2IHC,2Z8H


Conserved Protein Domain Family
BTB_POZ_BACH1
?
cd18277: BTB_POZ_BACH1 
Click on image for an interactive view with Cn3D
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 1 (BACH1)
BACH1, also called BTB-basic leucine zipper transcription factor 1, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. It can act as repressor or activator. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. It is also a negative regulator of nuclear factor erythroid 2-related factor 2 (Nrf2) that controls antioxidant response elements (ARE)-dependent gene expressions. BACH1 binds to NF-E2 binding sites in vitro, and plays important roles in coordinating transcription activation and repression by MafK. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.
Links
?
Statistics
?
PSSM-Id: 349586
Aligned: 4 rows
Threshold Bit Score: 242.664
Created: 11-Sep-2017
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
 
homodimer
Conserved site includes 38 residues -Click on image for an interactive view with Cn3D
Feature 1:homodimer interface [polypeptide binding site]
Evidence:
  • Structure:2IHC: Homo sapiens BACH1 forms a homodimer, contacts at 4A.
    - View structure with Cn3D
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1     #######  ###### ##  #     #              # #  ###       #                       
2IHC_A      3 SVFAYESSVHSTNVLLSLNDQRKKDVLCDVTIFVEGQRFRAHRSVLAACSSYFHSRIVgqaDGELNITLPEEVTVKGFEP 82  human
2Z8H_A     10 AVFAYESSVHSTNVLLSLNDQRKKDVLCDVTVLVEGQRFRAHRSVLAACSSYFHSRIVgqtDAELTVTLPEEVTVKGFEP 89  house mouse
O14867      7 SVFAYESSVHSTNVLLSLNDQRKKDVLCDVTIFVEGQRFRAHRSVLAACSSYFHSRIVgqaDGELNITLPEEVTVKGFEP 86  human
OPJ66498    9 VVFAYESSVHSTNVLLSLDDQRKQDILCDVTILVEDQRFRAHRAVLAACSSYFLSRIVgqvDADLIITLPEEVTLKGFSP 88  Patagioenas fascia...

Feature 1        ##  #######                ###  #  ##
2IHC_A     83 LIQFAYTAKLILSKENVDEVCKCVEFLsVHNIEESCFQFL 122 human
2Z8H_A     90 LIQFAYTAKLILSKDNVDEVCRCVEFLsVHNIEESCFQFL 129 house mouse
O14867     87 LIQFAYTAKLILSKENVDEVCKCVEFLsVHNIEESCFQFL 126 human
OPJ66498   89 LLQFAYTAKLVLNKDNVSEVCKCAEFLgVHNIEESCFQFL 128 Patagioenas fasciata monilis

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap