Conserved Protein Domain Family
Granin

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pfam01271: Granin 
Granin (chromogranin or secretogranin)
Statistics
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PSSM-Id: 279595
Aligned: 8 rows
Threshold Bit Score: 251.875
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
P05060  26 RNHNEGMVTRCIIEVLSNALSKSSAPPITPECRQVLKTSRKDVKDKETTENENTKFEVRLLRDPADASEAHESSSRGEAG 105 human
P16014  26 RDHNEEMVTRCIIEVLSNALSKSSVPTITPECRQVLKKSGKEVKGEEKGENQNSKFEVRLLRDPADASGTRWASSREDAG 105 house mouse
P23389  26 RNHNEEVVTHCIIEVLSNALLKSSAPPITPECRQVLKKNGKELKNEEKSENENTRFEVRLLRDPADTSEAPGLSSREDSG 105 cattle
P20616  27 AASFQRNQLLQKEPDLRLENVQRFPSPEMIRALEYIEKLRQQAHKEESSPDYNPYQGVSVPLQQKENGD---LPESSRDS 103 cattle
Q03517  27 AASFQRNQLLQKEPDLRLENVQKFPSPEMIRALEYIEKLRQQAHREESSPDYNPYQGVSVPLQLKENGEESHLAESSRDA 106 house mouse
P26339  25 MTKGDTKVMKCVLEVISDSLSKPSPMPVSPECLETLQ-GDERILSILRHQN-----LLKELQDLALQ------------- 85  house mouse
P10645  25 MNKGDTEVMKCIVEVISDTLSKPSPMPVSQECFETLR-GDERILSILRHQN-----LLKELQDLALQ------------- 85  human
P05059  25 MNKGDTEVMKCIVEVISDTLSKPSPMPVSKECFETLR-GDERILSILRHQN-----LLKELQDLALQ------------- 85  cattle
P05060 106 APgEEDIQGPTKADTEKWAEGGGHSRERADEpqwslypsDSQVSEEVKTRHSEKSQREDEEEEEGENYQKG-ERGEDSSE 184 human
P16014 106 AP-VEDSQGQTKVGNEKWTEGGGHSREGVDDqesl-rpsNQQASKEAKIYHSEERVGKEREKEEGKIYPMGeHREDAGEE 183 house mouse
P23389 106 EG---DAQVPTVAD----TESGGHSRERAGEp------pGSQVAKEAKTRYS-KSEGQNREEEMVKYQKRE--RGEVGSE 169 cattle
P20616 104 LSeDEWMKIIAEALRQAENEPQSAPKENKPY--------TLNSEKNFPMDMPDDYETQQWAERKLKHMRFP-PMYEENSR 174 cattle
Q03517 107 LSeDEWMRIILEALRQAENEPPSAPKENKPY--------ALNLEKNFPVDTPDDYETQQWPERKLKHMRFP-LMYEENSR 177 house mouse
P26339  86 ---------------------GAKERAQQPLk------------------------------QQQPPKQQQqQQQQQQQE 114 house mouse
P10645  86 ---------------------GAKERAHQ--------------------------------------------------Q 94  human
P05059  86 ---------------------GAKERTHQ--------------------------------------------------Q 94  cattle
P05060 185 EKHLEEPGETQNAFLNERKQASAIKKEELVARSETHAAgHSQEKTHSREKSSQESGEETGSQEnHPQESKGQPRSQEES- 263 human
P16014 184 KKHIEDSGEKPNTFSNKRSEASAKKKDESVARADAHSM-ELEEKTHSREQSSQESGEETRRQE-KPQELTDQDQSQEESq 261 house mouse
P23389 170 ERLSEGPGKAQTAFLNQRNQ-TPAKKEELVSRYDTQSA-RGLEKSHSRERSSQESGEETKSQEnWPQELQRHPEGQEAP- 246 cattle
P20616 175 DNPFKRTNEIVEEQYTPQNLATLESVFQELGKLTGPNS-QKRERADEEQKLYTDDEDDIYKANnIAYEDVVGGEDWNPV- 252 cattle
Q03517 178 ENPFKRTNEIVEEQYTPQSLATLESVFQELGKLTGPSN-QKRERVDEEQKLYTDDEDDVYKTNnIAYEDVVGGEDWSPI- 255 house mouse
P26339 115 QQHSSFEDELSEVFENQSPDAKHRDAAAEVPSRDTMEK---RKDSDKGQQDGFEATTEGPRPQaFPEPNQESPMMGDSE- 190 house mouse
P10645  95 KKHSGFEDELSEVLENQSSQAELKEAVEEPSSKDVMEK---REDSKEAEKS--GEATDGARPQaLPEPMQESKAEGNNQ- 168 human
P05059  95 KKHSSYEDELSEVLEKPNDQAEPKEVTEEVSSKDAAEK---RDDFKEVEKS--DEDSDGDRPQaSPGLGPGPKVEEDNQ- 168 cattle
P05060 264 -----------EEGEEDATSEVDKRrtRPRHHHGRSRPDRSSQGGSLPSEEKghpqeeseesnvsmaslgekrdhhsthy 332 human
P16014 262 egeegeegeegEEGEEDSASEVTKR--RPRHHHGRSGSNKSSYEGHPLSEERrpspkeskeadvatvrlgekrshhlahy 339 house mouse
P23389 247 -----------GESEEDASPEVDKRhsRPRHHHGRSRPDRSSQEGNPPLEEEshvgtgnsde---------ekarhpahf 306 cattle
P20616 253 -----------EEKIESQTQEEVRDs-KENADKTEQINDEMKRSGQLGLQDE---------------------------- 292 cattle
Q03517 256 -----------EEKIETQTQEEVRDs-KENTEKNEQINEEMKRSGQLGLPDE---------------------------- 295 house mouse
P26339 191 -----------SPGEDTA----TN------TQSPTSLPSQEHVDPQATGDSE---------------------------- 221 house mouse
P10645 169 -----------APGEEEEEEEEATN-----THPPASLPSQKYPGPQAEGDSE---------------------------- 204 human
P05059 169 -----------APGEEEE---APSN-----AHPLASLPSPKYPGPQAKEDSE---------------------------- 201 cattle
P05060 333 rASEEEPEYGEEIKGYPGVQapedlewerYRGRGSEEYRAPRPQSEESWDEEDKRNYPSLELDKMAHGYGEESEEERGLE 412 human
P16014 340 rASEEEPEYGEESRSYRGLQ---------YRGRGSEEDRAPRPRSEESQEREYKRNHPDSELESTANRHGEETEEERSYE 410 house mouse
P23389 307 rALEEGAEYGEEVRRHSAAQapgdlqgarFGGRGRGEHQALRRPSEESLEQENKRHGLSPDLN-MAQGYSEESEEERGPA 385 cattle
P20616 293 -D-LRKESKDQLSDDVSKVItylk-rlvnAAGSGRSQNGQTGERAIRLFEKPLDPQSIYQLIEISRNLQIPPEDLIDMLK 369 cattle
Q03517 296 --ENRRESKDQLSEDASKVItylr-rlvnAVGSGRSQSGPNGDRAARLLQKPLDSQSIYQLIEISRNLQIPPEDLIEMLK 372 house mouse
P26339 222 -------------RGLSAQQq------------ARKAKQEEKEEEEEEEAVAREKAGP-EEVP-TAASSSHFHAGYKAIQ 274 house mouse
P10645 205 -G--LSQGLVDREKGLSAEP-------------GWQAKREE-EEEEEEEAEAGEEAVPEEEGP-TVVLNPHPSLGYKEIR 266 human
P05059 202 -G--PSQGPASREKGLSAEQ-------------GRQTEREE-EEEKWEEAEAREKAVPEEESPPTAAFKPPPSLGNKETQ 264 cattle
P05060 413 PgKGRHHRGRGGEPRAYFMSDTREEKRFLGEGHHRVQEN---QMDKA-RRHPQGAWKELDRNYLNYGEE----GAP---G 481 human
P16014 411 GaNGRQHRGRGREPGAHSALDTREEKRLLDEGHYPVRES---PIDTA-KRYPQSKWQEQEKNYLNYGEE----GDQ---G 479 house mouse
P23389 386 --PGPSYRARGGEAAAYSTLGQTDEKRFLGETHHRVQES---QRDKArRRLPGE-----LRNYLDYGEEk---GEEaarG 452 cattle
P20616 370 --TGEKP---VEPEQELEIPVEPEDISEVDLDHPDLFQNkmlSKNGY-PKAPGHAVAEALSEGLSVEDIlnllGME---S 440 cattle
Q03517 373 --AGEKPNGLVEPEQDLELAVDLDDIPEADLDRPDMFQSkmlSKGGY-PKAPGRGMVEALPDGLSVEDIlnvlGME---N 446 house mouse
P26339 275 KdDGQSDSQAVDGDGKTEASEALPSEGKGELEHSQQEED---GEEAM-VGTPQG--------LFPQGGKg---------- 332 house mouse
P10645 267 KgESRSEALAVDGAGKPGAEEAQDPEGKGEQEHSQQKEE----EEEM-AVVPQG--------LFRGGKSg---------- 323 human
P05059 265 R---AAPGWPEDGAGKMGAEEAKPPEGKGEWAHSRQ------EEEEM-ARAPQV--------LFRGGKSg---------- 316 cattle
P05060 482 KWQQQGDLQDTKENREEARFQDKQYsshhtaekrkrLGELFNPYYDPLQWKSSHFERRDNMNDNFLE--GEEENELTLNE 559 human
P16014 480 RWWQQEEQLGPEESREEVRFPDRQYepypitekrkrLGALFNPYFDPLQWKNSDFEKRGNPDDSFLEdeGEDRNGVTLTE 559 house mouse
P23389 453 KWQPQGDPRDADENREEARLRGKQYaphhi--tekrLGELLNPFYDPSQWKSSRFERKDPMDDSFLE--GEEENGLTLNE 528 cattle
P20616 441 AANPKPPYFPNQYNREKVLSRLPYG-----------PGRSKANQLPKAVWMPDVENRQMAYENLNDK--DQELGEYLARM 507 cattle
Q03517 447 VVNQKSPYFPNQYSQDKALMRLPYG-----------PGKSRANQIPKVAWIPDVESRQAPYENLND----QELGEYLARM 511 house mouse
P26339 333 ---rELEHKQEEEEEEEER--------------------LSREWED-KRWSRMDQLAKELTAEKRLEg----EDDPDRSM 384 house mouse
P10645 324 -----------ELEQEEER--------------------LSKEWEDSKRWSKMDQLAKELTAEKRLEgqEEEEDNRDSSM 372 human
P05059 317 -----------EPEQEEQ---------------------LSKEWEDAKRWSKMDQLAKELTAEKRLEgeEEEEEDPDRSM 364 cattle
P05060 560 KNFFPEYNYDwwekkpfsedvnwGYEKRnlARVPKLDLKRQYDRVAQLDQLLHYRKKSAEFPDFYDSEEPVSTHQEAENE 639 human
P16014 560 KNSFPEYNYDwwerrpfsedvnwGYEKRsfARAPQLDLKRQYDGVAELDQLLHYRKKADEFPDFYDSEEQMGPHQEANDE 639 house mouse
P23389 529 KNFFPEYNYDwwekkpfeedvnwGYEKR--NPVPKLDLKRQYDRVAELDQLLHYRKKSAEFPDFYDSEEQMSPQHTAENE 606 cattle
P20616 508 LVKYPEIMNA-------------NPAKR--VPSQGSTEDDRQDENQIEQALKEHLSQHSSQETDKLASVSKRLPVGTPKS 572 cattle
Q03517 512 LVKYPELLNT-------------NQLKR--VPSPVSSEDDLQEEEQLEQAIKEHLGPGSSQEMERLAKVSKRIPVGSLKN 576 house mouse
P26339 385 KLSFRTR----------------AYGFR----DPGPQLRRGWRPSSREDSVEA----------RSDFEEKKE-------E 427 house mouse
P10645 373 KLSFRAR----------------AYGFR----GPGPQLRRGWRPSSREDSLEAG----LPLQVRGYPEEKKE-------E 421 human
P05059 365 RLSFRAR----------------GYGFR----GPGLQLRRGWRPNSREDSVEAG----LPLQVRGYPEEKKE-------E 413 cattle
P05060 640 KDRADQTvlTEDEKKELENLAAMDLELQKIAEKFS--QRG 677 human
P16014 640 KARADQRvlTAEEKKELENLAAMDLELQKIAEKFS--QRG 677 house mouse
P23389 607 EEKAGQGvlTEEEEKELENLAAMDLELQKIAEKFSgtRRG 646 cattle
P20616 573 DDTPNRP--YLDEDLLVKVLEYLNQEKAEKGREHIakRAM 610 cattle
Q03517 577 EDTPNRQ--YLDEDMLLKVLEYLNQEQAEQGREHLakRAM 614 house mouse
P26339 428 EGSANR----RAEDQELESLSAIEAELEKVAHQLQalRRG 463 house mouse
P10645 422 EGSANR----RPEDQELESLSAIEAELEKVAHQLQalRRG 457 human
P05059 414 EGSANR----RPEDQELESLSAIEAELEKVAHQLEelRRG 449 cattle
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