1QK9,1UB1,1IG4,1D9N


Conserved Protein Domain Family
MeCP2_MBD
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cd01396: MeCP2_MBD 
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MeCP2, MBD1, MBD2, MBD3, and MBD4 are members of a protein family that share the methyl-CpG-binding domain (MBD). The MBD, consists of about 70 residues and is defined as the minimal region required for binding to methylated DNA by a methyl-CpG-binding protein which binds specifically to methylated DNA. The MBD can recognize a single symmetrically methylated CpG either as naked DNA or within chromatin. MeCP2, MBD1 and MBD2 (and likely MBD3) form complexes with histone deacetylase and are involved in histone deacetylase-dependent repression of transcription. MBD4 is an endonuclease that forms a complex with the DNA mismatch-repair protein MLH1.
Links
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Statistics
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PSSM-Id: 238690
Aligned: 28 rows
Threshold Bit Score: 65.8569
Created: 10-Jan-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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DNA binding
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:DNA binding site [nucleic acid binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                    # # #        # #         #  #   #                                
1QK9_A     18 MYDDPt--LPEGWTRKLKQRKsgr-saGKYDVYLINPQG-KAFRSKVELIAYFekvg---dtsLDPNDFDFtv-----tG 85  human
AAM63666   29 PGDDNw--LPPDWRTEIRVRTsgt-kaGTVDKFYYEPITgRKFRSKNEVLYYLehgtpkkksvKTAENGDShse--hseG 103 thale cress
CAE05215   27 KIEPAgegLPHGWLKEYRPRKnqsgsrVKGDTFYIDPTNmYEFRSQKDVQRYLe--------sGDVTNCVMiqnkrkmeD 98  Japanese rice
NP_200746  76 PGDNW---LPPGWRVEDKIRTsga-taGSVDKYYYEPNTgRKFRSRTEVLYYLehgts-krgtKKAENTYFnpd--hfeG 148 thale cress
1IG4_A      5 WLDCPa--LGPGWKRREVFRKsga-tcGRSDTYYQSPTG-DRIRSKVELTRYLgp-------aCDLTLFDFkq-----gI 68  human
AAK40309  135 KPNIAq--PPHGWERQIRIRGeg--gtKFADVYYTSPTG-RKLRSLVEVDRFLqenpehvaqgVTLAQFSFqip--rplR 207 maize
NP_974851  57 WPSIPp--IPTGWSRSVHIRSes---tKFADVYYFPPSG-ERLRSSAEVQSFLdnhpeyvregVNRSQFSFqip--kplD 128 thale cress
BAB11480  120 KPNISr--PPAGWQRLLRIRGeg--gtRFADVYYVAPSG-KKLRSTVEVQKYLndnseyigegVKLSQFSFqip--kplQ 192 thale cress
T04569    108 KPGLPr--TPRGFKRSLILRKd----ySKMDAYYITPTG-KKLKSRNEIAAFIdanq--dykyALLGDFNFtvp--kvmE 176 thale cress
AAK40305   84 KPNIP---KPPPETERLVVMRgd---ySKMDTYYVMPNG-KRARCAGDVDKFLeanpe-ykdrISASDFSFapp--kvvE 153 maize

Feature 1            
1QK9_A     86 RGSGSGC 92  human
AAM63666  104 RGSARRQ 110 thale cress
CAE05215   99 LHTARNQ 105 Japanese rice
NP_200746 149 QGSNRVT 155 thale cress
1IG4_A     69 LCYPAPK 75  human
AAK40309  208 QDYVKKK 214 maize
NP_974851 129 DNYVKKR 135 thale cress
BAB11480  193 DDYVRKR 199 thale cress
T04569    177 ETVPSGI 183 thale cress
AAK40305  154 ETVSHNP 160 maize

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