Conserved Protein Domain Family
V-ATPase_V1_A

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TIGR01042: V-ATPase_V1_A 
V-type (H+)-ATPase V1, A subunit
This models eukaryotic vacuolar (H+)-ATPase that is responsible for acidifying cellular compartments. This enzyme shares extensive sequence similarity with archaeal ATP synthase. [Transport and binding proteins, Cations and iron carrying compounds]
Statistics
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PSSM-Id: 273411
Aligned: 16 rows
Threshold Bit Score: 1176.45
Created: 7-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q38676     8 DYGSIKKVSGPVVVADNMGGSAMYELVRVGTGELIGEIIRLEGDTATIQVYEETSGLTVGDGVLRTKQPLSVDLGPGILG 87  Acetabularia acetab...
Q38677     8 DYGSIKKVSGPVVVADNMGGSAMYELVRVGTGELIGEIIRLEGDTATIQVYEETSGLTVGDGVLRTKQPLSVDLGPGILG 87  Acetabularia acetab...
CAB55557  11 DYGVIKKVSGPVVVADKIAGAGCYELVRVGDQNLIGEIIRLEGDTATIQCYEETAGLQVGDIVKRTYSPLAVELGPGLLG 90  Scherffelia dubia
O23654    20 EYGYVRKVSGPVVVADGMAGAAMYELVRVGHDNLIGEIIRLEGDSATIQVYEETAGLTVNDPVLRTHKPLSVELGPGILG 99  thale cress
P13548    20 EYGYVRKVSGPVVVADGMAGAAMYELVRVGRDNLIGEIIRLEGDSATIQVYEETAGLMVNDPVLRTHKPLSVELGPGILG 99  mung bean
Q39442    20 EYGYIRKVSGPVVVADGMNGAAMYELVRVGHDNLIGEIIRLEGDSATIQVYEETGGLTVNDPVLRTHKPLSVELGPGILG 99  Beta vulgaris
AAA61760  15 EYGRVYAVSGPVVSAEAMSGSAMYELVRVGYYELVGEIIRLEGDMATIQVYEETSGVTVGDRVLRTGKPLSVELGPGIMG 94  fruit fly
CAA22076   6 SYGFVYGVSGPVVTAEKMAGSAMYELVRVGHQELVGEIIRLEGDYATIQVYEETSGVTIGDPVLRTGKPLSVELGPGIMG 85  Caenorhabditis elegans
CAA98761  24 EYGAIYSVSGPVVIAENMIGCAMYELVKVGHDNLVGEVIRIDGDKATIQVYEETAGLTVGDPVLRTGKPLSVELGPGLME 103 baker's yeast
CAB51771  24 EYGQIYSVSGPVVVAENMVGCAMYELVKVGHHNLVGEVIRLDGDKATIQVYEETAGVTVGDPVLRTGKPLSVELGPGLME 103 Eremothecium gossypii
Q38676    88 NIFDGIQRPLKAIADVSGDVFIPRGVNVPSLDQTKQWEFRP-SAFKVGDRVTGGDIIGIVPENSLLD-HKVMLLPQAKGT 165 Acetabularia acetab...
Q38677    88 NIFDGIQRPLKAIADVSGDVFIPRGVNVPSLDQTKQWEFHP-SSYRVGDRVTGGDIIGTVPENTLLD-HKVMLIPQAKGT 165 Acetabularia acetab...
CAB55557  91 QIFDGIQRPLKAIAEASGDCFIPRGVSVPSLDRSHMWEFIP-GALRMGDLATGGDIYGLVHENTLLD-HRIMLPPGAKGR 168 Scherffelia dubia
O23654   100 NIFDGIQRPLKTIARISGDVYIPRGVSVPALDKDCLWEFQP-NKFVEGDTITGGDLYATVFENTLMN-HLVALPPDAMGK 177 thale cress
P13548   100 NIFDGIQRPLKTIAKRSGDVYIPRGVSVPALDKDTLWEFQP-KKIGEGDLLTGGDLYATVFENTLMQ-HHIALPPDAMGK 177 mung bean
Q39442   100 NIFDGIQRPLKTIAKRSGDVYIPRGVSVPPLDKDTQWDFQP-KKLGVGDLLTGGDLYAIVDENSLMQ-HHVVLPPDAMGK 177 Beta vulgaris
AAA61760  95 SIFDGIQRPLRDIGVMTNSIYIPKGVNTTALSRSEMWEFNP-LNVRVGSHITGGDLYGVVHENTLVK-QRMIVAPRAKGT 172 fruit fly
CAA22076  86 SIFDGIQRPLKDIADITQSIYIPKGVSTNALSREARWDFVVsKDLRVGGHVTGGDIIGTVDENLLIK-HKILLPPSACGT 164 Caenorhabditis elegans
CAA98761 104 TIYDGIQRPLKAIKEESQSIYIPRGIDTPALDRTIKWQFTPg-KFQVGDHISGGDIYGSVFENSLISsHKILLPPRSRGT 182 baker's yeast
CAB51771 104 TIYDGIQRPLKAIKEQSQSIYIPRGVDAPALSREVKWAFKPg-KLGVGDHISGGDIFGSIFENSLLEdHKILLPPRARGT 182 Eremothecium gossypii
Q38676   166 VTYIAAPGNYTINEKIIEVEFQGAKYEYSMKQSWPVRSPRPVVEKLLADTPLLTGQRVLDSLFPGVRGGTCAIPGAFGCG 245 Acetabularia acetab...
Q38677   166 ITYIAPAGNYNINERIIEVEFQGTKYEYCMKQSWPVRSPRPVVEKLLADTPLLTGQRVLDSLFPGVRGGTCAIPGAFGCG 245 Acetabularia acetab...
CAB55557 169 ISYIAPPGQYTITEKVIELEFQGVKKEYSMMNLWPVRSPRPVAQKLLGSTPLLTGQRVLDAFFPSVLGGTCAIPGAFGCG 248 Scherffelia dubia
O23654   178 ITYIAPAGQYSLKDTVIELEFQGIKKSYTMLQSWPVRTPRPVASKLAADTPLLTGQRVLDALFPSVLGGTCAIPGAFGCG 257 thale cress
P13548   178 ITYIAPPGQYSITDTVLELEFQGVKKKFTMLQTWPVRTPRPVASKLAADTPLLTGQRVLDALFPSVLGGTCAIPGAFGCG 257 mung bean
Q39442   178 ITYIAPAGNYTIQDTVLELEFQGVVKKFTMLQTWPVRTPRPVASKLAADTPLLTGQRVLDALFPSVLGGTCAILGAFGCG 257 Beta vulgaris
AAA61760 173 VRYIAPAGNYNLEDIVLETEFDGEITKHTMLQVWPVRHARPVTEKLPANHPLFTGQRVLDSLFPCVQGGTTAIPGAFGCG 252 fruit fly
CAA22076 165 ITFVAPSGQYTVEDTLLELEFAGRKQKFSMLQIWPVRSPRPVTEKLAANNPLLCGQRVLDALFPCVQGGTTAIPGAFGCG 244 Caenorhabditis elegans
CAA98761 183 ITWIAPAGEYTLDEKILEVEFDGKKSDFTLYHTWPVRVPRPVTEKLSADYPLLTGQRVLDALFPCVQGGTTCIPGAFGCG 262 baker's yeast
CAB51771 183 ITWIAPAGEYTVDETVLEVEFDGKKYSYSMFHTWPVRVPRPVTEKLSADYPLLTGQRVLDSLFPCVQGGTTCIPGAFGCG 262 Eremothecium gossypii
Q38676   246 KTVISQALSKYSNSDGIVYVGCGERGNEMAEVLMDFPQLTMTMpDGREESIMKRTTLVANTSNMPVAAREASIYTGITLS 325 Acetabularia acetab...
Q38677   246 KTVISQALSKYSNSDGIVYVGCGERGNEMAEVLMDFPQLTMTMpDGREESIMKRTTLVANTSNMPVAAREASIYTGITLS 325 Acetabularia acetab...
CAB55557 249 KTVISQALSKFSNSDGIIYVGCGERGNEMAEVLYEFPALTMTMpDGREESIMKRTTLVANTSNMPVAAREASIYTGITLA 328 Scherffelia dubia
O23654   258 KTVISQALSKYSNSDAVVYVGCGERGNEMAEVLMDFPQLTMTLpDGREESVMKRTTLVANTSNMPVAAREASIYTGITIA 337 thale cress
P13548   258 KTVISQALSKYSNSDAVVYVGCGERGNEMAEVLMDFPQLTMTLpDGREESVMKRTTLVANTSNMPVAAREASIYTGITLA 337 mung bean
Q39442   258 KTVISQALSKYSNSDAVVYVGCGERGNEMAEVLMDFPQLTMTLpDGREESVMKRTTLVANTSNMPVAAREASIYTGITIA 337 Beta vulgaris
AAA61760 253 KTVISQALSKYSNSDVIIYVGCGERGNEMSEVLRDFPELTCEI-DGVTESIMKRTALVANTSNMPVAAREASIYTGITLS 331 fruit fly
CAA22076 245 KTVISQSLSKYSNSDAIIYVGCGERGNEMSEVLRDFPELTMEV-EGVTTSIMKRTALVANTSNMPVAAREASIYTGITLA 323 Caenorhabditis elegans
CAA98761 263 KTVISQSLSKYSNSDAIIYVGCGERGNEMAEVLMEFPELYTEM-SGTKEPIMKRTTLVANTSNMPVAAREASIYTGITLA 341 baker's yeast
CAB51771 263 KTVISQSLSKYSNSDAIIYVGCGERGNEMAEVLMEFPELFTEV-NGRKEPIMKRTTLVANTSNMPVAAREASIYTGITLA 341 Eremothecium gossypii
Q38676   326 EYFRDMGYNFAMMADSTSRWAEALREISGRLAEMPADSGYPAYLGARLASFYERSGRVACIGSPEREGSVTIVGAVSPPG 405 Acetabularia acetab...
Q38677   326 EYFRDMGYNFAMMADSTSRWAEALREISGRLAEMPADSGYPAYLGARLASFYERSGRVACIGSPEREGSVTIVGAVSPPG 405 Acetabularia acetab...
CAB55557 329 EYFRDMGYNFSMMADSTSRWAEALREISGRLAEMPADSGYPAYLGARLASFYERSGRVKCLGSPGREGSVTIVGAVSPPG 408 Scherffelia dubia
O23654   338 EYFRDMGYNVSMMADSTSRWAEALREISGRLAEMPADSGYPAYLAARLASFYERAGKVKCLGGPERNGSVTIVGAVSPPG 417 thale cress
P13548   338 EYFRDMGYNVSMMADSTSRWAEALREISGRLAEMPADSGYPAYLAARLASFYERPGKVKCLGGPERTGSVTIVGAVSPPG 417 mung bean
Q39442   338 EYFRDMGYNVSMMADSGSRWAEALREISGRLAEMPADSGYPAYLAARLASFYEAAGKVKCLGGPERNGSVTIVGAVSPPG 417 Beta vulgaris
AAA61760 332 EYFRDMGYNVAMMADSTSRWAEALREISGRLAEMPADSGYPAYLGARLATFYERAGRVKCLGNPEREGSVSIVGAVSPPG 411 fruit fly
CAA22076 324 EYFRDMGLNVAMMADSTSRWAEALREISGRLGEMPADSGYPAYLAARLASFYERAGRVKCLGSPEREGSVTIVGAVSPPG 403 Caenorhabditis elegans
CAA98761 342 EYFRDQGKNVSMIADSSSRWAEALREISGRLGEMPADQGFPAYLGAKLASFYERAGKAVALGSPDRTGSVSIVAAVSPAG 421 baker's yeast
CAB51771 342 EYFRDQGKNVSMIADSSSRWAEALREISGRLGEMPADQGFPAYLGAKLASFYERAGKAVALGSPDRVGSVSIVAAVSPAG 421 Eremothecium gossypii
Q38676   406 GDFSDPVTSATLGIVQVFWGLDKKLAQRKHFPSVNWLISYSKYLNALEPFYEKFDSDFVTLRQVAREVLQKEDELNEIVQ 485 Acetabularia acetab...
Q38677   406 GDFSDPVTSATLGIVQVFWGLDKKLAQRKHFPSVNWLISYSKYLNALEPFYEKFDNDFVDIRQVAREVLQKEDELNEIVQ 485 Acetabularia acetab...
CAB55557 409 GDFSDPVTSATLGIVQVFWGLDKKLAQRKHLPSVNWLISYSKYEKSLEPFYEGFDSEFASIRRKAKDILAKEDGLNEIVQ 488 Scherffelia dubia
O23654   418 GDFSDPVTSATLSIVQVFWGLDKKLAQRKHFPSVNWLISYSKYSTALESFYEKFDPDFINIRTKAREVLQREDDLNEIVQ 497 thale cress
P13548   418 GDFSDPVTSATLSIVQVFWGLDKKLAQRKHFPSVNWLISYSKYSTALESFYEQFDPDFINIRTKAREVLQREDDLNEIVQ 497 mung bean
Q39442   418 GDFSDPVTSATLSIVQVFWGLDKKLAQRKHFPSVNWLISYSKYSGALESFYEKFDSEFIDIRTKAREVLQREDDLNEIVQ 497 Beta vulgaris
AAA61760 412 GDFSDPVTSATLGIVQVFWGLDKKLAQRKHFPSINWLISYSKYMRALDEYYDKNYPEFVPLRTKVKEILQEEEDLSEIVQ 491 fruit fly
CAA22076 404 GDFADPVTSATLGIVQVFWGLDKKLAQRKHFPSINWLISYSEYMRALEEFYEKNYPEFVSLRTKCKEILQEEEDLSEIVQ 483 Caenorhabditis elegans
CAA98761 422 GDFSDPVTTATLGITQVFWGLDKKLAQRKHFPSINTSVSYSKYTNVLNKFYDSNYPEFPVLRDRMKEILSNAEELEQVVQ 501 baker's yeast
CAB51771 422 GDFSDPVTTSTLGITQVFWGLDKKLAQRKHFPSINTSVSYSKYTNVLNKYYDSNYPEFPVLRDRIKEILSNAEELEQVVQ 501 Eremothecium gossypii
Q38676   486 LVGKDALAESDKIILETARFLKEDYLQQNSFTKYDKYCPFYKSVGMMRNIVTFHRLATQAIERTAAgnvDGQKITFNIIK 565 Acetabularia acetab...
Q38677   486 LVGKDALAESDKIILETADFLKEDYLAQNSFTKYDKYCPFYKSVGMMRNIVTFHRLATQAIERTATgnsDGQKLLSNIIK 565 Acetabularia acetab...
CAB55557 489 LVGKDALAESNKIILETARLIKEDYLQQNSFTKYDKYCPFYKAVLMLKNMVLFYDLSNAAVEKTMSs-tDASKITLSIIK 567 Scherffelia dubia
O23654   498 LVGKDALAEGDKITLETAKLLREDYLAQNAFTPYDKFCPFYKSVWMMRNIIHFYNLANQAVERAAGm--DGQKITYTLIK 575 thale cress
P13548   498 LVGKDALAEGDKITLETAKLLREDYLAQNAFTPYDKFCPFYKSVWMMRNIIHFYNLANQAVERGAGs--DGQKITYSLIK 575 mung bean
Q39442   498 LVGKDALAETDKITLDTAKLLREDYLAQNAFTAYDKFCPFYKSVWMMRNIIHFYNLANQAVERGAGs--DGQKITYSLIK 575 Beta vulgaris
AAA61760 492 LVGKASLAETDKVTLEVAKLLKDDFLQQNSYSPYDRVCPFYKTVGMLRNIMAFYETARHCLESTAQ---SDNKITWNTIK 568 fruit fly
CAA22076 484 LVGKASLAESDKVTLEVAKIIKDDFLQQNGYTKYDRFCPFYKTVGMLKNMIGFYDLARHAVEATAQ---SDNKITWNVIK 560 Caenorhabditis elegans
CAA98761 502 LVGKSALSDSDKITLDVATLIKEDFLQQNGYSTYDAFCPIWKTFDMMRAFISYHDEAQKAVANGAN---------WSKLA 572 baker's yeast
CAB51771 502 LVGKSALSDKDKIVLDVATLIKEDFLQQNGYSTYDAFCPIWKTYDMMKAFVSYFDEAQKSVSNGAN---------WAVLS 572 Eremothecium gossypii
Q38676   566 AKLGDLLYKVSSQKFEDPS-DGEGVVTAHLNELNEELK 602 Acetabularia acetabulum
Q38677   566 AKLGDLLYKVSSQKFEDPS-DGESVVTGRLNELNDELK 602 Acetabularia acetabulum
CAB55557 568 NRLGNLMYSLVSMKFEDPA-DGEEVVKGRLVELGNQLR 604 Scherffelia dubia
O23654   576 HRLGDLFYRLVSQKFEDPA-EGEDTLVEKFKklyddln 612 thale cress
P13548   576 HRVGDLFYRLVSQKFEDPA-EGEAALVGQFQKLHEDLS 612 mung bean
Q39442   576 LRLGDLFYRLVSQKFEDPA-EGEDALVAKFKKLNEDLT 612 Beta vulgaris
AAA61760 569 ESMGGIMYQLSSMKFKDPVkDGEQKIKADYDQLYEDLQ 606 fruit fly
CAA22076 561 DSMGDLIYQLSAMKFKDPVaDGEAKIRKDYEDLAEAMA 598 Caenorhabditis elegans
CAA98761 573 DSTGDVKHAVSSSKFFEPS-RGEKEVHGEFEKLLSTMQ 609 baker's yeast
CAB51771 573 EATGDVKHAVSSSKFFEPS-RGEREVHAEFEKLFASIQ 609 Eremothecium gossypii
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