Similar studies for GEO DataSets (Select 4163) - GEO DataSets

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Items: 20

Select item 41631.

Recombinant Interferon α effect on natural killer cells in vitro

Analysis of natural killer (NK) cells sorted from healthy donor peripheral blood mononuclear cells (PBMCs) stimulated for 6h in media containing 1 or 100 ng/ml recombinant interferon (IFN)-alpha-2b. Results provide insight into the effects of type I IFNs on NK cells.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 2 agent, 3 dose, 2 growth protocol sets

Platform:: GPL570
Series:: GSE15743
4 Samples

Download data: CEL

DataSet

Accession:: GDS4163

ID:: 4163

Select item 2000157432.

IFN alpha-induced gene expression in human NK cells

(Submitter supplied) NK cells are believed to contribute to the control of hepatitis C virus infection and pathogenesis of liver disease. Standard treatment of both acute and chronic hepatitis C is based on the administration of interferon alpha, however, the effects of type I interferons on human NK cells have not been studied in the context of hepatitis C. We therefore first performed a microarray screen for genes differentially regulated in human NK cells after stimulation of PBMC with recombinant interferon alpha-2b. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS4163
Platform:: GPL570
4 Samples

Download data: CEL

Series

Accession:: GSE15743

ID:: 200015743

Select item 2001256863.

Transcriptomic profiling of peripheral blood NK cells of chronic HBV, HCV and HIV patients

(Submitter supplied) Background: NK cells during chronic viral infection have been well studied over the last decade. We performed an unbiased next-generation RNA-sequencing approach to identify commonalities or differences of the effect of HIV, HCV and HBV viremia on NK cell transcriptomes. Methods: Using cell sorting, we obtained CD3-CD56+ NK cells from blood of 6 HIV, 11 HCV, and 32 HBV infected and untreated patients. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL16791 GPL11154 GPL18573
62 Samples

Download data: TXT

Series

Accession:: GSE125686

ID:: 200125686

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 2001460754.

C19orf66 is an interferon-induced inhibitor of HCV replication restricting formation of the viral replication organelle

(Submitter supplied) Hepatitis C virus (HCV) infection constitutes a global health problem with 71 million people currently chronically infected. Recent studies have reported that C19orf66 is expressed as an interferon (IFN)-stimulated gene; however, the intrinsic regulation of this gene within the liver as well as its antiviral effects against HCV remains elusive. In this study, we observed an upregulation of C19orf66 in vivo and ex vivo in response to HCV infection and to IFN therapy. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
2 Samples

Download data: CSV

Series

Accession:: GSE146075

ID:: 200146075

Select item 2000593125.

Expression profiling of peripheral blood of chronic HCV infection

(Submitter supplied) In the present study, we studied chronic HCV patients who responded to IFN-based therapy as evidenced by absence of HCV RNA at the end of treatment, and focused on two issues that have not received much attention. Firstly, we evaluated whether specific genes or gene expression patterns in blood were able to distinguish responder patients with a viral relapse from responder patients who remained virus-negative after cessation of treatment. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
79 Samples

Download data: CEL

Series

Accession:: GSE59312

ID:: 200059312

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2002492406.

Hepatitis D infection induces IFN-β-mediated NK cell activation and TRAIL-dependent cytotoxicity

(Submitter supplied) The co-infection of hepatitis B (HBV) patients with the hepatitis D virus (HDV) causes the most severe form of viral hepatitis and thus drastically worsens the course of the disease. Therapy options for HBV/HDV patients are still limited. Here, we investigated the potential of natural killer (NK) cells that are crucial drivers of the innate immune response against viruses to target HDV-infected hepatocytes. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
10 Samples

Download data: TAR, TSV

Series

Accession:: GSE249240

ID:: 200249240

PubMed Full text in PMC Similar studies

Select item 2001075497.

Innate immune activity correlates with suppression of HIV replication and CD4+ T cell-associated HIV-1 DNA decline during treatment with pegylated IFN-α2a in chronic ART-suppressed HIV infection

(Submitter supplied) In study NCT00594880, we successfully administered weekly doses of pegylated interferon-α-2a (Peg-IFN-α2a) with antiretroviral therapy (ART) for 5 weeks, before continued Peg-IFN-α2a monotherapy to 12 weeks (primary endpoint) in chronic HIV-infected subjects. Subjects maintaining HIV viral load <400 copies/ml by primary endpoint were defined as responders. We now describe innate immune correlates and transcriptional profiles associated with viral control and decrease in integrated HIV DNA after Peg-IFN-α2a immunotherapy. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10558
50 Samples

Download data: TXT

Series

Accession:: GSE107549

ID:: 200107549

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000667008.

Liver gene expression profiles of interferon therapy in chronic hepatitis B Patients

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platforms:: GPL570 GPL5188
19 Samples

Download data: CEL

Series

Accession:: GSE66700

ID:: 200066700

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000666999.

Liver gene expression profiles of interferon therapy in chronic hepatitis B Patients (Exon)

(Submitter supplied) With 350 million carriers worldwide who may suffer from serious sequelae, including hepatocellular carcinoma, chronic hepatitis B virus (CHB) infection remains an important health issue. Current antiviral therapies hardly eradicate the virus. Therefore, there are still imperative need to develop new therapeutic strategies and predictors for treatment response to cure the disease and avoid futile treatment. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL5188
2 Samples

Download data: CEL

Series

Accession:: GSE66699

ID:: 200066699

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20006669810.

Liver gene expression profiles of interferon therapy in chronic hepatitis B Patients (mRNA)

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
17 Samples

Download data: CEL

Series

Accession:: GSE66698

ID:: 200066698

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20008434611.

Transcriptional response to hepatitis C virus infection and interferon alpha treatment in the human liver

(Submitter supplied) Hepatitis C virus (HCV) is widely used to investigate host-virus interactions and cellular responses to infection have been extensively studied in vitro. In human liver, interferon (IFN) stimulated gene expression can mask direct transcriptional responses to virus infection. To better characterize the direct effects of HCV infection in vivo, we analyze the transcriptomes of HCV-infected patients lacking an activated endogenous IFN system. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL11154
46 Samples

Download data: GTF, TXT

Series

Accession:: GSE84346

ID:: 200084346

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20004022412.

The blood transcriptional signature of chronic HCV

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platforms:: GPL10558 GPL96
28 Samples

Download data: CEL

Series

Accession:: GSE40224

ID:: 200040224

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20004022313.

The blood transcriptional signature of chronic HCV [Illumina data]

(Submitter supplied) This study characterizes the effects of chronic Hepatitis C virus (HCV) infection on gene expression by analyzing blood samples from 10 treatment-naive HCV patients and 6 healthy volunteers. Differential expression analysis of microarray data from peripheral blood mononuclear cells (PBMCs) identified a 136 gene signature, including 66 genes elevated in infected individuals. Most of the up-regulated genes were associated with interferon (IFN) activity (including members of the OAS and MX families, ISG15 and IRF7), suggesting an ongoing immune response. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10558
10 Samples

Download data: TXT

Series

Accession:: GSE40223

ID:: 200040223

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20004018414.

The blood transcriptional signature of chronic HCV [Affymetrix data]

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL96
18 Samples

Download data: CEL

Series

Accession:: GSE40184

ID:: 200040184

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20016276415.

Apolipoprotein A-I mimetic peptide L37pA attenuates IFNα-induced inflamation and promotes antiviral activity

(Submitter supplied) Apolipoprotein A-I mimetic peptides are amphipathic alpha helix peptides that display similar functions to apolipoprotein A-I, and preclinical studies have evaluated . In this study, we evaluated the effect of the long-term expression of L37pA in the liver by an adeno-associated virus (AAV-L37pA) on the expression of an adeno-associated virus encoding interferon-alpha (AAV-IFNα). Long-term IFNα expression in the liver leads to lethal hematological toxicity one month after AAV administration. more...