2ZXC


Conserved Protein Domain Family
Ceramidse_alk_C

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pfam17048: Ceramidse_alk_C 
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Neutral/alkaline non-lysosomal ceramidase, C-terminal
This family represents C-terminal domain of a group of neutral/alkaline ceramidases found in both bacteria and eukaryotes. The EC classification is EC:3.5.1.23. The enzyme hydrolyses ceramide to generate sphingosine and fatty acid. The enzyme plays a regulatory role in a variety of physiological events in eukaryotes and also functions as an exotoxin in particular bacteria. This C-terminal tail of the enzyme is highly conserved across all species and may play a role in the interaction of the enzyme with the plasma membranes. The tail is also vital for the stabilization of the enzyme as a whole.
Statistics
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PSSM-Id: 465340
Aligned: 126 rows
Threshold Bit Score: 171.574
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2ZXC_A               479 FVDMAVALRER--LpVEtSAIAPD-LSCcQMNFQTGVVADDPYIGKSFGDVLQQPR-EsYRI--GD-KVTVAFVTGHPKN 551 Pseudom...
OWR41276             562 LRDYTIAAVTGa-ViAP-GPEPQDyVNR-TISLIPSINIDTTPVGANFGDVIQQPPeV-VRp--GD-TVRAQFVGANPRN 634
goetting:GPOL_c46750 522 FDRLARTMAAG--RrSDlGPTPAD-TSGlQPNLLAPVPADTPVRDTTFGAVVASPR-TtYVA--GQ-SVSVSFSGAHPSN 594
goetting:NONO_c29360 526 FDRLARAVAAR--TdLGrGPAPLDwTTGaQPNLLPPVPADTPVAGRAFGDVLTAPK-PsYGR--GE-TVAVEFCGAHPNN 599
WP_025349911         528 FDRLARALAAR--VdLGrGPAPLDwTSGpQPSLLPPVPPDVPVLGRRFGDVLTAPH-PrYQH--GQ-TVTVEFCGTHPDN 601 Nocardi...
CAM02441             521 VAELATAMRDG--RrLPlGPVPPD-LSGsQLSLQPPIVMDVPQPMRAFGDVLTGPR-DsYRA--GE-RVSVVFAGAHPGN 593
EHR49457             513 AAELATALRDG--ReLQpGQPPAD-LSRsQLSLQPPVLLDTPVPGTAFGDVLTQPA-PsYPP--GS-RVSVTFSGAHPGN 585
BAI64297             569 INVVGTSLKNG--TpLGiGDRPNDrRPVa--SLQGKVVYDTPMFGMRYGQVTQQP----QDAiaGReEVTARFAGAHPNN 640
1_pfamImport           1 YTSLVESLILl-pDsVApGPSPADiLNE-QIELLPPPQPDSVPSGKSIGDVIDDVNgI-FPQ--GA-EISVTFYGANPRH 74 
7_pfamImport           1 YTDLIAPLVAGnkDdVDlGPTPDLkPAN-QSRIAPVPHPDKLPPGINFGDVISDVNmT-YTP--GD-TVKVTFHGANPRH 75 
2ZXC_A               552 DLR--T--------EKTFLEVVNigkdgKQTPVTVATDNDWDTQYRWERVg------ISASKATISWSIppGTEPGHYYI 615 Pseudom...
OWR41276             635 DLR--Q--------ESSYVAVERl---eLGHWTTVATDADWETRFYWERVgg---qsSGESRVTVMWTs-sEASNLPHRL 697
goetting:GPOL_c46750 595 RVR--RvpadgsrpTDGYYVIERf---dGGRWITAEDDTEAASELEWKRPdg----qDSASIVTITWRIpqGAA-GRHRI 664
goetting:NONO_c29360 600 DFH--T--------GATYFEVERa---dGDRWITGYDDNDWCTELHWSRPpg----qDSASIIAVHWTIpgDADAGRYRI 662
WP_025349911         602 DFR--T--------GGTYFEIQQg---dG---GRVFDDNDWCTELHWSRPdg----qPAASIIRIHWTIpdTMGPGRYRI 661 Nocardi...
CAM02441             594 DLH--R--------RGTYLQVQRd---eGGRWRTVADDGDWSTRLHWERDg------IAASKVTITWDVpgDVGPGGYRI 654
EHR49457             586 DPH--R--------GETFVEVQRr---dAQGWHTVADDGDWSTTLRVARKg------PTASEVVVTWEVp-RAAEGTHRI 645
BAI64297             641 NMH--H--------DGSYFVIERr---vGNTWKYYTADNNPDTFFEWKRIg------VSASQVTVRWKVpaNTPKGQYRI 701
1_pfamImport          75 NMK--L--------GATYLAVQQltn--dtQWTDVFVDTDWETRFLWKEAtnelnslFKYHHVTVIWNVplDQPSGTYRI 142
7_pfamImport          76 NMKvrL--------GSTYLEIQRdeh---gsWTTIYTDADWSTKFTWLETnssappaDITIYVIIEWNIptDETAGSYRV 144
2ZXC_A               616 RHYGNAKnfWT-QK--ISEIGGSTRSFEV 641 Pseudomonas aeruginosa
OWR41276             698 TYYGAARg--EgDI--ITPFTGVSNSFMI 722
goetting:GPOL_c46750 665 RYFGDVKs-TT-GR--LRPIVGVSPSFEV 689
goetting:NONO_c29360 663 RYHGDRRdgAS-----TTAFTGATTEFQV 686
WP_025349911         662 RYSGTCRd-AT-GA--LSTFTTRSPEFDI 686 Nocardia nova
CAM02441             655 RYHGHARh-LT-GA--ISAFTGTTRTFTV 679
EHR49457             646 RYHGDARd-AL-GR--VRSFTGTSSEFEV 670
BAI64297             702 RYYGNAKk----NSktITPFEGQTRVFQV 726
1_pfamImport         143 VYYGDTLtlLGq----RKPFQGQSSEFKV 167
7_pfamImport         145 LYHGDHMneVGt----ITPFTGMSREFQV 169
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