Conserved Protein Domain Family
SAM_Samd9_Samd9L
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cd09528: SAM_Samd9_Samd9L 
SAM domain of Samd9/Samd9L subfamily
SAM (sterile alpha motif) domain of Samd9/Samd9L subfamily is a putative protein-protein interaction domain. SAM is a widespread domain in signaling proteins. Samd9 is a tumor suppressor gene. It is involved in death signaling of malignant glioblastoma. Samd9 suppression blocks cancer cell death induced by HVJ-E or IFN-beta treatment. Deleterious mutations in Samd9 lead to normophosphatemic familial tumoral calcinosis, a cutaneous disorder characterized by cutaneous calcification or ossification.
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Statistics
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PSSM-Id: 188927
Aligned: 7 rows
Threshold Bit Score: 102.494
Created: 12-Mar-2010
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q5K651         12 DDWTKEDVNQWLESHK-IDQKHREILTEQDVNGAVLKWLKKEHLVDMGITHGPAIQIEELFKELR 75   human
XP_001378512   12 DDWTVEDVCQWITEKLkINSKYTEILKKEEVNGKSLKVSDKNDLVDMGIKHGPALQIINSFKELN 76   gray short-tailed opossum
XP_418660      73 EKWTKEEVKQFLIEDVnIDQKYAEILYSQDVTGSTLKLLTKADLVDMSIPHGPAVQIIHFLKKHG 137  chicken
Q69Z37         12 KDWTKEHVRKWVTEDLnIVEKYAQILFKEEVTGMVLQELTEEDLREMGLPRGPALLIKRMYNKLI 76   house mouse
XP_002194798    9 SEWVEDHVKCWLESTG-IKKEYVDKLHEEEVTGPALMELDESFLKDIGMKKGQIQILIHKRNELL 72   zebra finch
XP_002667323   19 RDWAPDHVRQWMIEIK-VDKEEANIVYNQKINGACLLLLKEPNLRELGLSMNAIILIVHNKGLLK 82   zebrafish
Q8IVG5         12 KDWTKEHVKKWVNEDLkINEQYGQILLSEEVTGLVLQELTEKDLVEMGLPWGPALLIKRSYNKLN 76   human
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