Conserved Protein Domain Family
RIC3

?
pfam15361: RIC3 
Resistance to inhibitors of cholinesterase homolog 3
RIC3 is a protein associated with nicotinic acetylcholine receptors (nAChRs), neurotransmitter-gated ion channels expressed at the neuromuscular junction and within the central and peripheral nervous systems. It can enhance functional expression of multiple nAChR subtypes. RIC3 promotes functional expression of homomeric alpha-7 and alpha-8 nicotinic acetylcholine receptors at the cell surface.
Statistics
?
PSSM-Id: 464671
Aligned: 26 rows
Threshold Bit Score: 90.1094
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Q0VFF9        18 CVSLLLPRAYIArgk---------------------------paAqegNTGLFQSSGHh--------------------P 50  tropical clawed...
XP_005164520  18 LVFVLFPRLFGGgsrdnqpyeprsnrraagpgpgigagavrnqqQl--QKGAAPQMSHs--------------------V 75 
XP_040028884  18 FTFVAVPRMFGVgtgaketrvdpr--------ytkkagavrgqpV----KPNAPGSSQt--------------------A 65 
XP_005475672  18 FMFVVLPRLYGFgsgta----------------------akdakLdsrYSRKAGPARGqp-----------------inM 58 
7_pfamImport   4 LMFVVLPRLFGVtgggtlkenafdpry--srkagpgpgamrgqpV----SVNAPGPSHg--------------------P 57 
XP_006011409  18 VVVVVVPRILGGgggsgarnsghfq------pnhrmkaglrqnpHl--NPDSGGPNEKa--------------------H 69 
XP_008109170  21 CAFVVMPRMFGGagranrgakaspgr-----hephqhrygrperLl--QSQMKSENSDtk------------------mY 75 
XP_015791142  37 CFAILWPKIFYP--------------------------------Mi--EVALRSPK-----------------------P 59 
EFO25418      38 CFAMLYPSMLHP--------------------------------Li--SSFFRTPPARktvtnrpp------ihpamssP 77 
Q22472        52 CFAMLYPTLFHPm-------------------------------Lm-gFLGRSPPSSPsinqqrppihpamgggsgqrhP 99  Caenorhabditis ...
Q0VFF9        51 KPtdGRPGGAHFPRSHMAEAMSKAKggtgg----------gggggTRPS---LVGQIIPIYGFGILLYILYILFKLSSKG 117 tropical clawed...
XP_005164520  76 ENmqQ-------MKKLMEQELKSDKyk----------------snNNKG---YVFTLMPIYAIGVGLFAAYKFLKIKSAS 129
XP_040028884  66 ENmqQ-------MKKLMEQDLKGDKyk----------------pnSSKG---YVFTLMPLYAVGVGVFAAYKFLKMKSAG 119
XP_005475672  59 NGagQSPENLQQMKKRVEQELKSDKyk----------------ssSNKG---YVFTLMPLYAIGVGVFAAYKFLKIRSTD 119
7_pfamImport  58 ESlqQ-------MKKLMEQELKNDKyk----------------tnNNKG---YVFTLMPLYAIGVGVFAAYKFLKVKQAQ 111
XP_006011409  70 QNmqQQQQQQQAARSAMREDIKSGKvk-----------------gESKG---FAFAIMPLYAIGVAVFAAFKFLKMKSKE 129
XP_008109170  76 QSiqQ-------MRNAMEKELKTERsr-----------------gNGKD---FALTLMPLYALGVGVFAVYKFLKMKAQE 128
XP_015791142  60 RSadNLAMVHPRVRQHVMRDMRYQKqgsvnqpfigassrstigqmKSKEsggIFNLLMPFYTIGLFVVFLYTILKFMSKD 139
EFO25418      78 RS---RPDLHPGMRMAASQPEMTTPp------------------sSSKG---MFAWMLPIYTVGVVAFLIYTLVKSKKKR 133
Q22472       100 GG---GADVHPAMRMAQAQAESQSG--------------------GSKG---MFTWMLPVYTIGVVLFLLYTLFKSKGKK 153 Caenorhabditis ...
Q0VFF9       118 -KStk--------------------------------------------------qEPTTQPVANGNLKRKIT------- 139 tropical clawed...
XP_005164520 130 dSE-------------------------------------------------------AQKAKTARGVKKSEEt------ 148
XP_040028884 120 -DK-------------------------------------------------------AQKEKLTKGAKKSVEa------ 137
XP_005475672 120 dKA--------------------------------------------------------QKDKFAKGAKKSMEa------ 137
7_pfamImport 112 yDQ-------------------------------------------------------GQKDSFVKGAKKSVEa------ 130
XP_006011409 130 eES-------------------------------------------------------SDNEKSKKGKKKTQEt------ 148
XP_008109170 129 eKL-------------------------------------------------------TKNEKNTE--DKTKEt------ 145
XP_015791142 140 dDRfddrfddpdeidedsiendkpivkdfqmdpdyrkfvfseeydehgdnikrkvnSQRLKKRVRNDKQSAAKntvqesi 219
EFO25418     134 rIKrhdysst----------------------------------------esesdeDYNRNDGRTGGIGKR--------- 164
Q22472       154 sKRkkrnyfd----------------------------------------seddddESESETKYGGKFGKK--------- 184 Caenorhabditis ...
Q0VFF9       140 ----DYELSQLQDKLKETEEAMEKII 161 tropical clawed frog
XP_005164520 149 ----ENQLNELEQRLAQTEKMLNSIL 170
XP_040028884 138 ----ENQLNELEQRLAQTERMLNSIL 159
XP_005475672 138 ----ENQLNELEQRLAQTERMLNSIL 159
7_pfamImport 131 ----ENQLNELEQRLAQTEKMLNSIL 152
XP_006011409 149 ----ENQLSELEQRLAQTEKMLNSLL 170
XP_008109170 146 ----EQQLLELEQHLAQTEKMLNSLL 167
XP_015791142 220 dlkkDEQICELKKRLQVTEDAMERIL 245
EFO25418     165 ------KLKGLQERLRQTEMAMEKIL 184
Q22472       185 ------KLEGLQKRLRETESAMSKIL 204 Caenorhabditis elegans
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap