2I5K


Conserved Protein Domain Family
UDPGP

?
pfam01704: UDPGP (this model, PSSM-Id:396322 is obsolete and has been replaced by 460300)
Click on image for an interactive view with Cn3D
UTP--glucose-1-phosphate uridylyltransferase
This family consists of UTP--glucose-1-phosphate uridylyltransferases, EC:2.7.7.9. Also known as UDP-glucose pyrophosphorylase (UDPGP) and Glucose-1-phosphate uridylyltransferase. UTP--glucose-1-phosphate uridylyltransferase catalyzes the interconversion of MgUTP + glucose-1-phosphate and UDP-glucose + MgPPi. UDP-glucose is an important intermediate in mammalian carbohydrate interconversion involved in various metabolic roles depending on tissue type. In Dictyostelium (slime mold) mutants in this enzyme abort the development cycle. Also within the family is UDP-N-acetylglucosamine or AGX1 and two hypothetical proteins from Borrelia burgdorferi the lyme disease spirochaete.
Statistics
?
PSSM-Id: 396322
Aligned: 79 rows
Threshold Bit Score: 370.3
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
2I5K_A          41 LDSFFTLFRRYLVE-KSsrTTLEwDKIKSPNPDE----VVK-YEIIs--QQPENVSNL----SKLAVLKLNGGLGTSMGC 108 baker's yeast
WP_015424819    19 irtFEAYYQKLVK---GekGLIGeDAIRPPSEKN----LID-YQQI---KHLSRTSIL----KNTVVIKLNGGLGTSMGL 83  Candidatus Cl...
WP_015752000    24 iDLFREYYQQLAS---GhtGKLSeAAIRPLDKANd---LLH-QDDLtaeAGTNGRHTL----DQTVMIKLNGGLGTSMGM 92  Desulfohalobi...
WP_014259044    39 inifkyyYSLLLS---GsqGKMAeADITPISPDD----LKD-YLELd-aYEAAGRKAL----PKVAIIKLNGGLGTSMGL 105 Desulfocurvib...
WP_015773692    36 intFKCYFNQFLY---GaqVKLSdRDVMAVHDDE----LAD-YDAMe-qFKDKGEKAL----GKTAVIKLNGGLGTSMGL 102 Desulfomicrob...
kribb:BBB_0904  35 isQFRHAYHVWASE--KesAWIReDAVEPLHGVRs---FHDvYKTI---DHDKAVHAF----AKTAFLKLNGGLGTSMGL 102 Bifidobacteri...
EJT43938        46 LSLFLHIFQRYILEnTSitHDLDpNEIRLLSAEE----IVE-FEDIq-nEELFDPALI----SKVAILKLDGKNNSIISK 115 Saccharomyces...
NP_997786       45 INNFFKSAMKTSGQ--SsqEKVD-TRMEPVPRDVlgsvTRD-RECL---KEWEKEGLRciaeNKVAVLLLAGGQGTRLGV 117 zebrafish
XP_003974070    47 iMGFFRKAMEMSSN--SknEKMD-TRMEPVPREVlgsvTRD-REGL---KTWEQSGLQciseSKVAVLLLAGGQGTRLGV 119 torafugu
XP_009435025    45 LNFFFQKAIEGFNQ-SShqKNVD-ARMEPVPREVlgsaTRD-QDQL---QAWESEGLFqisqNKVAVLLLAGGQGTRLGV 118 chimpanzee
2I5K_A         109 VGPKSVIEVR----EGNTFLDLSVRQIE------YLNRQYDSDVPLLLMNSFNTDKDTEHLIK--KYSA-NRIRI-RSFN 174 baker's yeast
WP_015424819    84 SKAKSLLPVK----NNLNFLDIISRQVL------TLRSLSGYDVLLLFMNSFNTEADTLKYLE--KYPDlGKQDLpLSFL 151 Candidatus Cl...
WP_015752000    93 PYAKSLLEVK----QGNNFLDVIVMQCN------GCDGQLQYSIPLALMDSFATHQETNDYLQ--QQGIrLGQDV-FTFL 159 Desulfohalobi...
WP_014259044   106 ETAKSLLAIK----AETCFLDVIIEQVE------RLRERYDIPVPLTLMNSFHTHSDSMLAIE--GFDN-GRTRVpLAFI 172 Desulfocurvib...
WP_015773692   103 ESAKSLIPVK----EGLSFLDLILLQAS------TVRTHYGVDFPQVFMNSFKTHMDTM--LKvgDFHN-GTTGIdLAFL 169 Desulfomicrob...
kribb:BBB_0904 103 QCAKSLLPVRrhkaRQMRFLDIILGQVL------TARTRLNVPLPVTFMNSFRTSDDTMKALR--HQRKfKQTDIpLEII 174 Bifidobacteri...
EJT43938       116 ASP--LLEVK----NGKCSLDIIVQQTQ------NLNTKWNSDVPLIFMTSLETESHTTNFLE--KHYSsDEVTW-KTIV 180 Saccharomyces...
NP_997786      118 SFPKGMYDVGl--pSHKTLFQIQAERIRkleqlaEKQHSRKCCIPWYIMTSGRTMDMTKDFFIqhKYFGlKEENV-VFFQ 194 zebrafish
XP_003974070   120 SDPKGMYDVGl--pSHKTLFQIQAERILklqqlaGQKQKTKCCIPWYIMTSGRTMEATEHFFSkhDYFGlDKKDI-IFFQ 196 torafugu
XP_009435025   119 AYPKGMYDVGl--pSRKTLFQIQAERILklqqvaEKYYGNKCIIPWYIMTSGRTMESTKEFFTkhKYFGlKKENV-IFFQ 195 chimpanzee
2I5K_A         175 QSRFPRVYKDSLLPVPTEYds-plDAWYPPGHGDLFESLHVSGELDALIAQGREILFVSNGDN-LGATVDLKILNHMIET 252 baker's yeast
WP_015424819   152 QNKFPRIRQDTLMPYENKEt---kLMWNPPGHGDIYTAL--GDLLDKMIAKDYRYAFVSNADN-LGAVVDTSIPAYMENN 225 Candidatus Cl...
WP_015752000   160 QHKFPKIRQDTLEPATYPEdp--eLEWNPPGHGDIYAALETSGLLNQLLSDGYRYAFVSNSDN-LGAVVDSRLLGAFADS 236 Desulfohalobi...
WP_014259044   173 QHMYPKIMRDTFLPARWPKnp--eLEWNPPGHGDLYTAMVTSKTLKRLEESGFEYAFISNSDN-LGAVMDLKILGYMASE 249 Desulfocurvib...
WP_015773692   170 QHRYPKIMAKDHSPASWPRnp--eLEWNPPGHGDIYTAMITSGILDALLDKGYLYAFISNSDN-LGAIMNRRLLGYMVHH 246 Desulfomicrob...
kribb:BBB_0904 175 QHQEPKIDAATGAPASWPTnp--dLEWCPPGHGDLFSTLWESGLLDTLLEHGFEYLFISNSDN-LGARPSRTLAQYFEDT 251 Bifidobacteri...
EJT43938       181 QSCFPVIDKNRLLPIDLQAnsnkeDLWYPCGTGNLTDTLYFSGELDNLIARGKEFLFVSNVNN-LGATVDLNILSYMVSE 259 Saccharomyces...
NP_997786      195 QGMLPAMDFNGKIILEGKCk----LAMAPDGNGGLYRALGTQNIVKDMETRGISYIHVYCVDNiLVKVADPAFIGFCTLK 270 zebrafish
XP_003974070   197 QGMLPAMDYNGKILLERKGk----VSMAPDGNGGLYRALGRQGVLDDMERRGIELIHVYCVDNiLVKVADPAFIGFCVQK 272 torafugu
XP_009435025   196 QGMLPAMSFDGKIILEEKNk----VSMAPDGNGGLYRALAAQNIVEDMEQRGIWSIHVYCVDNiLVKVADPRFIGFCIQK 271 chimpanzee
2I5K_A         253 GAEYIMELTDKTRADVKGGTLI--SYDGQVRLLEVAQVpKEHIDEFKNIRKFTNFNTNNL---WINLKAVK-RLI-ES-S 324 baker's yeast
WP_015424819   226 NIPFVMEVCLRSQMDKKGGHLCe-DKSGQLLLREIAQCpEEDLPRFQDIDYYKYFNTNNI---WIDLRALEwQMIaNE-G 300 Candidatus Cl...
WP_015752000   237 GTPFMIEVCRRTGADTKGGHLAr-HKDGRLILREIAQCpDEELDAFQDVERFKYFNTNNI---WIDLQQLR-DFIdAH-G 310 Desulfohalobi...
WP_014259044   250 DLPFLMEVAQRTPADKKGGHLCkvKESGRLALREVAQCpDEELAEFQNIEKYAFFNTNSI---WINLKVLE-KVFaYH-G 324 Desulfocurvib...
WP_015773692   247 NLPFLMEVARRTEQDKKGGHLCrlKKNKQLALREVAQCpDNEMESFCDIEKYKFFNTNSI---WIDLRILQ-SVFiSH-R 321 Desulfomicrob...
kribb:BBB_0904 252 GAPFMVEVANRTYADRKGGHIVrdTATGRLILREMSQVhPDDKDAAQDIAKHPYFNTNNI---WVRIDVLR-DMLaEHdG 327 Bifidobacteri...
EJT43938       260 KIDYLVEVVERTANDSNTGVLA--TYKNKLRLVDYDCL------SNESARNCRIVNTNNI---WIDLRSLK-RLV-ES-D 325 Saccharomyces...
NP_997786      271 GADCGAKVVEKTNPTEAVGVVC--KVDGRYQVVEYSEI-TLATAEKRSTDGRLMFNAGNIanhFFTLTFLR-EIVrTHeP 346 zebrafish
XP_003974070   273 GADCGAKVVEKTNPTEAVGVVC--KVDGSYQVVEYSEI-TLATAEKRSADGRLMFNAGNVanhFFTFSFLR-DVVqKHeP 348 torafugu
XP_009435025   272 GADCGAKVVEKTNPTEPVGVVC--RVDGVYQVVEYSEI-SLATAQKRSSDGRLLFNAGNIanhFFTVPFLR-DVVnVYeP 347 chimpanzee
2I5K_A         325 NLEMEI------IPNQ-KTIT-RDGheinVLQLETACGAAIRHF--------DGAHGVVVPR-SRFLPVKTCSD------ 381 baker's yeast
WP_015424819   301 LMLLPL------IVNP-KVVdg-----tpVYQLETAMGSAISVF--------NNSKALVVSR-ERFVPVKKTNE------ 353 Candidatus Cl...
WP_015752000   311 FPQLPI------IVNP-KTVNpRDEnstpVFQIETAMGAAVAAF--------PGALAVQVNR-DRFIPVKKTND------ 368 Desulfohalobi...
WP_014259044   325 MMPLDL------IANH-KTLDpRDPdsppVIQVETAMGSAISAF--------HTAAAVRVPR-TRFAPVKTSND------ 382 Desulfocurvib...
WP_015773692   322 MMPLDL------IINP-KSLDpRDPsspkVFQLETAMGSAITNF--------LNAQAVIVPR-KRFAPVKTTND------ 379 Desulfomicrob...
kribb:BBB_0904 328 VLPLPV------IINN-KTVDpTDPqspaVVQLETAMGAAIGLF--------EGAICVQVDR-MRFLPVKTTND------ 385 Bifidobacteri...
EJT43938       326 GLNLPIrsfdakIIHNnRELE--------CLQFRTQLADCIGCF--------SSAQAMKVAR-SRFLPLTTCRD------ 382 Saccharomyces...
NP_997786      347 QLQHHV------AQKKiPYVNtEGQ----LIKPDKPNGIKMEKFvfdifqfaKKFVVYEVLReDEFSPLKNADSqdgkdn 416 zebrafish
XP_003974070   349 RLQHHV------AQKKiPHVDaSGQ----LISPEKPNGIKMEKFvfdifqfaKKFVVYEVLReDEFSPLKNADSqdgkdt 418 torafugu
XP_009435025   348 QLQHHV------AQKKiPYVDtQGQ----LIKPDKPNGIKMEKFvfdifqfaKKFVVYEVLReDEFSPLKNADSqngkdn 417 chimpanzee
2I5K_A         382 ------LLLVKSDLFRLEHGslkldpsrf--gpnpliklgSHFkkVSGFNARIP-HIP-KIVELDHLTITGNVflgkDVT 451 baker's yeast
WP_015424819   354 ------LLALWSDAYELNEQyqivlkrgve-kapvieldeKYYgkIEDLQKRFSkGIP-SLSECKELKIYGDVsfgeDVI 425 Candidatus Cl...
WP_015752000   369 ------LLAVWSDCYIFTPDcrivpnperrlgtivikldsTYFkkIEQLTERFQhGAP-SLVACSSLTIHGDFafgpNVV 441 Desulfohalobi...
WP_014259044   383 ------LLNVMSDNFILSTDyeivpnpernrspvlvdldpTFYkkVDDFQDRFPeGVP-SLLNCTTFTVRGDVrfkggva 455 Desulfocurvib...
WP_015773692   380 ------LLLVMSDCFVRTERetiipnpdrstpmpsisldeNYFkkIDAFLARFPkNPP-SLLKCDSLVIEGDVrfeeDVr 452 Desulfomicrob...
kribb:BBB_0904 386 ------LFIMRSDRFHLTDSyemedgnyi---fpnvdldpRYYknIEDFNERFPyNVP-SLAAANSVSIKGDWtfgrDVI 455 Bifidobacteri...
EJT43938       383 ------LFLLKSNLYDLDANgtfnlyplkf-gllpsiklgDEFanYETFRIGIP-HIP-DILELDYLDVMGNVffgrRVI 453 Saccharomyces...
NP_997786      417 pttarhALMSLHHRWILNAG--------------------GHF--VDENGTHIP-AIP-SLKDGTDLPIKCEIsplvsyg 472 zebrafish
XP_003974070   419 pttarhALMSLHHRWVLNAG--------------------GHF--IDENGRRVP-AIP-SLKDGTDLPIKCEIsplvsyg 474 torafugu
XP_009435025   418 pttarhALMSLHHCWVLNAG--------------------GHF--IDENGSRLP-AIPrSATNGKSETITADV----NHN 470 chimpanzee
2I5K_A         452 LR 453 baker's yeast
WP_015424819   426 ce 427 Candidatus Cloacimonas acidaminovorans
WP_015752000   442 cr 443 Desulfohalobium retbaense
WP_014259044   456 cr 457 Desulfocurvibacter africanus
WP_015773692   453 cv 454 Desulfomicrobium baculatum
kribb:BBB_0904 456 mf 457 Bifidobacterium bifidum BGN4
EJT43938       454 LR 455 Saccharomyces kudriavzevii IFO 1802
NP_997786      473 ge 474 zebrafish
XP_003974070   475 ge 476 torafugu
XP_009435025   471 LK 472 chimpanzee
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap