Conserved Protein Domain Family
Syja_N
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pfam02383: Syja_N (this model, PSSM-Id:396798 is obsolete and has been replaced by 460545)
SacI homology domain
This Pfam family represents a protein domain which shows homology to the yeast protein SacI. The SacI homology domain is most notably found at the amino terminal of the inositol 5'-phosphatase synaptojanin.
Links
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Statistics
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PSSM-Id: 396798
Aligned: 462 rows
Threshold Bit Score: 111.899
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q54X05         79 FAILGY--IIseKSSHLLVATKIRNEgELl-gSyPINTIIETSWIKidlsylssYqsneiqTEEGwattLVDdsnidssv 155  Dictyostelium...
XP_002953781   69 PYILGYvvIG--Q-WGLLLVAEKFRVsAIlpgThEVKTVTKSHWLKiplqinlsM------QSVQvcnlLYNrgyqagit 139  Volvox carter...
XP_003059495   47 DACLGVvaVG--D-AVLLLLARKTKVaATlpnGhEVMSVQEARWHRa--------------AL------RN--------- 94   Micromonas pu...
Q57WG4        116 AALFGC--LRl-DRMYFLVATKVEEA-AVlpfGgAILRVGGTEWISfgipgsepLyltsg-------------------- 171  Trypanosoma b...
XP_003283904  116 LAILGY--IIseKSSHLLVATKIRNEgELl-gCyPINTIIETSWIKidlsylssYqsneiqNDEAwtttFVEetnidpsv 192  Dictyostelium...
EFA80244       93 NALLGY--IVaeRYSYLLVATKTRNEgDIl-gVhPIYVVMETQWIKielsylssCklpispHTPQtngnLCAistvvdnt 169  Heterostelium...
EGG23944      141 CAILGY--IVadRSAHLLVATKVRSEgELl-gLhPISVVLESSWIKielsypssYqpkmdtNSSAttssSTTsnlnssss 217  Cavenderia fa...
XP_001608593   74 EGILGC--IRflNYPYLYVITKKERVaVLl-nEhKVYLVKSVLLIPf--------------RD------DV--------- 121  malaria paras...
XP_002808809   75 EGIFGC--IRflNYPYLYVLIKKEKVgILf-dEhKIYNVKNILLIPf--------------VE------DI--------- 122  Plasmodium fa...
Q7RGR5         74 EGILGC--IKflNYPYLYVVTDKEKIgVLf-nEhVIYSVKSVLLISf--------------KE------DI--------- 121  Plasmodium yo...

Q54X05        156 ssnsnnnynnnyndnnennnnssgssffsflssssspsnnnnnnnnnnnnsnnnnnnnsnnnnsnnsgntnydslssssg 235  Dictyostelium...
XP_002953781  140 vegswh--------------------------------------------------------------------gmvegm 151  Volvox carter...
XP_003059495      --------------------------------------------------------------------------------      Micromonas pu...
Q57WG4            --------------------------------------------------------------------------------      Trypanosoma b...
XP_003283904  193 ssstsgallnnnsfl--------------------------------------------------nsfsssssppssnan 222  Dictyostelium...
EFA80244      170 s-----------------------------------------------------------------------------nt 172  Heterostelium...
EGG23944      218 svqqqqqqqqqqqqqqqdlnnnndnnvnnnnnsf------------nihgsnfstigsfsvgsygssigslpntsnlsss 285  Cavenderia fa...
XP_001608593      --------------------------------------------------------------------------------      malaria paras...
XP_002808809      --------------------------------------------------------------------------------      Plasmodium fa...
Q7RGR5            --------------------------------------------------------------------------------      Plasmodium yo...

Q54X05        236 gnsnnnnNYDSsygnnnnnn--nnnnnnsnNNNNnnnNNNNNnnnnsnnnndptvkqmlKDLQtfpLDG--THFYceLY- 310  Dictyostelium...
XP_002953781  152 ggglwgaWGKApeagakd-----ekamkdeIEKG---IERLLsfp------------------------idGAHF---Lc 196  Volvox carter...
XP_003059495   95 --------PARas----------------tREER-------------------------ANVAsmtEATmdNLYY---Yc 122  Micromonas pu...
Q57WG4        172 ------------------------------------------------------drnrlKEFEtysHEG--GYYY--Sdd 193  Trypanosoma b...
XP_003283904  223 ynnsnnsDLPTtat-------------ssnItsndpt-----------------vkeilKDLQtfpFDG--THFYceNY- 269  Dictyostelium...
EFA80244      173 nhnshgsSSSSnsg-------------sfsS----------------------------FNLQlypLEG--THFYceTY- 208  Heterostelium...
EGG23944      286 vggstqlHFNGqsqhsqqqqsqqtqqtqqsQQSQsqdDNGLPsesnit------tqtllNNLQsypIDG--THFYceSY- 356  Cavenderia fa...
XP_001608593  122 --------FGNf-----------------nDENE---LV--------------------QLFYnsvNHK--HIYFsyTY- 150  malaria paras...
XP_002808809  123 --------FDNy-----------------nEENE---LI--------------------DLFYnntNHK--YIYFsyTY- 151  Plasmodium fa...
Q7RGR5        122 --------FEKi-----------------nHENN---LV--------------------QIFYnsaNHK--YLYFsyTY- 150  Plasmodium yo...

Q54X05        311 ---DLTNYFPSNLNT-----------PHQYCSE----FT-------------WNEWMRKP-----FENASLShlcvvLLQ 354  Dictyostelium...
XP_002953781  197 dtlDITRPFPSY----------------RAVKDpswdFV-------------WNRWMSAPfrnlgLDHLCPP-----LLQ 242  Volvox carter...
XP_003059495  123 etfDATRAFAHACRNaasts-vtptkEPPPPDPe---WV-------------WNAWLAKP-----LNDLCIPracpaLLQ 180  Micromonas pu...
Q57WG4        194 --cDLRRPFP---------------------------FVsskdgngpqfhsdWSRQLRKPfitagVESCCSV-----LLR 239  Trypanosoma b...
XP_003283904  270 ---DLTNYFPSNYNTt----------PFQYCSE----FA-------------WNEWMRKP-----FENASLShlcvvLLQ 314  Dictyostelium...
EFA80244      209 ---DLTNYFPSSPKA-----------PDQFSPE----FT-------------WNEWLRRP-----FRTFSLPflcvvLLQ 252  Heterostelium...
EGG23944      357 ---DLTNYFPSNRTT-----------PYQFNSE----FT-------------WNEWIRRP-----FDQVSLSnlcvvLLQ 400  Cavenderia fa...
XP_001608593  151 ---NLPCSVQVNFYLqkeflrggiihSRDYANE----YL-------------WNGYHCKAfvrq-nvfICVP-----TIS 204  malaria paras...
XP_002808809  152 ---NLTYSVQENYFIqknyl--kggnVKYKNNP----YM-------------WNSYHSKYfikq-nifLCLS-----IIN 203  Plasmodium fa...
Q7RGR5        151 ---NLANSLQNNYFIqkeylkgniiyNKKYKNN----YI-------------WNFYHCKPflkk-nifICLF-----VIN 204  Plasmodium yo...

Q54X05        355 GYASVKS--------------------ISNLNV-SIAYLMKRSKLNPGTHFYSPGINENASPANEYESELIMWkVQDkqs 413  Dictyostelium...
XP_002953781  243 GLCESRLl------------------eDFDNAKyWVACISRRGCLHPGPRYKARGLNDYAEPGNELEVEQVIWrQQQr-- 302  Volvox carter...
XP_003059495  181 GLAesralid------------------avgapwRVAVFGRRSRAHPGTRYIARGLNADAAPGNEVEMEQIAWrEEEeee 242  Micromonas pu...
Q57WG4        240 GFAAEKEv------------------lLKDGSIlHVLLCGRQNNLNPGPRYFGRGLNAVNAVGNDHVYEYVMWrQGG--- 298  Trypanosoma b...
XP_003283904  315 GYVSIKP--------------------LSTLNA-SIGYIMKRSKLNPGTHFFSPGINENASPANEYENELIMWkYEDqqi 373  Dictyostelium...
EFA80244      253 GYASIKQlnnssksllplnspittnliHKTKNLaSICYLMKKSKLNPETYFYGHGINDKGGAANEYECEIILWrLT---- 328  Heterostelium...
EGG23944      401 GYASIRY--------------------IQALNT-TTCYIMKRSKLNPETLYHGHGINDRAGASNEYECEIIMWkYT---- 455  Cavenderia fa...
XP_001608593  205 GFYVQSKf-------------------LCEGKAiDVTFIARRCNKYAGTRYRKRGINAKGYAANQVETELILFqRN---- 261  malaria paras...
XP_002808809  204 GYFIQSKf-------------------LCSGKIiDISLVGRRSNKYAGTRFRKRGLNSYGYSANDVESEIILFeKN---- 260  Plasmodium fa...
Q7RGR5        205 GYLIQSKi-------------------SFSGKYvDIIFVARRSYKYAGTRYRKRGINYNGFSANEVESEIILHeKN---- 261  Plasmodium yo...

Q54X05        414 ilinniasssnsnlsdldkksnsnnnnnnnnnnnnnnnnnnststasttatataissslsissttaslslsssstapnti 493  Dictyostelium...
XP_002953781      --------------------------------------------------------------------------------      Volvox carter...
XP_003059495  243 eekggpetkgndasa----------------------------------------------------------------- 257  Micromonas pu...
Q57WG4            --------------------------------------------------------------------------------      Trypanosoma b...
XP_003283904  374 iisspdssknnnnannnntgvnskdskdvnnsdn---------------------------------------------- 407  Dictyostelium...
EFA80244          --------------------------------------------------------------------------------      Heterostelium...
EGG23944          --------------------------------------------------------------------------------      Cavenderia fa...
XP_001608593      --------------------------------------------------------------------------------      malaria paras...
XP_002808809      --------------------------------------------------------------------------------      Plasmodium fa...
Q7RGR5            --------------------------------------------------------------------------------      Plasmodium yo...

Q54X05        494 tttstaipkvdlnknndtddsnnnnnsnggltnnttniipnnnniNEKVIQWTSHVWRRGTVPLWWRAFSKNQgsneiel 573  Dictyostelium...
XP_002953781  303 ---------------------------------------------DGSLLLWSRYTWRRGSAPLWWGVSIKNNgigea-- 335  Volvox carter...
XP_003059495  258 ---------------------------sagggviggetnqnqtpkKTARARWSAYVWRRGSVPIRWGQEIKQSi------ 304  Micromonas pu...
Q57WG4        299 ---------------------------------------------GNGPIQFAKHTILRGTVPVHWSTRISKTi------ 327  Trypanosoma b...
XP_003283904  408 ---------snnsdekkhkedekhenhdnskketnlknenivfksGDKVIKWTSHIWRRGTVPLWWRAFSKNQgneiel- 477  Dictyostelium...
EFA80244      329 ---------------------------------------------GINTISWTSYLWRRGTIPLWWRARSKHQgndl--- 360  Heterostelium...
EGG23944      456 ---------------------------------------------TSQTIQWTSNVWRRGTIPIWWRSRLKQNgsdl--- 487  Cavenderia fa...
XP_001608593  262 ----------------------------------------------YE-TAILSYVQLRGSVPVFWTQGVN--------- 285  malaria paras...
XP_002808809  261 ----------------------------------------------NS-HVILSYTQLRGSVPIFWNQQVN--------- 284  Plasmodium fa...
Q7RGR5        262 ----------------------------------------------NISNGILSYVHLRGSVPVLWNQSIN--------- 286  Plasmodium yo...

Q54X05        574 flkdrGkenpNPF-----------EKSESYYQ----NL--LNRYekfyq-----------enkdtNlAgiptIQLINLLk 625  Dictyostelium...
XP_002953781  336 ------eikiRPHnt--------fKGSKRYVR----RL--QERYtpnpqldpdppvagadgepsrHvP----VTFVSLLr 391  Volvox carter...
XP_003059495  305 ---------gDAEitvaa--ddpyAGTATYFR----KLveTSRPpasavggdgg--ggaaepaspPfP----VTCVNLLr 363  Micromonas pu...
Q57WG4        328 ---------sEPAmmfsqnkeevlRGCDSYFSfvftQLvaIMRYdsgeq------------ltgrGpR----LRCVNMLr 382  Trypanosoma b...
XP_003283904  478 flkdrGkdnpNPF-----------EKSEIYYQ----NL--LNRYqkfye-----------ynkdsNlAgipsIQLVDLLk 529  Dictyostelium...
EFA80244      361 ------lvkdNPF-----------EYSDKYFT----GI--LDRYssi---------------yetNtAalptINLVSLLk 402  Heterostelium...
EGG23944      488 ------qvkdNAF-----------ENSEQYYL----NL--LNRYqhf---------------ydnNkNslpnINLVNLLk 529  Cavenderia fa...
XP_001608593  286 -----YhllkRPKikckk-ydaffTCTKRHFR----HL--LARY---------------------GyP----IIAINLLs 328  malaria paras...
XP_002808809  285 -----YkilkKPQinflk-tdinySCTQKHFQ----RL--YEKY---------------------GyP----ITVVNLLs 327  Plasmodium fa...
Q7RGR5        287 -----YkllkKPKikcme-ndinfICTKKHFS----YL--FKKY---------------------GyP----ITVVNLLs 329  Plasmodium yo...

Q54X05        626 qendKQ----EVILSQLYQKSCENVTty------------lNVDLQ--MYTFDWINILK 666  Dictyostelium discoideum AX4
XP_002953781  392 kglpDRdr-sEAKLASAFDFVVAQLRke------------hGMNLT--YIALDWHEMDK 435  Volvox carteri f. nagariensis
XP_003059495  364 capgKP----EMVLSEHFHEAVRGVRkgtnpdsraspptpsSAALA--VVNFDWHGNMK 416  Micromonas pusilla CCMP1545
Q57WG4        383 ----QShhssEEALTKHFTEAVTKSQaalq-------qafpGSQLD--LVHVDWLNMLK 428  Trypanosoma brucei
XP_003283904  530 qegdKQ----ELILSQLYQKCCENVIsy------------lNVDLQ--IYSFDWINSLK 570  Dictyostelium purpureum
EFA80244      403 m-ddPQ----EGPLGQLYQKLCNRVAst------------vNLNLN--LQSFDWHIHLK 442  Heterostelium album PN500
EGG23944      530 t-ddPQ----ESLLSQLYQKSCEKVMsl------------vNVNLN--LISFDWSGILK 569  Cavenderia fasciculata
XP_001608593  329 ----KKkqsdESNLSNEYEACIGVINrd------------lPPPIRiiYRHLDLRKAYK 371  malaria parasite P. vivax
XP_002808809  328 ----KKkysdEQKLSYHYKESIDRLNky------------iPKKIHiiYKHVDLRKAYK 370  Plasmodium falciparum 3D7
Q7RGR5        330 ----KNkysdEDLLSNTYKKCVNLINky------------iPTNIRiiYKHLDLRKLYK 372  Plasmodium yoelii yoelii
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