2OCP,2QRN


Conserved Protein Domain Family
dNK

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pfam01712: dNK 
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Deoxynucleoside kinase
This family consists of various deoxynucleoside kinases cytidine EC:2.7.1.74, guanosine EC:2.7.1.113, adenosine EC:2.7.1.76 and thymidine kinase EC:2.7.1.21 (which also phosphorylates deoxyuridine and deoxycytosine.) These enzymes catalyze the production of deoxynucleotide 5'-monophosphate from a deoxynucleoside. Using ATP and yielding ADP in the process.
Statistics
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PSSM-Id: 396326
Aligned: 13 rows
Threshold Bit Score: 204.859
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2OCP_D   5 LSIEGNIAVGKSTFVK-LLTKTYPe-WHVATE------PVATWqniqaagnq---kactaqslgNLLDMMYREPAR-WSY 72  human
P37530   7 IAIEGPIGAGKTTLAT-MLSQKFG--FPMINE------IVEDN---------------------PYLDKFYDNIKE-WSF 55  Bacillus subtilis sub...
O51255   7 IVIEGLIGVGKTTLGN-ILSKELE--VPFYSE------LNNDFt-------------------lAVLDKFYKDKSR-WAF 57  Lyme disease spirochete
Q74HC3   4 IVLSGPIGAGKSSLTS-LLAEHLG--TQAFYE------GVDNN---------------------PILPLYYKDMAH-YTF 52  Lactobacillus johnson...
Q74HC2   4 IVLSGPIGAGKSSLTG-ILSKYLG--TNPFYE------SVDDN---------------------PVLPLFYENPKK-YAF 52  Lactobacillus johnson...
P37529  12 ITVAGTVGVGKSTLTK-TLAKRLG--FKTSLE------EVDHN---------------------PYLEKFYHDFER-WSF 60  Bacillus subtilis sub...
P21974  12 LSIEGNISSGKTDVLN-ILRNINN--VVSFHD------VEDRYtpi----------------ekELIRKFHENPSR-WSY 65  Fowlpox virus strain ...
O00142  53 ICVEGNIASGKTTCLE-FFSNATD--VEVLTE------PVSKWrnv---------------rghNPLGLMYHDASR-WGL 107 human
2QRN_B  44 ISIEGNIAAGKSTFVN-ILKQLCEd-WEVVPE------PVARWcnvqstqdefeeltmsqknggNVLQMMYEKPER-WSF 114 human
O55749   4 ICIDGIIGAGKSTVTH-RLKKNL---YKCYEE------PIDKW---------------------TLLPNLYNDMKK-YAT 51  Invertebrate iridesce...
Q98468   3 ISVDGLMGSGKTTLLD-RLEKRG---FKVFRE------PVGEW---------------------KFLNKFYKNPKK-YAL 50  Paramecium bursaria C...
P28855  19 FCVEGNIGCGKSTLVKaLMERVAGsgVNVVEE------PVDQWvnh---------------ngkNYLELSYTDPTG-YAV 76  Ictalurid herpesvirus...
Q21233  75 IVVEGNIGSGKTTLAK-QLADQLG--FVHFPEfrmddiLVDRYgndlrnyyn----kfparyrlPDISMFYKNPSGeLSA 147 Caenorhabditis elegans
2OCP_D  73 TFQTFSFLSRLKVQLEPFpekllqARKPVQIFERSVYSDRyIFAKnlfenGSLSDIEWHIYQDWHSFLL--WEFASri-- 148 human
P37530  56 QLEMFFLCHRYKQLEDTSdh--flKKGQPVIADYHIYKNV-IFAE-----RTLSPHQLEKYKKIYHLLT--DDLPK---- 121 Bacillus subtilis sub...
O51255  58 PVQINFLNERFKLIKGV-------FRTKGGILDRSIYGDC-VFASllncdGHISDEEYKIYIDLLDNML--EHSQR---- 123 Lyme disease spirochete
Q74HC3  53 LLNTYLLNHRLAQINQA-------IRDHNSVSDRSIYEDA-LFFKmnvdsGIADPTEFKIYDSLLENMM--EQAPGnpsk 122 Lactobacillus johnson...
Q74HC2  53 LLQVYFLNTRFRSIKSA-------LTDDNNVLDRSIYEDA-LFFQmnadiGRATPEEVDTYYELLHNMM--SELDRmpkk 122 Lactobacillus johnson...
P37529  61 HLQIYFLAERFKEQKTIF------EAGGGFVQDRSIYEDTgIFAKmhadkGTMSKVDYKTYTSLFEAMVmtPYFPH---- 130 Bacillus subtilis sub...
P21974  66 ALQTHYCMKRVRMHLECF------VPSRVNILERSIFSDRyVFAEaatalGYMDDPEWALYCKQHDWYTdkLEIQ----- 134 Fowlpox virus strain ...
O00142 108 TLQTYVQLTMLDRHTRP-------QVSSVRLMERSIHSARyIFVEnlyrsGKMPEVDYVVLSEWFDWILrnMDVS----- 175 human
2QRN_B 115 TFQTYACLSRIRAQLASLngklkdAEKPVLFFERSVYSDRyIFASnlyesECMNETEWTIYQDWHDWMN--NQFGQsl-- 190 human
O55749  52 PFQFQVLFSQYDQYLSFK------DCKETVVVERCPWTSKnIFTSlmienNLFDLSAIDTYNNLYERLSy---------- 115 Invertebrate iridesce...
Q98468  51 ALQLEILVSFTKYT----------FTEDIVFTERCPQVSHyVFAKmlsakGTLTDEEMATYKNFYDKMN----LWK---- 112 Paramecium bursaria C...
P28855  77 PFQNLVFDSYVNVQ----------RLQNPDIMERSPMSATrVFCAvngsrGVIPATALPGMAARGEAVM--RTIAT---- 140 Ictalurid herpesvirus...
Q21233 148 AMQDRIFNCRFDQYLNALah--ilNTGQGVVLERTPHSDF-VFANamrdkNYIGHEYFKHYYFVRKNALpqLHFW----- 219 Caenorhabditis elegans
2OCP_D 149 tLHGFIYLQASPQVCLKRLYQRAREEEK----GIELAYLEQLHGQHEAWLIHkttklhfeaLMNI----P-VLVLDVN-- 217 human
P37530 122 -PNFIIYIKASLPTLLHRIEKRGRPFEK----KIETSYLEQLISDYEVAIKQ---------LQEAdpelT-VLTVDGD-- 184 Bacillus subtilis sub...
O51255 124 -PSLLVYLDCSIDEVERRIKNRNRSFEM----NIPRDYLEGLNRKYLKWYDE---------YNLS----S-KIKFSYD-- 182 Lyme disease spirochete
Q74HC3 123 kPDLLIYIHVSLDTMLHRIQKRGRKFEQlstdPSLKDYYARLLSYYEPWYEK---------YNAS----P-KMMIDGD-- 186 Lactobacillus johnson...
Q74HC2 123 nPDLLVHIDVSYDTMLKRIQKRGRNYEQlsydPTLEDYYKRLLRYYKPWYEK---------YDYS----P-KMTIDGD-- 186 Lactobacillus johnson...
P37529 131 -PDVLIYLEGDLENILNRIEQRGREMEL----QTSRSYWEEMHTRYENWISG---------FNAC----P-VLKLRIE-- 189 Bacillus subtilis sub...
P21974 135 -FDGIIYLRTIPESCKERINEKSITEKNy--pNISIDYLKTLHEKHELWLTQ---------CKKV----P-VLIIDGE-- 195 Fowlpox virus strain ...
O00142 176 -VDLIVYLRTNPETCYQRLKKRCREEEK----VIPLEYLEAIHHLHEEWLIK---------GSLFpmaaP-VLVIEADhh 240 human
2QRN_B 191 eLDGIIYLQATPETCLHRIYLRGRNEEQ----GIPLEYLEKLHYKHESWLLHrtlktnfdyLQEV----P-ILTLDVN-- 259 human
O55749 116 qVDHFIYIKVDSEMAFERIKKRDRFAEQ----NISFDYLKSLENKYATSLAT---------LSPS----T-VTIIDGS-- 175 Invertebrate iridesce...
Q98468 113 -PDVHIFLKCPIDVCEQRLKRRSDSY------TIDTEYMERLEKYYSIFNKY---------TNST----P-IKFIDAS-- 169 Paramecium bursaria C...
P28855 141 -RPVFVYLELPPEECLRRMRRRDRTGEA----GVGLDYLRLLHERYEAWLSS---------------------AEDVE-- 192 Ictalurid herpesvirus...
Q21233 220 -PHLVVYLNTPTNKCLENIKRRGNTDEIa---TVDERYLKTIEESYKDSLREyrnhskilaYDWTkpgdTdAVVEDIE-- 293 Caenorhabditis elegans
2OCP_D 218 -D-DFSEEVTKQEDLMREV-NTFVK 239 human
P37530 185 -SkDFVLNKSDFERIAAHV-KELIV 207 Bacillus subtilis subsp. subtilis str. 168
O51255 183 -NiN-IFSEEDRNKVISLIrDKLVL 205 Lyme disease spirochete
Q74HC3 187 -KyDFVANEDARRKVINAI-DQKLI 209 Lactobacillus johnsonii NCC 533
Q74HC2 187 -KlDFMASEEDRQEVLNQI-VAKLK 209 Lactobacillus johnsonii NCC 533
P37529 190 -DyDLLNDENSIENIVDQI-ASVIH 212 Bacillus subtilis subsp. subtilis str. 168
P21974 196 -E-DFIFDPCAKKKLINEV-TEFIN 217 Fowlpox virus strain NVSL
O00142 241 mErMLELFEQNRDRILTPEnRKHCP 265 human
2QRN_B 260 -E----DFKDKYESLVEKV-KEFLS 278 human
O55749 176 -N----TIEEVEFDVKTAI-NNFLS 194 Invertebrate iridescent virus 6
Q98468 170 -K----NEDEVEEDFMNQV-KDFVE 188 Paramecium bursaria Chlorella virus 1
P28855 193 -R---VDASRSREEIVDRViEILCR 213 Ictalurid herpesvirus 1 (strain Auburn)
Q21233 294 -RlDLDFFEWHSGDVMEEW-NTIVD 316 Caenorhabditis elegans
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