Conserved Protein Domain Family
Sema_4C

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cd11258: Sema_4C 
The Sema domain, a protein interacting module, of semaphorin 4C (Sema4C)
Sema4C acts as a Plexin B2 ligand to regulate the development of cerebellar granule cells and to modulate ureteric branching in the developing kidney. The binding of Sema4C to Plexin B2 results the phosphorylation of downstream regulator ErbB-2 and the plexin protein itself. The cytoplasmic region of Sema4C binds a neurite-outgrowth-related protein SFAP75, suggesting that Sema4C may also play a role in neural function. Sema4C belongs to the class 4 transmembrane semaphorin family of proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.
Statistics
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PSSM-Id: 200519
Aligned: 7 rows
Threshold Bit Score: 801.325
Created: 7-Apr-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
plexin bindingputative
Feature 1:plexin binding site [polypeptide binding site]
Evidence:
  • Comment:based on the binding of semaphorin 4A to its receptor Plexin B1

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                      ###                
Q64151         42 VRRFSQTGIQDFLTLTLTEHsGLLYVGAREALFAFSVEAL--ELQGAISWEAPAEKKIECTQKGKSNQTECFNFIRFLQP 119  house mouse
Q9C0C4         42 VRRFSQTGIQDFLTLTLTEPtGLLYVGAREALFAFSMEAL--ELQGAISWEAPVEKKTECIQKGKNNQTECFNFIRFLQP 119  human
NP_001131042   36 VRQSWHSGVSQVMTLTLDENrGALYVGAREVIFSLDLNNIgkELRPPIIWEAPADKKLECAQKGKSNQTECFNYIRFLEQ 115  African clawe...
NP_001100372   42 VRRFSQTGIQDFLTLTLTDRsGLLYVGAREALFAFSVEAL--ELQGVISWEAPAEKKIECTQKGKSNQTECFNFIRFLQP 119  Norway rat
XP_002932614  122 VRQSWRNGVSQVMTLTLDEDrGALYVGAREVIFSLDLSNIgkELRPPIIWQAPADKKAECAQKGKSNQTECFNYIRFLEE 201  western clawe...
NP_001121718   40 MARFRAVGVWNYTMLTLAEHeRVLYVGARENIFALDPNDIsrQLRPQIEWSAPAEKKKECAAKGKNNQTECFNYIRFLQS 119  zebrafish
XP_003227471  580 MRHFSSVGVSNYTTLTLADSdGLLYIGAREAIFALSTSNM--ELQDMILWEAPAEKKTECIQKGKSNQTDCFNYIRLLQP 657  green anole
Feature 1                                                  #                    # ## #            
Q64151        120 YNSSHLYVCGTYAFQPKCTYINMLTFTLdraeFEDGKGKCPYDPAKGHTGLLVDGELYSATLNNFLGTEPVILRYM-GTH 198  house mouse
Q9C0C4        120 YNASHLYVCGTYAFQPKCTYVNMLTFTLehgeFEDGKGKCPYDPAKGHAGLLVDGELYSATLNNFLGTEPIILRNM-GPH 198  human
NP_001131042  116 FNQTHLVTCGTYAFQPKCAYIELSDFTLdaenLEEGKGKVPYDPAKGHTGLILDGALYSATMNNFLGTEPVIQRIV-GQH 194  African clawe...
NP_001100372  120 YNASHLYVCGTYAFQPKCTYINMLTFTLdraeFEDGKGKCPYDPAKGHTGLLVDGELYSATLNNFLGTEPVILRNM-GPH 198  Norway rat
XP_002932614  202 YNQTHLITCGTYAFQPKCAYIALSGFTLdadnLEEGKGKVPYDPAKGYTGLILDGALYSATMNNFLGTEPVIMRIV-GQH 280  western clawe...
NP_001121718  120 YNHTHLYTCGTYAFQPKCTYINADHFTLdsaaLEDGKGKCPYDPAKGHTGLIVDKELYSATLNNFLGTEPVILRNLgQQH 199  zebrafish
XP_003227471  658 YNSSHMYTCGTYAFQPKCAYIDVATFSLdrqsFEDGKGKCPYDPAKGHTGLIVEEELYSATLYNFLGTEPVILRNL-GPQ 736  green anole
Feature 1            #  # #    #                               #                       ##### #    
Q64151        199 HSIKTEYLAFWLNEPHFVGSAFVPESVGSFTGDDDKIYFFFSERAVEYDCYSEQVVARVARVCKGDMGGARTLQKKWTTF 278  house mouse
Q9C0C4        199 HSMKTEYLAFWLNEPHFVGSAYVPESVGSFTGDDDKVYFFFRERAVESDCYAEQVVARVARVCKGDMGGARTLQRKWTTF 278  human
NP_001131042  195 NLMKTEYLASWLNEPNFVSSAHIPESVGSEIGDDDKIYFFFTERALEYDCQSEQVVSRVARICKGDLGGARTLQRKWTSF 274  African clawe...
NP_001100372  199 HPIKTEYLAFWLNEPHFVGSAFVPESVGSFTGDDDKIYFFFSERAVEYDCYSEQVVARVARVCKGDMGGARTLQKKWTTF 278  Norway rat
XP_002932614  281 NIMKTEYLASWLNEPNFVSSAHMPESVGSEIGDDDKIYYFFTERALEYDCSSEQVVSRVARICKGDLGGARTLQRKWTSF 360  western clawe...
NP_001121718  200 YSMKSEYLPAWLNEPNFVGSALVRESRNSKDGDDDKIYFFFSERAVELDCDSDLTVARVARVCKGDLGGTRTLQKKWTTF 279  zebrafish
XP_003227471  737 YSVKTEHLSTWLNEPHFVGSAFVQESKGSDNGDDDKVYFLFSERAVEYDCDIDQVVARVARVCKVTVGGARTLQKRWTTF 816  green anole
Feature 1                                                                                      ## 
Q64151        279 LKARLVCSAPDWKVYFNQLKAVHTLrGASWHNTTFFGVFQARWGd---mDLSAVCEYQLEQIQQVFEGPYKEYSE-QAQK 354  house mouse
Q9C0C4        279 LKARLACSAPNWQLYFNQLQAMHTLqDTSWHNTTFFGVFQAQWGd---mYLSAICEYQLEEIQRVFEGPYKEYHE-EAQK 354  human
NP_001131042  275 LKARLLCSIPELQLNFNLLKSVFKLeAKEWRSTHFYAAFQARWGd---sPVSAICQYSIQDIQKVFDGPYKEYRE-QSQK 350  African clawe...
NP_001100372  279 LKARLVCSAPDWKVYFNQLRAVHTLlGASWHNTTFFAVFQARWGd---mDLSAVCEYQLEHIQQVFEGPFKEYSE-QAQK 354  Norway rat
XP_002932614  361 LKARLLCSIPELQLNFNLLKSVFKLeAEEWRSTQFFAAFQARCLavssrKSLLYVGSQSGLVQLPFADCSKYRSC-ADCI 439  western clawe...
NP_001121718  280 QKARLMCSFPERHITFNNLRAVFTLpGADWRTTSFYGIFHAQWGd---vDVSAVCQYQIGEVKNVFDGPYKEYRE-SSQR 355  zebrafish
XP_003227471  817 LKARLLCSIPEQQLHFTRMQGSFTLnGDHWGDVDVSAVCQYEIL-----DVQKVFDGPYKEYSEIAQKWIRYSDKeIVPR 891  green anole
Feature 1                                          #   #  #                                       
Q64151        355 WARYTDPVPSPRPGSCINNWHRDNGYtSSLELPDNTLNFIKKHPLMEDQVKPRl-----GRPLLVKK--NTNFTHVVADR 427  house mouse
Q9C0C4        355 WDRYTDPVPSPRPGSCINNWHRRHGYtSSLELPDNILNFVKKHPLMEEQVGPRw-----SRPLLVKK--GTNFTHLVADR 427  human
NP_001131042  351 WGRYSDSVPSPRPGSCVTNWHRNHGVySSLELPDNTLNFVKKHPLMDDSVMSTh-----MRPLLVRR--GANFTTIAVQR 423  African clawe...
NP_001100372  355 WARYTDPVPTPRPGSCINNWHRDNGYtSSLELPDNTLNFIKKHPLMEEQVKPRl-----GRPLLVKK--NTNFTHVVADR 427  Norway rat
XP_002932614  440 LARDPYCAWNVNISRCVRADEQHRSV-LLQDIQDSDTSVCEVQNMNAVRYFSKnitigiGTNVVLPCqlSSNLAEPIWTF 518  western clawe...
NP_001121718  356 WGRYTGTVPSPRPGACITNFDRENGYnSSLQLPDATLNFAKKHPLMELRAEAR------PLLLTKGI--NFTRLAVDRVS 427  zebrafish
XP_003227471  892 PGADLSVDPRFRYGASAVQASACHSArSVHHGFQVALNFGRTKVVAKNVTVMV------GTDLVLPCrlTSNLAKALWTF 965  green anole
Feature 1                                                                                        
Q64151        428 v--pGLDGATYTVLFIGTGDGWLLKAVSL---GPWIHMVEELQVFDQEPVESLVLSQS---KKVLFAGSrSQLVQLSLA 498  house mouse
Q9C0C4        428 v--tGLDGATYTVLFIGTGDGWLLKAVSL---GPWVHLIEELQLFDQEPMRSLVLSQS---KKLLFAGSrSQLVQLPVA 498  human
NP_001131042  424 t--lGLDREPYDILFIGTENGWVNKAVSF---GSTVHIIEELQVFDKSYPVHSLALSAr--KSLLFVGSqSGLVQLPFA 495  African clawed...
NP_001100372  428 i--lGLDGATYTVLFIGTGDGWLLKAVSL---GPWIHMVEELQVFDQEPVESLVLSQS---KKVLFAGSrSQLVQLSLA 498  Norway rat
XP_002932614  519 dgqdMGSDQDDSVLFDATLQALVILGVGThhsGSYVCFSEEQGTRLTSENYQLTVVASp--SLILESRApLDGLGLVWM 595  western clawed...
NP_001121718  428 ----SLDQRSYNMLFIGTADGWLQRVVIL---GSEAHVIEEIQLFDRQQPVDSLTISHs--KKYLYIGSrSEVLQLPLA 497  zebrafish
XP_003227471  966 ng-qELPEEQTSVLYDAHLQALIILGVSMr--HGGKYRCVQLEELNELMSENYVVTVVsgsATSLEARApLENLGLVWM 1041 green anole

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