5AR1,3FTQ


Conserved Protein Domain Family
Septin
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pfam00735: Septin 
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Septin
Members of this family include CDC3, CDC10, CDC11 and CDC12/Septin. Members of this family bind GTP. As regards the septins, these are polypeptides of 30-65kDa with three characteriztic GTPase motifs (G-1, G-3 and G-4) that are similar to those of the Ras family. The G-4 motif is strictly conserved with a unique septin consensus of AKAD. Most septins are thought to have at least one coiled-coil region, which in some cases is necessary for intermolecular interactions that allow septins to polymerize to form rod-shaped complexes. In turn, these are arranged into tandem arrays to form filaments. They are multifunctional proteins, with roles in cytokinesis, sporulation, germ cell development, exocytosis and apoptosis.
Links
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Statistics
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PSSM-Id: 395596
Aligned: 13 rows
Threshold Bit Score: 388.581
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
5AR1_A  25 GITFTVMIVGQSGSGRSTFINTLCGQQVVDTs--------------------TTILLPTDtSTEIDLQLR-EETVELEDD 83  baker's yeast
P32457 117 GFSFNLLCVGPDGIGKTTLMKTLFNNDDIEAnlvkdyeeelandqeeeegqgEGHENQSQ-EQRHKVKIK-SYESVIEEN 194 Saccharomyces cerevis...
P40797 140 GFEFTLMVVGASGLGKSTLINSMFLSDIYNA---------------------EQYPGPSL-RKKKTVAVE-ATKVMLKEN 196 fruit fly
3FTQ_D   3 GFEFTLMVVGESGLGKSTLINSLFLTDLYPE---------------------RIIPGAAE-KIERTVQIE-ASTVEIEER 59  house mouse
P42207  33 GFEFTLMVVGESGLGKSTLVNSLFLTDLYPE---------------------RIIPDAIE-KQKQTVKLE-ASTVEIEER 89  fruit fly
P42209  23 GFDFTLMVAGESGLGKSTLINSLFLTNLYED---------------------RQVPDASA-RTAQTLTIE-RRGVEIEEG 79  house mouse
P28661 142 GFDFTLMVAGESGLGKSTLVNSLFLTDLYRD---------------------RKLLGAEE-RIMQTVEIT-KHAVDIEEK 198 house mouse
P39827  35 GFQFNIMVVGRSGLGKSTLVNTLFSSKLTTS---------------------QGRKSPSE-PIEKTTEIK-VASHSLLEN 91  Candida albicans SC5314
P32468  32 GGTFTVMLCGESGLGKTTFINTLFQTVLKRAd---------------------gQQHRQE-PIRKTVEID-ITRALLEEK 88  Saccharomyces cerevis...
P41901 107 GIDFTLMVAGQSGLGKTTFINSLFSTSLIDD------------------------------DIKENKPII-RYKSIVEGD 155 Saccharomyces cerevis...
Q09883  28 ECGLTIMLCGASGTGKTTFFNTLFATSLQPE---------------------KSYETAKEtIAKKTLEVK-KNKAVIEED 85  Schizosaccharomyces p...
P48010 116 GIDINLIVVGESSLGKTTFVNSFLQSNDTNFr-------------------------P---KK--TMDFVeHKATLSDGD 165 Schizosaccharomyces p...
P48008  50 GIPLNLMVVGDVGLGRTAFINTLCEKPLIRHn--------------------NNFD-PAEaSSVSPVEIVpYQTDIILED 108 Schizosaccharomyces p...

5AR1_A  84 eGVKIQLNIIDTPGFGDSLDN-SPSFEIISDYIRHQYDEILLEESRVRRnPRFKDGRVHCCLYLINPTGHGLKEIDVEFI 162 baker's yeast
P32457 195 -GVKLNLNVIDTEGFGDFLNNdQKSWDPIIKEIDSRFDQYLDAENKINR-HSINDKRIHACLYFIEPTGHYLKPLDLKFM 272 Saccharomyces cerevis...
P40797 197 -GVNLTLTVVDTPGFGDAVDN-SNCWVPILEYVDSKYEEYLTAESRVYR-KTISDSRVHCCLYFIAPSGHGLLPLDIACM 273 fruit fly
3FTQ_D  60 -GVKLRLTVVDTPGYGDAINC-RDCFKTIISYIDEQFERYLHDESGLNR-RHIIDNRVHCCFYFISPFGHGLKPLDVAFM 136 house mouse
P42207  90 -GVKLRLTVVDTPGFGDAIDN-SNSFGAILEYIDEQYERFLRDESGLNR-RNIVDNRIHCCFYFISPFGHGLKPLDVEFM 166 fruit fly
P42209  80 -GIKVKLTLVDTPGFGDSVDC-SDCWLPVVRFIEEQFEQYLRDESGLNR-KNIQDSRVHCCLYFISPFGRGLRPLDVAFL 156 house mouse
P28661 199 -GVRLRLTIVDTPGFGDAVNN-TECWKPVAEYIDQQFEQYFRDESGLNR-KNIQDNRVHCCLYFISPFGHGLRPLDVEFM 275 house mouse
P39827  92 -NVRLNINVIDTPGFGDQINN-EKCWEPLVKYVKEQHSQYLRKELTAQRdKFLADTRVHCILYFIPPNGQKLKQLDVQAL 169 Candida albicans SC5314
P32468  89 -HFELRVNVIDTPGFGDNVNN-NKAWQPLVDFIDDQHDSYMRQEQQPYR-TKKFDLRVHAVLYFIRPTGHGLKPIDIETM 165 Saccharomyces cerevis...
P41901 156 -GTHLNFNVIDTPGFGNNMDN-AFTWRTMVNYIDEEIRSYIFQEEQPDR-TKMVDNRVHCCLYFLRPSNKGIDTLDVVTM 232 Saccharomyces cerevis...
Q09883  86 -GFHINLTVLDTPGFGDFIDN-TSCWNTVAEYLDEQHERYLIHDQNSLR-VPRKDTRVHVCLYFITPVSFGMLPLDVLAM 162 Schizosaccharomyces p...
P48010 166 --QKFNLTIVDTPGFGDKSDN-SNCWRPIATNLLHRLNAYFQNEVKMDReTSEIDSRIHGCLFFINPNGHRLQPLEIYIM 242 Schizosaccharomyces p...
P48008 109 -GTKINLTVLDTPHFGEAIDN-ENNFDIILQYIESQYDNVLEEESRIKRnARFCDDRVHALIYFISPTGHGLRELDIELM 186 Schizosaccharomyces p...

5AR1_A 163 RQLGSLVNIIPVISKSDSLTRDELKLNKKLIMEDIDRWNLPIYNfpFDEDEIS----------DED-YETNMYLRTLLPF 231 baker's yeast
P32457 273 QSVYEKCNLIPVIAKSDILTDEEILSFKKTIMNQLIQSNIELFK--PPIYSND----------DAEnSHLSERLFSSLPY 340 Saccharomyces cerevis...
P40797 274 QSLSDKVNLVPVIAKADTMTPDEVHLFKKQILNEIAQHKIKIYDf-PATLEDA----------AEE-AKTTQNLRSRVPF 341 fruit fly
3FTQ_D 137 KAIHNKVNIVPVIAKADTLTLKERERLKKRILDEIEEHSIKIYHl-PDAESDE----------DEDfKEQTRLLKASIPF 205 house mouse
P42207 167 KKLHSKVNIVPVIAKADCLTKKEILRLKCRIMQEIESHGIKIYPl-PDCDSDE----------DEDyKEQVKQLKEAVPF 235 fruit fly
P42209 157 RAVHEKVNIIPVIGKADALMPRETQALKQKIRDQLKEEEINIYQf-PECDSDE----------DEEfKKQNEEMKENIPF 225 house mouse
P28661 276 KALHQRVNIVPILAKADTLTPPEVDRKKCKIREEIEHFGIKIYQf-PDCDSDE----------DEDfKLQDQALKESIPF 344 house mouse
P39827 170 KKLSEIANVVPIIAKSDSLTLDERSEFKKLLQSEFMKYNFNIYP--YDSEDLY----------EEE-RQLNEDIKSLIPF 236 Candida albicans SC5314
P32468 166 KRLSTRANLIPVIAKADTLTAQELQQFKSRIRQVIEAQEIRIFT--PPLDADSkedaksgsnpDSAaVEHARQLIEAMPF 243 Saccharomyces cerevis...
P41901 233 KKLAKRVNLIPVIAKSDLLTKEELKNFKTQVREIIRVQDIPVCFf-FGDEVLN----------------ATQDIFQKYPF 295 Saccharomyces cerevis...
Q09883 163 KELSTHVNLVPVIAKADTFTTPELTQIKQKIRRILEAQSIDVFH--PSTEYSD-----------YE---TAELLDSSLPY 226 Schizosaccharomyces p...
P48010 243 KKIDQFVNIIPVIGKADTMTSDELNHFKKRVIADMVREKIRYFR----EPHNE------------------KKAKIPIPF 300 Schizosaccharomyces p...
P48008 187 RRLAPRVNIIPAIAKADSLTAQELQTTKEMINADIEYYKIPVYDfpYDIEEDE-----------EAiINLSQQLRATIPF 255 Schizosaccharomyces p...

5AR1_A 232 AIIGSNEVYEMggDVGTIRGRKYPWGILDVEDSSISDFVILRNALLISHLHDLKNYTHEILYERYRTEALSG 303 baker's yeast
P32457 341 AVIGSNDIVENy-SGNQVRGRSYPWGVIEVDNDNHSDFNLLKNLLIKQFMEELKERTSKILYENYRSSKLAK 411 Saccharomyces cerevisiae S288C
P40797 342 AVVGANTIIEQ--DGKKVRGRRYPWGLVEVENLTHCDFIALRNMVIRTHLQDLKDVTNNVHYENYRCRKLSE 411 fruit fly
3FTQ_D 206 SVVGSNQLIEA--KGKKVRGRLYPWGVVEVENPEHNDFLKLRTMLI-THMQDLQEVTQDLHYENFRSERLKR 274 house mouse
P42207 236 AVCGANTLLEV--KGKKVRGRLYPWGVVEVENPDHCDFIKLRTMLI-THMQDLQEVTQEVHYENYRSDRLAK 304 fruit fly
P42209 226 AVVGSCEVVRD--GTRPVRGRRYSWGTVEVENPHHCDFLNLRRMLVQTHLQDLKEVTHDLLYEGYRARCLQS 295 house mouse
P28661 345 AVIGSNTVVEA--RGRRVRGRLYPWGIVEVENPGHCDFVKLRTMLVRTHMQDLKDVTRETHYENYRAQCIQS 414 house mouse
P39827 237 AIAGSETEIEI--NGEMVRGRKTKWGAINIEDVSQCEFVFLRDFLTRTHLQDLIETTALTHYETFRSKQLIA 306 Candida albicans SC5314
P32468 244 AIVGSEKKFDNg-QGTQVVARKYPWGLVEIENDSHCDFRKLRALLLRTYLLDLISTTQEMHYETYRRLRLEG 314 Saccharomyces cerevisiae S288C
P41901 296 SIIASNEYIFNe-KGEKVKGRQYKWGAVDIENEKYCDFKILQKTIFDWNLIDLVESTED-YYEKCRSEMLRT 365 Saccharomyces cerevisiae S288C
Q09883 227 AIISSVNEVCKd-DGEKSQGRRYPWGTSEIYEETHCDFLKLKKLLINRHMLELINTTETNIYERYRREQLTN 297 Schizosaccharomyces pombe 972h-
P48010 301 AIVGAGAPIEH--DGKCIRGRAYPWGLVDIDDPKQSDFCQLRNFLLYTHIEGLKHKTHKLIYDTFRTEKLVA 370 Schizosaccharomyces pombe 972h-
P48008 256 AIVSSDRLIEM--NGQTVRGRAYPWGVVEVDNPRHSDFLALRSALFATHIEDLHNITSNQLYETYRTEKLST 325 Schizosaccharomyces pombe 972h-
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