2YBF,1AYZ,1Q34,2AAK,5V0R


Conserved Protein Domain Family
UBCc_UBE2A_2B
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cd23790: UBCc_UBE2A_2B 
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Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain of ubiquitin-conjugating enzymes E2A, E2B and related proteins
The E2A/2B subfamily includes mammalian ubiquitin-conjugating enzymes UBE2A/RAD6A and UBE2B/RAD6B, yeast ubiquitin-conjugating enzyme E2 2 (UBC2/RAD6), plant ubiquitin-conjugating enzyme E2 1-3 (UBC1-3), and similar proteins. They are ubiquitin-conjugating enzymes (EC 2.3.2.23) that accept ubiquitin from the E1 complex and catalyze the covalent attachment to other proteins. Both UBE2A/RAD6A and UBE2B/RAD6B are required for post-replication repair of UV-damaged DNA. In vitro, they catalyze 'Lys-11', as well as 'Lys-48'-linked polyubiquitination. UBE2B might also catalyze 'Lys-63'-linked polyubiquitination. Saccharomyces cerevisiae UBC2 is required for DNA repair, damage-induced mutagenesis, and sporulation.
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Statistics
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PSSM-Id: 467410
Aligned: 76 rows
Threshold Bit Score: 225.85
Created: 10-Aug-2017
Updated: 27-Apr-2023
Structure
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Program:
Drawing:
Aligned Rows:
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active site
Conserved site include 1 residue -Click on image for an interactive view with Cn3D
Feature 1: active site cysteine [active site], 1 residue position
Conserved feature residue pattern:CClick to see conserved feature residue pattern help
Evidence:
  • Comment:forms a thioester with ubiquitin or ubiquitin-like proteins
  • Comment:serves as the point of attachment of ubiquitin prior to transfer to cellular target
  • Citation:PMID 9497353
  • Citation:PMID 9705497
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                        
2YBF_A         3 TPARRRLMRDFKRLQEDpp----vGVSGAPSEn-NIMQWNAVIFGPEGTPFEDGTFKLVIEFSEeYPNKPPTVRFLSKMF 77  human
XP_012647549   4 FSATRRLIRDFKSIRKDpp----nGISASPIGd-DIFKWEAIIIGPQDSPWDGGIFRLEMIFDEeYPNKPPKIKFITSIF 78  Babesia microti...
EKX40268       4 NAATLRLMSDLREMQKDap----eGASAAPLSeeNIFVWTATIFGPADTPWEGGIFSLRMTFCDqYPDKPPKVRFTTKVF 79  Guillardia thet...
KJE92441       8 SAAVLRLLSDYKHVQADpp----eGCSAAPVSedNLFQWNAAVSGPEGTPWEGGIYNMHLAFSDnYPTKPPKIRFVSEMF 83  Capsaspora owcz...
XP_001739461   6 SIALLRLTADLKTMLTDpp----vGISSGPIDesNLYFWQATIAGPENSPFEGGLFELRLTFSDeYPIKPPHVKFISEMF 81  Entamoeba dispa...
GBG31046      98 TASTQRLMTDLREMHNEpp----eGCSAAPANesNLYVWNASIIGPDESPWEGGIYGLRLHFPEqYPSKPPKVRFTCELF 173 Hondaea ferment...
XP_001704561   1 MSVTSRLMREYQKFSKTdi----pGVMALPDQk-DERCWNCIILGPAGTAWENGKLCIRMKFPNeYPIKPPSVHFVTSMY 75  Giardia intesti...
TNJ27452       1 MSATRRLAIEKRQLQMEiasrtmtGINAAPDEg-NAMIWNCVIRGPANSAWAEGFYCLQLRFPQnYPMNPPKAVFITRMY 79  Giardia muris
KAH7826569   423 IESSDPKIIAIRDTPPE-------GITASPVSeeNLFVWDAILVGPSETPWEGGLFPLRLQFPDnYPEKPPSIRFQCEMF 495 Monocercomonoid...
XP_005535931   1 MSASSVLAHEDARLGFE-------HETNHLVErsDLYTWGATIIGPEDSEWENAVLTLKLTFPEqYPEKPPRVRFTCEMF 73  Cyanidioschyzon...

Feature 1                  #                                                         
2YBF_A        78 HPNVYADGSICLDILQNRWSPTYDVSSILTSIQSLLDEPNPnSPANSQAAQLYQeNKREYEKRVSAIV 145 human
XP_012647549  79 HPNIYLDGSICLDILQNEWSPVFNISGILISIQSLLTDPNTrSPANNEAAVLYNtDILEYNKRVISCV 146 Babesia microti strain RI
EKX40268      80 HPNVYQDGTLCLDIIQNKWSPSYTVSSVLTSIQSLLTDPNCgSPANPEAAELFLqDRKAYNKRVRRLT 147 Guillardia theta CCMP2712
KJE92441      84 HPNIYSDGSICLDIIQDKWSPIYTISSILTSIQSLLADPNInSPANPDAASLYSkDIKAYKRRVRQCA 151 Capsaspora owczarzaki ATCC ...
XP_001739461  82 HPNVFKDGRICLDILQDKWSSVYSVSTILLAIQSLLTDPNPnSPANPQASALYTsNRKEYNKLVRACA 149 Entamoeba dispar SAW760
GBG31046     174 HPNVYSDGTLCLDIIQDQWSPIYTTSTILTSIQSLLTDPNPnSPANPEAAKLFVsEPKEYKKRVRRIA 241 Hondaea fermentalgiana
XP_001704561  76 HPNVYTDGSLCLDILQSQWSPCFTILSVLLSIQSLLTDPNPsSPANSDAAHKYNcDIDAYNREVRARM 143 Giardia intestinalis
TNJ27452      80 HPNVYSDGSLCLDLLQSSWSPALTVTNILISIQSLLLDPNPsSPANSDAASVYSnSREKYDERVRKCA 147 Giardia muris
KAH7826569   496 HPNVFQNGQICLDVIQKLWTPIFTVSSILISIQSLLTDPNPsSPANVTAAHLYQtDRKEYNKRVRRCA 563 Monocercomonoides exilis
XP_005535931  74 HPNVYHDGNVCLSLLSENWSAAYSVSSILIAIRSLLTDPNPnSPANPEAAHLFSmDYNDYKRRVRRIA 141 Cyanidioschyzon merolae str...

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