GEO DataSets

Temporal analysis of differentiated mNPC cultures transduced with three vectors: Helper-dependent (HD) human (HAd) and canine (CAV-2) adenoviruses and VSV-G-pseudotyped self-inactivating HIV-1 vector (LV). Results provide insight into the toxicogenomic profiles of these viral vectors in mNPCs.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 5 agent, 2 time sets

Platform:

GPL570

Series:

GSE47130

30 Samples

Download data: CEL

(Submitter supplied) With the goal of specifically dissecting the toxicogenomic signatures of the helper-dependent (HD) human (HAd5) and canine (CAV-2) adenovirus, the VSV-G-pseudotyped SIN HIV-1 (LV) and the Adenoviral-associated vector 2/9 for human neurons (AAV2/9), we transduced a bona fide human neuronal system with HD-HAd5, HD-CAV-2, LV and AAV2/9, we analysed the transcriptional response of more than 47,000 transcripts using gene chips. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS4861

Platform:

GPL570

30 Samples

Download data: CEL

(Submitter supplied) Brain gene transfer using viral vectors will likely become a therapeutic option for several disorders. Helper-dependent (HD) canine adenovirus type 2 vectors (CAV-2) are well suited for this goal. Indeed, these vectors are poorly immunogenic, efficiently transduce neurons, are retrogradely transported to afferent structures in the brain, and lead to long-term transgene expression. CAV-2 vectors have been exploited to unravel behavior, cognition, neural networks, axonal transport and therapy for orphan diseases. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

12 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens; Microcebus murinus

Type:

Expression profiling by array

Platform:

GPL570

59 Samples

Download data: CEL

(Submitter supplied) Parkinson disease (PD) is a neurodegenerative disease primarily associated with impaired movement affecting elderly people. To improve the understanding of the pathogenesis and to develop new therapies, we have developed a non-human primate model of PD using the lemurian Microcebus murinus (Mim). In this study, we tested the potential of canine adenovirus type 2 (CAV-2) as vector for gene transfer in the Mim brain by analyzing the gene expression changes in three regions involved in motor control: striatum, frontal cortex and midbrain. more...

Organism:

Homo sapiens; Microcebus murinus

Type:

Expression profiling by array

Platform:

GPL570

19 Samples

Download data: CEL, TXT

(Submitter supplied) Parkinson disease (PD) is a neurodegenerative disease primarily associated with impaired movement affecting elderly people. To improve the understanding of the pathogenesis and to develop new therapies, we have developed a non-human primate model of PD using the lemurian Microcebus murinus (Mim). In this study, we tested the potential of canine adenovirus type 2 (CAV-2) as vector for gene transfer in the Mim brain by analyzing the gene expression changes in three regions involved in motor control: striatum, frontal cortex and midbrain. more...

Organism:

Homo sapiens; Microcebus murinus

Type:

Expression profiling by array

Platform:

GPL570

20 Samples

Download data: CEL, TXT

(Submitter supplied) Parkinson disease (PD) is a neurodegenerative disease primarily associated with impaired movement affecting elderly people. To improve the understanding of the pathogenesis and to develop new therapies, we have developed a non-human primate model of PD using the lemurian Microcebus murinus (Mim). In this study, we tested the potential of canine adenovirus type 2 (CAV-2) as vector for gene transfer in the Mim brain by analyzing the gene expression changes in three regions involved in motor control: striatum, frontal cortex and midbrain. more...

Organism:

Homo sapiens; Microcebus murinus

Type:

Expression profiling by array

Platform:

GPL570

20 Samples

Download data: CEL, TXT

(Submitter supplied) In the context of lentiviral vector (LV)-mediated gene correction of hematopoietic stem and progenitor cells (HSPC), the viral origin of LV could trigger cellular responses with potential functional consequences that have not been investigated to date. Here, a time-course genome-wide transcriptional profiling of transduced human HSPC reveals a remarkably limited impact of LV on cellular gene expression, supporting some stealth features of the vector. more...

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL16791

93 Samples

Download data: TXT

(Submitter supplied) The innate immune response to 1st generation adenoviral vectors was ascertained through high level infection of primary cells from a inbred mouse strain, replete with an intact and functioning TLR system. Keywords: Immune Response

Organism:

Mus musculus

Type:

Expression profiling by array

Datasets:

GDS1528 GDS1529

Platforms:

GPL75 GPL76

24 Samples

Download data

Analysis of primary C57BL/6 embryonic fibroblasts infected with a 1st generation adenoviral (Ad) vector. Ad vectors are known to induce certain genes and impact innate response networks. Results provide insight into the innate immune response of cells to Ad transduction.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 infection sets

Platform:

GPL76

Series:

GSE3172

12 Samples

Download data

Analysis of primary C57BL/6 embryonic fibroblasts infected with a 1st generation adenoviral (Ad) vector. Ad vectors are known to induce certain genes and impact innate response networks. Results provide insight into the innate immune response of cells to Ad transduction.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 infection sets

Platform:

GPL75

Series:

GSE3172

12 Samples

Download data