GEO DataSets

(Submitter supplied) Comparative analysis of gene expression profiles provided novel insights into the genes that are transcriptionally active in infective and developing larvae of two closely related species. Species differences may indicate different metabolic adaptations that could affect host specificity, tissue tropism, and pathogenicity

Organism:

Brugia malayi; Onchocerca volvulus; Wolbachia endosymbiont strain TRS of Brugia malayi; Wuchereria bancrofti; Brugia pahangi

Type:

Expression profiling by array

Platform:

GPL10232

24 Samples

Download data: TXT

(Submitter supplied) Doxycycline treatment affects gene expression in Wolbachia and Brugia malayi adult female worms in vivo

Organism:

Brugia malayi; Onchocerca volvulus; Wuchereria bancrofti; Wolbachia endosymbiont strain TRS of Brugia malayi

Type:

Expression profiling by array

Platform:

GPL10232

8 Samples

Download data: TXT

(Submitter supplied) The filarial nematodes Brugia malayi, Wuchereria bancrofti and Onchocerca volvulus cause elephantiasis, dermatitis and blindness, resulting in severe morbidity in developing countries. 1.3 billion people are at risk of infection. Targeting the essential Wolbachia endobacteria of filarial nematodes with doxycycline has proven to be an effective therapy, resulting in a block in embryogenesis and worm development, and macrofilaricidal effects. more...

Organism:

Wolbachia endosymbiont strain TRS of Brugia malayi; Brugia malayi; Onchocerca volvulus; Litomosoides sigmodontis; Wuchereria bancrofti

Type:

Expression profiling by array

Platform:

GPL10232

6 Samples

Download data: CSV, TXT

(Submitter supplied) The Brugia malayi Version 2 (V.2) array contains 18,153 oligonucleotides, 878 based on Wuchereria bancrofti ESTs, 1,016 based on Onchocerca volvulus gene indices, 804 from the Wolbachia complete genome, and the remaining 15,455 based on B. malayi ESTs, TIGR gene indices, TIGR gene models, and L3 ESTs. Oligonucleotide selection: We patterned our oligo selection algorithm after PICK70 (J. DeRisi, personal communication). more...

Organism:

Brugia malayi; Onchocerca volvulus; Wuchereria bancrofti; Wolbachia endosymbiont strain TRS of Brugia malayi

3 Series

38 Samples

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