ClinVar for Gene (Select 2956) - ClinVar - NCBI

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	Variation	Gene (Protein Change)	Type (Consequence)	Condition	Classification, Review status
Select item 3230596	NM_000179.3(MSH6):c.992C>G (p.Ser331Ter)	MSH6 (S156* +8 more)	Single nucleotide variant (nonsense +2 more)	Hereditary cancer-predisposing syndrome	GPathogenic
Select item 3230593	NM_000179.3(MSH6):c.803A>G (p.Asp268Gly)	MSH6 (D138G +7 more)	Single nucleotide variant (missense variant +3 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3230592	NM_000179.3(MSH6):c.790G>T (p.Glu264Ter)	MSH6 (E134* +7 more)	Single nucleotide variant (nonsense +3 more)	Hereditary cancer-predisposing syndrome	GPathogenic
Select item 3230591	NM_000179.3(MSH6):c.778G>A (p.Gly260Ser)	MSH6 (G130S +7 more)	Single nucleotide variant (missense variant +3 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3230590	NM_000179.3(MSH6):c.716G>T (p.Arg239Met)	MSH6 (R109M +7 more)	Single nucleotide variant (missense variant +3 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3230588	NM_000179.3(MSH6):c.699T>C (p.Pro233=)	MSH6	Single nucleotide variant (synonymous variant +3 more)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 3230586	NM_000179.3(MSH6):c.619_627+320delinsAT	MSH6	Indel (splice donor variant +1 more)	Hereditary cancer-predisposing syndrome	GLikely pathogenic
Select item 3230585	NM_000179.3(MSH6):c.612G>C (p.Glu204Asp)	MSH6 (E105D +6 more)	Single nucleotide variant (missense variant +3 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3230584	NM_000179.3(MSH6):c.58G>A (p.Ala20Thr)	MSH6 (A20T +1 more)	Single nucleotide variant (missense variant +4 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3230583	NM_000179.3(MSH6):c.522A>C (p.Arg174Ser)	MSH6 (R118S +5 more)	Single nucleotide variant (missense variant +3 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3230582	NM_000179.3(MSH6):c.466del (p.Ser156fs)	MSH6 (S100fs +5 more)	Deletion (frameshift variant +3 more)	Hereditary cancer-predisposing syndrome	GPathogenic
Select item 3230581	NM_000179.3(MSH6):c.458-2A>T	MSH6	Single nucleotide variant (5 prime UTR variant +2 more)	Hereditary cancer-predisposing syndrome	GLikely pathogenic
Select item 3230579	NM_000179.3(MSH6):c.4063_4066dup (p.Leu1356fs)	MSH6 (L1054fs +14 more)	Duplication (frameshift variant +2 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3230578	NM_000179.3(MSH6):c.4059G>T (p.Leu1353Phe)	MSH6 (L302F +14 more)	Single nucleotide variant (missense variant +2 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3230577	NM_000179.3(MSH6):c.4034_4042dup (p.Ala1347_Glu1348insValAspAla)	MSH6	Duplication (inframe_insertion +3 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3230576	NM_000179.3(MSH6):c.3995T>A (p.Leu1332Ter)	MSH6 (L1030* +14 more)	Single nucleotide variant (nonsense +3 more)	Hereditary cancer-predisposing syndrome	GLikely pathogenic
Select item 3230575	NM_000179.3(MSH6):c.3992_4001+4del	MSH6	Deletion (splice donor variant +1 more)	Hereditary cancer-predisposing syndrome	GLikely pathogenic
Select item 3230574	NM_000179.3(MSH6):c.3978_3981dup (p.Gln1328fs)	MSH6 (Q1026fs +14 more)	Duplication (frameshift variant +3 more)	Hereditary cancer-predisposing syndrome	GLikely pathogenic
Select item 3230573	NM_000179.3(MSH6):c.3963A>C (p.Arg1321Ser)	MSH6 (E1317A +15 more)	Single nucleotide variant (missense variant +2 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3230572	NM_000179.3(MSH6):c.3957A>G (p.Lys1319=)	MSH6 (K1315R)	Single nucleotide variant (synonymous variant +3 more)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 3230571	NM_000179.3(MSH6):c.3932A>G (p.Glu1311Gly)	MSH6 (E1009G +15 more)	Single nucleotide variant (missense variant +2 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3230569	NM_000179.3(MSH6):c.3896G>C (p.Gly1299Ala)	MSH6 (A1295P +15 more)	Single nucleotide variant (missense variant +2 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3230568	NM_000179.3(MSH6):c.3875G>T (p.Gly1292Val)	MSH6 (E1288* +15 more)	Single nucleotide variant (missense variant +3 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3230567	NM_000179.3(MSH6):c.3866_3880del (p.Phe1289_Ala1293del)	MSH6	Deletion (inframe_deletion +3 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3230566	NM_000179.3(MSH6):c.3864del (p.Lys1288fs)	MSH6 (K1000fs +15 more)	Deletion (frameshift variant +2 more)	Hereditary cancer-predisposing syndrome	GPathogenic
Select item 3230564	NM_000179.3(MSH6):c.3830A>T (p.Asp1277Val)	MSH6 (D1102V +15 more)	Single nucleotide variant (missense variant +2 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3230563	NM_000179.3(MSH6):c.3829_3830delinsAT (p.Asp1277Ile)	MSH6 (D1102I +15 more)	Indel (missense variant +2 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3230562	NM_000179.3(MSH6):c.3823T>G (p.Cys1275Gly)	MSH6 (C1100G +15 more)	Single nucleotide variant (missense variant +2 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3230561	NM_000179.3(MSH6):c.3702A>G (p.Glu1234=)	MSH6	Single nucleotide variant (synonymous variant +1 more)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 3230560	NM_000179.3(MSH6):c.3593C>G (p.Ala1198Gly)	MSH6 (A1023G +14 more)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3230559	NM_000179.3(MSH6):c.3572_3573dup (p.Val1192fs)	MSH6 (V1017fs +14 more)	Duplication (frameshift variant +1 more)	Hereditary cancer-predisposing syndrome	GPathogenic
Select item 3230558	NM_000179.3(MSH6):c.3568T>A (p.Phe1190Ile)	MSH6 (F1015I +14 more)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3230557	NM_000179.3(MSH6):c.3566C>A (p.Thr1189Lys)	MSH6 (T1014K +14 more)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3230556	NM_000179.3(MSH6):c.3556+2dup	MSH6	Duplication (splice donor variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3230554	NM_000179.3(MSH6):c.3547A>T (p.Ile1183Leu)	MSH6 (I1008L +14 more)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3230553	NM_000179.3(MSH6):c.3515dup (p.Val1173fs)	MSH6 (V100fs +14 more)	Duplication (frameshift variant +1 more)	Hereditary cancer-predisposing syndrome	GPathogenic
Select item 3230552	NM_000179.3(MSH6):c.3514A>C (p.Arg1172=)	MSH6	Single nucleotide variant (synonymous variant +1 more)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 3230551	NM_000179.3(MSH6):c.3480C>T (p.Val1160=)	MSH6	Single nucleotide variant (synonymous variant +1 more)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 3230548	NM_000179.3(MSH6):c.3423T>C (p.Ser1141=)	MSH6	Single nucleotide variant (synonymous variant +1 more)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 3230547	NM_000179.3(MSH6):c.337C>A (p.His113Asn)	MSH6 (H113N +4 more)	Single nucleotide variant (missense variant +3 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3230546	NM_000179.3(MSH6):c.3180dup (p.Leu1061fs)	MSH6 (L1005fs +12 more)	Duplication (frameshift variant +3 more)	Hereditary cancer-predisposing syndrome	GPathogenic
Select item 3230545	NM_000179.3(MSH6):c.3166G>A (p.Val1056Met)	MSH6 (V1000M +9 more)	Single nucleotide variant (missense variant +2 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3230544	NM_000179.3(MSH6):c.313T>C (p.Trp105Arg)	MSH6 (W105R +4 more)	Single nucleotide variant (missense variant +3 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3230543	NM_000179.3(MSH6):c.3116A>T (p.Asn1039Ile)	MSH6 (N1013I +9 more)	Single nucleotide variant (missense variant +2 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3230542	NM_000179.3(MSH6):c.3037A>G (p.Lys1013Glu)	MSH6 (K1013E +9 more)	Single nucleotide variant (missense variant +2 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3230541	NM_000179.3(MSH6):c.3009T>C (p.Cys1003=)	MSH6	Single nucleotide variant (synonymous variant +2 more)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 3230540	NM_000179.3(MSH6):c.2999A>T (p.Lys1000Met)	MSH6 (K1000M +9 more)	Single nucleotide variant (missense variant +2 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3230538	NM_000179.3(MSH6):c.2724A>C (p.Glu908Asp)	MSH6 (E223D +9 more)	Single nucleotide variant (missense variant +2 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3230537	NM_000179.3(MSH6):c.2692C>T (p.Pro898Ser)	MSH6 (P213S +9 more)	Single nucleotide variant (missense variant +2 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3230536	NM_000179.3(MSH6):c.2623A>G (p.Met875Val)	MSH6 (M573V +8 more)	Single nucleotide variant (missense variant +2 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3230535	NM_000179.3(MSH6):c.261-2A>G	MSH6	Single nucleotide variant (5 prime UTR variant +2 more)	Hereditary cancer-predisposing syndrome	GLikely pathogenic
Select item 3230534	NM_000179.3(MSH6):c.2561A>G (p.Lys854Arg)	MSH6 (K552R +8 more)	Single nucleotide variant (missense variant +2 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3230533	NM_000179.3(MSH6):c.2500A>C (p.Ser834Arg)	MSH6 (S532R +8 more)	Single nucleotide variant (missense variant +2 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3230532	NM_000179.3(MSH6):c.2465T>G (p.Leu822Arg)	MSH6 (L520R +8 more)	Single nucleotide variant (missense variant +2 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3230529	NM_000179.3(MSH6):c.2386G>C (p.Glu796Gln)	MSH6 (E494Q +8 more)	Single nucleotide variant (missense variant +2 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3230528	NM_000179.3(MSH6):c.2224A>G (p.Asn742Asp)	MSH6 (N440D +8 more)	Single nucleotide variant (missense variant +2 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3230526	NM_000179.3(MSH6):c.221G>C (p.Gly74Ala)	MSH6 (E56Q +1 more)	Single nucleotide variant (missense variant +3 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3230524	NM_000179.3(MSH6):c.2143G>C (p.Asp715His)	MSH6 (D747H +8 more)	Single nucleotide variant (missense variant +2 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3230522	NM_000179.3(MSH6):c.2068T>G (p.Tyr690Asp)	MSH6 (Y388D +8 more)	Single nucleotide variant (missense variant +2 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3230521	NM_000179.3(MSH6):c.2064del (p.Phe689fs)	MSH6 (F387fs +8 more)	Deletion (frameshift variant +2 more)	Hereditary cancer-predisposing syndrome	GPathogenic
Select item 3230520	NM_000179.3(MSH6):c.205G>T (p.Ala69Ser)	MSH6 (A69S +1 more)	Single nucleotide variant (missense variant +3 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3230516	NM_000179.3(MSH6):c.1853A>G (p.Gln618Arg)	MSH6 (Q316R +8 more)	Single nucleotide variant (missense variant +2 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3230515	NM_000179.3(MSH6):c.185_199dup (p.Pro66_Pro67insArgSerAlaSerPro)	MSH6	Duplication (inframe_insertion +4 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3230514	NM_000179.3(MSH6):c.1831A>T (p.Ser611Cys)	MSH6 (S309C +8 more)	Single nucleotide variant (missense variant +2 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3230513	NM_000179.3(MSH6):c.1754del (p.Leu585fs)	MSH6 (L283fs +8 more)	Deletion (frameshift variant +2 more)	Hereditary cancer-predisposing syndrome	GPathogenic
Select item 3230511	NM_000179.3(MSH6):c.1647T>G (p.Ser549=)	MSH6	Single nucleotide variant (synonymous variant +2 more)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 3230510	NM_000179.3(MSH6):c.1630G>A (p.Glu544Lys)	MSH6 (E242K +8 more)	Single nucleotide variant (intron variant +2 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3230509	NM_000179.3(MSH6):c.1592C>T (p.Pro531Leu)	MSH6 (P229L +8 more)	Single nucleotide variant (missense variant +2 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3230508	NM_000179.3(MSH6):c.1574G>T (p.Ser525Ile)	MSH6 (S223I +8 more)	Single nucleotide variant (missense variant +2 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3230507	NM_000179.3(MSH6):c.1542T>G (p.Cys514Trp)	MSH6 (C212W +8 more)	Single nucleotide variant (missense variant +2 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3230505	NM_000179.3(MSH6):c.1536dup (p.Ile513fs)	MSH6 (I211fs +8 more)	Duplication (frameshift variant +2 more)	Hereditary cancer-predisposing syndrome	GPathogenic
Select item 3230504	NM_000179.3(MSH6):c.1520G>C (p.Arg507Thr)	MSH6 (R205T +8 more)	Single nucleotide variant (missense variant +2 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3230503	NM_000179.3(MSH6):c.1485A>G (p.Arg495=)	MSH6	Single nucleotide variant (synonymous variant +2 more)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 3230501	NM_000179.3(MSH6):c.1469A>T (p.Glu490Val)	MSH6 (E188V +8 more)	Single nucleotide variant (missense variant +2 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3230500	NM_000179.3(MSH6):c.1433A>C (p.Tyr478Ser)	MSH6 (Y176S +8 more)	Single nucleotide variant (missense variant +2 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3230498	NM_000179.3(MSH6):c.1405_1406insTGA (p.Tyr469delinsLeuAsn)	MSH6	Insertion (inframe_indel +2 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3230497	NM_000179.3(MSH6):c.1369G>T (p.Ala457Ser)	MSH6 (A155S +8 more)	Single nucleotide variant (missense variant +2 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3230496	NM_000179.3(MSH6):c.1362C>T (p.Gly454=)	MSH6	Single nucleotide variant (synonymous variant +2 more)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 3230495	NM_000179.3(MSH6):c.1260del (p.Phe421fs)	MSH6 (F119fs +8 more)	Deletion (frameshift variant +2 more)	Hereditary cancer-predisposing syndrome	GPathogenic
Select item 3230493	NM_000179.3(MSH6):c.1252T>G (p.Ser418Ala)	MSH6 (S116A +8 more)	Single nucleotide variant (missense variant +2 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3230492	NM_000179.3(MSH6):c.1222C>A (p.Pro408Thr)	MSH6 (P106T +8 more)	Single nucleotide variant (missense variant +2 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3230491	NM_000179.3(MSH6):c.1152G>A (p.Arg384=)	MSH6	Single nucleotide variant (synonymous variant +2 more)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 3230490	NM_000179.3(MSH6):c.109G>T (p.Ala37Ser)	MSH6 (A37S)	Single nucleotide variant (missense variant +4 more)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 3230488	NM_000179.3(MSH6):c.1011G>C (p.Leu337Phe)	MSH6 (L162F +8 more)	Single nucleotide variant (missense variant +2 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3211519	NM_000179.3(MSH6):c.3601C>A (p.Leu1201Ile)	MSH6 (L899I +14 more)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3211504	NM_000179.3(MSH6):c.2093A>C (p.Gln698Pro)	MSH6 (Q396P +8 more)	Single nucleotide variant (missense variant +2 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3211502	NM_000179.3(MSH6):c.1748G>A (p.Arg583Lys)	MSH6 (R408K +8 more)	Single nucleotide variant (missense variant +2 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3148719	NM_000179.3(MSH6):c.3865_3887dup (p.Lys1296fs)	MSH6 (K1008fs +14 more)	Duplication (frameshift variant +3 more)	Lynch syndrome 5	GLikely pathogenic
Select item 3148696	NM_000179.3(MSH6):c.3874_3899del (p.Lys1291_Gly1292insTer)	MSH6 (R1287fs)	Deletion (nonsense +3 more)	Lynch syndrome 5	GPathogenic
Select item 3148686	NM_000179.3(MSH6):c.3858_3859dup (p.Tyr1287fs)	MSH6 (Y1231fs +15 more)	Microsatellite (frameshift variant +2 more)	Lynch syndrome 5	GPathogenic
Select item 3148676	NM_000179.3(MSH6):c.692_693dup (p.Gln232fs)	MSH6 (Q176fs +7 more)	Duplication (frameshift variant +3 more)	Lynch syndrome 5	GPathogenic
Select item 3148673	NM_000179.3(MSH6):c.2187_2194del (p.Tyr730fs)	MSH6 (Y704fs +8 more)	Deletion (frameshift variant +2 more)	Lynch syndrome 5	GPathogenic
Select item 3148653	NM_000179.3(MSH6):c.1559delinsTAC (p.Gly520fs)	MSH6 (G345fs +8 more)	Indel (frameshift variant +2 more)	Lynch syndrome 5	GPathogenic
Select item 3076154	NM_000179.3(MSH6):c.696G>T (p.Gln232His)	MSH6 (Q102H +7 more)	Single nucleotide variant (missense variant +3 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3076153	NM_000179.3(MSH6):c.471G>T (p.Lys157Asn)	MSH6 (K101N +5 more)	Single nucleotide variant (missense variant +3 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3076151	NM_000179.3(MSH6):c.457+5G>A	MSH6	Single nucleotide variant (synonymous variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3076150	NM_000179.3(MSH6):c.386T>C (p.Val129Ala)	MSH6 (V103A +4 more)	Single nucleotide variant (missense variant +3 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3076149	NM_000179.3(MSH6):c.3616G>A (p.Ala1206Thr)	MSH6 (A1031T +14 more)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3076148	NM_000179.3(MSH6):c.3305C>T (p.Thr1102Ile)	MSH6 (T1003I +13 more)	Single nucleotide variant (missense variant +2 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3076147	NM_000179.3(MSH6):c.3298A>G (p.Thr1100Ala)	MSH6 (T1001A +13 more)	Single nucleotide variant (missense variant +2 more)	Hereditary cancer-predisposing syndrome	GUncertain significance

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