3LLR


Conserved Protein Domain Family
PWWP_DNMT3A
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cd20154: PWWP_DNMT3A 
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PWWP domain found in DNA (cytosine-5)-methyltransferase 3A (DNMT3A)
DNMT3A, also called DNA methyltransferase HsaIIIA, DNA MTase HsaIIIA, or M.HsaIIIA, is required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. It modifies DNA in a non-processive manner and also methylates non-CpG sites. It may preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. DNMT3A is recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. It contains a PWWP domain that binds methylated histone.
Links
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Statistics
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PSSM-Id: 438982
Aligned: 8 rows
Threshold Bit Score: 286.861
Created: 9-Jan-2019
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:putative methyl-histone binding site [polypeptide binding site]
Evidence:
  • Comment:based the structure of human DNMT3B with bound H3k36me3
  • Structure:3LLR: Human DNMT3A PWWP domain binds a chemical ligand in the methyl-histone binding site; contacts at 4A
    - View structure with Cn3D
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                         # #  #           #           #  # ###                           
3LLR_A         12 EDGRGFGIGELVWGKLRGFSWWPGRIVSWWMTGRSRaaEGTRWVMWFGDGKFSVVCVEKLMPLSSFcsaFHQATYNKQPM 91   human
NP_001018150  107 EDGRGFGINELVWGKLRGYSWWPGRVVSWRMTRRSPaaEGTRWVTWFGDGKFSVVCVEKLLPLSSFhnaFHQPTYNKQPM 186  zebrafish
Q9Y6K1        285 EDGRGFGIGELVWGKLRGFSWWPGRIVSWWMTGRSRaaEGTRWVMWFGDGKFSVVCVEKLMPLSSFcsaFHQATYNKQPM 364  human
Q4W5Z4        250 EDGRGLGIGELVWGKLRGFSWWPGRIVSWWMTGRSRaaEGTRWVMWFGDGKFSVVCVEKLLPLSSFssaFHQATYNKQPM 329  chicken
XP_014343300  283 EDGRGFGIGELVWGKLRGFSWWPGRIVSWWMTGRSRaaEGTRWVMWFGDGKFSVVCVEKLMPLSSFsnaFHQTTYNKQPM 362  coelacanth
XP_007898627  254 EDGRGFGIGELVWGKLRGFSWWPGRIVSWWMTGRSRaaEGTRWVMWFGDGKFSVVCVEKLMPLSTFstaFHQPTYSKQPM 333  elephant shark
OCT79201       71 EDGRGFGIGDLVWGKLRGFSWWPGRIVSWWMTGRSRaaEGTRWVMWFGDSKFSVVCVEKLLPLSSFagtYHQPTYSKQPM 150  African clawe...
ELK27408      418 EDGRGFGIGELVWGKLRGFSWWPGRIVSWWMTGRSRaaEGTRWVMWFGDGKFSVVCVEKLMPLSSFcsaFHQATYNKQPM 497  Myotis davidii

Feature 1                                                               
3LLR_A         92 YRKAIYEVLQVASSRAGKLFPVCHDSDEsDTAKAVEVQNKPMIEWALGGFQPSG 145  human
NP_001018150  187 YKKAIFEVLQVASTRAGKTFLSCPASDDtDSSKLVDVENKKMIEWAMSGFQPTG 240  zebrafish
Q9Y6K1        365 YRKAIYEVLQVASSRAGKLFPVCHDSDEsDTAKAVEVQNKPMIEWALGGFQPSG 418  human
Q4W5Z4        330 YRKAIYEVLQVASSRAGKIFPACPENDEtDTSKVVEIQNKQMIEWALGGFQPSG 383  chicken
XP_014343300  363 YRKAIYEVLQVASTRAGKIFPACPESDEtDTSKAIDIQNKQMVEWAFEGFQPTG 416  coelacanth
XP_007898627  334 YRKAIFEVLQVASSRAGNHFSVQAENDElDTGKAVETQTKQMIDWALEGFLPSG 387  elephant shark
OCT79201      151 YRKAIYEVLQVASTRARKVFPSCPENDEsDNSKAVEIQNKQMIEWALGGFQPSG 204  African clawed frog
ELK27408      498 YRKAIYEVLQVASSRAGKLFPACHDSDEsDTAKAVEVQNKQMIEWALGGFQPSG 551  Myotis davidii

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