 20 healthy controls. We randomly selected 5 samples from each group and combined them into a sample pool. In this way we obtained 12 sample pools and one pool was used for a single microarray. Changes in microRNA levels in the plasma were surveyed with Agilent Human microRNA Microarray (Release 14.0, 8x15K). more...

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL17725

12 Samples

Download data: TXT

(Submitter supplied) Investigation of gene expression profiles in blood of previous aSAH patients, aiming to gain insight into the pathogenesis of IA and aSAH, and to make a first step towards improvement of aSAH risk prediction. The results indicate that no gene expression differences are present in blood of previous aSAH patients compared to controls, besides one differentially co-expressed gene network without a clear relevant biological function.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL10904 GPL10558

226 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens; synthetic construct

Type:

Expression profiling by high throughput sequencing; Non-coding RNA profiling by array

Platforms:

GPL19117 GPL17303

35 Samples

Download data: CEL

(Submitter supplied) Gene expression information is useful in prioritizing candidate genes in linkage intervals. The data can also identify pathways involved in the pathophysiology of disease. We used microarrays to identify which genes are expressed in either intracranial arteries (control) or in intracranial aneurysms (case), and can therefore contribute to the disease phenotypes. We used microarrays to identify the pathway membership of expressed genes and the overrepresentation of pathways with expressed genes in the known linkage intervals for intracranial aneurysms. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL2507 GPL570

10 Samples

Download data: CEL, TXT

(Submitter supplied) Background and Purpose: Genome-wide association studies significantly link intracranial aneurysm (IA) to single-nucleotide polymorphisms (SNPs) in six genomic loci. To gain insight into the relevance of these IA associated SNPs, we aimed to identify regulatory regions and analyze overall gene expression in the human circle of Willis (CoW), on which these aneurysms develop. Methods: We performed chromatin immunoprecipitation and sequencing for histone modifications H3K4me1 and H3K27ac to identify regulatory regions, including distal enhancers and active promoters, in post mortem specimens of the human CoW. more...

Organism:

Homo sapiens

Type:

Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platforms:

GPL16791 GPL11154

14 Samples

Download data: BED, TDF, TXT, XLS, XLSX

(Submitter supplied) In the present study we aimed to investigate the systemic response to a rupture of intracranial aneurysms by an analysis of global gene expression profiles in peripheral blood cells. In addition, we sought to determine whether this approach could provide biomarkers related to clinical status of subarachnoid hemorrhage patients.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10558

61 Samples

Download data: TXT

(Submitter supplied) Cerebral aneurysms were induced in adult male mice using an elastase model. Single-cell RNA sequencing was then performed on circle of Willis samples obtained at 14 days post-aneurysm induction.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL30172

3 Samples

Download data: H5

(Submitter supplied) Cyclic circumferential stretch (CCS) induced by pulsatile blood pressure affects endothelial cell (EC) gene expression and regulates vascular mechanical properties. Although alterations in EC gene expression in response to increased CCS as observed in hypertensive patients is widely studied, the EC response to low or lack of CCS as observed in intracranial aneurysm (IA) disease has been poorly investigated. more...

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL20301

12 Samples

Download data: TXT

(Submitter supplied) Recent experimental studies have defined intracranial aneurysms as a macrophage-mediated chronic inflammatory disease affecting intracranial arteries. We used single cell RNA sequencing (scRNA-seq) to analyze the population of macrophages in aneurysm lesions at the growth phase.

Organism:

Rattus norvegicus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL20084

52 Samples

Download data: XLS, XLSX