Conserved Protein Domain Family
Tmemb_185A

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pfam10269: Tmemb_185A 
Transmembrane Fragile-X-F protein
This is a family of conserved transmembrane proteins that appear in humans to be expressed from a region upstream of the FragileXF site and to be intimately linked with the Fragile-X syndrome. Absence of TMEM185A does not necessarily lead to developmental delay, but might in combination with other, yet unknown, factors. Otherwise, the lack of the TMEM185A protein is either disposable (redundant) or its function can be complemented by the highly similar chromosome 2 retro-pseudogene product, TMEM185B.
Statistics
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PSSM-Id: 402059
Aligned: 24 rows
Threshold Bit Score: 139.898
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
CBI27072      28 LKLDHAVSYSWWIIFAPLWLFHA---VVARGRF-------SLPApSMPHDRHWAPFHAVTAT----PLLVAFELLLCIYL 93 
Q9U2T2        33 LKLDGKVSFSYAFVFAPLWACNL---LVFVGAIvgicsfcSKPP-SRNEIVMRVDFSAMLITatehIFLCTFVSLVFIKL 108 Caenorhabditis ...
CRZ25952      37 LRFDGTIELNYALVFLPLWICEF---IVFLGAIvaaisfvISPP-SLTESSLRSDFYGMILCtgehGLLILFEVLCCHKL 112
EDS32129      30 LRLDDYIDWPYWVIFIPLWVWKS---IATLGAIvgaivwcRYPH-YRVEGDSYAHFKAMLISlslhLILLMFELLACDRL 105
XP_011681120  30 LRLDETIQCSFWLVFLPLWFWKG---VVIVGAIvagvvwwKHPE-YRVEGEGYIDMKAIIIClalnSLLLIFEILACDQL 105
XP_004065037  30 LRLDGIIQWSYWAVFAPIWLWKL---MVIVGASvgtgvwaRNPQ-YRAEGETCVEFKAMLIAvgihLLLLMFEVLVCDRI 105
Q05AZ1        30 LRLDNIIQWSYWAVFAPIWLWKL---MVIVGASvgtgvwaRNPQ-YRAEGETCVEFKAMLIAvgihLLLLMFEVLVCDRI 105 tropical clawed...
Q4D9L8       117 VRLDYNKGWPWAAVFAPVWVALVpllLIGGLLVfhgvtrrEIAS-----------------------TLLGLMCFLVTFA 173 Trypanosoma cruzi
Q38EE7       117 VRLDYELSWKWPVVFIPLWIALAppiLLALGLLaagikqlDFLC-----------------------VCVGVEILLFVGS 173 Trypanosoma brucei
EGG19771     121 VKINHRVDWSWAKVFSPFWIIWG---LVVLAMIivaavsrRMRS---------------TVLmsksVAILVFGALIVANL 182
CBI27072      94 QHSYViKCIAAVNLKIVFLPLLALEAAILIDNIRMCKAL------MPGDDESIS--------------DEAIWETLPHFW 153
Q9U2T2       109 EFDYLfEPGYPLPWTIVFCPLFSLSILSIGIAIWSLRHD------KPFEFEFFY-------------------------- 156 Caenorhabditis ...
CRZ25952     113 QANATvD---ELPWLLVFVPIFALSLLSVVVAIWAIRND------KSFELELFF-------------------------- 157
EDS32129     106 TSG-------RHLWVLVFIPLIFGSVASVGACVWAVKHD------RSFELELFC-------------------------- 146
XP_011681120 106 ESSNAaKPW-RHPWLIVFMPLFLTSPVSIAACVWGFKHD------RGLELEAMC-------------------------- 152
XP_004065037 106 ERG-------SHFWLLVFMPLFFVSPVSVAACVWGFRHD------RSLELEILC-------------------------- 146
Q05AZ1       106 ERGN------HYFWLLVFMPLFFVSPVSVAACVWGFRHD------RSLELEILC-------------------------- 147 tropical clawed...
Q4D9L8       174 VAMFVvGLSGALTWTIALAPSAAIYVFQSCFILRYLLPFq----fRNGFAEFIP--------------PGSSVCLSRMYW 235 Trypanosoma cruzi
Q38EE7       174 IATFVaGLCGALSWPVALSPAIAFYAVRVLHIIPHLFPSrfvqnsEDGSGEVTF--------------SRKKYCL----- 234 Trypanosoma brucei
EGG19771     183 DHAIH------IDWTVVFIPVYFLLAVNICSIIPNTIYS------R--YLKRLQgekeyfnaatdyglGYAGWLYRRYIF 248
CBI27072     154 VAISMVFFIAATTFTLLKL----------CGDVAALGWWDLFINF------------GIAECFASIVCTRWYNPAIHRNS 211
Q9U2T2       157 -AINIVQLV----FIAFKL----------DKQVD----WTWAVVFiplwvvlslaavGVLYALVLSVVLIRSRHFIPAH- 216 Caenorhabditis ...
CRZ25952     158 -SINIVQFV----FVAFKL----------DGILD----WHWTIVFiplwvvlslsvvGVLYAFVLAVVLARSVHMLASQ- 217
EDS32129     147 -AVNALQFV----FLPLKL----------DGFVS----WSWEVVFvplwivlclslvAVLYSIIFCGILLRTPEVSHQQ- 206
XP_011681120 153 -SINILQFI----FIALKL----------DEIIT----WRWGVVFiplwiltclmclIVLYYVIWSLLILRATELMAEQ- 212
XP_004065037 147 -SVNILQFI----FIALRL----------DKIIH----WPWLVVCvplwilmsflclVVLYYIVWSVLFLRSMDVIAEQ- 206
Q05AZ1       148 -SVNILQFI----FIALRL----------DRIIT----WPWLVVCvplwilmsflclVVLYYIVWSVLFLRSMDVIAEQ- 207 tropical clawed...
Q4D9L8       236 GFLLETVFEKLCCFSFISLallraaqtggEDTSKLISFW---IVFtplily-fgcmtLVSAARRFFAGTVEGQSCLLSR- 310 Trypanosoma cruzi
Q38EE7       235 -FVVMVLFEEGCAIAFFTLlmlramqkseESKDEPLSFW---IVFspliac-lglkaLLHLCFCMICSKVEQPNQQASQ- 308 Trypanosoma brucei
EGG19771     249 EAMEVWFIV----FLVIRL----------DRIVT----WSWWINAipil----------vsmLIRLITIVADSKYLAKHT 300
CBI27072     212 HIRq-tGSSSMIIRYLDWNSglvvssdedqhqsrlcdlqdigghIMKIPLVGFQILLFMRLE------GTP----SSARH 280
Q9U2T2       217 --------RRQHVYSAILHT------------------------FFVIPALVCLVLLTGKLD------SMNwpdkGSVSE 258 Caenorhabditis ...
CRZ25952     218 --------RRQHLYSALCHT------------------------LLVIPILVFLLLLTGKLD------AISwsddEPVSQ 259
EDS32129     207 --------KKSAINSAIGNC------------------------ATVLPILVFQVLLADKLD------NEN-------LD 241
XP_011681120 213 --------RRANFMTAVTAV------------------------SLVAPLLTFEILLVNRLD------GIN--------D 246
XP_004065037 207 --------RRTHITMALSWM------------------------TIVVPLLTFEILLVHKLD------GHN--------A 240
Q05AZ1       208 --------RRTHITMAVSWM------------------------AIVVPLLTFEILLVHRLD------GHN--------Y 241 tropical clawed...
Q4D9L8       311 --------LCRALAAAMGYA----------------------------SLLFMACMLAAKCEaeqnhkAVSlhpsAAVAL 354 Trypanosoma cruzi
Q38EE7       309 --------KSTSAFLFVVYS----------------------------SMIYVACMIAAKANveinkwTDGfnpsAAVAV 352 Trypanosoma brucei
EGG19771     301 QGSeseEESSFNTFLICCYI------------------------ILIIPIVIFLGLLVSYLN------GKG--------- 341
CBI27072     281 IPIPLLFAPLFLL 293
Q9U2T2       259 LSYTLAMAPLQVS 271 Caenorhabditis elegans
CRZ25952     260 IAFIIVCAPLDLa 272
EDS32129     242 WPFIGVAGPLLLS 254
XP_011681120 247 YPVSAVFCPLYIS 259
XP_004065037 241 FSCIPIFVPLWLS 253
Q05AZ1       242 FAYIPIFVPLWLS 254 tropical clawed frog
Q4D9L8       355 LPLEVTLA--LAV 365 Trypanosoma cruzi
Q38EE7       353 IPIQVIFISLFLA 365 Trypanosoma brucei
EGG19771     342 FAIASVFIPIFIi 354
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